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217.898.5037 // MingyangJiang2015@u.northwestern.edu // 800 Hinman Ave APT 605 // Evanston, IL, 60202
Mingyang	
  Jiang	
  
LIST	
  OF	
  INVENTIONS	
  
PERSONAL
HIGHLIGHTSMICROWELLSTAMP
www.linkedin.com/in/MingyangJiang
• Enthusiastic	
  bioengineer,	
  critical	
  thinker,	
  and	
  innovative	
  problem	
  solver	
  
• Effectively	
  communicating	
  with	
  fellow	
  researchers	
  to	
  identify	
  new	
  research	
  needs	
  
• Efficiently	
  combining	
  engineering	
  and	
  biosciences	
  to	
  deliver	
  creative	
  solutions	
  
• Excellent	
  leader,	
  organizer	
  and	
  planner,	
  yet	
  good	
  at	
  dealing	
  with	
  ambiguity	
  
• Enjoy	
  working	
  in	
  multidisciplinary	
  teams	
  at	
  a	
  self-­‐motivated	
  fast	
  pace	
  
OViPokeTM	
  
OViPokeTM
	
   is	
   a	
   new	
   tool	
   designed	
   for	
   ovarian	
   biology	
   that	
   helps	
  
researchers	
   obtain	
   biologic	
   material	
   more	
   efficiently.	
   Unlike	
  
current	
  methods	
  of	
  oocyte	
  isolation	
  that	
  utilizes	
  2	
  syringe	
  needles	
  
to	
  perforate	
  the	
  ovary,	
  the	
  OViPokeTM
	
  is	
  a	
  pen-­‐shaped	
  device	
  that	
  
allows	
   the	
   researcher	
   to	
   have	
   precise	
   control	
   over	
   their	
  
experiment	
   and	
   maximum	
   perforation	
   in	
   a	
   short	
   period	
   of	
   time.	
  
OViPokeTM
	
  has	
  a	
  clean	
  and	
  simplified	
  design	
   for	
  easy	
  sterilization	
  
and	
  improved	
  durability.	
  
Microwell	
  Stamp	
  
Embryoid	
  body	
  formation	
  is	
  a	
  technique	
  used	
  to	
  differentiate	
  stem	
  
cells;	
  stem	
  cells	
  tend	
  to	
  grow	
  in	
  clumps	
  thus	
  uniform	
  distribution	
  is	
  
very	
  important	
  to	
  avoid	
  irregular	
  embryoid	
  body	
  shapes.	
  
The	
  PDMS	
  microwell	
  stamp	
  creates	
  microwell	
  structures	
  (diameter	
  
800µM)	
   on	
   an	
   agarose	
   base,	
   allowing	
   stem	
   cells	
   to	
   form	
   an	
  
optimally	
  shaped	
  embryoid	
  body	
  within	
  the	
  constraints	
  of	
  a	
  single	
  
microwell.	
  	
  This	
  design	
  eases	
  researchers	
  from	
  pipetting	
  each	
  cell	
  
individually,	
  and	
  costs	
  90%	
  less	
  than	
  commercial	
  products.	
  	
  
a.	
  3rd
	
  generation	
  stamp	
  design;	
  b.	
  Surface	
  of	
  a	
  stamp;	
  c.	
  Surface	
  of	
  
stamped	
  structures	
  under	
  microscope;	
  d.	
  Embryoid	
  bodies	
  in	
  well	
  
	
  
a	
   b	
  
c	
   d	
  
OviPokeWELLMODIFICATION
Cell	
  Culture	
  Plate	
  Well	
  Modification	
  
Zinc	
  spark	
  is	
  a	
  promising	
  biomarker	
  to	
  determine	
  the	
  readiness	
  of	
  
egg	
  for	
  in-­‐vitro	
  fertilization.	
  The	
  current	
  method	
  uses	
  a	
  dye-­‐coated	
  
glass	
  slide	
  to	
  capture	
  zinc,	
  losing	
  zinc	
  signal	
  due	
  to	
  the	
  2D	
  nature.	
  
This	
  well	
  modification	
  incorporates	
  zinc	
  dye	
  into	
  the	
  agarose	
  base,	
  
and	
   creates	
   a	
   3D	
   surrounding	
   structure	
   to	
   capture	
   more	
   zinc	
  
signal.	
  It	
  also	
  prevents	
  the	
  egg/cell	
  from	
  floating	
  around,	
  allowing	
  
for	
  more	
  stable	
  imaging	
  using	
  an	
  automated	
  microscope.	
  The	
  end	
  
goal	
  is	
  to	
  develop	
  a	
  new	
  clinical	
  tool	
  for	
  in-­‐vitro	
  fertilization.	
  	
