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Merck KGaA
Darmstadt, Germany
Aida Tsouroukdissian
Head of Demand Planning, Integrated Supply Chain
Operations
21 February 2019
How to make your
supply chain more
robust with
collaborative
forecasting &
transparency?
2
The life science business of
Merck KGaA, Darmstadt, Germany
operates as MilliporeSigma
in the U.S. and Canada.
Collaborative Forecasting | 21 February 2019
The first rule of forecasting –
that forecasts are always wrong –
is truer today than ever before.
Collaborative Forecasting | 21 February 2019
The Power of Resilience
Yossi Sheffi
Demonstrate how collaboration between biopharmaceutical manufacturers and
suppliers is crucial for supply robustness and control.
Learn
 How and when to collaborate to mitigate potential supply risk
 With whom to partner to have a successful collaboration process
 How collaboration adds value
 How to measure success of the collaboration process
How To Make Your Supply Chain More Robust with Collaborative Forecasting?
Objective
Collaborative Forecasting | 21 February 2019
01 Collaboration Challenges
02 Supplier Implications
03 Demand Planning & Capacity Process
04 Organization
05 Collaborative Opportunities
06 Questions
Collaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust with Collaborative Forecasting?
Forecasting Future Biologic Manufacturing Capacity Requirements
Challenges
New Drug Product
Classes
 Clinical Trial Results
 New Indications
Manufacturing Scale
 Bioreactor Size
 Titer Projections
 Number of Batches
 Yield
 Shelf-life
 Bill of Materials
Patient Demand
 Volume
 Uptake
 Dosage / Frequency of
Administration
 Competition
 Market Share
Biologic Product Launch
 Timing
 Approval by Regulatory
Authorities, By Geography
Collaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust with Collaborative Forecasting?
Implications of Bill-of-Material Forecasts for Suppliers
Forecast is Too Low
Supplier is unable to
meet customer demand
1. Out of stock
2. Disruptions
3. Allocation
Forecast is Too High
Supplier has too much
capacity
1. Increased cost of goods
2. Negative working capital
3. Increased pricesCollaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust with Collaborative Forecasting?
Our Process
Review
Business
Review
Demand
Review
Supply
Sales &
Operations
Planning
(S&OP)
Life Cycle
Management
(LCM)
Capacity
Review
Process Budgeting
OP
Collaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust with Collaborative Forecasting?
Long Range Planning Process
Demand
Planning
Monthly
Commercial
Demand
Review
• Commercial
Review
0-18 months
Quarterly
Portfolio
Review
• Business Review
3-5years
Annual
Strategic
Planning
Review
• Business Review
10 years
Semi-
Annual
Long Range
Planning
• Handover to Operations in
COGS/units for Capacity Planning
Assessment in June & November
• Portfolio
Review
➢ Understand upside opportunities
and downside risks
➢ Collaboration process with
customers
ISC
Reviews
➢ Long range demand plan
driving long range capacity
planning
➢ Annual process with twice
a year assessment of global
capacities and actions needed
to mitigate risks
Collaborative Forecasting | 21 February 201910
Monthly/Quarterly
Customer
Collaboration Review
Molecule
Mapping
S&OP Connection with Capacity Review Process
Portfolio
review
Demand Plan Phase In/Out & Trends Long Range Plan
Commercial Area
(0-18 months)
Business Area
(0-5 years)
How To Make Your Supply Chain More Robust with Collaborative Forecasting?
Demand Planning Trends
Review
Business
Review
Demand
Review
Supply
Sales &
Operations
Planning
(S&OP)
Capacity
Review
Process
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
S&OP
Portfolio Review
Long Range Plan (LRP)
Collaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust With Collaborative Forecasting?
What Do We Do With Your Forecasts?
Resources Global Supply NetworkManufacturing Production
Lines & Sites
Use Information to execute in the short-term and
make long-term Investment Decisions
Collaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust with Collaborative Forecasting?
Demand Planning – Your Collaboration Partner
Head of Global
Demand
Planning
Global
Portfolio
Planning
Tools & Data
Management
Commercial
Planning
Global
Strategic
Accounts
Regional
Accounts
Custom
Planning
Portfolio by
Customer
Collaborative Forecasting | 21 February 2019
Global
MKT
OPS
MKT
COMM
Global
DP
Global
COMM
SD
Communicate
up-to-date
requirements
monthly
Collaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust with Collaborative Forecasting?
What Can You – As Our Customer – Do?
1
By Manufacturing Site Location:
• Country/Region
2
By Molecule:
• Phase I, II, III
• Commercial
3
By Material:
• Supplier SKU – Identify “critical”
RM’s with Unit of Measure
• Quantity required by month with 12
Month rolling forecast
• Long Range Plan 3-5 years
Collaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust with Transparency?
What Can You – As Our Customer – Do?
Share your Confidence Level of the
accuracy of the forecast
Share the Market Outlook for the
molecule based on patient
demographics, competitive information
and more
Highlight changes based on previously
provided forecasts, risks and
opportunities
Share strategic information influencing
the Demand Plan
• Planned inventory strategy changes
• Terminal buys of pre-change inventory
• Risk mitigation activities, such as dual
sourcing
• Large capacity investments
• Brexit, Tariffs, Regulatory
1
2
3
4
Confidence
High
Medium
Low
Legend
Increase On Track Decrease
Be more
transparent
Collaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust with Transparency?
