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SOME GOOD…
SOME BAD…
SOME WONDERFUL…
MEDICATIONS &
SUPPLEMENTS
MICHELLE PECK & COMPANY
Michelle Peck, MSN, MPH, ANP-BC, GNP-BC, CLNC
Nurse Practitioner | Nursing Faculty | Legal Nurse
WEB nursepeck.com
PRESCRIBING CHALLENGES
AGE OVER 60
Adverse drug reactions
increase as the number of
prescribed medications
increases
Adherence to complex,
multiple drugs is difficult:
poor vision, poor memory,
limited funds, etc.
ADVERSE DRUG EVENTS
Multiple medications is
the primary risk factor
Multiple medical
conditions increases
risk
Many reactions
preventable
PRESCRIBING STRATEGIES
Prescribing ALL indicated
medications, may NOT be
the best approach
Triage medications - start
with most needed first,
assess impact and then
add second most
important…
Some conditions assumed
to be “aging” can be drug
effects - confusion, falls,
incontinence
Try Using One Drug to
Treat Multiple Problems
RISK FACTORS FOR ADVERSE
DRUG EVENTS INCREASE
> 6 DIAGNOSES
> 12 MED DOSES/DAY
> 9 MEDICATIONS
MULTIPLE PRESCRIBERS
A PREVIOUS REACTION
LOW BODY WEIGHT
AGE > 85 YEARS
KIDNEY, LIVER FUNCTION
BENEFIT VS.
Appropriate medication use requires that
benefits of therapy clearly outweigh the
associated risks.
Benefit-to-risk ratio is unique to an
individual; the very medication and dosage
that helps one patient may harm another.
BEER’S CRITERIA
Expert Panel from around the world
Developed this wonderful list of Medications to Avoid
if you are over 65
Recently Updated in 2012
Severity ratings of medications on High to Low Scale
Problems grouped based on Disease
Concerns listed independent of Disease
> 65 YEARS AVOID MEDS HIGH
ANTI-CHOLINERGIC PROPERTIES
Benadryl
Tricyclic antidepressants
Anti-spasmotics
Anti-psychotics
Anti-parkinsonian and muscle
relaxants
Urinary incontinence medications
AVOID DRUG-DISEASE
INTERACTIONS
Avoid NSAIDs (Aleve, Ibuprofen, Advil):
With Stomach, Colon Bleeding & Kidney Disease
Avoid Anticholinergic Medications:
With Prostate/Bladder Outlet Obstruction,
Alzheimer’s Disease & Chronic Constipation
Avoid Benzodiazepines/Tricyclic Antidepressants:
With Falling & Balance Disturbances
How YOU take
YOUR medication
matters!
Read the Rx label.
Know your
pharmacist.
Ask questions.
Often taking medications or vitamins with food or drinks
other than water can decrease the effectiveness.
Grapefruit juice should be avoided with medications and
supplements, it severely decreases effectiveness.
WHAT YOU TAKE WITH
MEDICATION MATTERS.
Levothyroxine Example:
Only 60-80% is absorbed.
Absorption occurs 3 hours of ingestion.
Maximal absorption when stomach is empty:
Calcium binds and will reduce absorption;
Coffee decreases absorption by 27-36%.
RISKS, ESPECIALLY TO
OLDER CONSUMERS
Many supplements contain active ingredients
that have strong biological effects in the body
This could make them unsafe in some situations
St. John’s Wort Example: May reduce the effectiveness
of prescription drugs used for heart disease,
depression, seizures, and certain cancers.
COMPLEMENTARY
AND
ALTERNATIVE
MEDICINE
CAM
What are examples
of CAM?
DIETARY
SUPPLEMENTS
A DIETARY SUPPLEMENT
A product (other than tobacco) intended to
supplement the diet that bears or contains one or
more of the following dietary ingredients
VITAMINS
MINERALS
HERBS OR OTHER BOTANICALS
AMINO ACIDS
CONCENTRATE, METABOLITE,
CONSTITUENT, EXTRACT OR
COMBINATION OF INGREDIENTS
Are dangerous
supplements
marketed and sold
to consumers?
http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm236774.htm
THE DIRTY DOZEN
ACONITE
BITTER ORANGE
CHAPARRAL
COLLOIDAL SILVER
COLTSFOOT
COMFREY
COUNTRY MALLOW
GERMANIUM
GREATER CELANDINE
KAVA
LOBELIA
YOHIMBE
Why are they still for sale?
Two national retailers we
contacted about specific
supplements said they
carried them because the
FDA has not banned them…
The FDA does not regulate
supplements so they cannot
ban them!
You have to be careful about
what supplements you take!
Most health care consumers DO NOT inform their
health care providers of their supplement use.
They think that either their provider does not care
or does not need to know.
This bad logic can lead to BIG FAILURE.
DIETARY SUPPLEMENTS
Example: St.
