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Iodine Deficiency Disorder
Md Khaleduzzaman
iam.khaleduzzaman@gmail.com
What do you usually
think of iodine?
Definition
Iodine Deficiency Disorders refer to a spectrum of health
consequences resulting from inadequate intake of iodine.
● Iodine is a micronutrient
● Necessary for functional thyroid gland
● Iodine also a trace element
Iodine deficiency leads
● Abortion
● Stillbirth
● Mental and physical retardation
● Deafness
These are collectively called Iodine Deficiency Disorder
(IDDs)
Epidemiology
Iodine deficiency (IDD) is the
single most important cause
of preventable mental
retardation.
Globally more than 2 billion
people at risk of IDD
There has been some
research on this subject in
Ethiopia.
Ethiopia
260 million people in Africa are at risk and
150,000 are affected by goiter.
78% of the total population of Ethiopia are
exposed to iodine deficiency.
Current global iodine status
Etiology and Pathogenesis
● Iodine deficiency occurs when either iodine intake is inadequate or the presence
of goitrogens (anti thyroid) in the diet is high.
● Groundwater and foods grown in these areas lack iodine.
● The resulting low level of thyroid hormones in the blood (hypothyroidism) is the
principal factor responsible for the damage done to the developing brain and the
other harmful effects known collectively as the Iodine Deficiency Disorders (IDDs).
● Consequently, if severe enough, iodine deficiency will impair thyroid function,
resulting in a lower metabolic rate, growth retardation and brain damage.
● The long-term consequence is irreversible mental retardation.
Clinical Features (Signs and Symptoms)
Fetus
● Abortion - Congenital anomalies
● Still birth - Increased perinatal mortality
● Endemic cretinism
Neonate
● Neonatal goiter
● Neonatal hypothyroidism
● Endemic mental retardation
Child and adolescent
● Goiter
● Impaired mental development and function
● Hypothyroidism
● Retarded physical development
Adult
● Hypothyroidism
● Impaired mental function
Most important consequences of the spectrum of IDD are:
● Goiter
● Mental retardation
● Hypothyroidism
● Cretinism
● Increased morbidity and mortality of infants and neonates

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IDD.pptx

  • 1. Iodine Deficiency Disorder Md Khaleduzzaman iam.khaleduzzaman@gmail.com
  • 2. What do you usually think of iodine?
  • 3. Definition Iodine Deficiency Disorders refer to a spectrum of health consequences resulting from inadequate intake of iodine. ● Iodine is a micronutrient ● Necessary for functional thyroid gland ● Iodine also a trace element
  • 4. Iodine deficiency leads ● Abortion ● Stillbirth ● Mental and physical retardation ● Deafness These are collectively called Iodine Deficiency Disorder (IDDs)
  • 5. Epidemiology Iodine deficiency (IDD) is the single most important cause of preventable mental retardation. Globally more than 2 billion people at risk of IDD There has been some research on this subject in Ethiopia.
  • 6. Ethiopia 260 million people in Africa are at risk and 150,000 are affected by goiter. 78% of the total population of Ethiopia are exposed to iodine deficiency.
  • 8. Etiology and Pathogenesis ● Iodine deficiency occurs when either iodine intake is inadequate or the presence of goitrogens (anti thyroid) in the diet is high. ● Groundwater and foods grown in these areas lack iodine. ● The resulting low level of thyroid hormones in the blood (hypothyroidism) is the principal factor responsible for the damage done to the developing brain and the other harmful effects known collectively as the Iodine Deficiency Disorders (IDDs). ● Consequently, if severe enough, iodine deficiency will impair thyroid function, resulting in a lower metabolic rate, growth retardation and brain damage. ● The long-term consequence is irreversible mental retardation.
  • 9. Clinical Features (Signs and Symptoms) Fetus ● Abortion - Congenital anomalies ● Still birth - Increased perinatal mortality ● Endemic cretinism Neonate ● Neonatal goiter ● Neonatal hypothyroidism ● Endemic mental retardation
  • 10. Child and adolescent ● Goiter ● Impaired mental development and function ● Hypothyroidism ● Retarded physical development Adult ● Hypothyroidism ● Impaired mental function
  • 11. Most important consequences of the spectrum of IDD are: ● Goiter ● Mental retardation ● Hypothyroidism ● Cretinism ● Increased morbidity and mortality of infants and neonates