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Authorised by the Board of Genetic Technologies
Genetic Technologies
Meet the CEO
March 25, 2021
Genetic basedpreventative
healthplatform
Notice: Forward looking statements
The purpose of the presentation is to provide an update of the business of Genetic Technologies Limited ACN: 009 212 328 (ASX:GTG; NASDAQ:GENE).
These slides have been prepared as a presentation aid only and the information they contain may require further explanation and/or clarification.
Accordingly, these slides and the information they contain should be read in conjunction with past and future announcements made by Genetic
Technologies and should not be relied upon as an independent source of information. Please refer to the Company’s website and/or the Company’s filings
to the ASX and SEC for further information.
The views expressed in this presentation contain information derived from publicly available sources that have not been independently verified. No
representation or warranty is made as to the accuracy, completeness or reliability of the information. Any forward looking statements in this presentation
have been prepared on the basis of a number of assumptions which may prove incorrect and the current intentions, plans, expectations and beliefs about
future events are subject to risks, uncertainties and other factors, many of which are outside Genetic Technologies’ control. Important factors that could
cause actual results to differ materially from assumptions or expectations expressed or implied in this presentation include known and unknown risks.
Because actual results could differ materially to assumptions made and Genetic Technologies’ current intentions, plans, expectations and beliefs about the
future, you are urged to view all forward looking statements contained in this presentation with caution.
This presentation should not be relied on as a recommendation or forecast by Genetic Technologies. Nothing in this presentation should be construed as
either an offer to sell or a solicitation of an offer to buy or sell shares in any jurisdiction.
2
* Defined terms are outlined in the Appendices to this presentation
01 02 03 04 05
Where are
we now
Our Overview
Prioritising the
market entry
strategy by region
Our Markets
Focused on three
distinct and target
routes to market
Our Channels
Executing through
cutting edge innovation
and ‘game changing’
partnerships
Our Portfolio
Building our internal
capability aligned to
execution
Our Capabilities
Our Vision
3
01 | Our Overview – Leader in Genomics
4
We aim to offer the most comprehensive suite of genetic risk assessment tests on the market
70%
1. Pro forma cash position following capital raise on 25 January 2021
Strong focus on R&D
Over a decade of R&D on the development
of polygenic risk scores
Up to 70%
Coverage from tests in development for serious
disease risk including major oncological, metabolic
and degenerative diseases
Multi-year
distribution agreement
License and distribution agreement for COVID-19
Risk Test with IBX for minimum of US$2.9 million
Launched CIT in USA & AUS for other tests
Publications and academic
collaborations
Multiple peer-reviewed publications and four
collaborations with prestigious academic and
medical establishments
Robust patent portfolio
15 patents granted and 7 patent
families pending
$24 million
Strong cash balance with 18-24 month runway1
Our Vision
Empowering a healthier life!
A diversified genomics and AI driven preventative
healthcare company; partnering to provide individualised
risk assessment of serious disease.
5
02 | Our Markets − Prioritising the Market Entry Strategy
6
1. GeneType for Breast Cancer and Colorectal Cancer certified for sale via online sales platform
Australia & New Zealand
Certification by Australian
regulators NATA, to sell into the
Australian market
Two products1 currently
certified and further products
expected to be submitted in
next 12 months
Asia
(Inc. SEA, China and India)
H2 2021 to commence a
scoping and Prioritising a
market entry strategy into Asia
Europe & UK
Looking to commence CE
certification with the view of
entering the European market
with our novel genetic risk tests
in CY2021
United States
Certification by US regulators
CLIA to sell into the USA
Colorectal launched March
2021
Two products1 currently
certified with further products
expected to be submitted in
next 12 months
03 | Our Channels − Pathways to Market
7
Consumer initiated testing (CIT)
with medical supervision
Launched US and
