SlideShare a Scribd company logo
1 of 38
Download to read offline
MECHANICAL VENTILATION
ESSENTIALS
HANDBOOK
Josh Cosa
MA RRT-ACCS RRT-NPS RCP
Table of contents
How to survive your first night on call
Mechanical ventilation 4
AC versus SIMV 5
Volume versus pressure 6
Parameters 7
Initial values 8
Assessing ventilation 9
Assessing oxygenation 10
PIP and plateau pressure monitoring 11
Mechanical ventilation of patients with obstructive airway disease
Airway disease versus alveolar disease 13
PIP monitoring 14
Flow monitoring 15
PEEP monitoring 16
Mechanical ventilation of patients with restrictive airway disease
Introduction to ARDS 18
Low tidal volume strategy 19
High respiratory rate strategy 20
Optimal PEEP strategy 21
Goals of lung protective modes 22
Pressure control 23
Bilevel mode 24
APRV mode 25
Assessing for extubation
Screening before weaning 27
Weaning using the SIMV strategy 28
Weaning using the SBT method 29
Weaning parameters 30
Tracheostomy 31
Weaning after prolonged mechanical ventilation 32
Managing patients with special considerations
Upper airway swelling 34
Neuromuscular weakness 35
Appendix
Reference list 37
www.medmastery.com
Chapter 1
HOW TO SURVIVE
YOUR FIRST NIGHT ON CALL
Become an expert by learning the most important clinical skills at www.medmastery.com.
4
Become an expert by learning the most important clinical skills at www.medmastery.com.
All
Full respiratory support
OR
What is mechanical
ventilation?
Mechanical ventilation
Ventilate
Oxygenate
CO2
CO2
CO2
CO2 CO2
CO2
CO2
CO2
Ventilation Oxygenation
O2
Itā€˜s not
that simple
Mode
Some
Partial respiratory support
Become an expert by learning the most important clinical skills at www.medmastery.com.
5
Become an expert by learning the most important clinical skills at www.medmastery.com.
AC versus SIMV
AC mode
SIMV mode
Reduce the work
of breathing
Respiratory rate (RR) = 15 breaths/min
Tidal volume (VT
) = 500 mL
Tidal
volume
(mL)
Tidal
volume
(mL)
i
n
s
p
i
r
a
t
o
r
y
i
n
s
p
i
r
a
t
o
r
y
e
x
p
i
r
a
t
o
r
y
e
x
p
i
r
a
t
o
r
y
Time (sec)
Time (sec)
500
500
1
1
3
3
5
5
2
2
4
4
6
6
Ideal for muscle recovery
Ventilator does work
Patient responsible for breath
Hypoventilation
AC SIMV
Which initial mode
of ventilation
should I use?
Reference:
Esteban A, Ferguson ND, Meade MO, et al. Evolution of
mechanical ventilation in response to clinical research.
Am J Respir Crit Care Med. 2008. 177: 170ā€“177.
Become an expert by learning the most important clinical skills at www.medmastery.com.
6
Become an expert by learning the most important clinical skills at www.medmastery.com.
RR = 14 breaths/min
VT
= 600 mL
Minute ventilation
= 0.6 L x 14 breaths/min
= 8.4 L/min
We can calculate minute ventilation
to ensure enough CO2
is exhaled.
RR = 14 breaths/min
VT
= ?
Minute ventilation
= VT
x 14 breaths/min
= ?
We canā€˜t calculate minute
ventilation without VT
!
Volume versus pressure
Why volume ventilation
and not pressure
ventilation?
Pressure
Note
Some people will still beneļ¬t from pressure,
but more will beneļ¬t from volume ventilation.
Volume
Minute ventilation
VT
x RR
Key:
amount of
CO2
exhaled
Become an expert by learning the most important clinical skills at www.medmastery.com.
7
Become an expert by learning the most important clinical skills at www.medmastery.com.
1. Tidal volume (VT
) 2. Respiratory rate (RR)
3. PEEP 4. FiO2
5. Flow
Which settings are
available for my
patient?
Parameters
Parameters
1. Tidal volume (VT
)
2. Respiratory rate (RR)
3. PEEP
4. FiO2
5. Flow
L or mL
breaths/min
cmH2
O
%
L/min
Become an expert by learning the most important clinical skills at www.medmastery.com.
8
Become an expert by learning the most important clinical skills at www.medmastery.com.
What are the initial
values for each
parameter?
Initial values
Parameters
1. VT
2. RR
3. PEEP
4. FiO2
5. Flow
Initial values
6ā€”8 mL/kg
10ā€”20 breaths/min
0ā€”5 cmH2
O
100%
40ā€”60 L/min
1. Tidal volume (VT
)
2. Respiratory rate (RR)
5. Flow
3. PEEP
4. FiO2
Use ideal body weight based on gender
and height, not actual weight.
6ā€“8 mL/kg
10ā€”20 breaths/min
40ā€”60 L/min
0ā€”5 cmH2
O
100%
65 kg
6ā€”8 mL/kg
10ā€”20 breaths/min
0ā€”5 cmH2
O
100%
40ā€”60 L/min
x = 390 mL ā‰ˆ 400 mL
15 breaths/min
5 cmH2
O
100%
60 L/min
Become an expert by learning the most important clinical skills at www.medmastery.com.
9
Become an expert by learning the most important clinical skills at www.medmastery.com.
Minute ventilation
= 400 mL x 15 breaths/min
= 6 L/min
How do I assess for
adequate ventilation?
Assessing ventilation
65 kg
400 mL
15 breaths/min
5 cmH2
O
100%
60 L/min
400 mL
15 breaths/min
5 cmH2
O
100%
60 L/min
VT
RR
PEEP
FiO2
Flow
VT
RR
PEEP
FiO2
Flow
Initial settings
Initial settings Ventilation = Removal of CO2
Is this adequate
removal of CO2
?
Check PaCO2
on ABG
ABG results (PaCO2
)
35ā€“45 mmHg
<35 mmHg
>45 mmHg
Interpretation
Acceptable range
Hyperventilating
Hypoventilating
Recommendation
Maintain settings
Decrease minute ventilation (VT
or RR)
Increase minute ventilation (Vt
or RR)
Become an expert by learning the most important clinical skills at www.medmastery.com.
10
Become an expert by learning the most important clinical skills at www.medmastery.com.
How do I assess for
adequate oxygenation?
Assessing oxygenation
400 mL
15 breaths/min
5 cmH2
O
100%
60 L/min
VT
RR
PEEP
FiO2
Flow
Initial settings
ABG results (PaO2
)
80ā€“100 mmHg
<80 mmHg
>100 mmHg
Interpretation
Acceptable range
Hypoxemia
Hyperoxemia
Recommendation
Maintain settings
Increase FiO2
? Increase PEEP
Reduce FiO2
Is this adequate
intake of O2
?
Check PaO2
on ABG
65 kg
400 mL
15 breaths/min
5 cmH2
O
100%
60 L/min
VT
RR
PEEP
FiO2
Flow
Initial settings
Become an expert by learning the most important clinical skills at www.medmastery.com.
11
Become an expert by learning the most important clinical skills at www.medmastery.com.
PIP = Peak inspiratory pressure
Plateau pressure
How do I monitor and
measure pressure
inside the lungs?
PIP and plateau pressure monitoring
PIP
Plateau
pressure
1 sec
< 30 cmH2
O
Inspiratory pause
Monitor regularly
Monitor regularly
< 35 cmH2
O
PIP is the highest level of pressure applied
to the lungs during inhalation.
Resistance anywhere along the path from
the ventilator to the lungs can cause an
increase in PIP.
PIP should be kept below 35 cmH2
O.
Plateau pressure is the pressure in the lungs
during peak inspiratory hold.
Plateau pressure should be kept below
30 cmH2
O.
Correct by
1. Checking for causes of resistance
2. Reducing VT
3. Changing mode.
PIP
Plateau pressure
< 35 cmH2
O
< 30 cmH2
O
www.medmastery.com
Chapter 2
MECHANICAL VENTILATION OF
PATIENTS WITH OBSTRUCTIVE
AIRWAY DISEASE
Become an expert by learning the most important clinical skills at www.medmastery.com.
13
Become an expert by learning the most important clinical skills at www.medmastery.com.
Alveolar disease
A problem with oxygenation.
Airway disease
A problem with ventilation.
Airway disease
Ventilation issue
ā€Obstructive diseaseā€
Airway disease versus alveolar disease
Which general lung
disease category does
the patient fall under?
airways
alveoli
alveoli
Blood
Oxygen
ā€Obstructiveā€ ā€Restrictiveā€ ARDS
Air trapping
O2
Normal
airways
Normal
alveoli
Collapsed
alveoli
Inflamed
airways
Airways
blocked
by mucus
Asthmatic
bronchial
tube
CO2
Signs
Increased PaCO2
Enlarged lungs on chest x-ray
Signs
Decreased PaO2
Lung size appears smaller on chest x-ray
CO2
PaCO2
Alveolar disease
Oxygenation issue
ā€Restrictive diseaseā€
O2
PaO2
Chest x-ray
Chest x-ray
Become an expert by learning the most important clinical skills at www.medmastery.com.
14
Become an expert by learning the most important clinical skills at www.medmastery.com.
How can I identify
and manage patients
with obstructive
airway disease?
PIP monitoring
Identify obstructive airway disease
Treat obstructive airway disease
Peak inspiratory pressure
(PIP) monitoring
Flow monitoring
Intrinsic positive end-
expiratory pressure (PEEP)
monitoring
Keep PIP < 35 cmH2
O
Decrease VT
Decrease RR
Increase flow
Bronchodilators
Steroids
Permissive hypercapnia may be necessary.
Monitoring and maintaining PIP at an acceptable level can help manage patients with obstructive airway disease.
PIP can indicate airway compromise or air trapping*
.
AND
Amount of PIP represents the severity of air trapping.
*
You should conļ¬rm with a chest x-ray.
CO2
Chest x-ray
Decrease VT
Reducing volume in, reduces volume needed to get out.
Decrease RR
Reducing RR allows more time to exhale.
Increase flow
Increasing flow shortens inspiration time and therefore
increases expiration time.
Bronchodilators
Steroids
Permissive hypercapnia
Remember, reducing VT
or RR may increase PaCO2
and you may need to tolerate hypercapnia in order
to treat these patients; just be sure to monitor pH
and PaCO2
on a case-by-case basis.
< 35 cmH2
O
Become an expert by learning the most important clinical skills at www.medmastery.com.
15
Become an expert by learning the most important clinical skills at www.medmastery.com.
Flow-time waveformā€“normal Flow-time waveformā€”air trapping
Flow monitoring
How can I identify
and treat patients
with obstructive
airway disease?
Time
(sec)
Flow
(L/min)
inspiration
expiration
Time
(sec)
Flow
(L/min)
inspiration
expiration
Examining the flow-time waveform on the ventilator can help manage patients with obstructive airway disease.
