2. Introduction
Dengue fever also known as break bone fever .
Is an infection tropical disease caused by the dengue virus.
Dengue is endemic in more then 110 countries .
It infects 50-100 million people world wide a year, leading to half a million
hospitalization and approximately 12500-25000 death .
Dengue has become a global problem since the second world war and is endemic
in more then 110 countries.
Dengue fever virus (DENV) is an (RNA) virus of the family Flaviviridae , Genus
flavivirus
There are four type of virus , which are called SEROTYPES .
3. transmission
Dengue is transmitted by several species of mosquito with in the genus added and principally A. aegypti.
An infection can be acquired via a single bite .
A female mosquito that takes a blood meal from a person infected with dengue fever becomes it self
infected with the virus the cells lining(endothelial cells)its guts.
About 8-10 days in later, the virus spreads to other tissue including the mosquito salivary gland and
subsequently released in its saliva.
4. mechanism
When a mosquito carrying dengue virus bites a person.
The virus enter the skin together with the mosquitos saliva.
In severe infection , the virus production inside the body is greatly increased and many more
organs.(such as the liver and the bone marrow) can be affected.
5.
6.
7. Sign and symptoms
Asymptomatic or mild symptoms such as an uncomplicated fever (80%)
More severe illness (5%)
In small proportion it is life threating
The incubation period(time between exposure and on set of symptoms ) ranges from 3-14 days but most
often it is 4-7 days.
Headache
Sudden on set fever .
Muscle and joint pains, and a rash
Dengue haemorrhagic fever
Resulting in bleeding ,low levels of blood platelets.
Dengue shock syndrome (low BP).
12. prevention
Reducing open collection of water through environmental modification.
People can prevent mosquito bites by wearing clothing that fully covers skin.