Australia CIT
platforms in 2020
with medical
supervision with:
InTeleLabs in the
US
Phenix Health in
Australia
Current products
include:
GeneType for
Breast Cancer
GeneType for
Colorectal Cancer
AUD$349 / US$249
per test
Direct to consumer testing (DTC)
with no medical supervision
Leveraged for
ancestry, gut
microbiome
testing and non
medical related
genomic tests
Scheduled for
development
following the
establishment of
the regulated
disease and
reimbursable
segments
Medical – Business to Business (B2B)
A communication
and execution
plan curated for
Medical
practitioners
Specialists
Surgeons
Allied Health
Certifying
reimbursable
Germline testing
platform
BRCA test
LYNCH Syndrome
test
(More to follow)*
`
`
* Corporates and Insurance market entry assessment in progress
03 | Our Channels − B2B Medical/Pharmacogenetics Pathway
8
Third Party Licensing
• Provides enhanced distribution and product
offering via:
• Licensing of own products for enhanced
distribution opportunities (ie. Infinity BiologiX
COVID-19 Risk Test)
• Licensing of novel products for enhanced
product offering (ie. PREDICTIX by Taliaz)
1. http://www9.health.gov.au/mbs/fullDisplay.cfm?type=item&q=73296&qt=ItemID
2. http://www9.health.gov.au/mbs/fullDisplay.cfm?type=item&q=73297&qt=ItemID
3. http://www9.health.gov.au/mbs/fullDisplay.cfm?type=item&q=73354&qt=item&criteria=lynch%20syndrome
Business to business sales via the medical
profession
• Adversely impacted by COVID-19 restrictions but
remains a key avenue for education and sales
• Combined with an educational program to target
health professionals mediated VR professional
industry education content providers
Certifying reimbursable Germline testing platform anticipated to be
completed by end of 1H CY2021
• BRCA test: Medicare Benefits Schedule:
• Item 73296 - Fee: $1,200.00 Benefit: 75% = $900.00 85% = $1,115.301
• Item 73297 - Fee: $400.00 Benefit: 75% = $300.00 85% = $340.002
• LYNCH Syndrome test: Medicare Benefits Schedule
• Item 73354 - Fee: $1,200.00 Benefit: 75% = $900.00 85% = $1,115.303
Colorectal Cancer
BreastCancer
04 | Our Portfolio − Innovation Pipeline
9
BRCA Panel LynchSyndrome
COVID-19
PRS Products Under Development to include >70% of Morbidity
Released 2019/2020 Germline Products Under Development
Distribution partnership confirmed
TGA Approved
Prostate Cancer Type 2 Diabetes
Cardiovascular
Disease
Melanoma
PREDICTIX by Taliaz Multitest
04 | Our Portfolio − Driving Growth
10
December
2020
April
2021
July
2021
H2
2021
Market Release to include >70% of Morbidity:
• Breast Cancer
• Colorectal Cancer
• Cardiovascular Disease
• Type 2 Diabetes
• Melanoma
• Prostate Cancer
Multi Test to provide
Risk assessment for
>70% of all morbidities
to launch
Revenue
Expectations
Q4 CY 2021
`
`
Moderate
Revenue
Expectations
Q2 CY 2021
100% Germline + PRS
test for Breast Cancer
and CRC to launch in AU
& USA BRCA
Panel
Lynch
Syndrome
Revenue
Expectations
Q4 CY 2021
Expanding into reimbursable space
IBX COVID Risk Test
released for sale March
31, 2021
Revenue
Expectations
Q2 CY 2021
CIT Platform in AUS and
USA selling BRC and CRC
04 | Our Portfolio − Expanding divisions
11
Emerging divisions
Existing divisions
Oncology
BC, CRC, PC,
Melanoma
Lifestyle
Ancestry/
Microbiome
Pharmoco-
genetics
COVID-19
Serious disease
risk (SDR)
Mental
Health
(by Taliaz)
Germline
Testing
(BRCA, Lynch
Syndrome)
CVD
(Heart Disease)
IHD, AF
Metabolic
Diseases
Diabetes
Genetic
Technologies
Enhanced Sales and Distribution
Capitalise on Licensing, JV and M&A opportunities
Partner with leading commercial labs in regions
Dedicated Innovation Hub
Developing and capturing the next
generation of innovation in genomics an AI
Enhanced IT infrastructure
Futureproofing our platform
Commercial Finance
Innovation underpinned by
controlled operating expenditure
Education and Advisory
Leveraging partnerships with institutions
Oversight and advise to guide ethics and inform innovation
Internal Structure
Resourced to deliver with significant medical and business
acumen inhouse to continue to drive value
Marketing and Positioning
Creating a consumer and patient led
infrastructure for a direct to consumer
e-commerce and B2B sales platform
Genetic based
preventative health
platform
05 | Our Capability − Future Focused
12
01 02 03 04 05
Positioned for
growth
Our Overview
Targeted and
deliberate
Our Markets
Focused and
distinct
Our Channels
Cutting edge
innovation
Our Portfolio
Aligned to
execute
Our Capabilities
Summary and Outlook
13
Genetic Technologies
Empowering a healthier life!
