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Optimising breast dosimetry:
Improving homogeneity through the
application of angled IMRT fields
M. Squires (BMRS (RT) MA MIR JP MBA(cand.))
S. Cheers (BAppSc (MRS))
• Significant side effects associated with dose inhomogeneity
• Risk associated with low dose integral splay
• Options exist that maximise dose uniformity and minimise low dose
Background
• The angled segment technique offers two additional clinically feasible
protocols
• To give the planner control over homogeneity (HI) and low dose
conformity (CI)
Aim
• Twenty previously optimised tangent plans copied
• Single medially angled off IMRT beam appended to the existing
beamset
• Plans (n=20) optimised and normalised (PTV V47.5 = 99.00%)
Method 1: Single medial segment
• Additional (laterally) angled off IMRT beam appended
• Plans (n=20) optimised and normalised (PTV V47.5 = 99.00%)
Method 2: Dual segments
• Statistically similar average absolute maximum dose
(Dmax 54.55Gy vs. 54.71Gy, p=0.33)
• Reduced V107%
(14.71cc vs. 23.17cc, p<0.01)
• Low dose (V1) integral splay volume was maintained
(6410.04cc vs. 6402.45cc, p=0.44)
• But, reduced contralaterally
(V1 splay over midline 6.60cm vs. 6.80cm, p=0.04)
• Ipsilateral mean lung dose slightly reduced
(5.23Gy vs. 5.33Gy, p=0.04)
Results 1: Single medial segment
• Reduced average maximum dose
(Dmax 53.79Gy vs. 54.71Gy, p=0.03)
• Reduced V107%
(1.90cc vs. 23.17cc, p<0.01)
• Homogeneity improved
(HI= 0.11 vs. 0.13, p=0.03)
• Ipsilateral mean lung dose unaffected
(5.33Gy vs. 5.33Gy, p=0.48)
• Low dose (V1) integral splay increased by 1.5%
(6501.14cc vs. 6402.45cc, p=0.04)
• Low dose (V1) appeared further contralaterally
(8.40cm vs. 6.80cm over midline, p=0.02)
Results 2: Dual segments
Comparative results
• The addition of a medial segment serves to partially reduce high dose
volumes whilst limiting the increase in low dose (win-win)
• Dual segments serve to fully reduce hotspot size at the expense of
increased low dose contralateral splay
• Each technique provides greater scope to customise dosimetry to
meet specific patient needs
Conclusions
References & Acknowledgements
ROC Gosford
[1] Pignol JP, Olivotto I, Rakovitch E, Gardner S, Sixel K, Beckham W, Vu TT, Truong P, Ackerman I, Paszat L 2008, ‘A Multicenter
Randomized Trial of Breast Intensity-Modulated Radiation Therapy to Reduce Acute Radiation Dermatitis.’ Journal of Clinical
Oncology. 1;26 (13) :2085-92.
[2] Donovan E, Bleakley N, Denholm E, Evans P, Gothard L, Hanson J, Peckitt C, Reise S, Ross G, Sharp G, Symonds-Tayler R,
Tait D, Yarnold J 2007, ‘Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in
patients prescribed breast radiotherapy.’ Radiotherapy & Oncology. 82(3):254-64.
[3] Harsolia A, Kestin L, Grills I, Wallace M, Jolly S, Jones C, Lala M, Martinez A, Schell S, Vicini F 2007, ‘Intensity-Modulated
Radiotherapy Results in Significant Decrease in Clinical Toxicities Compared With Conventional Wedge-Based Breast
Radiotherapy.’ International Journal of Radiation Oncology, Biology, Physics. 68: 1375-1380.
[4] Stovall M, Smith SA, Langholz BM, Boice JD Jr, Shore RE, Andersson M, Buchholz TA, Capanu M, Bernstein L, Lynch CF,
Malone KE, Anton-Culver H, Haile RW, Rosenstein BS, Reiner AS, Thomas DC, Bernstein JL 2008, ‘Dose to the Contralateral
Breast from Radiotherapy and Risk of Second Primary Breast Cancer in the WECARE Study.’ International Journal of Radiation
Oncology, Biology and Physics. 72:1021-30.
