Transgenic animals are animals whose genes have been altered by the transfer of genes from another species. The document discusses the history and methodology of creating transgenic animals, including early experiments in the 1970s injecting foreign genes into mice embryos. It notes both problems and advantages of transgenic animals, such as improving disease resistance but also animals struggling with the added genes. Examples of transgenic animals discussed include glowing fish created with jellyfish genes, faster growing salmon, pigs and monkeys modified for medical research, and mice engineered for studies of diseases like Huntington's. Recent experiments include goats made to produce human breast milk proteins and bioluminescent mice for cancer research.

1. Transgenic animals
by Maryana, Olena, Dasha, Nick ans Yaroslav

2. Agenda
Brief history
Methodology
Problems and ethical issues
Importance of transgenic animals
Transgenic fish, pig, monkey and mouse
Huntington’ disease
Recent experiments

3. Brief History
In the 1970s Rudolf Jaenisch successfully introduced
an outside gene into the mice embryos
DNA microinjection, the first technique to prove
successful in mammals, was first applied to mice
(Gordon and Ruddle, 1981) and then to various other
species such as rats, rabbits, sheep, pigs, birds, and fish
Jaenisch, 1976—retrovirus-mediated transgenesis
Gossler 1986—embryonic stem (ES) cell-mediated gene
transfer

4. Methodology

5. Problems and ethical issues
Drawbacks
Human health
animals struggle
a hormone substance
Advantages
improving resistance to diseases
bigger sizes
profitably for sellers

6. Importance of transgenic
animals
Agriculture
breeding
quality
disease resistance
Medical Applications
xenotransplantation
nutritional supplements and pharmaceuticals
human gene therapy
Industrial Applications

7. Some examples of
transgenic animals

8. Transgenic fish
Glow fish
“Zebrafish” (also known as “Danio rerio”), which
can glow with red, green, and yellow light inside
the aquarium filled with water
Produced by integrating a fluorescent protein gene
from jelly fish
Superfish
Advantage salmon – is gene modified atlantic
salmon. Advantages:
1. increased growth and size
2. grows about 10-11 times faster rather than normal
fish.

9. Transgenic pig
The doctors consider that
in quick time of pig will
become the best friends
of doctors. And will help
people to live far longer
Organs can be taken for
pigs. The point is that the
sizes of organs of pig and
man are almost identical

10. Transgenic monkey
Chinese scientists showed out monkeys for the
study of autism
Scientists are absolutely sure the experiment
helps medicine to win autism.

11. Transgenic mouse
OncoMouse has been genetically modified to carry a specific
gene called an activated oncogene
"Mighty mice" have the capability of running five to six
kilometers at a speed of 20 meters per minute

12. Huntington’s disease
Huntington's
disease (HD) is an
inherited disorder
that results in
death of brain
cells

14. Recent experiments and trends
Transgenic goats engineered to produce
human breast milk
Scientists from UC, created transgenic
goats by transferring human enzymes
and proteins into goat embryos for
breast milk
Production 60 percent of lysozyme and
lactoferrin which could be found in
human mother’s milk.
For orphans or for babies whose
mothers aren’t present, or can’t nurse
them
Bioluminescent transgenic mouse model for
study mammary gland tumor development
Research done by Cancer Biology and
Therapeutics Group, Ireland

15. Conclusion

16. Stay healthy and learn biology:)