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VALUE FOCUS
Medtech & Device Industry
Fourth Quarter 2021
This quarterly update includes a broad outlook that divides the healthcare industry into four sectors: (1) Biotechnology & Life Sciences (2) Medical
Devices (3) Healthcare Technology and (4) Large, Diversified Healthcare Companies. The update includes a review of market performance,
valuation multiple trends, operating metrics, and other market data. This issue also includes a review of M&A and IPO activity during the third
quarter of 2021.
Mercer Capital has broad experience in providing valuation services to medtech and device start-ups, larger public and private companies, and
private equity and venture capital funds involved in the sector. Please contact us to discuss how we may be of help.
BUSINESS VALUATION &
FINANCIAL ADVISORY SERVICES
Copyright © 2021 Mercer Capital Management, Inc. All rights reserved. It is illegal under Federal law to reproduce this publication or any portion of its contents without the
publisher’s permission. Media quotations with source attribution are encouraged. Reporters requesting additional information or editorial comment should contact Barbara
Walters Price at 901.685.2120. Mercer Capital’s Industry Focus is published quarterly and does not constitute legal or financial consulting advice. It is offered as an informa-
tion service to our clients and friends. Those interested in specific guidance for legal or accounting matters should seek competent professional advice. Inquiries to discuss
specific valuation matters are welcomed. To add your name to our mailing list to receive this complimentary publication, visit our web site at www.mercercapital.com.
Contact Us
BUSINESS VALUATION &
FINANCIAL ADVISORY SERVICES
Medtech & Device Industry Services
Mercer Capital provides valuation services to start ups, larger public
and private companies, and private equity and venture capital funds.
Contact a Mercer Capital professional to discuss your needs in confidence.
Sujan Rajbhandary, CFA
901.322.9749
sujanr@mercercapital.com
Travis W. Harms, CFA, CPA/ABV
901.322.9760
harmst@mercercapital.com
J. David Smith, ASA, CFA
713.239.1005
smithd@mercercapital.com
Daniel P. McLeod. CFA
901.322.9716
mcleodd@mercercapital.com
Follow Mercer Capital Mercer Capital @MercerCapital
In This Issue
Mercer Capital’s expertise in the medtech and device
industry spans the following segments:
•	 Biotechnology and life sciences
•	 Medical devices
•	 Healthcare technology
•	 Large, diversified
Our services include:
•	 Purchase price allocations
•	 Impairment testing
•	 Portfolio valuation for LP reporting
•	 Transaction and valuation advisory
•	 Equity compensation valuation for tax
compliance
Learn More about Mercer Capital &
our Medtech & Device Services at
www.mercercapital.com
Stock Market Update	 1
Revenue Multiples	 3
EBITDA Multiples	 4
Select Operating Metrics	 5
Public Medical Device Companies 6
Mergers  Acquisitions 10
Industry Public Offerings 12
© 2021 Mercer Capital // www.mercercapital.com 1
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
Industry stock price performance was generally positive during the third quarter of 2021. The SP 500 was flat
quarter-over-quarter ending up 0.2%, and three of the four Medtech subsectors outperformed the broad index
with only the Healthcare Technology group underperforming.
•	 A market-capitalization weighted index of companies included in our biotechnology and life sciences
sector increased 1.6% over the quarter ended September 2021. The top performer of the group was
Sartorius Stedim Biotech, which posted a 18.4% return. Sartorius develops and manufactures laboratory
technologies and equipment for the pharma and food industries, as well as for public research institutes
and laboratories.
•	 The medical device sector index increased 3.8% in third quarter of 2021. The group’s best performer
was Terumo Corp which returned 17.4%. Terumo is a manufacturer and supplier of pharmaceuticals and
medical tools and equipment including health foods, transfusion and infusion equipment, disposable
medical supply, clinical testing systems, artificial organs, and electronic thermometers.
•	 The healthcare technology sector fell 8.6% over the period. Evolent Health increased 46.8% over the
period and was responsible for the largest returns of the group. EVH provides a platform that enables
providers to migrate their economic orientation from fee-for-service reimbursement to payment models
that reward high-quality and cost-effective care, and value-based payment models.
•	 The large, diversified sector increased 3.7% over the quarter. The top performer within the group
was Danaher which increased 13.5% during the period. DHR designs, manufactures, and markets
professional, medical, industrial and commercial products, and provides services in the sectors of test
and measurement, environmental, life sciences, dental, and industrial technologies.
Stock Market
Update
© 2021 Mercer Capital // www.mercercapital.com 2
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
YTD Stock Price Performance
Individual sub-sector performance represented by market capitalization weighted indices for each group.
Data Source: Bloomberg LP; Mercer Capital Analysis
3Q 2021 Stock Price Performance
Individual sub-sector performance represented by market capitalization weighted indices for each group.
Source: Bloomberg LP; Mercer Capital Analysis
Stock Market
Update
(cont.)
-15%
-10%
-5%
0%
5%
10%
15%
20%
Jun 30, 2021 Jul 31, 2021 Aug 31, 2021 Sep 30, 2021
Biotechnology  Life Sciences Medical Devices Healthcare Technology Large, Diversified SP 500
-30%
-20%
-10%
0%
10%
20%
30%
40%
50%
Dec 31,
2020
Jan 31,
2021
Feb 28,
2021
Mar 31,
2021
Apr 30,
2021
May 31,
2021
Jun 30,
2021
Jul 31,
2021
Aug 31,
2021
Sep 30,
2021
Biotechnology  Life Sciences Medical Devices Healthcare Technology Large, Diversified SP 500
© 2021 Mercer Capital // www.mercercapital.com 3
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
4.85x
3.65x
3.98x
4.48x 4.33x 4.09x
4.43x 4.64x
4.23x
4.21x
0.00x
1.00x
2.00x
3.00x
4.00x
5.00x
6.00x
7.00x
8.00x
9.00x
4Q15 1Q16 2Q16 3Q16 4Q16 1Q17 2Q17 3Q17
75% Quartile Median 25% Quartile
Biotechnology  Life Sciences
EV / Trailing LTM Revenue
Healthcare Technology
EV / Trailing LTM Revenue
Medical Devices
EV / Trailing LTM Revenue
Large, Diversified
EV / Trailing LTM Revenue
11.08x
5.33x
3.15x
0.00x
2.00x
4.00x
6.00x
8.00x
10.00x
12.00x
3Q 2021
2Q 2021
1Q 2021
4Q 2020
3Q 2020
2Q 2020
1Q 2020
4Q 2019
6.13x
4.99x
4.50x
0.00x
1.00x
2.00x
3.00x
4.00x
5.00x
6.00x
7.00x
3Q 2021
2Q 2021
1Q 2021
4Q 2020
3Q 2020
2Q 2020
1Q 2020
4Q 2019
9.06x
5.78x
4.15x
0.00x
2.00x
4.00x
6.00x
8.00x
10.00x
12.00x
14.00x
3Q 2021
2Q 2021
1Q 2021
4Q 2020
3Q 2020
2Q 2020
1Q 2020
4Q 2019
Median Revenue multiples from each MCM group. Data source: Bloomberg
Revenue Multiples
13.63x
6.99x
4.71x
0.00x
2.00x
4.00x
6.00x
8.00x
10.00x
12.00x
14.00x
16.00x
3Q 2021
2Q 2021
1Q 2021
4Q 2020
3Q 2020
2Q 2020
1Q 2020
4Q 2019
© 2021 Mercer Capital // www.mercercapital.com 4
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
4.85x
3.65x
3.98x
4.48x 4.33x 4.09x
4.43x 4.64x
4.23x
4.21x
0.00x
1.00x
2.00x
3.00x
4.00x
5.00x
6.00x
7.00x
8.00x
9.00x
4Q15 1Q16 2Q16 3Q16 4Q16 1Q17 2Q17 3Q17
75% Quartile Median 25% Quartile
Biotechnology  Life Sciences
EV / Trailing LTM EBITDA
Healthcare Technology
EV / Trailing LTM EBITDA
Medical Devices
EV / Trailing LTM EBITDA
Large, Diversified
EV / Trailing LTM EBITDA
76.4x
33.1x
15.4x
0.0x
10.0x
20.0x
30.0x
40.0x
50.0x
60.0x
70.0x
80.0x
90.0x
3Q 2021
2Q 2021
1Q 2021
4Q 2020
3Q 2020
2Q 2020
1Q 2020
4Q 2019
42.8x
21.9x
11.9x
0.0x
5.0x
10.0x
15.0x
20.0x
25.0x
30.0x
35.0x
40.0x
45.0x
3Q 2021
2Q 2021
1Q 2021
4Q 2020
3Q 2020
2Q 2020
1Q 2020
4Q 2019
20.7x
12.8x
9.7x
0.0x
5.0x
10.0x
15.0x
20.0x
25.0x
3Q 2021
2Q 2021
1Q 2021
4Q 2020
3Q 2020
2Q 2020
1Q 2020
4Q 2019
Median EBITDA multiples from each MCM group. Data source: Bloomberg
EBITDA Multiples
40.3x
26.8x
18.8x
0.0x
5.0x
10.0x
15.0x
20.0x
25.0x
30.0x
35.0x
40.0x
45.0x
3Q 2021
2Q 2021
1Q 2021
4Q 2020
3Q 2020
2Q 2020
1Q 2020
4Q 2019
© 2021 Mercer Capital // www.mercercapital.com 5
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
Median measures for each group. | Data Source: Bloomberg
TTM Gross Margin TTM Operating Margin TTM RD / Revenue TTM EBITDA Margin
Sector 3Q 2021 2Q 2021 3Q 2021 2Q 2021 3Q 2021 2Q 2021 3Q 2021 2Q 2021
Biotechnology  Life Sciences 63.7% 67.6% 20.6% 21.4% 17.9% 18.5% 29.3% 29.7%
Medical Devices 67.4% 66.9% 20.6% 17.2% 7.0% 6.7% 31.1% 29.7%
Healthcare Technology 61.4% 60.4% 2.5% 3.0% 13.6% 13.8% 17.8% 17.2%
Large, Diversified 58.2% 57.6% 25.0% 22.3% 8.4% 8.6% 35.8% 34.6%
Overall Median 62.9% 64.2% 19.4% 18.1% 8.1% 8.2% 29.1% 29.4%
Revenue Growth L-T FWD Op. Earn.