John’s Wort can
increase the
metabolism of
other drugs
making them
less effective…
Example: Kava Kava is
associated with liver
toxicity…
Example: Echinacea
decreases immune
response with long-term
use…
The “G-Team” Ginkgo
Biloba, Garlic & Ginger
all have antiplatelet
effects and can lead to
uncontrolled bleeding…
TO CHOOSE GOOD
SUPPLEMENTS LOOK FOR
U.S.P. notation
GMP or cGMP notation
Consumer Lab seal
Consider manufacturer
distributor
Look at brand used in
studies reporting positive
outcome
Look for third party testing
The USP Verified Mark and What It Means
Contains the ingredients and amounts listed on the label
Does not contain harmful levels of specified contaminants
Will break down and release into the body
Made according to FDA current Good Manufacturing
Practices using sanitary and well-controlled procedures
TO CHOOSE A SUPPLEMENT
Look for available quality clinical research
Check for long tradition of use (safety)
Check that active ingredient(s) are identified
Review mechanism of action determined
Verify available from a reliable source
 Ingredients and potency documented
Quality assurance documented, seal of approval
What common vitamin
deficiency in older adults can
cause symptoms of fatigue,
memory impairment,
irritability, depression and
personality changes?
B12
OLDER ADULTS
1.6 to 2.3 times more
likely to have
vitamin B12 deficiency
3.7 to 4 times more
likely to have
vitamin D deficiency
How much daily
Vitamin D
should you take if
you are
over 70 years old?
HOW MUCH DAILY VITAMIN D?
Older skin cannot synthesize vitamin D as well
Likely to spend more time indoors
Inadequate dietary intakes of vitamin D
51–70 years
600 IU
(15 mcg)
600 IU
(15 mcg)
>70 years
800 IU
(20 mcg)
800 IU
(20 mcg)
Age Male Female
SAVVY CONSUMERS SHARE
INFORMATION WITH THEIR
HEALTH CARE TEAM
1. Please list which supplements you take, how often,
and why you take them.
2. Are you currently taking or have you recently taken
any over-the-counter medications (e.g., aspirin, cold
medicine, stool softener, pain reliever, etc.)?
3. What prescription medication(s) are you currently
taking, if any?
SPECIAL THANKS FOR
CONTENT & IDEAS
UC IRVINE, REYNOLDS GRANT
UNIVERSITY CINCINNATI/HEALTH ALLIANCE,
REYNOLDS GRANT
THE AMERICAN GERIATRICS SOCIETY, BEER’S CRITERIA
US FOOD AND DRUG ADMINISTRATION
Geriatric Population. What you need to know about medication and supplement safety... Some good...Some bad...Some wonderful! Special focus on Geriatrics.

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Geriatric Population. What you need to know about medication and supplement safety... Some good...Some bad...Some wonderful! Special focus on Geriatrics.

  • 1. SOME GOOD… SOME BAD… SOME WONDERFUL… MEDICATIONS & SUPPLEMENTS MICHELLE PECK & COMPANY Michelle Peck, MSN, MPH, ANP-BC, GNP-BC, CLNC Nurse Practitioner | Nursing Faculty | Legal Nurse WEB nursepeck.com
  • 2. PRESCRIBING CHALLENGES AGE OVER 60 Adverse drug reactions increase as the number of prescribed medications increases Adherence to complex, multiple drugs is difficult: poor vision, poor memory, limited funds, etc.
  • 3. ADVERSE DRUG EVENTS Multiple medications is the primary risk factor Multiple medical conditions increases risk Many reactions preventable
  • 4. PRESCRIBING STRATEGIES Prescribing ALL indicated medications, may NOT be the best approach Triage medications - start with most needed first, assess impact and then add second most important… Some conditions assumed to be “aging” can be drug effects - confusion, falls, incontinence Try Using One Drug to Treat Multiple Problems
  • 5. RISK FACTORS FOR ADVERSE DRUG EVENTS INCREASE > 6 DIAGNOSES > 12 MED DOSES/DAY > 9 MEDICATIONS MULTIPLE PRESCRIBERS A PREVIOUS REACTION LOW BODY WEIGHT AGE > 85 YEARS KIDNEY, LIVER FUNCTION
  • 6. BENEFIT VS. Appropriate medication use requires that benefits of therapy clearly outweigh the associated risks. Benefit-to-risk ratio is unique to an individual; the very medication and dosage that helps one patient may harm another.
  • 7. BEER’S CRITERIA Expert Panel from around the world Developed this wonderful list of Medications to Avoid if you are over 65 Recently Updated in 2012 Severity ratings of medications on High to Low Scale Problems grouped based on Disease Concerns listed independent of Disease
  • 8.
  • 9.