Identify obstructive airway disease
Treat obstructive airway disease
As long as the expiratory limb reaches zero, the lung
is fully deflated and the patient is not air trapping.
A shift in the waveform, such that the expiratory limb
does not return to zero, indicates air trapping.
Decrease VT
Reducing volume, in reduces volume needed to get out.
Decrease RR
Reducing RR allows more time to exhale.
Increase flow
Increasing flow shortens inspiration time and therefore
increases expiration time.
Bronchodilators
Steroids
Permissive hypercapnia
Remember, reducing VT
or RR may increase PaCO2
and you may need to tolerate hypercapnia in order
to treat these patients; just be sure to monitor pH
and PaCO2
on case-by-case basis.
< 35 cmH2
O
Keep PIP < 35 cmH2
O
Decrease VT
Decrease RR
Increase flow
Bronchodilators
Steroids
Permissive hypercapnia may be necessary.
Peak inspiratory pressure
(PIP) monitoring
Flow monitoring
Intrinsic positive end-
expiratory pressure (PEEP)
monitoring
Become an expert by learning the most important clinical skills at www.medmastery.com.
16
Become an expert by learning the most important clinical skills at www.medmastery.com.
PEEP monitoring
What other tools do I
have to identify and
treat air trapping?
600 mL
15 breaths/min
5 cmH2
O
40%
60 L/min
VT
RR
PEEP
FiO2
Flow
Expiratory hold
Expiratory pause
Date/Time
RR
12
breats/min
VT
600
mL
FiO2
30
%
PEEP
5
cmH2
O
PEEP (total)
Reference:
M J Tobin; R F Lodato. PEEP, auto-PEEP, and waterfalls.
Chest. 1989;96(3):449-451. doi:10.1378/chest.96.3.449
Keep PIP < 35 cmH2
O
Decrease VT
Decrease RR
Increase flow
Bronchodilators
Steroids
Increase PEEP
Permissive hypercapnia may be necessary.
Increase set PEEP
To keep work of breathing to a minimum you want
intrinsic PEEP = extrinsic PEEP. In patients with
obstructive airway disease, air trapping causes the
intrinsic PEEP > extrinsic PEEP. By performing an
expiratory hold and determining the total PEEP and
calculating the intrinsic PEEP, you can increase the set
PEEP by this amount to reduce the work of breathing.
Determining the amount of intrinsic PEEP (inadvertent PEEP or auto PEEP)ā€”the difference between the set PEEP
and the total PEEPā€”can help manage patients with obstructive airway disease.
Depressing the expiratory hold or expiratory pause
button on the ventilator keeps the lungs at maximal
exhalation for about 1 second and allows you to
measure the total PEEP.
You can then calculate the intrinsic PEEP:
Total PEEP - set PEEP = intrinsic PEEP
Intrinsic PEEP > 0 air trapping
Identify obstructive airway disease
Treat obstructive airway disease
Decrease VT
Reducing volume in, reduces volume needed to get out.
Decrease RR
Reducing RR allows more time to exhale.
Increase flow
Increasing flow shortens inspiration time and therefore
increases expiration time.
Bronchodilators
Steroids
Permissive hypercapnia
Remember, reducing VT
or RR may increase PaCO2
and you may need to tolerate hypercapnia in order
to treat these patients; just be sure to monitor pH
and PaCO2
on case-by-case basis.
< 35 cmH2
O
Peak inspiratory pressure
(PIP) monitoring
Flow monitoring
Intrinsic positive end-
expiratory pressure (PEEP)
monitoring
(Tobin 1989)
www.medmastery.com
MECHANICAL VENTILATION OF
PATIENTS WITH RESTRICTIVE
AIRWAY DISEASE
Chapter 3
Become an expert by learning the most important clinical skills at www.medmastery.com.
18
Become an expert by learning the most important clinical skills at www.medmastery.com.
What happens in the
lungs in acute respiratory
syndrome (ARDS)?
Introduction to ARDS
alveoli
Alveolar collapse
Refractory hypoxemia
Severity of ARDS = Oxygenation status
P/F ratio =
PaO2
FiO2
Recruitment
Fluids ļ¬ll airsac
Normal
Supplemental
oxygen does
not help!
ARDS
Decreased volume in
Increased recoil
Shallow and rapid
breathing
ARDS Severity
Mild
Moderate
Severe
*
on PEEP 5+; **
observed in cohort
PaO2
/ FiO2
*
200-300
100-200
< 100
Mortality **
27%
32%
45%
Become an expert by learning the most important clinical skills at www.medmastery.com.
19
Become an expert by learning the most important clinical skills at www.medmastery.com.
What strategies can I
use to treat patients
with ARDS?
Low tidal volume strategy
You can use volume control mode with a low tidal volume strategy to manage patients with ARDS.
Add more VT
?
Increasing volume in does not help because the extra
volume just enters the normal alveoli and overextends
them, further increasing the plateau pressure above
the acceptable 30 cmH2
O. This can damage the lung.
Instead, it is better to reduce the VT
to keep plateau
pressure down and reduce the risk of barotrauma.
6ā€“8 mL/kg 4ā€“6m L/kg
VT
by 1 mL/kg
Volume control mode
Low tidal
volume strategy
High respiratory
rate strategy
Optimal PEEP strategy
Note
Reducing VT
may cause an increase in PaCO2
and
a decrease in pH.
According to the ARDSnet protocol,
compared to barotrauma, respiratory
acidosis is the lesser of the evils.
1. Reduce VT
Become an expert by learning the most important clinical skills at www.medmastery.com.
20
Become an expert by learning the most important clinical skills at www.medmastery.com.
Air trapping in restrictive lung disease is bad, but air
trapping may help your ARDS patient!!!
Air trapping can act like PEEP and help recruit and
stabilize the collapsed alveoli.
What strategies can I
use to treat patients
with ARDS?
High respiratory rate strategy
High respiratory rate
Low tidal volume
Plateau pressure ā‰¤ 30 cmH2
O
pH as low as 7.30
Alveolar
recruitment
PaCO2
pH
35
7.35
45
7.45
<7.30
Treating ARDS patients with a high RR strategy is
like walking a ļ¬ne line... and you may need to adjust,
and readjust, RR as necessary to balance PaCO2
and
plateau pressure.
Volume control mode
Low tidal
volume strategy
High respiratory
rate strategy
Optimal PEEP strategy
You can use volume control mode with a high respiratory rate (RR) strategy to manage patients with ARDS.
Increase RR PaCO2
Air trapping
Become an expert by learning the most important clinical skills at www.medmastery.com.
21
Become an expert by learning the most important clinical skills at www.medmastery.com.
PEEP
PEEP
What strategies can I
use to treat patients
with ARDS?
Optimal PEEP strategy
PaO2
Static compliance
ABG
PEEP that produces the highest PaO2
=
Optimal PEEP
PEEP that produces the highest static compliance =
Optimal PEEP
*
Use inspiratory hold.
Static compliance =
Tidal
volume
Plateau
pressure
Volume control mode
Low tidal
volume strategy
High respiratory
rate strategy
Optimal PEEP strategy
You can use volume control mode with an optimal PEEP strategy to manage patients with ARDS.
Alveolar
recruitment
Lots of needle sticks (ABG)
Highest PaO2
= best oxygenation
(not necessarily best lung compliance)
Easier to ensure no negative
hemodynamic effects of a high PEEP.
Still a debated topic... and so you
might want to switch modes!
Volume control ???
In this strategy, you adjust PEEP up and down to ļ¬nd the PEEP at which
the lung is the most compliant. To determine when the lung is most
compliant you can monitor PaO2
or calculate the static compliance.
Become an expert by learning the most important clinical skills at www.medmastery.com.
22
Become an expert by learning the most important clinical skills at www.medmastery.com.
Goals of lung protective modes
What is lung
protection?
Switch
mode + PEEP Inhalation
ā€Sweet spotā€
Pressure
Volume
VT
Lung protective modes:
Pressure control
Bilevel
APRV
When treating patients with ARDS it is common to switch from AC volume control to a mode that is more
lung protective.
We are trying to protect the lungs from two things:
1. alveolar collapse
2. overdistension barotrauma!
1. alveolar collapse 2. overdistension
When using AC volume control you need to constantly
adjust and readjust tidal volume and PEEP to keep the
lungs in the sweet spot.
Other lung protective modes have been developed that
are less frustrating and make it easier to keep the lung
in the sweet spot.
Become an expert by learning the most important clinical skills at www.medmastery.com.
23
Become an expert by learning the most important clinical skills at www.medmastery.com.
CON
Asynchrony
Set i-time may not match the patientā€˜s desired
i-time, causing patient to be out-of-sync with
venilator anxiety!
1. Adjust and readjust i-time
2. Sedate patient
3. Switch to another mode
Pressure control
Which lung protective
modes can I use to treat
patients with ARDS?
Bilevel?
APRV?
PRO
VT
= Lung compliance
In pressure control mode, the VT
changes with
lung compliance so you can easily monitor
improvement in lung function.
1
10
20
Pressure
(PIP)
(cmH2
O)
Time (sec)
i-time
0.8-1.2 sec
20 cmH2
O
PEEP > 5 cmH2
O
30 cmH2
O
30
3
2 4 5 6
Pressure control mode is a lung protective mode that can be used to treat patients with ARDS.
Pressure
control
Pressure control
Bilevel mode
APRV mode
Initial settings
PIP 20ā€“30 cmH2
O
i-time 0.8ā€“1.2 sec
PEEP >5 cmH2
O
Monitor PaCO2
(ABG)
Adjust RR as necessary
Become an expert by learning the most important clinical skills at www.medmastery.com.
24
Become an expert by learning the most important clinical skills at www.medmastery.com.
Bilevel mode
Which lung protective
modes can I use to treat
patients with ARDS?
Pressure
(cmH2
O)
Time (sec)
T high
spontaneous breaths
P high
T low
P low
30 cmH2
O
Pressure
(cmH2
O)
Time (sec)
i-time
PIP
e-time
PEEP
30 cmH2
O
triggered breath
Bilevel
Pressure
control
Pressure control
Bilevel mode
APRV mode
Bilevel mode is a lung protective mode that can be used to treat patients with ARDS.
Bilevel
1. Max/min pressure support
(P high/P low).
2. Set RR. But, breaths are
spontaneous and can be
taken any time.
3. Set T high (T low*
).
Pressure support
1. Max/min total pressure
(PIP/PEEP).
2. Set RR. Breaths are controlled
(or triggered at set times).
PRO
Protect lung from
exceeding high
pressure.
Lessen anxiety
because patient
can breathe freely.
Initial settings
P high 20ā€“30 cmH2
O
T high 0.8ā€“1.2 sec
RR 20-30 breaths/min
PEEP (P low) >10 cmH2
O
Pressure support 0ā€“10 cmH2
O
*
This method closely resembles
the pressure control method.
NOTE
Physicians may choose to closely
resemble the APRV initial settings.
*
T low is automatically set based on T high and RR.