Growth
Debt / EV Debt / EBITDA
Sector Q / Q Y / Y 3Q 2021 2Q 2021 3Q 2021 2Q 2021 3Q 2021 2Q 2021
Biotechnology  Life Sciences 6.6% 21.7% 15.4% 15.7% 5.9% 6.0% 1.7 1.7
Medical Devices 2.7% 10.3% 15.0% 15.9% 6.7% 9.2% 1.0 0.9
Healthcare Technology 4.4% 10.0% 12.5% 11.3% 8.3% 10.6% 0.9 1.2
Large, Diversified 5.9% 31.0% 8.7% 10.2% 16.4% 13.1% 2.4 2.0
Overall Median 4.6% 17.6% 12.5% 12.6% 8.3% 8.7% 1.7 1.8
Select
Operating
Metrics
© 2021 Mercer Capital // www.mercercapital.com 6
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
Price ∆ Stock Price EV TTM Rev
TTM
EBITDA FWD EBITDA EV / Rev.
EV /
EBITDA
EV /
FWD EBITDA
3Q 2021 2Q 2021 3Q 2020 Quarterly Annual 3Q 2021 3Q 2021 3Q 2021 FY 2022 FY 2023 3Q 2021 3Q 2021 2022 2023
Biotechnology  Life Sciences
Biogen Inc BIIB $283 $346 $284 -18.3% -0.2% $45,860 $11,101 $3,047 $4,254 $3,895 4.13x 15.0x 10.8x 11.8x
Bio-Rad Laboratories Inc BIO 746 644 515 15.8% 44.7% 17,327 2,980 755 719 665 5.82 22.9 24.1 26.1
BioMarin Pharmaceutical Inc BMRN 77 83 76 -7.4% 1.6% 14,180 1,849 61 58 334 7.67 230.6 244.7 42.5
Sartorius Stedim Biotech DIM 560 473 345 18.4% 62.4% 51,990 3,154 789 1,031 1,148 16.48 65.9 50.5 45.3
Eurofins Scientific SE ERF 128 113 79 13.1% 63.1% 28,172 15,246 4,504 1,797 1,445 1.85 6.3 15.7 19.5
Gilead Sciences Inc GILD 70 68 61 2.5% 15.4% 108,422 27,482 14,969 15,145 13,211 3.95 7.2 7.2 8.2
Illumina Inc ILMN 406 473 309 -14.3% 31.2% 64,750 3,966 1,181 1,223 1,002 16.33 54.8 53.0 64.6
Incyte Corp INCY 69 84 90 -18.2% -23.4% 12,964 2,913 740 688 1,107 4.45 17.5 18.8 11.7
IQVIA Holdings Inc IQV 240 242 158 -1.1% 52.0% 56,820 13,536 2,719 2,991 3,327 4.20 20.9 19.0 17.1
Lonza Group AG LONN 751 709 614 6.0% 22.3% 59,335 4,372 1,268 1,584 1,912 13.57 46.8 37.5 31.0
Mettler-Toledo International Inc MTD 1,377 1,385 966 -0.6% 42.6% 33,350 3,619 1,079 1,100 1,198 9.22 30.9 30.3 27.8
Regeneron Pharmaceuticals Inc REGN 605 559 560 8.4% 8.1% 54,888 13,543 7,637 9,372 7,133 4.05 7.2 5.9 7.7
Vertex Pharmaceuticals Inc VRTX 181 202 272 -10.0% -33.3% 40,974 7,130 3,768 4,550 4,945 5.75 10.9 9.0 8.3
Waters Corp WAT 357 346 196 3.4% 82.6% 22,969 2,671 926 961 1,008 8.60 24.8 23.9 22.8
($Millions, except per share figures)
Data Source: Bloomberg
Public Medical Device Companies
© 2021 Mercer Capital // www.mercercapital.com 7
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
Public Medical Device Companies (continued)
Price ∆ Stock Price EV TTM Rev
TTM
EBITDA FWD EBITDA EV / Rev.
EV /
EBITDA
EV /
FWD EBITDA
3Q 2021 2Q 2021 3Q 2020 Quarterly Annual 3Q 2021 3Q 2021 3Q 2021 FY 2022 FY 2023 3Q 2021 3Q 2021 2022 2023
Medical Devices
Terumo Corp 4543 $47 $40 $39 17.4% 20.5% $36,847 $5,693 $1,462 $183,897 $203,850 6.47x 25.2x 0.2x 0.2x
Sysmex Corp 6869 125 119 95 5.5% 32.3% 25,856 2,770 713 94,804 105,443 9.33 36.3 0.3 0.2
Olympus Corp 7733 22 20 21 10.9% 7.2% 30,539 6,632 1,412 207,137 233,998 4.60 21.6 0.1 0.1
ABIOMED Inc ABMD 326 312 277 4.3% 17.5% 13,995 813 253 278 327 17.22 55.3 50.4 42.8
Align Technology Inc ALGN 665 611 327 8.9% 103.3% 51,436 3,756 1,073 1,238 1,506 13.69 47.9 41.5 34.1
Baxter International Inc BAX 80 80 79 0.3% 1.4% 43,392 12,451 2,921 3,038 3,407 3.49 14.9 14.3 12.7
Boston Scientific Corp BSX 43 43 38 1.5% 13.6% 69,296 11,469 2,590 3,364 3,835 6.04 26.8 20.6 18.1
Coloplast A/S COLOB 157 164 155 -4.5% 1.1% 31,582 3,034 1,122 7,614 8,298 10.41 28.1 4.1 3.8
Edwards Lifesciences Corp EW 113 104 80 9.3% 41.8% 69,456 5,095 1,723 1,775 2,001 13.63 40.3 39.1 34.7
Hologic Inc HOLX 74 67 66 10.6% 11.0% 21,023 5,663 3,124 1,404 1,425 3.71 6.7 15.0 14.8
IDEXX Laboratories Inc IDXX 622 632 393 -1.5% 58.2% 53,607 3,135 1,049 1,039 1,165 17.10 51.1 51.6 46.0
Intuitive Surgical Inc ISRG 331 307 237 8.1% 40.1% 114,121 5,489 2,111 2,528 2,736 20.79 54.1 45.1 41.7
ResMed Inc RMD 263 246 170 7.1% 54.9% 38,971 3,091 1,092 1,285 1,415 12.61 35.7 30.3 27.5
Smith  Nephew PLC SN/ 17 21 19 -19.0% -9.0% 17,411 5,124 1,587 1,361 1,503 3.40 11.0 12.8 11.6
Stryker Corp SYK 264 259 206 1.8% 27.8% 109,866 16,669 4,851 4,815 5,311 6.59 22.6 22.8 20.7
Teleflex Inc TFX 376 401 339 -6.2% 11.0% 19,289 2,759 1,024 852 898 6.99 18.8 22.6 21.5
Zimmer Biomet Holdings Inc ZBH 146 161 135 -8.8% 8.2% 37,150 7,884 2,515 2,525 2,695 4.71 14.8 14.7 13.8
($Millions, except per share figures)
Data Source: Bloomberg
© 2021 Mercer Capital // www.mercercapital.com 8
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
Price ∆ Stock Price EV TTM Rev
TTM
EBITDA FWD EBITDA EV / Rev.