14
Thank You
15
Appendices
16
Corporate Overview
Top 50 share registry breakdown
17
72%
7%
21%
Bank of Melon (Custodian for US ADRs)
Board and Management
Other
Financial Information
Share price (AUD) as at 24 March 2021 0.9c
ADR price (USD) as at 24 March 2021 $4.06
Ord Share on Issue (M)1 9,012
ASX 52-week trading (low/high) 0.3/1.4c
Nasdaq 52-week trading (low/high) $1.45/10.30
Market Cap (A$M/$USM) 81.15/61.01
Cash (31 December 2020) $16.4m
Debt (31 December 2020) nil
1. American Depository Receipts (ADRs) areinterchangeable viacustodian Bankof Mellon with 70%of stockheld intheUSA
2.600 shareson the ASX equate to 1 ADR (American Depository Receipts) intheUSA which areinterchangeable viacustodian Bankof Mellon
Dual Listed on the ASX and Nasdaq
Financial Overview
• Strong proforma cash position of A$24 million to provide runway for commercialisation
and further product development
• Cash burn of $1.48 million a decrease on prior quarter (Q1 FY21: $1.88 million) as a result
of a reduction in administrative costs despite increased products in development and
focus on product distribution and marketing
• Strong interest from US based institutional investors as evidenced by completion of post
quarter end US$6.56 million capital raise on the 25th January used to:
• Support the introduction and distribution of its new products in the United States
and Europe
• Reimbursement studies for the polygenic risk tests;
• Implementation of its consumer-initiated testing platforms;
• Preparation for its COVID-19 PRS Test;
• Introduction of germline testing division;
• General product research and development; and
• For general working capital and potential acquisitions.
$A ‘000s 30 Sept 2020 31 Dec 2020 Change
Net operating cashflow (1,875) (1,481) (21%)
Research and Development 438 358 (18%)
Cash 18,095 16,435 (9%)
18
Our Board and Management
Dr. Lindsay Wakefield
MBBS
Non – Executive Director
Mr. Peter Rubinstein
BEc, LLB
Chairman - Non – Executive Director
Dr. Jerzy “George” Muchnicki
MBBS
Executive Director & Chief Medical Officer
Mr Nick Burrows
B.Com, FAICD, FCA, FGIA, FTIA, F Fin
Non – Executive Director
Simon Morriss
GAICD
Chief Executive Officer
Richard Allman
BSc, PhD, Microbiology
Chief Scientific Officer
19
Defined Terms
Common Complex Diseases (CCP) – A complex disease is caused by the interaction of multiple genes and environmental factors. Complex diseases are also called multifactorial. Examples
of common complex diseases include cancer and heart disease.
Polygenic Risk Score (PRS) - A polygenic risk score tells you how a person's risk compares to others with a different genetic constitution. However, polygenic scores do not provide a
baseline or timeframe for the progression of a disease. For example, consider two people with high polygenic risk scores for having coronary heart disease.
Serious Disease Risk (SDR) - Risk associated with acquiring COVID-19 and requiring hospitalisation withs its associated morbidities and mortalities.
Germline Testing – Germline testing is done on cells that do not have cancer. It is done to see if a person has a gene mutation that is known to increase the risk of developing cancers and
other health problems. This test uses cells (such as blood or skin cells) that do not have any cancer cells. Germline mutations can sometimes be passed down from parents.
Clinical Laboratory Improvement Amendments (CLIA) - Regulates laboratory testing and require clinical laboratories to be certified by the Center for Medicare and Medicaid Services
(CMS) before they can accept human samples for diagnostic testing
National Association of Testing Authorities (NATA) - the authority responsible for the accreditation of laboratories, inspection bodies, calibration services, producers of certified reference
materials and proficiency testing scheme providers throughout Australia. It is also Australia's compliance monitoring authority for the OECD Principles of GLP. NATA provides independent
assurance of technical competence through a proven network of best practice industry experts for customers who require confidence in the delivery of their products and services.
Next Generation Sequencing (NGS) – Next-generation sequencing (NGS), also known as high-throughput sequencing, is the catch-all term used to describe a number of different modern
sequencing technologies. These technologies allow for sequencing of DNA and RNA much more quickly and cheaply than the previously used Sanger sequencing, and as such revolutionised the
study of genomics and molecular biology.
Laboratory Developed Tests (LDT) – A type of in vitro diagnostic test that is designed, manufactured and used within a single laboratory.
Consumer Initiated Tests (CIT) - laboratory testing that is initiated by the consumer without a physician order but reviewed and communicated back to the consumer via a physician.