Become an expert by learning the most important clinical skills at www.medmastery.com.
25
Become an expert by learning the most important clinical skills at www.medmastery.com.
APRV mode
Which lung protective
modes can I use to treat
patients with ARDS?
APRV
Bilevel
+ Pressure
support
APRV mode is a lung protective mode that can be used to treat patients with ARDS.
Time (sec)
P high
P low
T high
T low
RR
Pressure
(cmH2
O)
Time (sec)
P high
PEEP
T high
T low
RR = 30
Pressure
(cmH2
O)
APRV
1. Set P high/P low. (No pressure support.)
2. Set T high (traditionally set longer).
3. Set T low (traditionally set shorter to prevent lung deflation).
Bilevel
1. Set P high/P low (PEEP).
2. Set T high (T low*
).
3. Set RR.
Pressure control
Bilevel mode
APRV mode
Initial settings
P high 20ā€“30 cmH2
O
T high 4ā€“6 sec
P low 0ā€“5 cmH2
O
T low 0.2ā€“0.8 sec
*
T low is automatically determined
based on T high and RR.
www.medmastery.com
ASSESSING FOR EXTUBATION
Chapter 4
Become an expert by learning the most important clinical skills at www.medmastery.com.
27
Become an expert by learning the most important clinical skills at www.medmastery.com.
3. Hemodynamic status
No active myocardial infarction
No (or low) vasopressor infusion
4. Sedation status
No neuromuscular
blocking agents
2. Ventilation status
< 35 breaths / minute
1. Oxygenation status
SpO2
ā‰„ 90% on FiO2
ā‰¤ 40%
PEEP ā‰¤ 5 cmH2
O
What should I screen
before weaning my
patient?
Screening before weaning
O2
CO2
O2
CO2
Before weaning you need to screen your patient to make sure they meet the following criteria.
Become an expert by learning the most important clinical skills at www.medmastery.com.
28
Become an expert by learning the most important clinical skills at www.medmastery.com.
Tidal
volume
(mL)
i
n
s
p
i
r
a
t
o
r
y
e
x
p
i
r
a
t
o
r
y
Time
(sec)
500
1 3 5
2 4 6 7
Spontaneous
breaths
Pressure support < 20 cmH2
O
What strategies can
I use to wean my
intubated patients?
Weaning using the SIMV strategy
You can use the SIMV strategy to wean your patient off the ventilator.
1. Check patient meets screening criteria.
2. Switch patient from AC SIMV
(with same settings).
3. Reduce RRā€”gradually.
Reducing the RR allows for more opportunity for
spontaneous breathing.
SIMV strategy
SBT
(CPAP or T-piece)
Reduce RR to as
low as possible.
Reference:
Hess Dean, RRT, PhD, FCCP. Ventilator modes
used in weaning. Chest 2001. 120: 474S-476S.
PRO
Patient assessment
You are often more successful with
something you are familiar with.
CON
Poor outcomes
4. Observe patientā€˜s spontaneous ability.
5. Add pressure support as needed.
Added pressure support can assist low volume
spontaneous breaths; but be careful not to add
more than 20 cmH2
O support this probably
means patient isnā€˜t ready.
(Hess 2011)
Become an expert by learning the most important clinical skills at www.medmastery.com.
29
Become an expert by learning the most important clinical skills at www.medmastery.com.
What strategies can
I use to wean my
intubated patients?
Weaning using the SBT method
CPAP T-piece
CPAP
5 cmH2
O
Pressure support
6-8 cmH2
O
CPAP
0 cmH2
O
Pressure support
0 cmH2
O
SIMV
SBT
SIMV strategy
SBT
(CPAP or T-piece)
You can use the SBT method to wean your patient off the ventilator.
1. Check patient meets screening criteria.
2. Switch patient from AC T-piece.
3. Remove all pressure support (but leave connected
to ventilator).
Keeping patient connected to ventilator
allows you to monitor spontaneous breaths and VT
.
4. Cycle between no support and support, with
increasing duration of no support.
No support for 2 hours.
1. Check patient meets screening criteria.
2. Switch patient from AC CPAP
3. CPAP of 5cmH2
O helps distend alveoli.
4. Add pressure support of 6ā€“8 cmH2
O.
Sink or swim method
Even though the SBT method can be considered a
sink or swim method, it appears to be better than
SIMV because the patient breaths spontaneously
with little support.
Become an expert by learning the most important clinical skills at www.medmastery.com.
30
Become an expert by learning the most important clinical skills at www.medmastery.com.
1. Respiratory 2. Cardiovascular
3. Neurologic 4. Psychologic
Which weaning
parameters do I
monitor to help
guide my decision
to extubate?
Weaning parameters
RSBI = RR/VT
RSBI < 105
RSBI < 80
Stable with
minimum
pressors
FiO2
< 40%
PEEP < 5-8
No seizures
p/f > 150
Follow
instructions
WOB O2
No dyspnea
Awake
RR < 35
breaths/min
Alert Anxiety
Stress
Fear
Before extubating, you need to monitor your patient and make sure they meet the following weaning parameters.
And... you should always evaluate to ensure there has been
a reversal of the primary cause for mechanical ventilation.
Key
Reversal of the primary cause
for mechanical ventilation.
Become an expert by learning the most important clinical skills at www.medmastery.com.
31
Become an expert by learning the most important clinical skills at www.medmastery.com.
How do I know
if a patient requires
a tracheostomy?
Tracheostomy
Ventilatory
capability
Ventilatory
demand
Multiple failed weaning attempts
Secrection clearance
Neuromuscular impairment
After prolonged mechanical ventilation, some patients will require a tracheostomy.
The length of time mechanical ventilation is needed
is often dependent on the severity of the disease.
And, once a patient has been on ventilation for two
weeks, a tracheostomy is commonly considered.
Become an expert by learning the most important clinical skills at www.medmastery.com.
32
Become an expert by learning the most important clinical skills at www.medmastery.com.
TIPS protocol
How do I wean my
patients with a
tracheostomy?
Weaning after prolonged
mechanical ventilation
You can still
wean after
tracheostomy
Go slow!
Barlow hospital
TIPS protocol
Step 1: AC to SIMV of 10/min and PS of 20
Step 2: SIMV of 8/min and PS of 20
Step 3: SIMV of 6/min and PS of 20
Step 4: SIMV of 4/min and PS of 20
Step 5: SIMV of 4/min and PS of 18
Step 6: SIMV of 4/min and PS of 16
Step 7: SIMV of 4/min and PS of 14
Step 8: SIMV of 4/min and PS of 12
Step 9: SIMV of 4/min and PS of 10
Step 10: 1 hour
Step 11: 2 hours
Step 12: 4 hours
Step 13: 6 hours
Step 14: 8 hours
Step 15: 10 hours
Step 16: 12 hours
Step 17: 16 hours
Step 18: 20 hours
Step 19: 24 hours
4 breaths/min (SIMV)
Pressure support (PS)
to 10 cmH2
O
CPAP and PS to 0
Patient can be extubated
Up to 3 steps per day at 4-
hour intervals.
Up to 2 steps per day.
If patient is breathing comfortably
at the 9th step, a slow-paced,
spontaneous breathing trial can
be started.
After completion of daily steps,
put back on step 9 for rest of day.
If patient is breathing comfortably
after 19th step, they can be
removed from ventilator.
SBT: Reduce to CPAP of 0
and PS of 0 and monitor for:
Reduce the pressure support (PS):
Reduce to SIMV:
www.medmastery.com
MANAGING PATIENTS WITH
SPECIAL CONSIDERATIONS
Chapter 5
Become an expert by learning the most important clinical skills at www.medmastery.com.
34
Become an expert by learning the most important clinical skills at www.medmastery.com.
How do I know if my
patientā€˜s upper airway
swelling is reduced
enough to extubate?
Upper airway swelling
Leak No leak
Deflate cuff
How do we know
when the swelling
has decreased
enough in order to
extubate the patient?
Leak No leak
Deflate cuff and listen for a leak.
Swelling
reduced
OK to
extubate
Swelling
still present
Check
daily
Become an expert by learning the most important clinical skills at www.medmastery.com.
35
Become an expert by learning the most important clinical skills at www.medmastery.com.
How do I know if my
patientā€˜s neuromuscular
weakness has improved
enough to extubate?
Neuromuscular weakness
better than
-20 cmH2
O
worse than
-20 cmH2
O
check
daily
Remember a lower
pressure (more
negative) is better!
NIF
Negative inspiratory force
NIF/MIP
OK to
extubate
Check
daily
OR MIP
Maximum inspiratory pressure
The amount of force that is generated
by the patient in an inspiration.
APPENDIX
www.medmastery.com
37
Reference list
Chiumello, D, Pelosi, P, Calvi, E, et al. 2002. Different modes of assisted
ventilation in patients with acute respiratory failure. Eur Respir J. 20: 925ā€“933.
PMID: 12412685
Christopher, KL, Neff, TA, Bowman, JL, et al. 1985. Demand and continuous
flow intermittent mandatory ventilation systems. Chest. 87: 625ā€“630.
PMID: 3886315
Esteban, A, Anzueto, A, AlĆ­a, I, et al. 2000. How is mechanical ventilation
employed in the intensive care unit? An international utilization review. Am J
Respir Crit Care Med. 161: 1450ā€“1458. PMID: 10806138
Hess, D. 2001. Ventilator modes used in weaning. Chest. 120: 474Sā€“476S.
PMID: 11742968
Lazoff, SA and Bird, K. 2022. Synchronized intermittent Mandatory Ventilation.
Treasure Island (FL): StatPearls Publishing. PMID: 31751036
Marini, JJ, Smith, TC and Lamb, VJ. 1988. External work output and force
generation during synchronized intermittent mechanical ventilation. Effect of
machine assistance on breathing effort. Am Rev Respir Dis. 138: 1169ā€“1179.
PMID: 3202477
Mireles-Cabodevila, E, Dugar, S and Chatburn, RL. 2018. APRV for ARDS: the
complexities of a mode and how it affects even the best trials. J Thorac Dis. 10:
S1058ā€“S1063. PMID: 29850185
Mora Carpio, AL and Mora, JI. 2022. Positive end-expiratory pressure. Treasure
Island (FL): StatPearls Publishing. www.ncbi.nlm.nih.gov.
Prella, M, Feihl, F and Domenighetti, G. 2002. Effects of short-term pressure-
controlled ventilation on gas exchange, airway pressures, and gas distribution
in patients with acute lung injury/ARDS: comparison with volume-controlled
ventilation. Chest. 122: 1382ā€“1388. PMID: 12377869
Putensen, C, Mutz, NJ, Putensen-Himmer, G, et al. 1999. Spontaneous
breathing during ventilatory support improves ventilation-perfusion
distributions in patients with acute respiratory distress syndrome. Am J Respir
Crit Care Med. 159: 1241ā€“1248. PMID: 10194172
Sassoon, CS, Del Rosario, N, Fei, R, et al. 1994. Influence of pressure- and
flow-triggered synchronous intermittent mandatory ventilation on inspiratory
muscle work. Crit Care Med. 22: 1933ā€“1941. PMID: 7988129
Tobin, MJ and Lodato, RF. 1989. PEEP, auto-PEEP, and waterfalls. Chest.