EV /
EBITDA
EV /
FWD EBITDA
3Q 2021 2Q 2021 3Q 2020 Quarterly Annual 3Q 2021 3Q 2021 3Q 2021 FY 2022 FY 2023 3Q 2021 3Q 2021 2022 2023
Healthcare Technology
M3 Inc 2413 $72 $73 $61 -1.8% 16.6% $47,763 $1,487 $541 $102,841 $95,867 32.12x 88.3x 0.5x 0.5x
Cerner Corp CERN 71 78 71 -9.5% -1.3% 21,899 5,708 1,651 1,900 2,049 3.84 13.3 11.5 10.7
Craneware PLC CRW 33 30 20 10.0% 64.8% 1,108 76 19 51 55 14.66 58.3 21.7 20.0
Evolent Health Inc EVH 31 21 12 46.8% 149.8% 2,755 932 43 59 78 2.96 64.6 47.1 35.3
HealthStream Inc HSTM 29 28 20 2.3% 42.4% 860 254 45 52 52 3.38 19.0 16.5 16.5
Inovalon Holdings Inc INOV 40 34 26 18.2% 52.3% 3,999 750 227 270 305 5.33 17.6 14.8 13.1
Allscripts Healthcare Solutions Inc MDRX 13 19 8 -27.8% 64.3% 1,917 1,498 265 277 294 1.28 7.2 6.9 6.5
NextGen Healthcare Inc NXGN 14 17 13 -15.0% 10.7% 931 549 96 112 123 1.69 9.7 8.3 7.6
Omnicell Inc OMCL 148 151 75 -2.0% 98.8% 6,508 1,070 197 239 289 6.08 33.1 27.2 22.5
Teladoc Health Inc TDOC 127 166 219 -23.7% -42.2% 20,635 1,862 (407) 261 374 11.08 nm 78.9 55.2
Tabula Rasa HealthCare Inc TRHC 26 50 41 -47.6% -35.7% 1,016 323 (19) 20 25 3.15 nm 51.6 40.3
Vocera Communications Inc VCRA 46 40 29 14.8% 57.4% 1,548 225 13 39 46 6.88 116.8 40.0 33.3
Veeva Systems Inc VEEV 288 311 281 -7.3% 2.5% 38,426 1,380 385 757 871 27.85 99.8 50.8 44.1
($Millions, except per share figures)
Data Source: Bloomberg
Public Medical Device Companies (continued)
© 2021 Mercer Capital // www.mercercapital.com 9
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
Price ∆ Stock Price EV TTM Rev
TTM
EBITDA FWD EBITDA EV / Rev.
EV /
EBITDA
EV /
FWD EBITDA
3Q 2021 2Q 2021 3Q 2020 Quarterly Annual 3Q 2021 3Q 2021 3Q 2021 FY 2022 FY 2023 3Q 2021 3Q 2021 2022 2023
Large, Diversified
Agilent Technologies Inc A $157 $147 $100 6.7% 57.0% $49,245 $6,142 $1,745 $1,742 $1,907 8.02x 28.2x 28.3x 25.8x
AbbVie Inc ABBV 107 110 82 -3.2% 29.3% 256,815 55,169 30,773 30,675 32,573 4.66 8.3 8.4 7.9
Abbott Laboratories ABT 118 115 107 2.3% 10.2% 217,268 42,308 13,021 12,598 11,503 5.14 16.7 17.2 18.9
Amgen Inc AMGN 211 240 245 -12.1% -13.9% 144,406 25,767 14,937 16,006 16,073 5.60 9.7 9.0 9.0
Becton Dickinson and Co BDX 246 242 230 1.4% 7.1% 85,155 19,896 7,266 5,679 6,135 4.28 11.7 15.0 13.9
Danaher Corp DHR 304 268 215 13.5% 41.8% 241,084 26,720 9,573 9,974 10,480 9.02 25.2 24.2 23.0
Johnson  Johnson JNJ 162 164 145 -1.4% 11.3% 428,073 89,190 35,242 32,928 35,416 4.80 12.1 13.0 12.1
Medtronic PLC MDT 125 124 102 1.5% 23.0% 184,390 27,927 7,125 10,124 11,082 6.60 25.9 18.2 16.6
Koninklijke Philips NV PHIA 44 50 46 -10.4% -4.2% 48,792 45,358 9,479 3,021 3,307 1.08 5.1 16.1 14.8
PerkinElmer Inc PKI 173 154 125 12.3% 38.3% 24,222 4,855 1,892 1,725 1,195 4.99 12.8 14.0 20.3
Roche Holding AG ROG 366 377 332 -2.8% 10.3% 265,202 131,362 52,254 25,304 25,942 2.02 5.1 10.5 10.2
Siemens Healthineers AG SHL 65 61 44 6.0% 46.9% 89,728 19,950 4,338 4,195 4,695 4.50 20.7 21.4 19.1
Thermo Fisher Scientific Inc TMO 571 504 441 13.3% 29.7% 234,452 38,250 13,318 12,132 11,010 6.13 17.6 19.3 21.3
($Millions, except per share figures)
Data Source: Bloomberg
Public Medical Device Companies (continued)
© 2021 Mercer Capital // www.mercercapital.com 10
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
Announced Transactions During 3Q 2021
Implied EV
Acquirer Target
Announce
Date
Transaction
Value
Implied
EV Revenue EBIT EBITDA Target Sector
Baxter International Inc. Hill-Rom Holdings, Inc. 9/2/21 $12,269 $11,996 4.10x 30.0x 20.9x Health Care Equipment
Merck Sharp  Dohme Corp. Acceleron Pharma Inc. 9/30/21 11,621 11,030 97.82 nm nm Biotechnology
Advent International Corporation; GIC Special Investments
Pte. Ltd.
Swedish Orphan Biovitrum AB
(publ)
9/1/21 9,434 9,407 5.61 21.7 14.4 Biotechnology
Insight Venture Management, LLC; Nordic Capital; 22C
Capital LLC
Inovalon Holdings, Inc. 8/19/21 7,433 7,315 10.18 75.0 32.9 Health Care Technology
PerkinElmer, Inc. BioLegend, Inc. 7/26/21 5,250 5,250 nm nm nm Biotechnology
Sanofi Translate Bio, Inc. 8/3/21 3,098 2,571 11.42 61.7 41.8 Biotechnology
Amgen Inc. TeneoBio, Inc. 7/27/21 2,500 2,500 nm nm nm Biotechnology
Bayer Aktiengesellschaft Vividion Therapeutics, Inc. 8/5/21 2,281 1,968 45.57 nm nm Biotechnology
Pfizer Inc. Trillium Therapeutics Inc. 8/23/21 2,104 1,883 nm nm nm Biotechnology
Sanofi Kadmon Holdings, Inc. 9/8/21 2,065 1,784 nm nm nm Biotechnology
Grifols, S.A. Biotest Aktiengesellschaft 9/17/21 1,536 2,230 3.75 nm 358.4 Biotechnology
GE Healthcare Inc. BK Medical Holding Company, Inc. 9/23/21 1,450 1,450 nm nm nm Health Care Equipment
Medtronic plc Intersect ENT, Inc. 8/6/21 1,074 1,016 9.90 nm nm Health Care Equipment
Pacific Biosciences of California, Inc. Omniome, Inc. 7/20/21 756 756 nm nm nm Biotechnology
Bioventus Inc. Misonix, Inc. 7/29/21 574 543 7.33 nm nm Health Care Equipment
Inotiv, Inc. Envigo RMS, Inc. 9/21/21 591 543 2.20 nm 22.2 Life Sciences Tools and
Services
planmeca Verwaltungs GmbH KaVo Dental GmbH 9/7/21 455 455 1.44 nm nm Health Care Equipment
Waystar, Inc. Patientco Holdings, Inc. 7/15/21 450 450 nm nm nm Health Care Technology
Hikma Pharmaceuticals PLC Custopharm, Inc. 9/27/21 425 425 nm nm nm Life Sciences Tools and
Services
Abcam US Group Holdings Inc. BioVision, Inc. 8/2/21 343 343 10.14 27.2 nm Life Sciences Tools and
Services
Transaction values over $100 million; Presented in $millionsData
Source: Capital IQ
Mergers  Acquisitions
© 2021 Mercer Capital // www.mercercapital.com 11
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
Mergers  Acquisitions (continued)
Announced Transactions During 3Q 2021
Implied EV
Acquirer Target
Announce
Date
Transaction
Value
Implied
EV Revenue EBIT EBITDA Target Sector
Boston Scientific Corporation Devoro Medical, Inc. 9/21/21 336 387 nm nm nm Health Care Equipment
WCG Clinical, Inc. NCT Holdings, Inc. 7/26/21 330 330 nm nm nm Life Sciences Tools and
Services
ModivCare Inc. VRI Intermediate Holdings, LLC 8/3/21 315 315 5.63 nm 15.0 Health Care Technology
Surgical Science Sweden AB (publ) 3D Systems 7/28/21 305 305 7.48 52.6 nm Health Care Technology
Mesa Laboratories, Inc. Agena Bioscience, Inc. 9/14/21 300 300 nm nm nm Life Sciences Tools and
Services
Agiliti, Inc. Sizewise Rentals, LLC 9/14/21 230 230 1.48 nm 7.7 Health Care Equipment
AzurRx BioPharma, Inc. (nka:First Wave BioPharma, Inc.) First Wave Bio, Inc. 9/13/21 226 226 17.09 nm nm Biotechnology
Omnicell, Inc. FDS Amplicare 7/26/21 177 177 6.10 nm nm Health Care Technology
Repligen Corporation Avitide, Inc. 9/16/21 150 150 60.00 nm nm Life Sciences Tools and
Services
Thompson Street Capital Partners; Thompson Street
Capital Partners VI, L.P.