  • 10. > 65 YEARS AVOID MEDS HIGH ANTI-CHOLINERGIC PROPERTIES Benadryl Tricyclic antidepressants Anti-spasmotics Anti-psychotics Anti-parkinsonian and muscle relaxants Urinary incontinence medications
  • 11. AVOID DRUG-DISEASE INTERACTIONS Avoid NSAIDs (Aleve, Ibuprofen, Advil): With Stomach, Colon Bleeding & Kidney Disease Avoid Anticholinergic Medications: With Prostate/Bladder Outlet Obstruction, Alzheimer’s Disease & Chronic Constipation Avoid Benzodiazepines/Tricyclic Antidepressants: With Falling & Balance Disturbances
  • 12. How YOU take YOUR medication matters!
  • 13. Read the Rx label. Know your pharmacist. Ask questions. Often taking medications or vitamins with food or drinks other than water can decrease the effectiveness. Grapefruit juice should be avoided with medications and supplements, it severely decreases effectiveness.
  • 14. WHAT YOU TAKE WITH MEDICATION MATTERS. Levothyroxine Example: Only 60-80% is absorbed. Absorption occurs 3 hours of ingestion. Maximal absorption when stomach is empty: Calcium binds and will reduce absorption; Coffee decreases absorption by 27-36%.
  • 15. RISKS, ESPECIALLY TO OLDER CONSUMERS Many supplements contain active ingredients that have strong biological effects in the body This could make them unsafe in some situations St. John’s Wort Example: May reduce the effectiveness of prescription drugs used for heart disease, depression, seizures, and certain cancers.
  • 19.
  • 20. A DIETARY SUPPLEMENT A product (other than tobacco) intended to supplement the diet that bears or contains one or more of the following dietary ingredients VITAMINS MINERALS HERBS OR OTHER BOTANICALS AMINO ACIDS CONCENTRATE, METABOLITE, CONSTITUENT, EXTRACT OR COMBINATION OF INGREDIENTS
  • 23. THE DIRTY DOZEN ACONITE BITTER ORANGE CHAPARRAL COLLOIDAL SILVER COLTSFOOT COMFREY COUNTRY MALLOW GERMANIUM GREATER CELANDINE KAVA LOBELIA YOHIMBE Why are they still for sale? Two national retailers we contacted about specific supplements said they carried them because the FDA has not banned them… The FDA does not regulate supplements so they cannot ban them!
  • 24. You have to be careful about what supplements you take! Most health care consumers DO NOT inform their health care providers of their supplement use. They think that either their provider does not care or does not need to know. This bad logic can lead to BIG FAILURE.
  • 25. DIETARY SUPPLEMENTS Example: St. John’s Wort can increase the metabolism of other drugs making them less effective…
  • 26. Example: Kava Kava is associated with liver toxicity…
  • 28. The “G-Team” Ginkgo Biloba, Garlic & Ginger all have antiplatelet effects and can lead to uncontrolled bleeding…
  • 29. TO CHOOSE GOOD SUPPLEMENTS LOOK FOR U.S.P. notation GMP or cGMP notation Consumer Lab seal Consider manufacturer distributor Look at brand used in studies reporting positive outcome Look for third party testing
  • 30. The USP Verified Mark and What It Means Contains the ingredients and amounts listed on the label Does not contain harmful levels of specified contaminants Will break down and release into the body Made according to FDA current Good Manufacturing Practices using sanitary and well-controlled procedures
  • 31.
  • 32. TO CHOOSE A SUPPLEMENT Look for available quality clinical research Check for long tradition of use (safety) Check that active ingredient(s) are identified Review mechanism of action determined Verify available from a reliable source  Ingredients and potency documented Quality assurance documented, seal of approval
  • 33. What common vitamin deficiency in older adults can cause symptoms of fatigue, memory impairment, irritability, depression and personality changes? B12
  • 34. OLDER ADULTS 1.6 to 2.3 times more likely to have vitamin B12 deficiency 3.7 to 4 times more likely to have vitamin D deficiency
  • 35. How much daily Vitamin D should you take if you are over 70 years old?
  • 36. HOW MUCH DAILY VITAMIN D? Older skin cannot synthesize vitamin D as well Likely to spend more time indoors Inadequate dietary intakes of vitamin D 51–70 years 600 IU (15 mcg) 600 IU (15 mcg) >70 years 800 IU (20 mcg) 800 IU (20 mcg) Age Male Female
  • 37. SAVVY CONSUMERS SHARE INFORMATION WITH THEIR HEALTH CARE TEAM 1. Please list which supplements you take, how often, and why you take them. 2. Are you currently taking or have you recently taken any over-the-counter medications (e.g., aspirin, cold medicine, stool softener, pain reliever, etc.)? 3. What prescription medication(s) are you currently taking, if any?
  • 38. SPECIAL THANKS FOR CONTENT & IDEAS UC IRVINE, REYNOLDS GRANT UNIVERSITY CINCINNATI/HEALTH ALLIANCE, REYNOLDS GRANT THE AMERICAN GERIATRICS SOCIETY, BEER’S CRITERIA US FOOD AND DRUG ADMINISTRATION