96: 449ā€“451. PMID: 2670461
Varpula, T, Valta, P, Niemi, R, et al. 2004. Airway pressure release ventilation
as a primary ventilatory mode in acute respiratory distress syndrome. Acta
Anaesthesiol Scand. 48: 722ā€“731. PMID: 15196105
Zhou, Y, Jin, X, Lv, Y, et al. 2017. Early application of airway pressure
release ventilation may reduce the duration of mechanical ventilation in
acute respiratory distress syndrome. Intensive Care Med. 43: 1648ā€“1659.
PMID: 28936695
Become an expert by learning the most important clinical skills at www.medmastery.com.

More Related Content

Similar to Medmastery Mechanical Ventilation Essentials_Handbook.pdf

Weaning from mechanical ventilator
Weaning from mechanical ventilatorWeaning from mechanical ventilator
Weaning from mechanical ventilatorDr Subodh Chaturvedi
Ā 
Basic Mechanical Ventilation.pptx
Basic Mechanical Ventilation.pptxBasic Mechanical Ventilation.pptx
Basic Mechanical Ventilation.pptxAranayaDev
Ā 
Moderate sedation monitoring
Moderate sedation monitoring Moderate sedation monitoring
Moderate sedation monitoring Ashraf Abdulhalim
Ā 
Mechanical ventilation Ł…Ł†ŲŖŲÆŁ‰ ŲŖŁ…Ų±ŁŠŲ¶ Ł…Ų³ŲŖŲ“ŁŁ‰ ŲŗŲ²Ų© Ų§Ł„Ų§ŁˆŲ±ŁˆŲØ
Mechanical ventilation Ł…Ł†ŲŖŲÆŁ‰ ŲŖŁ…Ų±ŁŠŲ¶ Ł…Ų³ŲŖŲ“ŁŁ‰ ŲŗŲ²Ų© Ų§Ł„Ų§ŁˆŲ±ŁˆŲØMechanical ventilation Ł…Ł†ŲŖŲÆŁ‰ ŲŖŁ…Ų±ŁŠŲ¶ Ł…Ų³ŲŖŲ“ŁŁ‰ ŲŗŲ²Ų© Ų§Ł„Ų§ŁˆŲ±ŁˆŲØ
Mechanical ventilation Ł…Ł†ŲŖŲÆŁ‰ ŲŖŁ…Ų±ŁŠŲ¶ Ł…Ų³ŲŖŲ“ŁŁ‰ ŲŗŲ²Ų© Ų§Ł„Ų§ŁˆŲ±ŁˆŲØegh-nsg
Ā 
Mechanical ventilation
Mechanical ventilationMechanical ventilation
Mechanical ventilationBakti Setiadi
Ā 
Bilgrami, Irma ā€” Reading the Vent Like an ECG
Bilgrami, Irma ā€” Reading the Vent Like an ECGBilgrami, Irma ā€” Reading the Vent Like an ECG
Bilgrami, Irma ā€” Reading the Vent Like an ECGSMACC Conference
Ā 
Ventilatory support
Ventilatory supportVentilatory support
Ventilatory supportHusni Ajaj
Ā 
Pulmonary function test
Pulmonary function testPulmonary function test
Pulmonary function testraghu srikanti
Ā 
Anaecon India - Spirometery
Anaecon India - SpirometeryAnaecon India - Spirometery
Anaecon India - SpirometerySarthak Jain
Ā 
Respiratory failure and the acute respiratory distress syndrome (and shock)
Respiratory failure and the acute respiratory distress syndrome (and shock)  Respiratory failure and the acute respiratory distress syndrome (and shock)
Respiratory failure and the acute respiratory distress syndrome (and shock) Jim Lavelle
Ā 
PV Curve and Lung Recruitment
PV Curve and Lung RecruitmentPV Curve and Lung Recruitment
PV Curve and Lung RecruitmentDr.Mahmoud Abbas
Ā 
mechanical ventilation in children
mechanical ventilation in children mechanical ventilation in children
mechanical ventilation in children mariem ahmed
Ā 
Etco2 in non-intubated patient: a must in ed
Etco2 in  non-intubated patient: a must in edEtco2 in  non-intubated patient: a must in ed
Etco2 in non-intubated patient: a must in ednisaiims
Ā 
Basic modes of mechanical ventilation
Basic modes of mechanical ventilationBasic modes of mechanical ventilation
Basic modes of mechanical ventilationdrsangeet
Ā 
Ventilatory support in special situations balamugesh
Ventilatory support in special situations   balamugeshVentilatory support in special situations   balamugesh
Ventilatory support in special situations balamugeshDang Thanh Tuan
Ā 
Postoperative Ventilation in Paediatric Cardiac Surgical Patients
Postoperative Ventilation in Paediatric Cardiac Surgical PatientsPostoperative Ventilation in Paediatric Cardiac Surgical Patients
Postoperative Ventilation in Paediatric Cardiac Surgical Patientsdr amarja nagre
Ā 
Postoperative Ventilation in Paediatric Cardiac Surgical Patients
Postoperative Ventilation in Paediatric Cardiac Surgical PatientsPostoperative Ventilation in Paediatric Cardiac Surgical Patients
Postoperative Ventilation in Paediatric Cardiac Surgical Patientsdr amarja nagre
Ā 

Similar to Medmastery Mechanical Ventilation Essentials_Handbook.pdf (20)

Weaning from mechanical ventilator
Weaning from mechanical ventilatorWeaning from mechanical ventilator
Weaning from mechanical ventilator
Ā 
Basic Mechanical Ventilation.pptx
Basic Mechanical Ventilation.pptxBasic Mechanical Ventilation.pptx
Basic Mechanical Ventilation.pptx
Ā 
Moderate sedation monitoring
Moderate sedation monitoring Moderate sedation monitoring
Moderate sedation monitoring
Ā 
Venti
VentiVenti
Venti
Ā 
ASSISSTED VENTILATION.pdf
ASSISSTED VENTILATION.pdfASSISSTED VENTILATION.pdf
ASSISSTED VENTILATION.pdf
Ā 
Mechanical ventilation Ł…Ł†ŲŖŲÆŁ‰ ŲŖŁ…Ų±ŁŠŲ¶ Ł…Ų³ŲŖŲ“ŁŁ‰ ŲŗŲ²Ų© Ų§Ł„Ų§ŁˆŲ±ŁˆŲØ
Mechanical ventilation Ł…Ł†ŲŖŲÆŁ‰ ŲŖŁ…Ų±ŁŠŲ¶ Ł…Ų³ŲŖŲ“ŁŁ‰ ŲŗŲ²Ų© Ų§Ł„Ų§ŁˆŲ±ŁˆŲØMechanical ventilation Ł…Ł†ŲŖŲÆŁ‰ ŲŖŁ…Ų±ŁŠŲ¶ Ł…Ų³ŲŖŲ“ŁŁ‰ ŲŗŲ²Ų© Ų§Ł„Ų§ŁˆŲ±ŁˆŲØ
Mechanical ventilation Ł…Ł†ŲŖŲÆŁ‰ ŲŖŁ…Ų±ŁŠŲ¶ Ł…Ų³ŲŖŲ“ŁŁ‰ ŲŗŲ²Ų© Ų§Ł„Ų§ŁˆŲ±ŁˆŲØ
Ā 
Mechanical ventilation
Mechanical ventilationMechanical ventilation
Mechanical ventilation
Ā 
Pulmonary function test
Pulmonary function testPulmonary function test
Pulmonary function test
Ā 
Bilgrami, Irma ā€” Reading the Vent Like an ECG
Bilgrami, Irma ā€” Reading the Vent Like an ECGBilgrami, Irma ā€” Reading the Vent Like an ECG
Bilgrami, Irma ā€” Reading the Vent Like an ECG
Ā 
Ventilatory support
Ventilatory supportVentilatory support
Ventilatory support
Ā 
Pulmonary function test
Pulmonary function testPulmonary function test
Pulmonary function test
Ā 
Anaecon India - Spirometery
Anaecon India - SpirometeryAnaecon India - Spirometery
Anaecon India - Spirometery
Ā 
Respiratory failure and the acute respiratory distress syndrome (and shock)
Respiratory failure and the acute respiratory distress syndrome (and shock)  Respiratory failure and the acute respiratory distress syndrome (and shock)
Respiratory failure and the acute respiratory distress syndrome (and shock)
Ā 
PV Curve and Lung Recruitment
PV Curve and Lung RecruitmentPV Curve and Lung Recruitment
PV Curve and Lung Recruitment
Ā 
mechanical ventilation in children
mechanical ventilation in children mechanical ventilation in children
mechanical ventilation in children
Ā 
Etco2 in non-intubated patient: a must in ed
Etco2 in  non-intubated patient: a must in edEtco2 in  non-intubated patient: a must in ed
Etco2 in non-intubated patient: a must in ed
Ā 
Basic modes of mechanical ventilation
Basic modes of mechanical ventilationBasic modes of mechanical ventilation
Basic modes of mechanical ventilation
Ā 
Ventilatory support in special situations balamugesh
Ventilatory support in special situations   balamugeshVentilatory support in special situations   balamugesh
Ventilatory support in special situations balamugesh
Ā 
Postoperative Ventilation in Paediatric Cardiac Surgical Patients
Postoperative Ventilation in Paediatric Cardiac Surgical PatientsPostoperative Ventilation in Paediatric Cardiac Surgical Patients
Postoperative Ventilation in Paediatric Cardiac Surgical Patients
Ā 
Postoperative Ventilation in Paediatric Cardiac Surgical Patients
Postoperative Ventilation in Paediatric Cardiac Surgical PatientsPostoperative Ventilation in Paediatric Cardiac Surgical Patients
Postoperative Ventilation in Paediatric Cardiac Surgical Patients
Ā 

Recently uploaded

Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls ServiceKesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Servicemakika9823
Ā 
Call Girls Service Navi Mumbai Samaira 8617697112 Independent Escort Service ...
Call Girls Service Navi Mumbai Samaira 8617697112 Independent Escort Service ...Call Girls Service Navi Mumbai Samaira 8617697112 Independent Escort Service ...