Vector Laboratories, Inc. 8/10/21 124 124 nm nm nm Life Sciences Tools and
Services
Sartorius Stedim Biotech GmbH Cellgenix Gmbh 7/2/21 118 232 nm nm nm Biotechnology
Transaction values over $100 million; Presented in $millionsData
Source: Capital IQ
© 2021 Mercer Capital // www.mercercapital.com 12
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
Completed Initial Public Offerings During 3Q 2021
Issuer Ticker IPO Date IPO Price
Gross
Proceeds ($mil)
9/30/21
Stock Price
Return Since
IPO
9/30/20
Market Cap Industry
medmix AG SWX:MEDX 9/30/21 $48.23 $337.6 $47.15 -2.2% $1,945.7 Health Care Equipment
Modulight Oyj HLSE:MODU 9/29/21 7.54 91.8 12.68 68.2% 540.4 Health Care Equipment
Bioretec Oy HLSE:BRETEC 9/27/21 3.51 2.0 3.25 -7.6% 45.4 Health Care Equipment
Cue Health Inc. NasdaqGS:HLTH 9/23/21 16.00 200.0 11.81 -26.2% 1,697.7 Health Care Equipment
Tyra Biosciences, Inc. NasdaqGS:TYRA 9/14/21 16.00 172.8 17.59 9.9% 721.6 Biotechnology
Definitive Healthcare Corp. NasdaqGS:DH 9/14/21 27.00 420.0 42.83 58.6% 3,748.4 Health Care Technology
PROCEPT BioRobotics Corporation NasdaqGM:PRCT 9/14/21 25.00 163.9 38.15 52.6% 1,650.1 Health Care Equipment
Pasithea Therapeutics Corp. NasdaqCM:KTTA 9/14/21 5.00 24.0 3.04 -39.2% 39.7 Biotechnology
SeqLL Inc. NasdaqCM:SQL 8/26/21 4.25 13.0 3.64 -14.4% 43.3 Life Sciences Tools and
Services
RenovoRx, Inc. NasdaqCM:RNXT 8/25/21 9.00 16.7 6.04 -32.9% 50.6 Biotechnology
BiVictriX Therapeutics Plc AIM:BVX 8/10/21 0.28 10.4 0.26 -4.9% 17.4 Biotechnology
Eliem Therapeutics, Inc. NasdaqGM:ELYM 8/9/21 12.50 80.0 17.98 43.8% 477.3 Biotechnology
Ulisse Biomed S.p.A. BIT:UBM 8/5/21 2.37 5.3 5.82 145.7% 42.2 Biotechnology
Adagio Therapeutics, Inc. NasdaqGM:ADGI 8/5/21 17.00 309.4 42.24 148.5% 4,699.3 Biotechnology
IN8bio, Inc. NasdaqGM:INAB 7/30/21 10.00 40.0 6.85 -31.5% 128.5 Biotechnology
Immuneering Corporation NasdaqGM:IMRX 7/29/21 15.00 112.5 26.55 77.0% 688.7 Biotechnology
RxSight, Inc. NasdaqGM:RXST 7/29/21 16.00 117.6 12.67 -20.8% 346.1 Health Care Supplies
Omega Therapeutics, Inc. NasdaqGS:OMGA 7/29/21 17.00 125.8 18.85 10.9% 900.2 Biotechnology
Tenaya Therapeutics, Inc. NasdaqGS:TNYA 7/29/21 15.00 180.0 20.65 37.7% 852.4 Biotechnology
Icosavax, Inc. NasdaqGS:ICVX 7/29/21 15.00 182.0 29.59 97.3% 1,165.5 Biotechnology
Nuvalent, Inc. NasdaqGS:NUVL 7/28/21 17.00 165.8 22.55 32.6% 1,088.8 Biotechnology
Rallybio Corporation NasdaqGS:RLYB 7/28/21 13.00 80.6 17.58 35.2% 564.8 Biotechnology
Data Source: Capital IQ
Initial Public Offerings
© 2021 Mercer Capital // www.mercercapital.com 13
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
Initial Public Offerings (continued)
Completed Initial Public Offerings During 3Q 2021
Issuer Ticker IPO Date IPO Price
Gross
Proceeds ($mil)
9/30/21
Stock Price
Return Since
IPO
9/30/20 Market
Cap Industry
Candel Therapeutics, Inc. NasdaqGM:CADL 7/26/21 8.00 72.0 10.84 35.5% 311.0 Biotechnology
Cytek Biosciences, Inc. NasdaqGS:CTKB 7/22/21 17.00 247.6 21.41 25.9% 2,847.4 Life Sciences Tools and
Services
SOPHiA GENETICS SA NasdaqGS:SOPH 7/22/21 $18.00 $234.0 $17.53 -2.6% 1,138.9 Health Care Technology
Caribou Biosciences, Inc. NasdaqGS:CRBU 7/22/21 16.00 304.0 23.87 49.2% 1,431.5 Biotechnology
Modus Therapeutics Holding AB (publ) OM:MODTX 7/22/21 0.74 3.8 0.47 -36.4% 7.5 Biotechnology
Absci Corporation NasdaqGS:ABSI 7/21/21 16.00 200.0 11.63 -27.3% 1,076.4
Life Sciences Tools and
Services
HCW Biologics Inc. NasdaqGM:HCWB 7/19/21 8.00 56.0 3.19 -60.1% 114.0 Biotechnology
Imago BioSciences, Inc. NasdaqGS:IMGO 7/15/21 16.00 134.4 20.03 25.2% 669.7 Biotechnology
Erasca, Inc. NasdaqGS:ERAS 7/15/21 16.00 300.0 21.22 32.6% 2,572.3 Biotechnology
Stevanato Group S.p.A. NYSE:STVN 7/15/21 21.00 672.0 25.31 20.5% 6,699.5 Life Sciences Tools and
Services
TScan Therapeutics, Inc. NasdaqGM:TCRX 7/15/21 15.00 100.0 8.34 -44.4% 197.7 Biotechnology
Rapid Micro Biosystems, Inc. NasdaqGS:RPID 7/14/21 20.00 158.4 18.47 -7.7% 758.8
Life Sciences Tools and
Services
Sight Sciences, Inc. NasdaqGS:SGHT 7/14/21 24.00 240.0 22.70 -5.4% 1,072.9 Health Care Equipment
Sera Prognostics, Inc. NasdaqGM:SERA 7/14/21 16.00 75.0 11.11 -30.6% 341.1 Biotechnology
Ikonisys S.A. ENXTPA:ALIKO 7/13/21 6.79 4.8 3.30 -51.4% 31.3 Biotechnology
Unicycive Therapeutics, Inc. NasdaqCM:UNCY 7/13/21 5.00 25.0 2.83 -43.4% 41.1 Biotechnology
LungLife AI, Inc. AIM:LLAI 7/8/21 2.42 23.4 2.67 10.1% 67.9 Biotechnology
Colan Totte.Co.,Ltd. TSE:7792 7/8/21 10.02 21.5 9.75 -2.6% 87.0 Health Care Equipment
TransCode Therapeutics, Inc. NasdaqCM:RNAZ 7/8/21 4.00 25.0 2.99 -25.3% 38.5 Biotechnology
BCC Co., Ltd. TSE:7376 7/6/21 11.76 3.1 18.54 57.7% 20.5 Health Care Technology
Data Source: Capital IQ
© 2021 Mercer Capital // www.mercercapital.com 14
Mercer Capital’s Value Focus: Medtech  Device Industry Fourth Quarter 2021
Initial Public
Offerings
(continued)
Medtech  Device IPOs
0
20
40
60
80
100
120
140
160
180
200
220
240
$0
$2
$4
$6
$8
$10
$12
$14
$16
$18
$20
$22
$24
2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 3Q 2021 YTD
Number
of
IPOs
Gross
Proceeds
($Billions)
Aggregate Gross Proceeds Number of IPOs
Source: Capital IQ; Mercer Capital Analysis
Mercer Capital
www.mercercapital.com

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Mercer Capital's Value Focus : Medtech and Device | Q4 2021

  • 1. VALUE FOCUS Medtech & Device Industry Fourth Quarter 2021 This quarterly update includes a broad outlook that divides the healthcare industry into four sectors: (1) Biotechnology & Life Sciences (2) Medical Devices (3) Healthcare Technology and (4) Large, Diversified Healthcare Companies. The update includes a review of market performance, valuation multiple trends, operating metrics, and other market data. This issue also includes a review of M&A and IPO activity during the third quarter of 2021. Mercer Capital has broad experience in providing valuation services to medtech and device start-ups, larger public and private companies, and private equity and venture capital funds involved in the sector. Please contact us to discuss how we may be of help. BUSINESS VALUATION & FINANCIAL ADVISORY SERVICES