Direct to Consumer (DTC) – laboratory testing that is initiated by the consumer without a physician order. The results are reported back directly to the consumer.
Genome Wide Association Studies (GWAS) - an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the
genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to
understand how genes contribute to the disease and develop better prevention and treatment strategies.
20

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Genetic Technologies CEO to Provide Business Update

  • 1. Authorised by the Board of Genetic Technologies Genetic Technologies Meet the CEO March 25, 2021 Genetic basedpreventative healthplatform
  • 2. Notice: Forward looking statements The purpose of the presentation is to provide an update of the business of Genetic Technologies Limited ACN: 009 212 328 (ASX:GTG; NASDAQ:GENE). These slides have been prepared as a presentation aid only and the information they contain may require further explanation and/or clarification. Accordingly, these slides and the information they contain should be read in conjunction with past and future announcements made by Genetic Technologies and should not be relied upon as an independent source of information. Please refer to the Company’s website and/or the Company’s filings to the ASX and SEC for further information. The views expressed in this presentation contain information derived from publicly available sources that have not been independently verified. No representation or warranty is made as to the accuracy, completeness or reliability of the information. Any forward looking statements in this presentation have been prepared on the basis of a number of assumptions which may prove incorrect and the current intentions, plans, expectations and beliefs about future events are subject to risks, uncertainties and other factors, many of which are outside Genetic Technologies’ control. Important factors that could cause actual results to differ materially from assumptions or expectations expressed or implied in this presentation include known and unknown risks. Because actual results could differ materially to assumptions made and Genetic Technologies’ current intentions, plans, expectations and beliefs about the future, you are urged to view all forward looking statements contained in this presentation with caution. This presentation should not be relied on as a recommendation or forecast by Genetic Technologies. Nothing in this presentation should be construed as either an offer to sell or a solicitation of an offer to buy or sell shares in any jurisdiction. 2 * Defined terms are outlined in the Appendices to this presentation
  • 3. 01 02 03 04 05 Where are we now Our Overview Prioritising the market entry strategy by region Our Markets Focused on three distinct and target routes to market Our Channels Executing through cutting edge innovation and ‘game changing’ partnerships Our Portfolio Building our internal capability aligned to execution Our Capabilities Our Vision 3
  • 4. 01 | Our Overview – Leader in Genomics 4 We aim to offer the most comprehensive suite of genetic risk assessment tests on the market 70% 1. Pro forma cash position following capital raise on 25 January 2021 Strong focus on R&D Over a decade of R&D on the development of polygenic risk scores Up to 70% Coverage from tests in development for serious disease risk including major oncological, metabolic and degenerative diseases Multi-year distribution agreement License and distribution agreement for COVID-19 Risk Test with IBX for minimum of US$2.9 million Launched CIT in USA & AUS for other tests Publications and academic collaborations Multiple peer-reviewed publications and four collaborations with prestigious academic and medical establishments Robust patent portfolio 15 patents granted and 7 patent families pending $24 million Strong cash balance with 18-24 month runway1
  • 5. Our Vision Empowering a healthier life! A diversified genomics and AI driven preventative healthcare company; partnering to provide individualised risk assessment of serious disease. 5
  • 6. 02 | Our Markets − Prioritising the Market Entry Strategy 6 1. GeneType for Breast Cancer and Colorectal Cancer certified for sale via online sales platform Australia & New Zealand Certification by Australian regulators NATA, to sell into the Australian market Two products1 currently certified and further products expected to be submitted in next 12 months Asia (Inc. SEA, China and India) H2 2021 to commence a scoping and Prioritising a market entry strategy into Asia Europe & UK Looking to commence CE certification with the view of entering the European market with our novel genetic risk tests in CY2021 United States Certification by US regulators CLIA to sell into the USA Colorectal launched March 2021 Two products1 currently certified with further products expected to be submitted in next 12 months