  
	
  
OTHER
Rapid	
  Soil	
  Nematode	
  Extraction	
  	
  
This	
  floating	
  apparatus	
  efficiently	
  extract	
  the	
  nematode-­‐containing	
  
layer	
  of	
  solution	
  after	
  soil	
  flocculation	
  –	
  the	
  1st
	
  step	
  of	
  developing	
  a	
  
hand-­‐held	
  nematode	
  detector	
  (left).	
  
Improved	
  Pearl	
  Millet	
  Grain	
  Processing	
  Machine	
  
An	
  insert	
  that	
  extends	
  the	
  grain	
  feeder	
  to	
  minimize	
  loss	
  (right).	
  
Foam	
  

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ListOfInventions_Jiang_Mingyang_InsightPD

  • 1.   217.898.5037 // MingyangJiang2015@u.northwestern.edu // 800 Hinman Ave APT 605 // Evanston, IL, 60202 Mingyang  Jiang   LIST  OF  INVENTIONS   PERSONAL HIGHLIGHTSMICROWELLSTAMP www.linkedin.com/in/MingyangJiang • Enthusiastic  bioengineer,  critical  thinker,  and  innovative  problem  solver   • Effectively  communicating  with  fellow  researchers  to  identify  new  research  needs   • Efficiently  combining  engineering  and  biosciences  to  deliver  creative  solutions   • Excellent  leader,  organizer  and  planner,  yet  good  at  dealing  with  ambiguity   • Enjoy  working  in  multidisciplinary  teams  at  a  self-­‐motivated  fast  pace   OViPokeTM   OViPokeTM   is   a   new   tool   designed   for   ovarian   biology   that   helps   researchers   obtain   biologic   material   more   efficiently.   Unlike   current  methods  of  oocyte  isolation  that  utilizes  2  syringe  needles   to  perforate  the  ovary,  the  OViPokeTM  is  a  pen-­‐shaped  device  that   allows   the   researcher   to   have   precise   control   over   their   experiment   and   maximum   perforation   in   a   short   period   of   time.   OViPokeTM  has  a  clean  and  simplified  design   for  easy  sterilization   and  improved  durability.   Microwell  Stamp   Embryoid  body  formation  is  a  technique  used  to  differentiate  stem   cells;  stem  cells  tend  to  grow  in  clumps  thus  uniform  distribution  is   very  important  to  avoid  irregular  embryoid  body  shapes.   The  PDMS  microwell  stamp  creates  microwell  structures  (diameter   800µM)   on   an   agarose   base,   allowing   stem   cells   to   form   an   optimally  shaped  embryoid  body  within  the  constraints  of  a  single   microwell.    This  design  eases  researchers  from  pipetting  each  cell   individually,  and  costs  90%  less  than  commercial  products.     a.  3rd  generation  stamp  design;  b.  Surface  of  a  stamp;  c.  Surface  of   stamped  structures  under  microscope;  d.  Embryoid  bodies  in  well     a   b   c   d   OviPokeWELLMODIFICATION Cell  Culture  Plate  Well  Modification   Zinc  spark  is  a  promising  biomarker  to  determine  the  readiness  of   egg  for  in-­‐vitro  fertilization.  The  current  method  uses  a  dye-­‐coated   glass  slide  to  capture  zinc,  losing  zinc  signal  due  to  the  2D  nature.   This  well  modification  incorporates  zinc  dye  into  the  agarose  base,   and   creates   a   3D   surrounding   structure   to   capture   more   zinc   signal.  It  also  prevents  the  egg/cell  from  floating  around,  allowing   for  more  stable  imaging  using  an  automated  microscope.  The  end   goal  is  to  develop  a  new  clinical  tool  for  in-­‐vitro  fertilization.       OTHER Rapid  Soil  Nematode  Extraction     This  floating  apparatus  efficiently  extract  the  nematode-­‐containing   layer  of  solution  after  soil  flocculation  –  the  1st  step  of  developing  a   hand-­‐held  nematode  detector  (left).   Improved  Pearl  Millet  Grain  Processing  Machine   An  insert  that  extends  the  grain  feeder  to  minimize  loss  (right).   Foam