  • 2. Copyright © 2021 Mercer Capital Management, Inc. All rights reserved. It is illegal under Federal law to reproduce this publication or any portion of its contents without the publisher’s permission. Media quotations with source attribution are encouraged. Reporters requesting additional information or editorial comment should contact Barbara Walters Price at 901.685.2120. Mercer Capital’s Industry Focus is published quarterly and does not constitute legal or financial consulting advice. It is offered as an informa- tion service to our clients and friends. Those interested in specific guidance for legal or accounting matters should seek competent professional advice. Inquiries to discuss specific valuation matters are welcomed. To add your name to our mailing list to receive this complimentary publication, visit our web site at www.mercercapital.com. Contact Us BUSINESS VALUATION & FINANCIAL ADVISORY SERVICES Medtech & Device Industry Services Mercer Capital provides valuation services to start ups, larger public and private companies, and private equity and venture capital funds. Contact a Mercer Capital professional to discuss your needs in confidence. Sujan Rajbhandary, CFA 901.322.9749 sujanr@mercercapital.com Travis W. Harms, CFA, CPA/ABV 901.322.9760 harmst@mercercapital.com J. David Smith, ASA, CFA 713.239.1005 smithd@mercercapital.com Daniel P. McLeod. CFA 901.322.9716 mcleodd@mercercapital.com Follow Mercer Capital Mercer Capital @MercerCapital In This Issue Mercer Capital’s expertise in the medtech and device industry spans the following segments: • Biotechnology and life sciences • Medical devices • Healthcare technology • Large, diversified Our services include: • Purchase price allocations • Impairment testing • Portfolio valuation for LP reporting • Transaction and valuation advisory • Equity compensation valuation for tax compliance Learn More about Mercer Capital & our Medtech & Device Services at www.mercercapital.com Stock Market Update 1 Revenue Multiples 3 EBITDA Multiples 4 Select Operating Metrics 5 Public Medical Device Companies 6 Mergers Acquisitions 10 Industry Public Offerings 12
  • 3. © 2021 Mercer Capital // www.mercercapital.com 1 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 Industry stock price performance was generally positive during the third quarter of 2021. The SP 500 was flat quarter-over-quarter ending up 0.2%, and three of the four Medtech subsectors outperformed the broad index with only the Healthcare Technology group underperforming. • A market-capitalization weighted index of companies included in our biotechnology and life sciences sector increased 1.6% over the quarter ended September 2021. The top performer of the group was Sartorius Stedim Biotech, which posted a 18.4% return. Sartorius develops and manufactures laboratory technologies and equipment for the pharma and food industries, as well as for public research institutes and laboratories. • The medical device sector index increased 3.8% in third quarter of 2021. The group’s best performer was Terumo Corp which returned 17.4%. Terumo is a manufacturer and supplier of pharmaceuticals and medical tools and equipment including health foods, transfusion and infusion equipment, disposable medical supply, clinical testing systems, artificial organs, and electronic thermometers. • The healthcare technology sector fell 8.6% over the period. Evolent Health increased 46.8% over the period and was responsible for the largest returns of the group. EVH provides a platform that enables providers to migrate their economic orientation from fee-for-service reimbursement to payment models that reward high-quality and cost-effective care, and value-based payment models. • The large, diversified sector increased 3.7% over the quarter. The top performer within the group was Danaher which increased 13.5% during the period. DHR designs, manufactures, and markets professional, medical, industrial and commercial products, and provides services in the sectors of test and measurement, environmental, life sciences, dental, and industrial technologies. Stock Market Update
  • 4. © 2021 Mercer Capital // www.mercercapital.com 2 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 YTD Stock Price Performance Individual sub-sector performance represented by market capitalization weighted indices for each group. Data Source: Bloomberg LP; Mercer Capital Analysis 3Q 2021 Stock Price Performance Individual sub-sector performance represented by market capitalization weighted indices for each group. Source: Bloomberg LP; Mercer Capital Analysis Stock Market Update (cont.) -15% -10% -5% 0% 5% 10% 15% 20% Jun 30, 2021 Jul 31, 2021 Aug 31, 2021 Sep 30, 2021 Biotechnology Life Sciences Medical Devices Healthcare Technology Large, Diversified SP 500 -30% -20% -10% 0% 10% 20% 30% 40% 50% Dec 31, 2020 Jan 31, 2021 Feb 28, 2021 Mar 31, 2021 Apr 30, 2021 May 31, 2021 Jun 30, 2021 Jul 31, 2021 Aug 31, 2021 Sep 30, 2021 Biotechnology Life Sciences Medical Devices Healthcare Technology Large, Diversified SP 500
  • 5. © 2021 Mercer Capital // www.mercercapital.com 3 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 4.85x 3.65x 3.98x 4.48x 4.33x 4.09x 4.43x 4.64x 4.23x 4.21x 0.00x 1.00x 2.00x 3.00x 4.00x 5.00x 6.00x 7.00x 8.00x 9.00x 4Q15 1Q16 2Q16 3Q16 4Q16 1Q17 2Q17 3Q17 75% Quartile Median 25% Quartile Biotechnology Life Sciences EV / Trailing LTM Revenue Healthcare Technology EV / Trailing LTM Revenue Medical Devices EV / Trailing LTM Revenue Large, Diversified EV / Trailing LTM Revenue 11.08x 5.33x 3.15x 0.00x 2.00x 4.00x 6.00x 8.00x 10.00x 12.00x 3Q 2021 2Q 2021 1Q 2021 4Q 2020 3Q 2020 2Q 2020 1Q 2020 4Q 2019 6.13x 4.99x 4.50x 0.00x 1.00x 2.00x 3.00x 4.00x 5.00x 6.00x 7.00x 3Q 2021 2Q 2021 1Q 2021 4Q 2020 3Q 2020 2Q 2020 1Q 2020 4Q 2019 9.06x 5.78x 4.15x 0.00x 2.00x 4.00x 6.00x 8.00x 10.00x 12.00x 14.00x 3Q 2021 2Q 2021 1Q 2021 4Q 2020 3Q 2020 2Q 2020 1Q 2020 4Q 2019 Median Revenue multiples from each MCM group. Data source: Bloomberg Revenue Multiples 13.63x 6.99x 4.71x 0.00x 2.00x 4.00x 6.00x 8.00x 10.00x 12.00x 14.00x 16.00x 3Q 2021 2Q 2021 1Q 2021 4Q 2020 3Q 2020 2Q 2020 1Q 2020 4Q 2019