What Can We – As Your Supplier – Do?
1
By Product Classification
• Lead Times
• Potential disruptions
2
3
By Forecast
• Trends
• Highlight deviations
By Process
• Provide guidance
• Share best practices
Collaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust?
What Do We Do With Your Forecasts?
Actions:
1. Analyze and
confirm forecast
by request date
2. Enter
information into
planning system
3. Hand over to
Operations’
Partners –
Highlight
changes, trends,
risks &
opportunities
4. Drives decisions
Result:
Improved Service Levels
Collaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust with Transparency?
Portfolio Segmentation
Collaborative Forecasting | 21 February 2019
How To Make Your Supply Chain More Robust with Transparency?
Together, We Can Strengthen Our Supply Chains
1 Realize the Power of Collaboration
2
3
Implement a Supply Chain strategy with
collaboration as a core element between
Planning : Planning teams
Develop mutually agreed KPIs and jointly
improve on-time delivery metrics
& meet patients’ needs for
life-saving & life-enhancing drugs
110
85
95
76
105
100
92
100
95
100
105
94
75%
70%
82%
76%
82% 83% 84% 86% 88% 89% 91%
0%
10%
20%
30%
40%
50%
60%
70%
80%
90%
100%
0
20
40
60
80
100
120
# of Lines % OTIF Target
Collaborative Forecasting | 21 February 2019
Closing
remarks
"Curiosity is not only about finding
new ideas.
It is about being able to deal with
the new, the complex. It is about
being able and willing to continue
even if the new brings unpleasant
feelings with it.”
Carl Naughton
Linguistic Researcher at the University of Cologne,
Germany
Educational Speaker & Member of the Merck KGaA ,
Darmstadt, Germany Curiosity Council
Stay Ahead.
Supply
robustness &
Control
Collaborative Forecasting | 21 February 2019
Any Questions?
aida.tsouroukdissian@emdmillipore.com
The vibrant M is a trademark of Merck KGaA, Darmstadt, Germany or its affiliates. All other trademarks are the property of their respective owners. Detailed
information on trademarks is available via publicly accessible resources.
© 2019 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

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How to make your supply chain more robust with collaborative forecasting & transparency?

  • 1. Merck KGaA Darmstadt, Germany Aida Tsouroukdissian Head of Demand Planning, Integrated Supply Chain Operations 21 February 2019 How to make your supply chain more robust with collaborative forecasting & transparency?
  • 2. 2 The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the U.S. and Canada.
  • 3. Collaborative Forecasting | 21 February 2019
  • 4. The first rule of forecasting – that forecasts are always wrong – is truer today than ever before. Collaborative Forecasting | 21 February 2019 The Power of Resilience Yossi Sheffi
  • 5. Demonstrate how collaboration between biopharmaceutical manufacturers and suppliers is crucial for supply robustness and control. Learn  How and when to collaborate to mitigate potential supply risk  With whom to partner to have a successful collaboration process  How collaboration adds value  How to measure success of the collaboration process How To Make Your Supply Chain More Robust with Collaborative Forecasting? Objective Collaborative Forecasting | 21 February 2019
  • 6. 01 Collaboration Challenges 02 Supplier Implications 03 Demand Planning & Capacity Process 04 Organization 05 Collaborative Opportunities 06 Questions Collaborative Forecasting | 21 February 2019
  • 7. How To Make Your Supply Chain More Robust with Collaborative Forecasting? Forecasting Future Biologic Manufacturing Capacity Requirements Challenges New Drug Product Classes  Clinical Trial Results  New Indications Manufacturing Scale  Bioreactor Size  Titer Projections  Number of Batches  Yield  Shelf-life  Bill of Materials Patient Demand  Volume  Uptake  Dosage / Frequency of Administration  Competition  Market Share Biologic Product Launch  Timing  Approval by Regulatory Authorities, By Geography Collaborative Forecasting | 21 February 2019
  • 8. How To Make Your Supply Chain More Robust with Collaborative Forecasting? Implications of Bill-of-Material Forecasts for Suppliers Forecast is Too Low Supplier is unable to meet customer demand 1. Out of stock 2. Disruptions 3. Allocation Forecast is Too High Supplier has too much capacity 1. Increased cost of goods 2. Negative working capital 3. Increased pricesCollaborative Forecasting | 21 February 2019
  • 9. How To Make Your Supply Chain More Robust with Collaborative Forecasting? Our Process Review Business Review Demand Review Supply Sales & Operations Planning (S&OP) Life Cycle Management (LCM) Capacity Review Process Budgeting OP Collaborative Forecasting | 21 February 2019
  • 10. How To Make Your Supply Chain More Robust with Collaborative Forecasting? Long Range Planning Process Demand Planning Monthly Commercial Demand Review • Commercial Review 0-18 months Quarterly Portfolio Review • Business Review 3-5years Annual Strategic Planning Review • Business Review 10 years Semi- Annual Long Range Planning • Handover to Operations in COGS/units for Capacity Planning Assessment in June & November • Portfolio Review ➢ Understand upside opportunities and downside risks ➢ Collaboration process with customers ISC Reviews ➢ Long range demand plan driving long range capacity planning ➢ Annual process with twice a year assessment of global capacities and actions needed to mitigate risks Collaborative Forecasting | 21 February 201910 Monthly/Quarterly Customer Collaboration Review Molecule Mapping
