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CASE REPORT


                   LIPOMA AT THE FLOOR OF MOUTH
                                Naheed Akhtar Jadoon and Kamran Iqbal
                                Gomal Medical College, D.I.Khan, Pakistan

ABSTRACT
      Lipomas mostly develop in the subcutaneous tissues but deeper tissues may be involved as well; the
oral cavity is not commonly affected. The overall incidence in the oral cavity is thought to be between 1%
and 4.4% of all benign intraoral lesions. The present report shows a 60 years old male who presented with
large intraoral mass on the floor of the tongue. Excision biopsy was performed and the histological report
proved to be a lipoma.

INTRODUCTION
       The peak incidence of lipomas is in the
fifth or sixth decades of life while it is uncom-
mon in children. Mostly lipomas develop in the
subcutaneous tissues but deeper tissues may
be involved as well; the oral cavity is not com-
monly affected. 1 The overall incidence in the
oralcavity is between 1% and 4.4% of all benignoral
lesions. 2,3 Oral lipomas can occur in various
anatomic sites including the major salivary
glands, buccal mucosa, lip, tongue, palate, vesti-
bule, and floor of mouth.4,5 Although benign in
nature, their continuous growth may cause inter-
ference with speech and mastication due to tu-           Fig. 2: Swelling in the floor of mouth after exci-
mors’ dimension. Some studies showed a female                    sion.
preponderance while others did not found gender
preference.4,6
                                                         DISCUSSION
CASE REPORT                                                     Mostly lipomas develop in the subcutane-
      A 60 years old patient came to OPD with a          ous tissues rarely they develop in the deep tis-
cystic swelling in the floor of mouth approximately      sues. The most commonly involved sites are trunk
5 cm in size. (Fig.1) A longitudinal incision was        and the lower limbs and seldom the oral and max-
given over the tumor. Blunt dissection was used          illofacial region.1,6 The occurrence is higher in fe-
through out and the lesion literally popped out          males than males with the ratio 2:1 but oral are
from the surrounding.                                    more common in men than women or have no
                                                         gender predilection. 7 Lipomas may develop in
                                                         patients over 40 years old, the buccal mucosa and
                                                         vestibule are the most commonly involved intra-
                                                         oral sites. Superficial lipomas in oral and maxillo-
                                                         facial region sometimes can be clinically diag-
                                                         nosed. Palpation reveals a soft, painless, and
                                                         mobile mass, which gradually enlarges over the
                                                         course of several months or years. Usually, deep
                                                         lipomas are not palpable. It is difficult to distin-
                                                         guish between the mass and the adjacent tissues,
                                                         especially when the mass is adherent to muscles
                                                         and salivary glands. Hence, the imaging examina-
                                                         tion may be necessary. There are many imaging
                                                         techniques that could be used to identify soft tis-
                                                         sue masses, such as computerized tomography
Fig. 1: Picture showing swelling on the floor of         (CT), magnetic resonance imaging (MRI) and ul-
        the mouth.                                       trasonography. Ultrasonography is suitable for