  • 6. © 2021 Mercer Capital // www.mercercapital.com 4 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 4.85x 3.65x 3.98x 4.48x 4.33x 4.09x 4.43x 4.64x 4.23x 4.21x 0.00x 1.00x 2.00x 3.00x 4.00x 5.00x 6.00x 7.00x 8.00x 9.00x 4Q15 1Q16 2Q16 3Q16 4Q16 1Q17 2Q17 3Q17 75% Quartile Median 25% Quartile Biotechnology Life Sciences EV / Trailing LTM EBITDA Healthcare Technology EV / Trailing LTM EBITDA Medical Devices EV / Trailing LTM EBITDA Large, Diversified EV / Trailing LTM EBITDA 76.4x 33.1x 15.4x 0.0x 10.0x 20.0x 30.0x 40.0x 50.0x 60.0x 70.0x 80.0x 90.0x 3Q 2021 2Q 2021 1Q 2021 4Q 2020 3Q 2020 2Q 2020 1Q 2020 4Q 2019 42.8x 21.9x 11.9x 0.0x 5.0x 10.0x 15.0x 20.0x 25.0x 30.0x 35.0x 40.0x 45.0x 3Q 2021 2Q 2021 1Q 2021 4Q 2020 3Q 2020 2Q 2020 1Q 2020 4Q 2019 20.7x 12.8x 9.7x 0.0x 5.0x 10.0x 15.0x 20.0x 25.0x 3Q 2021 2Q 2021 1Q 2021 4Q 2020 3Q 2020 2Q 2020 1Q 2020 4Q 2019 Median EBITDA multiples from each MCM group. Data source: Bloomberg EBITDA Multiples 40.3x 26.8x 18.8x 0.0x 5.0x 10.0x 15.0x 20.0x 25.0x 30.0x 35.0x 40.0x 45.0x 3Q 2021 2Q 2021 1Q 2021 4Q 2020 3Q 2020 2Q 2020 1Q 2020 4Q 2019
  • 7. © 2021 Mercer Capital // www.mercercapital.com 5 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 Median measures for each group. | Data Source: Bloomberg TTM Gross Margin TTM Operating Margin TTM RD / Revenue TTM EBITDA Margin Sector 3Q 2021 2Q 2021 3Q 2021 2Q 2021 3Q 2021 2Q 2021 3Q 2021 2Q 2021 Biotechnology Life Sciences 63.7% 67.6% 20.6% 21.4% 17.9% 18.5% 29.3% 29.7% Medical Devices 67.4% 66.9% 20.6% 17.2% 7.0% 6.7% 31.1% 29.7% Healthcare Technology 61.4% 60.4% 2.5% 3.0% 13.6% 13.8% 17.8% 17.2% Large, Diversified 58.2% 57.6% 25.0% 22.3% 8.4% 8.6% 35.8% 34.6% Overall Median 62.9% 64.2% 19.4% 18.1% 8.1% 8.2% 29.1% 29.4% Revenue Growth L-T FWD Op. Earn. Growth Debt / EV Debt / EBITDA Sector Q / Q Y / Y 3Q 2021 2Q 2021 3Q 2021 2Q 2021 3Q 2021 2Q 2021 Biotechnology Life Sciences 6.6% 21.7% 15.4% 15.7% 5.9% 6.0% 1.7 1.7 Medical Devices 2.7% 10.3% 15.0% 15.9% 6.7% 9.2% 1.0 0.9 Healthcare Technology 4.4% 10.0% 12.5% 11.3% 8.3% 10.6% 0.9 1.2 Large, Diversified 5.9% 31.0% 8.7% 10.2% 16.4% 13.1% 2.4 2.0 Overall Median 4.6% 17.6% 12.5% 12.6% 8.3% 8.7% 1.7 1.8 Select Operating Metrics
  • 8. © 2021 Mercer Capital // www.mercercapital.com 6 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 Price ∆ Stock Price EV TTM Rev TTM EBITDA FWD EBITDA EV / Rev. EV / EBITDA EV / FWD EBITDA 3Q 2021 2Q 2021 3Q 2020 Quarterly Annual 3Q 2021 3Q 2021 3Q 2021 FY 2022 FY 2023 3Q 2021 3Q 2021 2022 2023 Biotechnology Life Sciences Biogen Inc BIIB $283 $346 $284 -18.3% -0.2% $45,860 $11,101 $3,047 $4,254 $3,895 4.13x 15.0x 10.8x 11.8x Bio-Rad Laboratories Inc BIO 746 644 515 15.8% 44.7% 17,327 2,980 755 719 665 5.82 22.9 24.1 26.1 BioMarin Pharmaceutical Inc BMRN 77 83 76 -7.4% 1.6% 14,180 1,849 61 58 334 7.67 230.6 244.7 42.5 Sartorius Stedim Biotech DIM 560 473 345 18.4% 62.4% 51,990 3,154 789 1,031 1,148 16.48 65.9 50.5 45.3 Eurofins Scientific SE ERF 128 113 79 13.1% 63.1% 28,172 15,246 4,504 1,797 1,445 1.85 6.3 15.7 19.5 Gilead Sciences Inc GILD 70 68 61 2.5% 15.4% 108,422 27,482 14,969 15,145 13,211 3.95 7.2 7.2 8.2 Illumina Inc ILMN 406 473 309 -14.3% 31.2% 64,750 3,966 1,181 1,223 1,002 16.33 54.8 53.0 64.6 Incyte Corp INCY 69 84 90 -18.2% -23.4% 12,964 2,913 740 688 1,107 4.45 17.5 18.8 11.7 IQVIA Holdings Inc IQV 240 242 158 -1.1% 52.0% 56,820 13,536 2,719 2,991 3,327 4.20 20.9 19.0 17.1 Lonza Group AG LONN 751 709 614 6.0% 22.3% 59,335 4,372 1,268 1,584 1,912 13.57 46.8 37.5 31.0 Mettler-Toledo International Inc MTD 1,377 1,385 966 -0.6% 42.6% 33,350 3,619 1,079 1,100 1,198 9.22 30.9 30.3 27.8 Regeneron Pharmaceuticals Inc REGN 605 559 560 8.4% 8.1% 54,888 13,543 7,637 9,372 7,133 4.05 7.2 5.9 7.7 Vertex Pharmaceuticals Inc VRTX 181 202 272 -10.0% -33.3% 40,974 7,130 3,768 4,550 4,945 5.75 10.9 9.0 8.3 Waters Corp WAT 357 346 196 3.4% 82.6% 22,969 2,671 926 961 1,008 8.60 24.8 23.9 22.8 ($Millions, except per share figures) Data Source: Bloomberg Public Medical Device Companies
  • 9. © 2021 Mercer Capital // www.mercercapital.com 7 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 Public Medical Device Companies (continued) Price ∆ Stock Price EV TTM Rev TTM EBITDA FWD EBITDA EV / Rev. EV / EBITDA EV / FWD EBITDA 3Q 2021 2Q 2021 3Q 2020 Quarterly Annual 3Q 2021 3Q 2021 3Q 2021 FY 2022 FY 2023 3Q 2021 3Q 2021 2022 2023 Medical Devices Terumo Corp 4543 $47 $40 $39 17.4% 20.5% $36,847 $5,693 $1,462 $183,897 $203,850 6.47x 25.2x 0.2x 0.2x Sysmex Corp 6869 125 119 95 5.5% 32.3% 25,856 2,770 713 94,804 105,443 9.33 36.3 0.3 0.2 Olympus Corp 7733 22 20 21 10.9% 7.2% 30,539 6,632 1,412 207,137 233,998 4.60 21.6 0.1 0.1 ABIOMED Inc ABMD 326 312 277 4.3% 17.5% 13,995 813 253 278 327 17.22 55.3 50.4 42.8 Align Technology Inc ALGN 665 611 327 8.9% 103.3% 51,436 3,756 1,073 1,238 1,506 13.69 47.9 41.5 34.1 Baxter International Inc BAX 80 80 79 0.3% 1.4% 43,392 12,451 2,921 3,038 3,407 3.49 14.9 14.3 12.7 Boston Scientific Corp BSX 43 43 38 1.5% 13.6% 69,296 11,469 2,590 3,364 3,835 6.04 26.8 20.6 18.1 Coloplast A/S COLOB 157 164 155 -4.5% 1.1% 31,582 3,034 1,122 7,614 8,298 10.41 28.1 4.1 3.8 Edwards Lifesciences Corp EW 113 104 80 9.3% 41.8% 69,456 5,095 1,723 1,775 2,001 13.63 40.3 39.1 34.7 Hologic Inc HOLX 74 67 66 10.6% 11.0% 21,023 5,663 3,124 1,404 1,425 3.71 6.7 15.0 14.8 IDEXX Laboratories Inc IDXX 622 632 393 -1.5% 58.2% 53,607 3,135 1,049 1,039 1,165 17.10 51.1 51.6 46.0 Intuitive Surgical Inc ISRG 331 307 237 8.1% 40.1% 114,121 5,489 2,111 2,528 2,736 20.79 54.1 45.1 41.7 ResMed Inc RMD 263 246 170 7.1% 54.9% 38,971 3,091 1,092 1,285 1,415 12.61 35.7 30.3 27.5 Smith Nephew PLC SN/ 17 21 19 -19.0% -9.0% 17,411 5,124 1,587 1,361 1,503 3.40 11.0 12.8 11.6 Stryker Corp SYK 264 259 206 1.8% 27.8% 109,866 16,669 4,851 4,815 5,311 6.59 22.6 22.8 20.7 Teleflex Inc TFX 376 401 339 -6.2% 11.0% 19,289 2,759 1,024 852 898 6.99 18.8 22.6 21.5 Zimmer Biomet Holdings Inc ZBH 146 161 135 -8.8% 8.2% 37,150 7,884 2,515 2,525 2,695 4.71 14.8 14.7 13.8 ($Millions, except per share figures) Data Source: Bloomberg