  • 7. 03 | Our Channels − Pathways to Market 7 Consumer initiated testing (CIT) with medical supervision Launched US and Australia CIT platforms in 2020 with medical supervision with: InTeleLabs in the US Phenix Health in Australia Current products include: GeneType for Breast Cancer GeneType for Colorectal Cancer AUD$349 / US$249 per test Direct to consumer testing (DTC) with no medical supervision Leveraged for ancestry, gut microbiome testing and non medical related genomic tests Scheduled for development following the establishment of the regulated disease and reimbursable segments Medical – Business to Business (B2B) A communication and execution plan curated for Medical practitioners Specialists Surgeons Allied Health Certifying reimbursable Germline testing platform BRCA test LYNCH Syndrome test (More to follow)* ` ` * Corporates and Insurance market entry assessment in progress
  • 8. 03 | Our Channels − B2B Medical/Pharmacogenetics Pathway 8 Third Party Licensing • Provides enhanced distribution and product offering via: • Licensing of own products for enhanced distribution opportunities (ie. Infinity BiologiX COVID-19 Risk Test) • Licensing of novel products for enhanced product offering (ie. PREDICTIX by Taliaz) 1. http://www9.health.gov.au/mbs/fullDisplay.cfm?type=item&q=73296&qt=ItemID 2. http://www9.health.gov.au/mbs/fullDisplay.cfm?type=item&q=73297&qt=ItemID 3. http://www9.health.gov.au/mbs/fullDisplay.cfm?type=item&q=73354&qt=item&criteria=lynch%20syndrome Business to business sales via the medical profession • Adversely impacted by COVID-19 restrictions but remains a key avenue for education and sales • Combined with an educational program to target health professionals mediated VR professional industry education content providers Certifying reimbursable Germline testing platform anticipated to be completed by end of 1H CY2021 • BRCA test: Medicare Benefits Schedule: • Item 73296 - Fee: $1,200.00 Benefit: 75% = $900.00 85% = $1,115.301 • Item 73297 - Fee: $400.00 Benefit: 75% = $300.00 85% = $340.002 • LYNCH Syndrome test: Medicare Benefits Schedule • Item 73354 - Fee: $1,200.00 Benefit: 75% = $900.00 85% = $1,115.303
  • 9. Colorectal Cancer BreastCancer 04 | Our Portfolio − Innovation Pipeline 9 BRCA Panel LynchSyndrome COVID-19 PRS Products Under Development to include >70% of Morbidity Released 2019/2020 Germline Products Under Development Distribution partnership confirmed TGA Approved Prostate Cancer Type 2 Diabetes Cardiovascular Disease Melanoma PREDICTIX by Taliaz Multitest
  • 10. 04 | Our Portfolio − Driving Growth 10 December 2020 April 2021 July 2021 H2 2021 Market Release to include >70% of Morbidity: • Breast Cancer • Colorectal Cancer • Cardiovascular Disease • Type 2 Diabetes • Melanoma • Prostate Cancer Multi Test to provide Risk assessment for >70% of all morbidities to launch Revenue Expectations Q4 CY 2021 ` ` Moderate Revenue Expectations Q2 CY 2021 100% Germline + PRS test for Breast Cancer and CRC to launch in AU & USA BRCA Panel Lynch Syndrome Revenue Expectations Q4 CY 2021 Expanding into reimbursable space IBX COVID Risk Test released for sale March 31, 2021 Revenue Expectations Q2 CY 2021 CIT Platform in AUS and USA selling BRC and CRC
  • 11. 04 | Our Portfolio − Expanding divisions 11 Emerging divisions Existing divisions Oncology BC, CRC, PC, Melanoma Lifestyle Ancestry/ Microbiome Pharmoco- genetics COVID-19 Serious disease risk (SDR) Mental Health (by Taliaz) Germline Testing (BRCA, Lynch Syndrome) CVD (Heart Disease) IHD, AF Metabolic Diseases Diabetes Genetic Technologies
  • 12. Enhanced Sales and Distribution Capitalise on Licensing, JV and M&A opportunities Partner with leading commercial labs in regions Dedicated Innovation Hub Developing and capturing the next generation of innovation in genomics an AI Enhanced IT infrastructure Futureproofing our platform Commercial Finance Innovation underpinned by controlled operating expenditure Education and Advisory Leveraging partnerships with institutions Oversight and advise to guide ethics and inform innovation Internal Structure Resourced to deliver with significant medical and business acumen inhouse to continue to drive value Marketing and Positioning Creating a consumer and patient led infrastructure for a direct to consumer e-commerce and B2B sales platform Genetic based preventative health platform 05 | Our Capability − Future Focused 12
  • 13. 01 02 03 04 05 Positioned for growth Our Overview Targeted and deliberate Our Markets Focused and distinct Our Channels Cutting edge innovation Our Portfolio Aligned to execute Our Capabilities Summary and Outlook 13
  • 14. Genetic Technologies Empowering a healthier life! 14