Gomal Journal of Medical Sciences January-June 2012, Vol. 10, No. 1                                       158
evaluation of superficial structures, like oral and         4.    Jablokow VR and Bavafa S. Lipomas of the
maxillofacial region when the mass is difficult to                Tongue—report of two cases. J Surg Oncol
identify on ultrasonogram, CT or MRI is neces-                    1982; 21: 114-6.
sary. Lipoma has a characteristic radiographic              5.    Fasig JH, Robinson RA, McCulloch TM, Fletcher
appearance. On CT scan it shows a high density                    MS, Miller CK. Spindle cell lipoma of the
from 83 to 143 Haunsfield units with well or poorly               parotid: fine-needle aspiration and histologic
defined margins depending on the capsule. De-                     findings. Arch Pathol Lab Med 2001; 125:
spite the close histological similarity to normal                 820-1.
adipose tissue, lipomas usually have chromosomal            6.    Epivatianos A, Markopoulos AK, Papanayotou
aberrations such as translocations involving 12q13-               P Benign tumors of adipose tissue of the oral
                                                                   .
15, locus interstitial deletions of 13q, and rear-                cavity: a clinicopathologic study of 13 cases. J
rangements involving 8q11-13 locus.8 The clinical                 Oral Maxillofac Surg 2000; 58: 1113-7.
differential diagnosis includes ranula, dermoid
                                                            7.    MacGregor AJ and Dyson DP Oral lipoma. A
                                                                                                  .
cyst, thyroglossal duct cyst, ectopic thyroid tis-                review of the literature and report of twelve new
sue, pleomorphic adenoma and mucoepidermoid                       cases. Oral Surg Oral Med Oral Pathol 1966;
carcinoma, angiolipoma, fibrolipoma and malig-                    21: 770-7.
nant lymphoma.9-11 A histopathologic differential
diagnosis appropriate to the oral cavity would in-          8.    Enzinger FW and Weiss SW. Soft tissue tumors.
                                                                  4th ed. St. Louis: Mosby 2001.
clude fibrosarcoma if spindle cells are not local-
ized and numerous.12 Other lesions should be also           9.    Del Castillo Pardo de Vera JL, CebrianCarretero
considered: they include schwanoma, myxoid-                       JL, Gomez Garcia E. Chronic lingual ulceration
neurofibroma, leiomyoma, nodular fasciitis, myxo-                 caused by lipoma of the oral cavity. Case report.
lipoma, fibrolipoma, malignant fibrous histiocy-                  Med Oral 2004; 9: 166-7.
toma, myxoidliposarcoma, and myxoid solitary                10.   Capodiferro S, Scully C, Maiorano E, Lo Muzio
fibrous tumor.                                                    L, Favia G. Liposarcoma circumscriptum (li-
                                                                  poma-like) of the tongue: report of a case. Oral
      The prognosis of this tumor is always                       Dis 2004; 10: 398-400.
good. In adults, the recurrence is rare after
complete resection; nonetheless, Cao reported re-           11.   Piattelli A, Rubini C, Fioroni M, Iezzi G. Spindle-
currence in patients under 18 years age and de-                   cell lipoma of the cheek: a case report. Oral
velopment of liposarcoma after several recur-                     Oncol 2000; 36: 495-6.
rences. Long-term follow-up is necessary in pa-             12.   Tosios K, Papanicolaou SI, Kapranos N,
tients under 18 years old.13 Complete resection                   Papadogeorgakis N. Spindle cell lipoma of the
should be emphasized during the first surgical                    oral cavity. Int J Oral Maxillofac Surg 1995; 24:
operation, which is the key factor in order to avoid              363-4.
recurrence.14 Well encapsulated lipomas, as the             13.   Zhong LP, Zhao SF, Chen GF, Ping FY.
present case, easily shell out with no possibility of             Ultrasonographic appearance of lipoma in the
recurrence or damage to the surrounding struc-                    oral and maxillofacial region. Oral Surg Oral Med
tures.                                                            Oral Pathol Oral Radiol Endod 2004; 98:
                                                                  738-40.
REFERENCES
                                                            14.   Furlong MA, Fanburg-Smith JC, Childers EL. Li-
1.   Dattilo DJ, Ige JT, Nwana EJ. Intraoral lipoma of            poma of the oral and maxillofacial region: site
     the tongue and submandibular space: Report                   and subclassification of 125 cases. Oral Surg.
     of a Case. J Oral MaxillofacSurg 1996; 54:                   Oral Med Oral Pathol Oral Radiol Endod 2004;
     915-7.                                                       98: 441-50.
2.   Fregnani ER, Pires FR, Falzoni R, Lopes MA,
     Vargas PA. Lipomas of the oral cavity: clinical
     findings, histological classification and prolifera-
     tive activity of 46 cases. Int J Oral Maxillofac       Corresponding author:
     Surg 2003; 32: 49-53.
                                                            Naheed Akhtar Jadoon
3.   Lombardi T, Odell EW. Spindle cell lipoma of the
     oral cavity: report of a case. J Oral Pathol Med       Gomal Medical College
     1994; 23: 237-9.                                       D.I.Khan, Pakistan