Call Girls Service Navi Mumbai Samaira 8617697112 Independent Escort Service ...Call girls in Ahmedabad High profile
Ā 
Call Girls Service Bellary Road Just Call 7001305949 Enjoy College Girls Service
Call Girls Service Bellary Road Just Call 7001305949 Enjoy College Girls ServiceCall Girls Service Bellary Road Just Call 7001305949 Enjoy College Girls Service
Call Girls Service Bellary Road Just Call 7001305949 Enjoy College Girls Servicenarwatsonia7
Ā 
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...narwatsonia7
Ā 
Call Girl Number in Vashi MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoy
Call Girl Number in Vashi MumbaišŸ“² 9833363713 šŸ’ž Full Night EnjoyCall Girl Number in Vashi MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoy
Call Girl Number in Vashi MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoybabeytanya
Ā 
CALL ON āž„9907093804 šŸ” Call Girls Baramati ( Pune) Girls Service
CALL ON āž„9907093804 šŸ” Call Girls Baramati ( Pune)  Girls ServiceCALL ON āž„9907093804 šŸ” Call Girls Baramati ( Pune)  Girls Service
CALL ON āž„9907093804 šŸ” Call Girls Baramati ( Pune) Girls ServiceMiss joya
Ā 
Call Girls Service Jaipur Grishma WhatsApp ā¤8445551418 VIP Call Girls Jaipur
Call Girls Service Jaipur Grishma WhatsApp ā¤8445551418 VIP Call Girls JaipurCall Girls Service Jaipur Grishma WhatsApp ā¤8445551418 VIP Call Girls Jaipur
Call Girls Service Jaipur Grishma WhatsApp ā¤8445551418 VIP Call Girls Jaipurparulsinha
Ā 
VIP Call Girls Indore Kirti šŸ’ššŸ˜‹ 9256729539 šŸš€ Indore Escorts
VIP Call Girls Indore Kirti šŸ’ššŸ˜‹  9256729539 šŸš€ Indore EscortsVIP Call Girls Indore Kirti šŸ’ššŸ˜‹  9256729539 šŸš€ Indore Escorts
VIP Call Girls Indore Kirti šŸ’ššŸ˜‹ 9256729539 šŸš€ Indore Escortsaditipandeya
Ā 
VIP Call Girls Pune Vrinda 9907093804 Short 1500 Night 6000 Best call girls S...
VIP Call Girls Pune Vrinda 9907093804 Short 1500 Night 6000 Best call girls S...VIP Call Girls Pune Vrinda 9907093804 Short 1500 Night 6000 Best call girls S...
VIP Call Girls Pune Vrinda 9907093804 Short 1500 Night 6000 Best call girls S...Miss joya
Ā 
VIP Call Girls Pune Sanjana 9907093804 Short 1500 Night 6000 Best call girls ...
VIP Call Girls Pune Sanjana 9907093804 Short 1500 Night 6000 Best call girls ...VIP Call Girls Pune Sanjana 9907093804 Short 1500 Night 6000 Best call girls ...
VIP Call Girls Pune Sanjana 9907093804 Short 1500 Night 6000 Best call girls ...Miss joya
Ā 
ā™›VVIP Hyderabad Call Girls ChintalkuntašŸ–•7001035870šŸ–•Riya Kappor Top Call Girl ...
ā™›VVIP Hyderabad Call Girls ChintalkuntašŸ–•7001035870šŸ–•Riya Kappor Top Call Girl ...ā™›VVIP Hyderabad Call Girls ChintalkuntašŸ–•7001035870šŸ–•Riya Kappor Top Call Girl ...
ā™›VVIP Hyderabad Call Girls ChintalkuntašŸ–•7001035870šŸ–•Riya Kappor Top Call Girl ...astropune
Ā 
Call Girls Colaba Mumbai ā¤ļø 9920874524 šŸ‘ˆ Cash on Delivery
Call Girls Colaba Mumbai ā¤ļø 9920874524 šŸ‘ˆ Cash on DeliveryCall Girls Colaba Mumbai ā¤ļø 9920874524 šŸ‘ˆ Cash on Delivery
Call Girls Colaba Mumbai ā¤ļø 9920874524 šŸ‘ˆ Cash on Deliverynehamumbai
Ā 
Vip Call Girls Anna Salai Chennai šŸ‘‰ 8250192130 ā£ļøšŸ’Æ Top Class Girls Available
Vip Call Girls Anna Salai Chennai šŸ‘‰ 8250192130 ā£ļøšŸ’Æ Top Class Girls AvailableVip Call Girls Anna Salai Chennai šŸ‘‰ 8250192130 ā£ļøšŸ’Æ Top Class Girls Available
Vip Call Girls Anna Salai Chennai šŸ‘‰ 8250192130 ā£ļøšŸ’Æ Top Class Girls AvailableNehru place Escorts
Ā 
Call Girl Bangalore Nandini 7001305949 Independent Escort Service Bangalore
Call Girl Bangalore Nandini 7001305949 Independent Escort Service BangaloreCall Girl Bangalore Nandini 7001305949 Independent Escort Service Bangalore
Call Girl Bangalore Nandini 7001305949 Independent Escort Service Bangalorenarwatsonia7
Ā 
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore EscortsCall Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escortsvidya singh
Ā 
Best Rate (Hyderabad) Call Girls Jahanuma āŸŸ 8250192130 āŸŸ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma āŸŸ 8250192130 āŸŸ High Class Call Girl...Best Rate (Hyderabad) Call Girls Jahanuma āŸŸ 8250192130 āŸŸ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma āŸŸ 8250192130 āŸŸ High Class Call Girl...astropune
Ā 
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...indiancallgirl4rent
Ā 
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...Miss joya
Ā 
Call Girl Number in Panvel MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoy
Call Girl Number in Panvel MumbaišŸ“² 9833363713 šŸ’ž Full Night EnjoyCall Girl Number in Panvel MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoy
Call Girl Number in Panvel MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoybabeytanya
Ā 

Recently uploaded (20)

Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls ServiceKesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Kesar Bagh Call Girl Price 9548273370 , Lucknow Call Girls Service
Ā 
Call Girls Service Navi Mumbai Samaira 8617697112 Independent Escort Service ...
Call Girls Service Navi Mumbai Samaira 8617697112 Independent Escort Service ...Call Girls Service Navi Mumbai Samaira 8617697112 Independent Escort Service ...
Call Girls Service Navi Mumbai Samaira 8617697112 Independent Escort Service ...
Ā 
Call Girls Service Bellary Road Just Call 7001305949 Enjoy College Girls Service
Call Girls Service Bellary Road Just Call 7001305949 Enjoy College Girls ServiceCall Girls Service Bellary Road Just Call 7001305949 Enjoy College Girls Service
Call Girls Service Bellary Road Just Call 7001305949 Enjoy College Girls Service
Ā 
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...Bangalore Call Girls Nelamangala Number 7001035870  Meetin With Bangalore Esc...
Bangalore Call Girls Nelamangala Number 7001035870 Meetin With Bangalore Esc...
Ā 
Call Girl Number in Vashi MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoy
Call Girl Number in Vashi MumbaišŸ“² 9833363713 šŸ’ž Full Night EnjoyCall Girl Number in Vashi MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoy
Call Girl Number in Vashi MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoy
Ā 
sauth delhi call girls in Bhajanpura šŸ” 9953056974 šŸ” escort Service
sauth delhi call girls in Bhajanpura šŸ” 9953056974 šŸ” escort Servicesauth delhi call girls in Bhajanpura šŸ” 9953056974 šŸ” escort Service
sauth delhi call girls in Bhajanpura šŸ” 9953056974 šŸ” escort Service
Ā 
CALL ON āž„9907093804 šŸ” Call Girls Baramati ( Pune) Girls Service
CALL ON āž„9907093804 šŸ” Call Girls Baramati ( Pune)  Girls ServiceCALL ON āž„9907093804 šŸ” Call Girls Baramati ( Pune)  Girls Service
CALL ON āž„9907093804 šŸ” Call Girls Baramati ( Pune) Girls Service
Ā 
Call Girls Service Jaipur Grishma WhatsApp ā¤8445551418 VIP Call Girls Jaipur
Call Girls Service Jaipur Grishma WhatsApp ā¤8445551418 VIP Call Girls JaipurCall Girls Service Jaipur Grishma WhatsApp ā¤8445551418 VIP Call Girls Jaipur
Call Girls Service Jaipur Grishma WhatsApp ā¤8445551418 VIP Call Girls Jaipur
Ā 
VIP Call Girls Indore Kirti šŸ’ššŸ˜‹ 9256729539 šŸš€ Indore Escorts
VIP Call Girls Indore Kirti šŸ’ššŸ˜‹  9256729539 šŸš€ Indore EscortsVIP Call Girls Indore Kirti šŸ’ššŸ˜‹  9256729539 šŸš€ Indore Escorts
VIP Call Girls Indore Kirti šŸ’ššŸ˜‹ 9256729539 šŸš€ Indore Escorts
Ā 
VIP Call Girls Pune Vrinda 9907093804 Short 1500 Night 6000 Best call girls S...
VIP Call Girls Pune Vrinda 9907093804 Short 1500 Night 6000 Best call girls S...VIP Call Girls Pune Vrinda 9907093804 Short 1500 Night 6000 Best call girls S...
VIP Call Girls Pune Vrinda 9907093804 Short 1500 Night 6000 Best call girls S...
Ā 
VIP Call Girls Pune Sanjana 9907093804 Short 1500 Night 6000 Best call girls ...
VIP Call Girls Pune Sanjana 9907093804 Short 1500 Night 6000 Best call girls ...VIP Call Girls Pune Sanjana 9907093804 Short 1500 Night 6000 Best call girls ...
VIP Call Girls Pune Sanjana 9907093804 Short 1500 Night 6000 Best call girls ...
Ā 
ā™›VVIP Hyderabad Call Girls ChintalkuntašŸ–•7001035870šŸ–•Riya Kappor Top Call Girl ...
ā™›VVIP Hyderabad Call Girls ChintalkuntašŸ–•7001035870šŸ–•Riya Kappor Top Call Girl ...ā™›VVIP Hyderabad Call Girls ChintalkuntašŸ–•7001035870šŸ–•Riya Kappor Top Call Girl ...
ā™›VVIP Hyderabad Call Girls ChintalkuntašŸ–•7001035870šŸ–•Riya Kappor Top Call Girl ...
Ā 
Call Girls Colaba Mumbai ā¤ļø 9920874524 šŸ‘ˆ Cash on Delivery
Call Girls Colaba Mumbai ā¤ļø 9920874524 šŸ‘ˆ Cash on DeliveryCall Girls Colaba Mumbai ā¤ļø 9920874524 šŸ‘ˆ Cash on Delivery
Call Girls Colaba Mumbai ā¤ļø 9920874524 šŸ‘ˆ Cash on Delivery
Ā 
Vip Call Girls Anna Salai Chennai šŸ‘‰ 8250192130 ā£ļøšŸ’Æ Top Class Girls Available
Vip Call Girls Anna Salai Chennai šŸ‘‰ 8250192130 ā£ļøšŸ’Æ Top Class Girls AvailableVip Call Girls Anna Salai Chennai šŸ‘‰ 8250192130 ā£ļøšŸ’Æ Top Class Girls Available
Vip Call Girls Anna Salai Chennai šŸ‘‰ 8250192130 ā£ļøšŸ’Æ Top Class Girls Available
Ā 
Call Girl Bangalore Nandini 7001305949 Independent Escort Service Bangalore
Call Girl Bangalore Nandini 7001305949 Independent Escort Service BangaloreCall Girl Bangalore Nandini 7001305949 Independent Escort Service Bangalore
Call Girl Bangalore Nandini 7001305949 Independent Escort Service Bangalore
Ā 
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore EscortsCall Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Call Girls Horamavu WhatsApp Number 7001035870 Meeting With Bangalore Escorts
Ā 
Best Rate (Hyderabad) Call Girls Jahanuma āŸŸ 8250192130 āŸŸ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma āŸŸ 8250192130 āŸŸ High Class Call Girl...Best Rate (Hyderabad) Call Girls Jahanuma āŸŸ 8250192130 āŸŸ High Class Call Girl...