  • 10. © 2021 Mercer Capital // www.mercercapital.com 8 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 Price ∆ Stock Price EV TTM Rev TTM EBITDA FWD EBITDA EV / Rev. EV / EBITDA EV / FWD EBITDA 3Q 2021 2Q 2021 3Q 2020 Quarterly Annual 3Q 2021 3Q 2021 3Q 2021 FY 2022 FY 2023 3Q 2021 3Q 2021 2022 2023 Healthcare Technology M3 Inc 2413 $72 $73 $61 -1.8% 16.6% $47,763 $1,487 $541 $102,841 $95,867 32.12x 88.3x 0.5x 0.5x Cerner Corp CERN 71 78 71 -9.5% -1.3% 21,899 5,708 1,651 1,900 2,049 3.84 13.3 11.5 10.7 Craneware PLC CRW 33 30 20 10.0% 64.8% 1,108 76 19 51 55 14.66 58.3 21.7 20.0 Evolent Health Inc EVH 31 21 12 46.8% 149.8% 2,755 932 43 59 78 2.96 64.6 47.1 35.3 HealthStream Inc HSTM 29 28 20 2.3% 42.4% 860 254 45 52 52 3.38 19.0 16.5 16.5 Inovalon Holdings Inc INOV 40 34 26 18.2% 52.3% 3,999 750 227 270 305 5.33 17.6 14.8 13.1 Allscripts Healthcare Solutions Inc MDRX 13 19 8 -27.8% 64.3% 1,917 1,498 265 277 294 1.28 7.2 6.9 6.5 NextGen Healthcare Inc NXGN 14 17 13 -15.0% 10.7% 931 549 96 112 123 1.69 9.7 8.3 7.6 Omnicell Inc OMCL 148 151 75 -2.0% 98.8% 6,508 1,070 197 239 289 6.08 33.1 27.2 22.5 Teladoc Health Inc TDOC 127 166 219 -23.7% -42.2% 20,635 1,862 (407) 261 374 11.08 nm 78.9 55.2 Tabula Rasa HealthCare Inc TRHC 26 50 41 -47.6% -35.7% 1,016 323 (19) 20 25 3.15 nm 51.6 40.3 Vocera Communications Inc VCRA 46 40 29 14.8% 57.4% 1,548 225 13 39 46 6.88 116.8 40.0 33.3 Veeva Systems Inc VEEV 288 311 281 -7.3% 2.5% 38,426 1,380 385 757 871 27.85 99.8 50.8 44.1 ($Millions, except per share figures) Data Source: Bloomberg Public Medical Device Companies (continued)
  • 11. © 2021 Mercer Capital // www.mercercapital.com 9 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 Price ∆ Stock Price EV TTM Rev TTM EBITDA FWD EBITDA EV / Rev. EV / EBITDA EV / FWD EBITDA 3Q 2021 2Q 2021 3Q 2020 Quarterly Annual 3Q 2021 3Q 2021 3Q 2021 FY 2022 FY 2023 3Q 2021 3Q 2021 2022 2023 Large, Diversified Agilent Technologies Inc A $157 $147 $100 6.7% 57.0% $49,245 $6,142 $1,745 $1,742 $1,907 8.02x 28.2x 28.3x 25.8x AbbVie Inc ABBV 107 110 82 -3.2% 29.3% 256,815 55,169 30,773 30,675 32,573 4.66 8.3 8.4 7.9 Abbott Laboratories ABT 118 115 107 2.3% 10.2% 217,268 42,308 13,021 12,598 11,503 5.14 16.7 17.2 18.9 Amgen Inc AMGN 211 240 245 -12.1% -13.9% 144,406 25,767 14,937 16,006 16,073 5.60 9.7 9.0 9.0 Becton Dickinson and Co BDX 246 242 230 1.4% 7.1% 85,155 19,896 7,266 5,679 6,135 4.28 11.7 15.0 13.9 Danaher Corp DHR 304 268 215 13.5% 41.8% 241,084 26,720 9,573 9,974 10,480 9.02 25.2 24.2 23.0 Johnson Johnson JNJ 162 164 145 -1.4% 11.3% 428,073 89,190 35,242 32,928 35,416 4.80 12.1 13.0 12.1 Medtronic PLC MDT 125 124 102 1.5% 23.0% 184,390 27,927 7,125 10,124 11,082 6.60 25.9 18.2 16.6 Koninklijke Philips NV PHIA 44 50 46 -10.4% -4.2% 48,792 45,358 9,479 3,021 3,307 1.08 5.1 16.1 14.8 PerkinElmer Inc PKI 173 154 125 12.3% 38.3% 24,222 4,855 1,892 1,725 1,195 4.99 12.8 14.0 20.3 Roche Holding AG ROG 366 377 332 -2.8% 10.3% 265,202 131,362 52,254 25,304 25,942 2.02 5.1 10.5 10.2 Siemens Healthineers AG SHL 65 61 44 6.0% 46.9% 89,728 19,950 4,338 4,195 4,695 4.50 20.7 21.4 19.1 Thermo Fisher Scientific Inc TMO 571 504 441 13.3% 29.7% 234,452 38,250 13,318 12,132 11,010 6.13 17.6 19.3 21.3 ($Millions, except per share figures) Data Source: Bloomberg Public Medical Device Companies (continued)
  • 12. © 2021 Mercer Capital // www.mercercapital.com 10 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 Announced Transactions During 3Q 2021 Implied EV Acquirer Target Announce Date Transaction Value Implied EV Revenue EBIT EBITDA Target Sector Baxter International Inc. Hill-Rom Holdings, Inc. 9/2/21 $12,269 $11,996 4.10x 30.0x 20.9x Health Care Equipment Merck Sharp Dohme Corp. Acceleron Pharma Inc. 9/30/21 11,621 11,030 97.82 nm nm Biotechnology Advent International Corporation; GIC Special Investments Pte. Ltd. Swedish Orphan Biovitrum AB (publ) 9/1/21 9,434 9,407 5.61 21.7 14.4 Biotechnology Insight Venture Management, LLC; Nordic Capital; 22C Capital LLC Inovalon Holdings, Inc. 8/19/21 7,433 7,315 10.18 75.0 32.9 Health Care Technology PerkinElmer, Inc. BioLegend, Inc. 7/26/21 5,250 5,250 nm nm nm Biotechnology Sanofi Translate Bio, Inc. 8/3/21 3,098 2,571 11.42 61.7 41.8 Biotechnology Amgen Inc. TeneoBio, Inc. 7/27/21 2,500 2,500 nm nm nm Biotechnology Bayer Aktiengesellschaft Vividion Therapeutics, Inc. 8/5/21 2,281 1,968 45.57 nm nm Biotechnology Pfizer Inc. Trillium Therapeutics Inc. 8/23/21 2,104 1,883 nm nm nm Biotechnology Sanofi Kadmon Holdings, Inc. 9/8/21 2,065 1,784 nm nm nm Biotechnology Grifols, S.A. Biotest Aktiengesellschaft 9/17/21 1,536 2,230 3.75 nm 358.4 Biotechnology GE Healthcare Inc. BK Medical Holding Company, Inc. 9/23/21 1,450 1,450 nm nm nm Health Care Equipment Medtronic plc Intersect ENT, Inc. 8/6/21 1,074 1,016 9.90 nm nm Health Care Equipment Pacific Biosciences of California, Inc. Omniome, Inc. 7/20/21 756 756 nm nm nm Biotechnology Bioventus Inc. Misonix, Inc. 7/29/21 574 543 7.33 nm nm Health Care Equipment Inotiv, Inc. Envigo RMS, Inc. 9/21/21 591 543 2.20 nm 22.2 Life Sciences Tools and Services planmeca Verwaltungs GmbH KaVo Dental GmbH 9/7/21 455 455 1.44 nm nm Health Care Equipment Waystar, Inc. Patientco Holdings, Inc. 7/15/21 450 450 nm nm nm Health Care Technology Hikma Pharmaceuticals PLC Custopharm, Inc. 9/27/21 425 425 nm nm nm Life Sciences Tools and Services Abcam US Group Holdings Inc. BioVision, Inc. 8/2/21 343 343 10.14 27.2 nm Life Sciences Tools and Services Transaction values over $100 million; Presented in $millionsData Source: Capital IQ Mergers Acquisitions