Gomal Journal of Medical Sciences January-June 2012, Vol. 10, No. 1                                             159

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lipoma at floor of mouth

  • 1. CASE REPORT LIPOMA AT THE FLOOR OF MOUTH Naheed Akhtar Jadoon and Kamran Iqbal Gomal Medical College, D.I.Khan, Pakistan ABSTRACT Lipomas mostly develop in the subcutaneous tissues but deeper tissues may be involved as well; the oral cavity is not commonly affected. The overall incidence in the oral cavity is thought to be between 1% and 4.4% of all benign intraoral lesions. The present report shows a 60 years old male who presented with large intraoral mass on the floor of the tongue. Excision biopsy was performed and the histological report proved to be a lipoma. INTRODUCTION The peak incidence of lipomas is in the fifth or sixth decades of life while it is uncom- mon in children. Mostly lipomas develop in the subcutaneous tissues but deeper tissues may be involved as well; the oral cavity is not com- monly affected. 1 The overall incidence in the oralcavity is between 1% and 4.4% of all benignoral lesions. 2,3 Oral lipomas can occur in various anatomic sites including the major salivary glands, buccal mucosa, lip, tongue, palate, vesti- bule, and floor of mouth.4,5 Although benign in nature, their continuous growth may cause inter- ference with speech and mastication due to tu- Fig. 2: Swelling in the floor of mouth after exci- mors’ dimension. Some studies showed a female sion. preponderance while others did not found gender preference.4,6 DISCUSSION CASE REPORT Mostly lipomas develop in the subcutane- A 60 years old patient came to OPD with a ous tissues rarely they develop in the deep tis- cystic swelling in the floor of mouth approximately sues. The most commonly involved sites are trunk 5 cm in size. (Fig.1) A longitudinal incision was and the lower limbs and seldom the oral and max- given over the tumor. Blunt dissection was used illofacial region.1,6 The occurrence is higher in fe- through out and the lesion literally popped out males than males with the ratio 2:1 but oral are from the surrounding. more common in men than women or have no gender predilection. 7 Lipomas may develop in patients over 40 years old, the buccal mucosa and vestibule are the most commonly involved intra- oral sites. Superficial lipomas in oral and maxillo- facial region sometimes can be clinically diag- nosed. Palpation reveals a soft, painless, and mobile mass, which gradually enlarges over the course of several months or years. Usually, deep lipomas are not palpable. It is difficult to distin- guish between the mass and the adjacent tissues, especially when the mass is adherent to muscles and salivary glands. Hence, the imaging examina- tion may be necessary. There are many imaging techniques that could be used to identify soft tis- sue masses, such as computerized tomography Fig. 1: Picture showing swelling on the floor of (CT), magnetic resonance imaging (MRI) and ul- the mouth. trasonography. Ultrasonography is suitable for Gomal Journal of Medical Sciences January-June 2012, Vol. 10, No. 1 158
