ICH S7B guideline1 regulates in vitro IKr assay (such as hERG safety assay) and in vitro QT assay for identifying and assessing the potential of a test compound to delay ventricular repolarization. Ventricular repolarization is a complex physiological process determined by the duration of the cardiac action potential. It is the net result of the activities of many highly interdependent membrane ion channels and transporters. Many compounds can affect the activities of the ion channels or transporters, thus have the potential of delaying the ventricular repolarization and leading to prolonged QT interval.

2. Herg safety assay
Staffed with a group of experts that have gained years of experience in ion channel safety
assays and cardiotoxicity assessment, Creative Bioarray offers hERG safety assay in
accordance with the ICH S7B guideline to evaluate compound cardiovascular safety and to
support drug development. Inhibition assays of other ion channels are also available.
ICH S7B guideline1 regulates in vitro IKr assay (such as hERG safety assay) and in vitro QT
assay for identifying and assessing the potential of a test compound to delay ventricular
repolarization. Ventricular repolarization is a complex physiological process determined by
the duration of the cardiac action potential. It is the net result of the activities of many
highly interdependent membrane ion channels and transporters. Many compounds can
affect the activities of the ion channels or transporters, thus have the potential of delaying
the ventricular repolarization and leading to prolonged QT interval.

5. Contact
Email: contact@creative-bioarray.com
Phone No. 1-631-619-7922
Facebook: @Creative Bioarray
Twitter: @CreaBioarray
Web: https://www.creative-bioarray.com/Services/hERG-Safety.htm

6. Contact
Email: contact@creative-bioarray.com
Phone No. 1-631-619-7922
Facebook: @Creative Bioarray
Twitter: @CreaBioarray
Web: https://www.creative-bioarray.com/Services/hERG-Safety.htm