  • 17. Corporate Overview Top 50 share registry breakdown 17 72% 7% 21% Bank of Melon (Custodian for US ADRs) Board and Management Other Financial Information Share price (AUD) as at 24 March 2021 0.9c ADR price (USD) as at 24 March 2021 $4.06 Ord Share on Issue (M)1 9,012 ASX 52-week trading (low/high) 0.3/1.4c Nasdaq 52-week trading (low/high) $1.45/10.30 Market Cap (A$M/$USM) 81.15/61.01 Cash (31 December 2020) $16.4m Debt (31 December 2020) nil 1. American Depository Receipts (ADRs) areinterchangeable viacustodian Bankof Mellon with 70%of stockheld intheUSA 2.600 shareson the ASX equate to 1 ADR (American Depository Receipts) intheUSA which areinterchangeable viacustodian Bankof Mellon Dual Listed on the ASX and Nasdaq
  • 18. Financial Overview • Strong proforma cash position of A$24 million to provide runway for commercialisation and further product development • Cash burn of $1.48 million a decrease on prior quarter (Q1 FY21: $1.88 million) as a result of a reduction in administrative costs despite increased products in development and focus on product distribution and marketing • Strong interest from US based institutional investors as evidenced by completion of post quarter end US$6.56 million capital raise on the 25th January used to: • Support the introduction and distribution of its new products in the United States and Europe • Reimbursement studies for the polygenic risk tests; • Implementation of its consumer-initiated testing platforms; • Preparation for its COVID-19 PRS Test; • Introduction of germline testing division; • General product research and development; and • For general working capital and potential acquisitions. $A ‘000s 30 Sept 2020 31 Dec 2020 Change Net operating cashflow (1,875) (1,481) (21%) Research and Development 438 358 (18%) Cash 18,095 16,435 (9%) 18
  • 19. Our Board and Management Dr. Lindsay Wakefield MBBS Non – Executive Director Mr. Peter Rubinstein BEc, LLB Chairman - Non – Executive Director Dr. Jerzy “George” Muchnicki MBBS Executive Director & Chief Medical Officer Mr Nick Burrows B.Com, FAICD, FCA, FGIA, FTIA, F Fin Non – Executive Director Simon Morriss GAICD Chief Executive Officer Richard Allman BSc, PhD, Microbiology Chief Scientific Officer 19
  • 20. Defined Terms Common Complex Diseases (CCP) – A complex disease is caused by the interaction of multiple genes and environmental factors. Complex diseases are also called multifactorial. Examples of common complex diseases include cancer and heart disease. Polygenic Risk Score (PRS) - A polygenic risk score tells you how a person's risk compares to others with a different genetic constitution. However, polygenic scores do not provide a baseline or timeframe for the progression of a disease. For example, consider two people with high polygenic risk scores for having coronary heart disease. Serious Disease Risk (SDR) - Risk associated with acquiring COVID-19 and requiring hospitalisation withs its associated morbidities and mortalities. Germline Testing – Germline testing is done on cells that do not have cancer. It is done to see if a person has a gene mutation that is known to increase the risk of developing cancers and other health problems. This test uses cells (such as blood or skin cells) that do not have any cancer cells. Germline mutations can sometimes be passed down from parents. Clinical Laboratory Improvement Amendments (CLIA) - Regulates laboratory testing and require clinical laboratories to be certified by the Center for Medicare and Medicaid Services (CMS) before they can accept human samples for diagnostic testing National Association of Testing Authorities (NATA) - the authority responsible for the accreditation of laboratories, inspection bodies, calibration services, producers of certified reference materials and proficiency testing scheme providers throughout Australia. It is also Australia's compliance monitoring authority for the OECD Principles of GLP. NATA provides independent assurance of technical competence through a proven network of best practice industry experts for customers who require confidence in the delivery of their products and services. Next Generation Sequencing (NGS) – Next-generation sequencing (NGS), also known as high-throughput sequencing, is the catch-all term used to describe a number of different modern sequencing technologies. These technologies allow for sequencing of DNA and RNA much more quickly and cheaply than the previously used Sanger sequencing, and as such revolutionised the study of genomics and molecular biology. Laboratory Developed Tests (LDT) – A type of in vitro diagnostic test that is designed, manufactured and used within a single laboratory. Consumer Initiated Tests (CIT) - laboratory testing that is initiated by the consumer without a physician order but reviewed and communicated back to the consumer via a physician. Direct to Consumer (DTC) – laboratory testing that is initiated by the consumer without a physician order. The results are reported back directly to the consumer. Genome Wide Association Studies (GWAS) - an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies. 20