  • 2. evaluation of superficial structures, like oral and 4. Jablokow VR and Bavafa S. Lipomas of the maxillofacial region when the mass is difficult to Tongue—report of two cases. J Surg Oncol identify on ultrasonogram, CT or MRI is neces- 1982; 21: 114-6. sary. Lipoma has a characteristic radiographic 5. Fasig JH, Robinson RA, McCulloch TM, Fletcher appearance. On CT scan it shows a high density MS, Miller CK. Spindle cell lipoma of the from 83 to 143 Haunsfield units with well or poorly parotid: fine-needle aspiration and histologic defined margins depending on the capsule. De- findings. Arch Pathol Lab Med 2001; 125: spite the close histological similarity to normal 820-1. adipose tissue, lipomas usually have chromosomal 6. Epivatianos A, Markopoulos AK, Papanayotou aberrations such as translocations involving 12q13- P Benign tumors of adipose tissue of the oral . 15, locus interstitial deletions of 13q, and rear- cavity: a clinicopathologic study of 13 cases. J rangements involving 8q11-13 locus.8 The clinical Oral Maxillofac Surg 2000; 58: 1113-7. differential diagnosis includes ranula, dermoid 7. MacGregor AJ and Dyson DP Oral lipoma. A . cyst, thyroglossal duct cyst, ectopic thyroid tis- review of the literature and report of twelve new sue, pleomorphic adenoma and mucoepidermoid cases. Oral Surg Oral Med Oral Pathol 1966; carcinoma, angiolipoma, fibrolipoma and malig- 21: 770-7. nant lymphoma.9-11 A histopathologic differential diagnosis appropriate to the oral cavity would in- 8. Enzinger FW and Weiss SW. Soft tissue tumors. 4th ed. St. Louis: Mosby 2001. clude fibrosarcoma if spindle cells are not local- ized and numerous.12 Other lesions should be also 9. Del Castillo Pardo de Vera JL, CebrianCarretero considered: they include schwanoma, myxoid- JL, Gomez Garcia E. Chronic lingual ulceration neurofibroma, leiomyoma, nodular fasciitis, myxo- caused by lipoma of the oral cavity. Case report. lipoma, fibrolipoma, malignant fibrous histiocy- Med Oral 2004; 9: 166-7. toma, myxoidliposarcoma, and myxoid solitary 10. Capodiferro S, Scully C, Maiorano E, Lo Muzio fibrous tumor. L, Favia G. Liposarcoma circumscriptum (li- poma-like) of the tongue: report of a case. Oral The prognosis of this tumor is always Dis 2004; 10: 398-400. good. In adults, the recurrence is rare after complete resection; nonetheless, Cao reported re- 11. Piattelli A, Rubini C, Fioroni M, Iezzi G. Spindle- currence in patients under 18 years age and de- cell lipoma of the cheek: a case report. Oral velopment of liposarcoma after several recur- Oncol 2000; 36: 495-6. rences. Long-term follow-up is necessary in pa- 12. Tosios K, Papanicolaou SI, Kapranos N, tients under 18 years old.13 Complete resection Papadogeorgakis N. Spindle cell lipoma of the should be emphasized during the first surgical oral cavity. Int J Oral Maxillofac Surg 1995; 24: operation, which is the key factor in order to avoid 363-4. recurrence.14 Well encapsulated lipomas, as the 13. Zhong LP, Zhao SF, Chen GF, Ping FY. present case, easily shell out with no possibility of Ultrasonographic appearance of lipoma in the recurrence or damage to the surrounding struc- oral and maxillofacial region. Oral Surg Oral Med tures. Oral Pathol Oral Radiol Endod 2004; 98: 738-40. REFERENCES 14. Furlong MA, Fanburg-Smith JC, Childers EL. Li- 1. Dattilo DJ, Ige JT, Nwana EJ. Intraoral lipoma of poma of the oral and maxillofacial region: site the tongue and submandibular space: Report and subclassification of 125 cases. Oral Surg. of a Case. J Oral MaxillofacSurg 1996; 54: Oral Med Oral Pathol Oral Radiol Endod 2004; 915-7. 98: 441-50. 2. Fregnani ER, Pires FR, Falzoni R, Lopes MA, Vargas PA. Lipomas of the oral cavity: clinical findings, histological classification and prolifera- tive activity of 46 cases. Int J Oral Maxillofac Corresponding author: Surg 2003; 32: 49-53. Naheed Akhtar Jadoon 3. Lombardi T, Odell EW. Spindle cell lipoma of the oral cavity: report of a case. J Oral Pathol Med Gomal Medical College 1994; 23: 237-9. D.I.Khan, Pakistan Gomal Journal of Medical Sciences January-June 2012, Vol. 10, No. 1 159