  • 13. © 2021 Mercer Capital // www.mercercapital.com 11 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 Mergers Acquisitions (continued) Announced Transactions During 3Q 2021 Implied EV Acquirer Target Announce Date Transaction Value Implied EV Revenue EBIT EBITDA Target Sector Boston Scientific Corporation Devoro Medical, Inc. 9/21/21 336 387 nm nm nm Health Care Equipment WCG Clinical, Inc. NCT Holdings, Inc. 7/26/21 330 330 nm nm nm Life Sciences Tools and Services ModivCare Inc. VRI Intermediate Holdings, LLC 8/3/21 315 315 5.63 nm 15.0 Health Care Technology Surgical Science Sweden AB (publ) 3D Systems 7/28/21 305 305 7.48 52.6 nm Health Care Technology Mesa Laboratories, Inc. Agena Bioscience, Inc. 9/14/21 300 300 nm nm nm Life Sciences Tools and Services Agiliti, Inc. Sizewise Rentals, LLC 9/14/21 230 230 1.48 nm 7.7 Health Care Equipment AzurRx BioPharma, Inc. (nka:First Wave BioPharma, Inc.) First Wave Bio, Inc. 9/13/21 226 226 17.09 nm nm Biotechnology Omnicell, Inc. FDS Amplicare 7/26/21 177 177 6.10 nm nm Health Care Technology Repligen Corporation Avitide, Inc. 9/16/21 150 150 60.00 nm nm Life Sciences Tools and Services Thompson Street Capital Partners; Thompson Street Capital Partners VI, L.P. Vector Laboratories, Inc. 8/10/21 124 124 nm nm nm Life Sciences Tools and Services Sartorius Stedim Biotech GmbH Cellgenix Gmbh 7/2/21 118 232 nm nm nm Biotechnology Transaction values over $100 million; Presented in $millionsData Source: Capital IQ
  • 14. © 2021 Mercer Capital // www.mercercapital.com 12 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 Completed Initial Public Offerings During 3Q 2021 Issuer Ticker IPO Date IPO Price Gross Proceeds ($mil) 9/30/21 Stock Price Return Since IPO 9/30/20 Market Cap Industry medmix AG SWX:MEDX 9/30/21 $48.23 $337.6 $47.15 -2.2% $1,945.7 Health Care Equipment Modulight Oyj HLSE:MODU 9/29/21 7.54 91.8 12.68 68.2% 540.4 Health Care Equipment Bioretec Oy HLSE:BRETEC 9/27/21 3.51 2.0 3.25 -7.6% 45.4 Health Care Equipment Cue Health Inc. NasdaqGS:HLTH 9/23/21 16.00 200.0 11.81 -26.2% 1,697.7 Health Care Equipment Tyra Biosciences, Inc. NasdaqGS:TYRA 9/14/21 16.00 172.8 17.59 9.9% 721.6 Biotechnology Definitive Healthcare Corp. NasdaqGS:DH 9/14/21 27.00 420.0 42.83 58.6% 3,748.4 Health Care Technology PROCEPT BioRobotics Corporation NasdaqGM:PRCT 9/14/21 25.00 163.9 38.15 52.6% 1,650.1 Health Care Equipment Pasithea Therapeutics Corp. NasdaqCM:KTTA 9/14/21 5.00 24.0 3.04 -39.2% 39.7 Biotechnology SeqLL Inc. NasdaqCM:SQL 8/26/21 4.25 13.0 3.64 -14.4% 43.3 Life Sciences Tools and Services RenovoRx, Inc. NasdaqCM:RNXT 8/25/21 9.00 16.7 6.04 -32.9% 50.6 Biotechnology BiVictriX Therapeutics Plc AIM:BVX 8/10/21 0.28 10.4 0.26 -4.9% 17.4 Biotechnology Eliem Therapeutics, Inc. NasdaqGM:ELYM 8/9/21 12.50 80.0 17.98 43.8% 477.3 Biotechnology Ulisse Biomed S.p.A. BIT:UBM 8/5/21 2.37 5.3 5.82 145.7% 42.2 Biotechnology Adagio Therapeutics, Inc. NasdaqGM:ADGI 8/5/21 17.00 309.4 42.24 148.5% 4,699.3 Biotechnology IN8bio, Inc. NasdaqGM:INAB 7/30/21 10.00 40.0 6.85 -31.5% 128.5 Biotechnology Immuneering Corporation NasdaqGM:IMRX 7/29/21 15.00 112.5 26.55 77.0% 688.7 Biotechnology RxSight, Inc. NasdaqGM:RXST 7/29/21 16.00 117.6 12.67 -20.8% 346.1 Health Care Supplies Omega Therapeutics, Inc. NasdaqGS:OMGA 7/29/21 17.00 125.8 18.85 10.9% 900.2 Biotechnology Tenaya Therapeutics, Inc. NasdaqGS:TNYA 7/29/21 15.00 180.0 20.65 37.7% 852.4 Biotechnology Icosavax, Inc. NasdaqGS:ICVX 7/29/21 15.00 182.0 29.59 97.3% 1,165.5 Biotechnology Nuvalent, Inc. NasdaqGS:NUVL 7/28/21 17.00 165.8 22.55 32.6% 1,088.8 Biotechnology Rallybio Corporation NasdaqGS:RLYB 7/28/21 13.00 80.6 17.58 35.2% 564.8 Biotechnology Data Source: Capital IQ Initial Public Offerings
  • 15. © 2021 Mercer Capital // www.mercercapital.com 13 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 Initial Public Offerings (continued) Completed Initial Public Offerings During 3Q 2021 Issuer Ticker IPO Date IPO Price Gross Proceeds ($mil) 9/30/21 Stock Price Return Since IPO 9/30/20 Market Cap Industry Candel Therapeutics, Inc. NasdaqGM:CADL 7/26/21 8.00 72.0 10.84 35.5% 311.0 Biotechnology Cytek Biosciences, Inc. NasdaqGS:CTKB 7/22/21 17.00 247.6 21.41 25.9% 2,847.4 Life Sciences Tools and Services SOPHiA GENETICS SA NasdaqGS:SOPH 7/22/21 $18.00 $234.0 $17.53 -2.6% 1,138.9 Health Care Technology Caribou Biosciences, Inc. NasdaqGS:CRBU 7/22/21 16.00 304.0 23.87 49.2% 1,431.5 Biotechnology Modus Therapeutics Holding AB (publ) OM:MODTX 7/22/21 0.74 3.8 0.47 -36.4% 7.5 Biotechnology Absci Corporation NasdaqGS:ABSI 7/21/21 16.00 200.0 11.63 -27.3% 1,076.4 Life Sciences Tools and Services HCW Biologics Inc. NasdaqGM:HCWB 7/19/21 8.00 56.0 3.19 -60.1% 114.0 Biotechnology Imago BioSciences, Inc. NasdaqGS:IMGO 7/15/21 16.00 134.4 20.03 25.2% 669.7 Biotechnology Erasca, Inc. NasdaqGS:ERAS 7/15/21 16.00 300.0 21.22 32.6% 2,572.3 Biotechnology Stevanato Group S.p.A. NYSE:STVN 7/15/21 21.00 672.0 25.31 20.5% 6,699.5 Life Sciences Tools and Services TScan Therapeutics, Inc. NasdaqGM:TCRX 7/15/21 15.00 100.0 8.34 -44.4% 197.7 Biotechnology Rapid Micro Biosystems, Inc. NasdaqGS:RPID 7/14/21 20.00 158.4 18.47 -7.7% 758.8 Life Sciences Tools and Services Sight Sciences, Inc. NasdaqGS:SGHT 7/14/21 24.00 240.0 22.70 -5.4% 1,072.9 Health Care Equipment Sera Prognostics, Inc. NasdaqGM:SERA 7/14/21 16.00 75.0 11.11 -30.6% 341.1 Biotechnology Ikonisys S.A. ENXTPA:ALIKO 7/13/21 6.79 4.8 3.30 -51.4% 31.3 Biotechnology Unicycive Therapeutics, Inc. NasdaqCM:UNCY 7/13/21 5.00 25.0 2.83 -43.4% 41.1 Biotechnology LungLife AI, Inc. AIM:LLAI 7/8/21 2.42 23.4 2.67 10.1% 67.9 Biotechnology Colan Totte.Co.,Ltd. TSE:7792 7/8/21 10.02 21.5 9.75 -2.6% 87.0 Health Care Equipment TransCode Therapeutics, Inc. NasdaqCM:RNAZ 7/8/21 4.00 25.0 2.99 -25.3% 38.5 Biotechnology BCC Co., Ltd. TSE:7376 7/6/21 11.76 3.1 18.54 57.7% 20.5 Health Care Technology Data Source: Capital IQ
  • 16. © 2021 Mercer Capital // www.mercercapital.com 14 Mercer Capital’s Value Focus: Medtech Device Industry Fourth Quarter 2021 Initial Public Offerings (continued) Medtech Device IPOs 0 20 40 60 80 100 120 140 160 180 200 220 240 $0 $2 $4 $6 $8 $10 $12 $14 $16 $18 $20 $22 $24 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 3Q 2021 YTD Number of IPOs Gross Proceeds ($Billions) Aggregate Gross Proceeds Number of IPOs Source: Capital IQ; Mercer Capital Analysis