5. Corresponding Values of SBP/DBP for Clinic, HBPM, Daytime, Nighttime, and 24-Hour ABPM
Measurements
6.
7. w-onset or uncontrolled hypertension in adults
Conditions
• Drug-resistant/induced hypertension
• brupt onset of hypertension
• Onset of hypertension at <30 y
• Exacerbation of previously controlled hypertension
• Disproportionate TOD for degree of hypertension
• ccelerated/malignant hypertension
• Onset of diastolic hypertension in older adults (age ≥65 y)
• Unprovoked or excessive hypokalemia
Yes No
15. BP thresholds and recommendations for treatment and follow-up
Normal BP
(BP <120/80
mm Hg)
Promote optimal
lifestyle habits
Elevated BP
(BP 120-129/<80
mm Hg)
Nonpharmacologic
therapy
(Class I)
Stage 1 hypertension
(BP 130-139/80-89
mm Hg)
Clinical ASCVD
or estimated 10-y CVD risk
≥10%*
No Yes
Nonpharmacologic
Stage 2 hypertension
(BP ≥ 140/90 mm Hg)
Nonpharmacologic therapy
Reassess in Reassess in
1 y 3-6 mo
(Class IIa) (Class I)
Nonpharmacologic
therapy
(Class I)
therapy and
BP-lowering medication
(Class I)
and
BP-lowering medication†
(Class I)
18. Choice of initial drug
•Thiazide diuretics
•CCBs
•ACE inhibitors
•ARB
19. •2 first-line agents of different classes, either as separate
agents or in a fixed-dose combination, is recommended in
adults with stage 2 hypertension and an average BP more
than 20/10 mm Hg above their BP target.
• Initiation of antihypertensive drug therapy with a single
antihypertensive drug is reasonable in adults with stage 1
hypertension and BP goal <130/80 mm Hg with dosage
titration and sequential addition of other agents to achieve
the BP target.
• Monthly follow up
20. Stable Ischaemic HD
addition of dihydropyridine CCBs to beta blockers is recommended.
In previous MI patients, continue beta blockers beyond 3 years
21. Heart Failure
• Nondihydropyridine CCBs are not recommended in the treatment of
hypertension in adults with HFrEF.
• In adults with HFpEF who present with symptoms of volume overload,
diuretics should be prescribed to control hypertension.
• Adults with HFpEF and persistent hypertension after management of volume
overload should be prescribed ACE inhibitors or ARBs and beta blockers
titrated to attain SBP of less than 130 mm Hg.
22. reatment of hypertension in patients with CKD
BP goal <130/80 mm Hg
(Class I)
Albuminuria
(≥300 mg/d or ≥300 mg/g
creatinine)
Yes No
ACE inhibitor Usual “first-line”
(Class IIa) medication choices
ACE inhibitor
intolerant
Yes No
ARB* ACE inhibitor*
(Class IIb) (Class IIa)
23. CKD
• Target BP < 130/80
• ACE inhibitor slows kidney disease progression
• ARB may be reasonable if an ACE inhibitor is not tolerated.
• POST RENAL TRANSPLANT CASES : Calcium channel blockers
24. ACUTE STROKE
• In adults with an acute ischemic stroke, BP should be <185/110 mm Hg before
administration of intravenous tissue plasminogen activator and should be
maintained below 180/105 mm Hg for at least the first 24 hours after initiating
drug therapy.
• If not thrombolysing, the benefit of initiating or reinitiating treatment of
hypertension within the first 48 to 72 hours is uncertain
25. Patient
qualifies for IV
thrombolysis
therapy
Yes
Lower SBP to <185 mm Hg and
DBP <110 mm Hg before
initiation of IV thrombolysis
(Class I)
And
Maintain BP <180/105 mm Hg for
first 24 h after IV thrombosis
(Class I)
No
BP ≤220/110 mm Hg
Initiating or reinitiating treatment of
hypertension within the first 48-72
hours after an acute ischemic stroke is
ineffective to prevent death or
dependency
(Class III: No Benefit)
For preexisting hypertension,
reinitiate antihypertensive drugs
after neurological stability
(Class IIa)
BP >220/110 mm Hg
Lower BP 15%
during first 24 h
(Class IIb)
27. Diabetes Mellitus
• Target BP is <130/80 mm Hg
• Initiate treatment if BP >130/80 mm Hg
• ACE inhibitors or ARBs may be considered in the presence of
albuminuria
• Diuretics and CCBs also useful
28. ATRIAL FIBRILLATION ARBs recommended
COR LOE
I B-NR
Recommendations for Treatment of Hypertension in Patients With Valvular
Heart Disease
In adults with asymptomatic aortic stenosis, hypertension should be treated with
pharmacotherapy, starting at a low dose and gradually titrating upward as needed.
In patients with chronic aortic insufficiency, treatment of systolic
hypertension with agents that do not slow the heart rate (i.e., avoid beta
IIa C-LD blockers) is reasonable.