Best Rate (Hyderabad) Call Girls Jahanuma āŸŸ 8250192130 āŸŸ High Class Call Girl...
Ā 
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
(Rocky) Jaipur Call Girl - 9521753030 Escorts Service 50% Off with Cash ON De...
Ā 
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...
VIP Call Girls Pune Vani 9907093804 Short 1500 Night 6000 Best call girls Ser...
Ā 
Call Girl Number in Panvel MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoy
Call Girl Number in Panvel MumbaišŸ“² 9833363713 šŸ’ž Full Night EnjoyCall Girl Number in Panvel MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoy
Call Girl Number in Panvel MumbaišŸ“² 9833363713 šŸ’ž Full Night Enjoy
Ā 

Medmastery Mechanical Ventilation Essentials_Handbook.pdf

  • 2. Table of contents How to survive your first night on call Mechanical ventilation 4 AC versus SIMV 5 Volume versus pressure 6 Parameters 7 Initial values 8 Assessing ventilation 9 Assessing oxygenation 10 PIP and plateau pressure monitoring 11 Mechanical ventilation of patients with obstructive airway disease Airway disease versus alveolar disease 13 PIP monitoring 14 Flow monitoring 15 PEEP monitoring 16 Mechanical ventilation of patients with restrictive airway disease Introduction to ARDS 18 Low tidal volume strategy 19 High respiratory rate strategy 20 Optimal PEEP strategy 21 Goals of lung protective modes 22 Pressure control 23 Bilevel mode 24 APRV mode 25 Assessing for extubation Screening before weaning 27 Weaning using the SIMV strategy 28 Weaning using the SBT method 29 Weaning parameters 30 Tracheostomy 31 Weaning after prolonged mechanical ventilation 32 Managing patients with special considerations Upper airway swelling 34 Neuromuscular weakness 35 Appendix Reference list 37
  • 3. www.medmastery.com Chapter 1 HOW TO SURVIVE YOUR FIRST NIGHT ON CALL
  • 4. Become an expert by learning the most important clinical skills at www.medmastery.com. 4 Become an expert by learning the most important clinical skills at www.medmastery.com. All Full respiratory support OR What is mechanical ventilation? Mechanical ventilation Ventilate Oxygenate CO2 CO2 CO2 CO2 CO2 CO2 CO2 CO2 Ventilation Oxygenation O2 Itā€˜s not that simple Mode Some Partial respiratory support
  • 5. Become an expert by learning the most important clinical skills at www.medmastery.com. 5 Become an expert by learning the most important clinical skills at www.medmastery.com. AC versus SIMV AC mode SIMV mode Reduce the work of breathing Respiratory rate (RR) = 15 breaths/min Tidal volume (VT ) = 500 mL Tidal volume (mL) Tidal volume (mL) i n s p i r a t o r y i n s p i r a t o r y e x p i r a t o r y e x p i r a t o r y Time (sec) Time (sec) 500 500 1 1 3 3 5 5 2 2 4 4 6 6 Ideal for muscle recovery Ventilator does work Patient responsible for breath Hypoventilation AC SIMV Which initial mode of ventilation should I use? Reference: Esteban A, Ferguson ND, Meade MO, et al. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med. 2008. 177: 170ā€“177.
  • 6. Become an expert by learning the most important clinical skills at www.medmastery.com. 6 Become an expert by learning the most important clinical skills at www.medmastery.com. RR = 14 breaths/min VT = 600 mL Minute ventilation = 0.6 L x 14 breaths/min = 8.4 L/min We can calculate minute ventilation to ensure enough CO2 is exhaled. RR = 14 breaths/min VT = ? Minute ventilation = VT x 14 breaths/min = ? We canā€˜t calculate minute ventilation without VT ! Volume versus pressure Why volume ventilation and not pressure ventilation? Pressure Note Some people will still beneļ¬t from pressure, but more will beneļ¬t from volume ventilation. Volume Minute ventilation VT x RR Key: amount of CO2 exhaled
  • 7. Become an expert by learning the most important clinical skills at www.medmastery.com. 7 Become an expert by learning the most important clinical skills at www.medmastery.com. 1. Tidal volume (VT ) 2. Respiratory rate (RR) 3. PEEP 4. FiO2 5. Flow Which settings are available for my patient? Parameters Parameters 1. Tidal volume (VT ) 2. Respiratory rate (RR) 3. PEEP 4. FiO2 5. Flow L or mL breaths/min cmH2 O % L/min
  • 8. Become an expert by learning the most important clinical skills at www.medmastery.com. 8 Become an expert by learning the most important clinical skills at www.medmastery.com. What are the initial values for each parameter? Initial values Parameters 1. VT 2. RR 3. PEEP 4. FiO2 5. Flow Initial values 6ā€”8 mL/kg 10ā€”20 breaths/min 0ā€”5 cmH2 O 100% 40ā€”60 L/min 1. Tidal volume (VT ) 2. Respiratory rate (RR) 5. Flow 3. PEEP 4. FiO2 Use ideal body weight based on gender and height, not actual weight. 6ā€“8 mL/kg 10ā€”20 breaths/min 40ā€”60 L/min 0ā€”5 cmH2 O 100% 65 kg 6ā€”8 mL/kg 10ā€”20 breaths/min 0ā€”5 cmH2 O 100% 40ā€”60 L/min x = 390 mL ā‰ˆ 400 mL 15 breaths/min 5 cmH2 O 100% 60 L/min
  • 9. Become an expert by learning the most important clinical skills at www.medmastery.com. 9 Become an expert by learning the most important clinical skills at www.medmastery.com. Minute ventilation = 400 mL x 15 breaths/min = 6 L/min How do I assess for adequate ventilation? Assessing ventilation 65 kg 400 mL 15 breaths/min 5 cmH2 O 100% 60 L/min 400 mL 15 breaths/min 5 cmH2 O 100% 60 L/min VT RR PEEP FiO2 Flow VT RR PEEP FiO2 Flow Initial settings Initial settings Ventilation = Removal of CO2 Is this adequate removal of CO2 ? Check PaCO2 on ABG ABG results (PaCO2 ) 35ā€“45 mmHg <35 mmHg >45 mmHg Interpretation Acceptable range Hyperventilating Hypoventilating Recommendation Maintain settings Decrease minute ventilation (VT or RR) Increase minute ventilation (Vt or RR)
  • 10. Become an expert by learning the most important clinical skills at www.medmastery.com. 10 Become an expert by learning the most important clinical skills at www.medmastery.com. How do I assess for adequate oxygenation? Assessing oxygenation 400 mL 15 breaths/min 5 cmH2 O 100% 60 L/min VT RR PEEP FiO2 Flow Initial settings ABG results (PaO2 ) 80ā€“100 mmHg <80 mmHg >100 mmHg Interpretation Acceptable range Hypoxemia Hyperoxemia Recommendation Maintain settings Increase FiO2 ? Increase PEEP Reduce FiO2 Is this adequate intake of O2 ? Check PaO2 on ABG 65 kg 400 mL 15 breaths/min 5 cmH2 O 100% 60 L/min VT RR PEEP FiO2 Flow Initial settings
  • 11. Become an expert by learning the most important clinical skills at www.medmastery.com. 11 Become an expert by learning the most important clinical skills at www.medmastery.com. PIP = Peak inspiratory pressure Plateau pressure How do I monitor and measure pressure inside the lungs? PIP and plateau pressure monitoring PIP Plateau pressure 1 sec < 30 cmH2 O Inspiratory pause Monitor regularly Monitor regularly < 35 cmH2 O PIP is the highest level of pressure applied to the lungs during inhalation. Resistance anywhere along the path from the ventilator to the lungs can cause an increase in PIP. PIP should be kept below 35 cmH2 O. Plateau pressure is the pressure in the lungs during peak inspiratory hold. Plateau pressure should be kept below 30 cmH2 O. Correct by 1. Checking for causes of resistance 2. Reducing VT 3. Changing mode. PIP Plateau pressure < 35 cmH2 O < 30 cmH2 O
  • 12. www.medmastery.com Chapter 2 MECHANICAL VENTILATION OF PATIENTS WITH OBSTRUCTIVE AIRWAY DISEASE
  • 13. Become an expert by learning the most important clinical skills at www.medmastery.com. 13 Become an expert by learning the most important clinical skills at www.medmastery.com. Alveolar disease A problem with oxygenation. Airway disease A problem with ventilation. Airway disease Ventilation issue ā€Obstructive diseaseā€ Airway disease versus alveolar disease Which general lung disease category does the patient fall under? airways alveoli alveoli Blood Oxygen ā€Obstructiveā€ ā€Restrictiveā€ ARDS Air trapping O2 Normal airways Normal alveoli Collapsed alveoli Inflamed airways Airways blocked by mucus Asthmatic bronchial tube CO2 Signs Increased PaCO2 Enlarged lungs on chest x-ray Signs Decreased PaO2 Lung size appears smaller on chest x-ray CO2 PaCO2 Alveolar disease Oxygenation issue ā€Restrictive diseaseā€ O2 PaO2 Chest x-ray Chest x-ray
  • 14. Become an expert by learning the most important clinical skills at www.medmastery.com. 14 Become an expert by learning the most important clinical skills at www.medmastery.com. How can I identify and manage patients with obstructive airway disease? PIP monitoring Identify obstructive airway disease Treat obstructive airway disease Peak inspiratory pressure (PIP) monitoring Flow monitoring Intrinsic positive end- expiratory pressure (PEEP) monitoring Keep PIP < 35 cmH2 O Decrease VT Decrease RR Increase flow Bronchodilators Steroids Permissive hypercapnia may be necessary. Monitoring and maintaining PIP at an acceptable level can help manage patients with obstructive airway disease. PIP can indicate airway compromise or air trapping* . AND Amount of PIP represents the severity of air trapping. * You should conļ¬rm with a chest x-ray. CO2 Chest x-ray Decrease VT Reducing volume in, reduces volume needed to get out. Decrease RR Reducing RR allows more time to exhale. Increase flow Increasing flow shortens inspiration time and therefore increases expiration time. Bronchodilators Steroids Permissive hypercapnia Remember, reducing VT or RR may increase PaCO2 and you may need to tolerate hypercapnia in order to treat these patients; just be sure to monitor pH and PaCO2 on a case-by-case basis. < 35 cmH2 O