  • 11. S&OP Connection with Capacity Review Process Portfolio review Demand Plan Phase In/Out & Trends Long Range Plan Commercial Area (0-18 months) Business Area (0-5 years) How To Make Your Supply Chain More Robust with Collaborative Forecasting? Demand Planning Trends Review Business Review Demand Review Supply Sales & Operations Planning (S&OP) Capacity Review Process Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec S&OP Portfolio Review Long Range Plan (LRP) Collaborative Forecasting | 21 February 2019
  • 12. How To Make Your Supply Chain More Robust With Collaborative Forecasting? What Do We Do With Your Forecasts? Resources Global Supply NetworkManufacturing Production Lines & Sites Use Information to execute in the short-term and make long-term Investment Decisions Collaborative Forecasting | 21 February 2019
  • 13. How To Make Your Supply Chain More Robust with Collaborative Forecasting? Demand Planning – Your Collaboration Partner Head of Global Demand Planning Global Portfolio Planning Tools & Data Management Commercial Planning Global Strategic Accounts Regional Accounts Custom Planning Portfolio by Customer Collaborative Forecasting | 21 February 2019 Global MKT OPS MKT COMM Global DP Global COMM SD
  • 14. Communicate up-to-date requirements monthly Collaborative Forecasting | 21 February 2019 How To Make Your Supply Chain More Robust with Collaborative Forecasting? What Can You – As Our Customer – Do? 1 By Manufacturing Site Location: • Country/Region 2 By Molecule: • Phase I, II, III • Commercial 3 By Material: • Supplier SKU – Identify “critical” RM’s with Unit of Measure • Quantity required by month with 12 Month rolling forecast • Long Range Plan 3-5 years
  • 15. Collaborative Forecasting | 21 February 2019 How To Make Your Supply Chain More Robust with Transparency? What Can You – As Our Customer – Do? Share your Confidence Level of the accuracy of the forecast Share the Market Outlook for the molecule based on patient demographics, competitive information and more Highlight changes based on previously provided forecasts, risks and opportunities Share strategic information influencing the Demand Plan • Planned inventory strategy changes • Terminal buys of pre-change inventory • Risk mitigation activities, such as dual sourcing • Large capacity investments • Brexit, Tariffs, Regulatory 1 2 3 4 Confidence High Medium Low Legend Increase On Track Decrease
  • 16. Be more transparent Collaborative Forecasting | 21 February 2019 How To Make Your Supply Chain More Robust with Transparency? What Can We – As Your Supplier – Do? 1 By Product Classification • Lead Times • Potential disruptions 2 3 By Forecast • Trends • Highlight deviations By Process • Provide guidance • Share best practices
  • 17. Collaborative Forecasting | 21 February 2019 How To Make Your Supply Chain More Robust? What Do We Do With Your Forecasts? Actions: 1. Analyze and confirm forecast by request date 2. Enter information into planning system 3. Hand over to Operations’ Partners – Highlight changes, trends, risks & opportunities 4. Drives decisions Result: Improved Service Levels
  • 18. Collaborative Forecasting | 21 February 2019 How To Make Your Supply Chain More Robust with Transparency? Portfolio Segmentation
  • 19. Collaborative Forecasting | 21 February 2019 How To Make Your Supply Chain More Robust with Transparency? Together, We Can Strengthen Our Supply Chains 1 Realize the Power of Collaboration 2 3 Implement a Supply Chain strategy with collaboration as a core element between Planning : Planning teams Develop mutually agreed KPIs and jointly improve on-time delivery metrics & meet patients’ needs for life-saving & life-enhancing drugs 110 85 95 76 105 100 92 100 95 100 105 94 75% 70% 82% 76% 82% 83% 84% 86% 88% 89% 91% 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% 0 20 40 60 80 100 120 # of Lines % OTIF Target
  • 20. Collaborative Forecasting | 21 February 2019 Closing remarks "Curiosity is not only about finding new ideas. It is about being able to deal with the new, the complex. It is about being able and willing to continue even if the new brings unpleasant feelings with it.” Carl Naughton Linguistic Researcher at the University of Cologne, Germany Educational Speaker & Member of the Merck KGaA , Darmstadt, Germany Curiosity Council
  • 21. Stay Ahead. Supply robustness & Control Collaborative Forecasting | 21 February 2019 Any Questions? aida.tsouroukdissian@emdmillipore.com
  • 22. The vibrant M is a trademark of Merck KGaA, Darmstadt, Germany or its affiliates. All other trademarks are the property of their respective owners. Detailed information on trademarks is available via publicly accessible resources. © 2019 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.