  • 15. Become an expert by learning the most important clinical skills at www.medmastery.com. 15 Become an expert by learning the most important clinical skills at www.medmastery.com. Flow-time waveformā€“normal Flow-time waveformā€”air trapping Flow monitoring How can I identify and treat patients with obstructive airway disease? Time (sec) Flow (L/min) inspiration expiration Time (sec) Flow (L/min) inspiration expiration Examining the flow-time waveform on the ventilator can help manage patients with obstructive airway disease. Identify obstructive airway disease Treat obstructive airway disease As long as the expiratory limb reaches zero, the lung is fully deflated and the patient is not air trapping. A shift in the waveform, such that the expiratory limb does not return to zero, indicates air trapping. Decrease VT Reducing volume, in reduces volume needed to get out. Decrease RR Reducing RR allows more time to exhale. Increase flow Increasing flow shortens inspiration time and therefore increases expiration time. Bronchodilators Steroids Permissive hypercapnia Remember, reducing VT or RR may increase PaCO2 and you may need to tolerate hypercapnia in order to treat these patients; just be sure to monitor pH and PaCO2 on case-by-case basis. < 35 cmH2 O Keep PIP < 35 cmH2 O Decrease VT Decrease RR Increase flow Bronchodilators Steroids Permissive hypercapnia may be necessary. Peak inspiratory pressure (PIP) monitoring Flow monitoring Intrinsic positive end- expiratory pressure (PEEP) monitoring
  • 16. Become an expert by learning the most important clinical skills at www.medmastery.com. 16 Become an expert by learning the most important clinical skills at www.medmastery.com. PEEP monitoring What other tools do I have to identify and treat air trapping? 600 mL 15 breaths/min 5 cmH2 O 40% 60 L/min VT RR PEEP FiO2 Flow Expiratory hold Expiratory pause Date/Time RR 12 breats/min VT 600 mL FiO2 30 % PEEP 5 cmH2 O PEEP (total) Reference: M J Tobin; R F Lodato. PEEP, auto-PEEP, and waterfalls. Chest. 1989;96(3):449-451. doi:10.1378/chest.96.3.449 Keep PIP < 35 cmH2 O Decrease VT Decrease RR Increase flow Bronchodilators Steroids Increase PEEP Permissive hypercapnia may be necessary. Increase set PEEP To keep work of breathing to a minimum you want intrinsic PEEP = extrinsic PEEP. In patients with obstructive airway disease, air trapping causes the intrinsic PEEP > extrinsic PEEP. By performing an expiratory hold and determining the total PEEP and calculating the intrinsic PEEP, you can increase the set PEEP by this amount to reduce the work of breathing. Determining the amount of intrinsic PEEP (inadvertent PEEP or auto PEEP)ā€”the difference between the set PEEP and the total PEEPā€”can help manage patients with obstructive airway disease. Depressing the expiratory hold or expiratory pause button on the ventilator keeps the lungs at maximal exhalation for about 1 second and allows you to measure the total PEEP. You can then calculate the intrinsic PEEP: Total PEEP - set PEEP = intrinsic PEEP Intrinsic PEEP > 0 air trapping Identify obstructive airway disease Treat obstructive airway disease Decrease VT Reducing volume in, reduces volume needed to get out. Decrease RR Reducing RR allows more time to exhale. Increase flow Increasing flow shortens inspiration time and therefore increases expiration time. Bronchodilators Steroids Permissive hypercapnia Remember, reducing VT or RR may increase PaCO2 and you may need to tolerate hypercapnia in order to treat these patients; just be sure to monitor pH and PaCO2 on case-by-case basis. < 35 cmH2 O Peak inspiratory pressure (PIP) monitoring Flow monitoring Intrinsic positive end- expiratory pressure (PEEP) monitoring (Tobin 1989)
  • 17. www.medmastery.com MECHANICAL VENTILATION OF PATIENTS WITH RESTRICTIVE AIRWAY DISEASE Chapter 3
  • 18. Become an expert by learning the most important clinical skills at www.medmastery.com. 18 Become an expert by learning the most important clinical skills at www.medmastery.com. What happens in the lungs in acute respiratory syndrome (ARDS)? Introduction to ARDS alveoli Alveolar collapse Refractory hypoxemia Severity of ARDS = Oxygenation status P/F ratio = PaO2 FiO2 Recruitment Fluids ļ¬ll airsac Normal Supplemental oxygen does not help! ARDS Decreased volume in Increased recoil Shallow and rapid breathing ARDS Severity Mild Moderate Severe * on PEEP 5+; ** observed in cohort PaO2 / FiO2 * 200-300 100-200 < 100 Mortality ** 27% 32% 45%
  • 19. Become an expert by learning the most important clinical skills at www.medmastery.com. 19 Become an expert by learning the most important clinical skills at www.medmastery.com. What strategies can I use to treat patients with ARDS? Low tidal volume strategy You can use volume control mode with a low tidal volume strategy to manage patients with ARDS. Add more VT ? Increasing volume in does not help because the extra volume just enters the normal alveoli and overextends them, further increasing the plateau pressure above the acceptable 30 cmH2 O. This can damage the lung. Instead, it is better to reduce the VT to keep plateau pressure down and reduce the risk of barotrauma. 6ā€“8 mL/kg 4ā€“6m L/kg VT by 1 mL/kg Volume control mode Low tidal volume strategy High respiratory rate strategy Optimal PEEP strategy Note Reducing VT may cause an increase in PaCO2 and a decrease in pH. According to the ARDSnet protocol, compared to barotrauma, respiratory acidosis is the lesser of the evils. 1. Reduce VT
  • 20. Become an expert by learning the most important clinical skills at www.medmastery.com. 20 Become an expert by learning the most important clinical skills at www.medmastery.com. Air trapping in restrictive lung disease is bad, but air trapping may help your ARDS patient!!! Air trapping can act like PEEP and help recruit and stabilize the collapsed alveoli. What strategies can I use to treat patients with ARDS? High respiratory rate strategy High respiratory rate Low tidal volume Plateau pressure ā‰¤ 30 cmH2 O pH as low as 7.30 Alveolar recruitment PaCO2 pH 35 7.35 45 7.45 <7.30 Treating ARDS patients with a high RR strategy is like walking a ļ¬ne line... and you may need to adjust, and readjust, RR as necessary to balance PaCO2 and plateau pressure. Volume control mode Low tidal volume strategy High respiratory rate strategy Optimal PEEP strategy You can use volume control mode with a high respiratory rate (RR) strategy to manage patients with ARDS. Increase RR PaCO2 Air trapping
  • 21. Become an expert by learning the most important clinical skills at www.medmastery.com. 21 Become an expert by learning the most important clinical skills at www.medmastery.com. PEEP PEEP What strategies can I use to treat patients with ARDS? Optimal PEEP strategy PaO2 Static compliance ABG PEEP that produces the highest PaO2 = Optimal PEEP PEEP that produces the highest static compliance = Optimal PEEP * Use inspiratory hold. Static compliance = Tidal volume Plateau pressure Volume control mode Low tidal volume strategy High respiratory rate strategy Optimal PEEP strategy You can use volume control mode with an optimal PEEP strategy to manage patients with ARDS. Alveolar recruitment Lots of needle sticks (ABG) Highest PaO2 = best oxygenation (not necessarily best lung compliance) Easier to ensure no negative hemodynamic effects of a high PEEP. Still a debated topic... and so you might want to switch modes! Volume control ??? In this strategy, you adjust PEEP up and down to ļ¬nd the PEEP at which the lung is the most compliant. To determine when the lung is most compliant you can monitor PaO2 or calculate the static compliance.
  • 22. Become an expert by learning the most important clinical skills at www.medmastery.com. 22 Become an expert by learning the most important clinical skills at www.medmastery.com. Goals of lung protective modes What is lung protection? Switch mode + PEEP Inhalation ā€Sweet spotā€ Pressure Volume VT Lung protective modes: Pressure control Bilevel APRV When treating patients with ARDS it is common to switch from AC volume control to a mode that is more lung protective. We are trying to protect the lungs from two things: 1. alveolar collapse 2. overdistension barotrauma! 1. alveolar collapse 2. overdistension When using AC volume control you need to constantly adjust and readjust tidal volume and PEEP to keep the lungs in the sweet spot. Other lung protective modes have been developed that are less frustrating and make it easier to keep the lung in the sweet spot.
  • 23. Become an expert by learning the most important clinical skills at www.medmastery.com. 23 Become an expert by learning the most important clinical skills at www.medmastery.com. CON Asynchrony Set i-time may not match the patientā€˜s desired i-time, causing patient to be out-of-sync with venilator anxiety! 1. Adjust and readjust i-time 2. Sedate patient 3. Switch to another mode Pressure control Which lung protective modes can I use to treat patients with ARDS? Bilevel? APRV? PRO VT = Lung compliance In pressure control mode, the VT changes with lung compliance so you can easily monitor improvement in lung function. 1 10 20 Pressure (PIP) (cmH2 O) Time (sec) i-time 0.8-1.2 sec 20 cmH2 O PEEP > 5 cmH2 O 30 cmH2 O 30 3 2 4 5 6 Pressure control mode is a lung protective mode that can be used to treat patients with ARDS. Pressure control Pressure control Bilevel mode APRV mode Initial settings PIP 20ā€“30 cmH2 O i-time 0.8ā€“1.2 sec PEEP >5 cmH2 O Monitor PaCO2 (ABG) Adjust RR as necessary
  • 24. Become an expert by learning the most important clinical skills at www.medmastery.com. 24 Become an expert by learning the most important clinical skills at www.medmastery.com. Bilevel mode Which lung protective modes can I use to treat patients with ARDS? Pressure (cmH2 O) Time (sec) T high spontaneous breaths P high T low P low 30 cmH2 O Pressure (cmH2 O) Time (sec) i-time PIP e-time PEEP 30 cmH2 O triggered breath Bilevel Pressure control Pressure control Bilevel mode APRV mode Bilevel mode is a lung protective mode that can be used to treat patients with ARDS. Bilevel 1. Max/min pressure support (P high/P low). 2. Set RR. But, breaths are spontaneous and can be taken any time. 3. Set T high (T low* ). Pressure support 1. Max/min total pressure (PIP/PEEP). 2. Set RR. Breaths are controlled (or triggered at set times). PRO Protect lung from exceeding high pressure. Lessen anxiety because patient can breathe freely. Initial settings P high 20ā€“30 cmH2 O T high 0.8ā€“1.2 sec RR 20-30 breaths/min PEEP (P low) >10 cmH2 O Pressure support 0ā€“10 cmH2 O * This method closely resembles the pressure control method. NOTE Physicians may choose to closely resemble the APRV initial settings. * T low is automatically set based on T high and RR.
  • 25. Become an expert by learning the most important clinical skills at www.medmastery.com. 25 Become an expert by learning the most important clinical skills at www.medmastery.com. APRV mode Which lung protective modes can I use to treat patients with ARDS? APRV Bilevel + Pressure support APRV mode is a lung protective mode that can be used to treat patients with ARDS. Time (sec) P high P low T high T low RR Pressure (cmH2 O) Time (sec) P high PEEP T high T low RR = 30 Pressure (cmH2 O) APRV 1. Set P high/P low. (No pressure support.) 2. Set T high (traditionally set longer). 3. Set T low (traditionally set shorter to prevent lung deflation). Bilevel 1. Set P high/P low (PEEP). 2. Set T high (T low* ). 3. Set RR. Pressure control Bilevel mode APRV mode Initial settings P high 20ā€“30 cmH2 O T high 4ā€“6 sec P low 0ā€“5 cmH2 O T low 0.2ā€“0.8 sec * T low is automatically determined based on T high and RR.
  • 27. Become an expert by learning the most important clinical skills at www.medmastery.com. 27 Become an expert by learning the most important clinical skills at www.medmastery.com. 3. Hemodynamic status No active myocardial infarction No (or low) vasopressor infusion 4. Sedation status No neuromuscular blocking agents 2. Ventilation status < 35 breaths / minute 1. Oxygenation status SpO2 ā‰„ 90% on FiO2 ā‰¤ 40% PEEP ā‰¤ 5 cmH2 O What should I screen before weaning my patient? Screening before weaning O2 CO2 O2 CO2 Before weaning you need to screen your patient to make sure they meet the following criteria.
  • 28. Become an expert by learning the most important clinical skills at www.medmastery.com. 28 Become an expert by learning the most important clinical skills at www.medmastery.com. Tidal volume (mL) i n s p i r a t o r y e x p i r a t o r y Time (sec) 500 1 3 5 2 4 6 7 Spontaneous breaths Pressure support < 20 cmH2 O What strategies can I use to wean my intubated patients? Weaning using the SIMV strategy You can use the SIMV strategy to wean your patient off the ventilator. 1. Check patient meets screening criteria. 2. Switch patient from AC SIMV (with same settings). 3. Reduce RRā€”gradually. Reducing the RR allows for more opportunity for spontaneous breathing. SIMV strategy SBT (CPAP or T-piece) Reduce RR to as low as possible. Reference: Hess Dean, RRT, PhD, FCCP. Ventilator modes used in weaning. Chest 2001. 120: 474S-476S. PRO Patient assessment You are often more successful with something you are familiar with. CON Poor outcomes 4. Observe patientā€˜s spontaneous ability. 5. Add pressure support as needed. Added pressure support can assist low volume spontaneous breaths; but be careful not to add more than 20 cmH2 O support this probably means patient isnā€˜t ready. (Hess 2011)
  • 29. Become an expert by learning the most important clinical skills at www.medmastery.com. 29 Become an expert by learning the most important clinical skills at www.medmastery.com. What strategies can I use to wean my intubated patients? Weaning using the SBT method CPAP T-piece CPAP 5 cmH2 O Pressure support 6-8 cmH2 O CPAP 0 cmH2 O Pressure support 0 cmH2 O SIMV SBT SIMV strategy SBT (CPAP or T-piece) You can use the SBT method to wean your patient off the ventilator. 1. Check patient meets screening criteria. 2. Switch patient from AC T-piece. 3. Remove all pressure support (but leave connected to ventilator). Keeping patient connected to ventilator allows you to monitor spontaneous breaths and VT . 4. Cycle between no support and support, with increasing duration of no support. No support for 2 hours. 1. Check patient meets screening criteria. 2. Switch patient from AC CPAP 3. CPAP of 5cmH2 O helps distend alveoli. 4. Add pressure support of 6ā€“8 cmH2 O. Sink or swim method Even though the SBT method can be considered a sink or swim method, it appears to be better than SIMV because the patient breaths spontaneously with little support.
  • 30. Become an expert by learning the most important clinical skills at www.medmastery.com. 30 Become an expert by learning the most important clinical skills at www.medmastery.com. 1. Respiratory 2. Cardiovascular 3. Neurologic 4. Psychologic Which weaning parameters do I monitor to help guide my decision to extubate? Weaning parameters RSBI = RR/VT RSBI < 105 RSBI < 80 Stable with minimum pressors FiO2 < 40% PEEP < 5-8 No seizures p/f > 150 Follow instructions WOB O2 No dyspnea Awake RR < 35 breaths/min Alert Anxiety Stress Fear Before extubating, you need to monitor your patient and make sure they meet the following weaning parameters. And... you should always evaluate to ensure there has been a reversal of the primary cause for mechanical ventilation. Key Reversal of the primary cause for mechanical ventilation.
  • 31. Become an expert by learning the most important clinical skills at www.medmastery.com. 31 Become an expert by learning the most important clinical skills at www.medmastery.com. How do I know if a patient requires a tracheostomy? Tracheostomy Ventilatory capability Ventilatory demand Multiple failed weaning attempts Secrection clearance Neuromuscular impairment After prolonged mechanical ventilation, some patients will require a tracheostomy. The length of time mechanical ventilation is needed is often dependent on the severity of the disease. And, once a patient has been on ventilation for two weeks, a tracheostomy is commonly considered.
  • 32. Become an expert by learning the most important clinical skills at www.medmastery.com. 32 Become an expert by learning the most important clinical skills at www.medmastery.com. TIPS protocol How do I wean my patients with a tracheostomy? Weaning after prolonged mechanical ventilation You can still wean after tracheostomy Go slow! Barlow hospital TIPS protocol Step 1: AC to SIMV of 10/min and PS of 20 Step 2: SIMV of 8/min and PS of 20 Step 3: SIMV of 6/min and PS of 20 Step 4: SIMV of 4/min and PS of 20 Step 5: SIMV of 4/min and PS of 18 Step 6: SIMV of 4/min and PS of 16 Step 7: SIMV of 4/min and PS of 14 Step 8: SIMV of 4/min and PS of 12 Step 9: SIMV of 4/min and PS of 10 Step 10: 1 hour Step 11: 2 hours Step 12: 4 hours Step 13: 6 hours Step 14: 8 hours Step 15: 10 hours Step 16: 12 hours Step 17: 16 hours Step 18: 20 hours Step 19: 24 hours 4 breaths/min (SIMV) Pressure support (PS) to 10 cmH2 O CPAP and PS to 0 Patient can be extubated Up to 3 steps per day at 4- hour intervals. Up to 2 steps per day. If patient is breathing comfortably at the 9th step, a slow-paced, spontaneous breathing trial can be started. After completion of daily steps, put back on step 9 for rest of day. If patient is breathing comfortably after 19th step, they can be removed from ventilator. SBT: Reduce to CPAP of 0 and PS of 0 and monitor for: Reduce the pressure support (PS): Reduce to SIMV:
  • 34. Become an expert by learning the most important clinical skills at www.medmastery.com. 34 Become an expert by learning the most important clinical skills at www.medmastery.com. How do I know if my patientā€˜s upper airway swelling is reduced enough to extubate? Upper airway swelling Leak No leak Deflate cuff How do we know when the swelling has decreased enough in order to extubate the patient? Leak No leak Deflate cuff and listen for a leak. Swelling reduced OK to extubate Swelling still present Check daily
  • 35. Become an expert by learning the most important clinical skills at www.medmastery.com. 35 Become an expert by learning the most important clinical skills at www.medmastery.com. How do I know if my patientā€˜s neuromuscular weakness has improved enough to extubate? Neuromuscular weakness better than -20 cmH2 O worse than -20 cmH2 O check daily Remember a lower pressure (more negative) is better! NIF Negative inspiratory force NIF/MIP OK to extubate Check daily OR MIP Maximum inspiratory pressure The amount of force that is generated by the patient in an inspiration.
  • 37. 37 Reference list Chiumello, D, Pelosi, P, Calvi, E, et al. 2002. Different modes of assisted ventilation in patients with acute respiratory failure. Eur Respir J. 20: 925ā€“933. PMID: 12412685 Christopher, KL, Neff, TA, Bowman, JL, et al. 1985. Demand and continuous flow intermittent mandatory ventilation systems. Chest. 87: 625ā€“630. PMID: 3886315 Esteban, A, Anzueto, A, AlĆ­a, I, et al. 2000. How is mechanical ventilation employed in the intensive care unit? An international utilization review. Am J Respir Crit Care Med. 161: 1450ā€“1458. PMID: 10806138 Hess, D. 2001. Ventilator modes used in weaning. Chest. 120: 474Sā€“476S. PMID: 11742968 Lazoff, SA and Bird, K. 2022. Synchronized intermittent Mandatory Ventilation. Treasure Island (FL): StatPearls Publishing. PMID: 31751036 Marini, JJ, Smith, TC and Lamb, VJ. 1988. External work output and force generation during synchronized intermittent mechanical ventilation. Effect of machine assistance on breathing effort. Am Rev Respir Dis. 138: 1169ā€“1179. PMID: 3202477 Mireles-Cabodevila, E, Dugar, S and Chatburn, RL. 2018. APRV for ARDS: the complexities of a mode and how it affects even the best trials. J Thorac Dis. 10: S1058ā€“S1063. PMID: 29850185 Mora Carpio, AL and Mora, JI. 2022. Positive end-expiratory pressure. Treasure Island (FL): StatPearls Publishing. www.ncbi.nlm.nih.gov. Prella, M, Feihl, F and Domenighetti, G. 2002. Effects of short-term pressure- controlled ventilation on gas exchange, airway pressures, and gas distribution in patients with acute lung injury/ARDS: comparison with volume-controlled ventilation. Chest. 122: 1382ā€“1388. PMID: 12377869 Putensen, C, Mutz, NJ, Putensen-Himmer, G, et al. 1999. Spontaneous breathing during ventilatory support improves ventilation-perfusion distributions in patients with acute respiratory distress syndrome. Am J Respir Crit Care Med. 159: 1241ā€“1248. PMID: 10194172 Sassoon, CS, Del Rosario, N, Fei, R, et al. 1994. Influence of pressure- and flow-triggered synchronous intermittent mandatory ventilation on inspiratory muscle work. Crit Care Med. 22: 1933ā€“1941. PMID: 7988129 Tobin, MJ and Lodato, RF. 1989. PEEP, auto-PEEP, and waterfalls. Chest. 96: 449ā€“451. PMID: 2670461 Varpula, T, Valta, P, Niemi, R, et al. 2004. Airway pressure release ventilation as a primary ventilatory mode in acute respiratory distress syndrome. Acta Anaesthesiol Scand. 48: 722ā€“731. PMID: 15196105 Zhou, Y, Jin, X, Lv, Y, et al. 2017. Early application of airway pressure release ventilation may reduce the duration of mechanical ventilation in acute respiratory distress syndrome. Intensive Care Med. 43: 1648ā€“1659. PMID: 28936695
  • 38. Become an expert by learning the most important clinical skills at www.medmastery.com.