[5] Czerminska M, Lyatskaya Y n.d., Improving Homogeneity in Breast Radiotherapy Plans , viewed 27 January 2016,
http://chapter.aapm.org/NE/DOCUMENTS/Presentations/2012Summer/Czerminska_NE_AAPM_breast.pdf

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Optimising breast dosimetry: Improving homogeneity through the application of angled IMRT fields

  • 1. Optimising breast dosimetry: Improving homogeneity through the application of angled IMRT fields M. Squires (BMRS (RT) MA MIR JP MBA(cand.)) S. Cheers (BAppSc (MRS))
  • 2. • Significant side effects associated with dose inhomogeneity • Risk associated with low dose integral splay • Options exist that maximise dose uniformity and minimise low dose Background
  • 3. • The angled segment technique offers two additional clinically feasible protocols • To give the planner control over homogeneity (HI) and low dose conformity (CI) Aim
  • 4. • Twenty previously optimised tangent plans copied • Single medially angled off IMRT beam appended to the existing beamset • Plans (n=20) optimised and normalised (PTV V47.5 = 99.00%) Method 1: Single medial segment
  • 5. • Additional (laterally) angled off IMRT beam appended • Plans (n=20) optimised and normalised (PTV V47.5 = 99.00%) Method 2: Dual segments
  • 6. • Statistically similar average absolute maximum dose (Dmax 54.55Gy vs. 54.71Gy, p=0.33) • Reduced V107% (14.71cc vs. 23.17cc, p<0.01) • Low dose (V1) integral splay volume was maintained (6410.04cc vs. 6402.45cc, p=0.44) • But, reduced contralaterally (V1 splay over midline 6.60cm vs. 6.80cm, p=0.04) • Ipsilateral mean lung dose slightly reduced (5.23Gy vs. 5.33Gy, p=0.04) Results 1: Single medial segment
  • 7. • Reduced average maximum dose (Dmax 53.79Gy vs. 54.71Gy, p=0.03) • Reduced V107% (1.90cc vs. 23.17cc, p<0.01) • Homogeneity improved (HI= 0.11 vs. 0.13, p=0.03) • Ipsilateral mean lung dose unaffected (5.33Gy vs. 5.33Gy, p=0.48) • Low dose (V1) integral splay increased by 1.5% (6501.14cc vs. 6402.45cc, p=0.04) • Low dose (V1) appeared further contralaterally (8.40cm vs. 6.80cm over midline, p=0.02) Results 2: Dual segments
  • 9. • The addition of a medial segment serves to partially reduce high dose volumes whilst limiting the increase in low dose (win-win) • Dual segments serve to fully reduce hotspot size at the expense of increased low dose contralateral splay • Each technique provides greater scope to customise dosimetry to meet specific patient needs Conclusions
  • 10. References & Acknowledgements ROC Gosford [1] Pignol JP, Olivotto I, Rakovitch E, Gardner S, Sixel K, Beckham W, Vu TT, Truong P, Ackerman I, Paszat L 2008, ‘A Multicenter Randomized Trial of Breast Intensity-Modulated Radiation Therapy to Reduce Acute Radiation Dermatitis.’ Journal of Clinical Oncology. 1;26 (13) :2085-92. [2] Donovan E, Bleakley N, Denholm E, Evans P, Gothard L, Hanson J, Peckitt C, Reise S, Ross G, Sharp G, Symonds-Tayler R, Tait D, Yarnold J 2007, ‘Randomised trial of standard 2D radiotherapy (RT) versus intensity modulated radiotherapy (IMRT) in patients prescribed breast radiotherapy.’ Radiotherapy & Oncology. 82(3):254-64. [3] Harsolia A, Kestin L, Grills I, Wallace M, Jolly S, Jones C, Lala M, Martinez A, Schell S, Vicini F 2007, ‘Intensity-Modulated Radiotherapy Results in Significant Decrease in Clinical Toxicities Compared With Conventional Wedge-Based Breast Radiotherapy.’ International Journal of Radiation Oncology, Biology, Physics. 68: 1375-1380. [4] Stovall M, Smith SA, Langholz BM, Boice JD Jr, Shore RE, Andersson M, Buchholz TA, Capanu M, Bernstein L, Lynch CF, Malone KE, Anton-Culver H, Haile RW, Rosenstein BS, Reiner AS, Thomas DC, Bernstein JL 2008, ‘Dose to the Contralateral Breast from Radiotherapy and Risk of Second Primary Breast Cancer in the WECARE Study.’ International Journal of Radiation Oncology, Biology and Physics. 72:1021-30. [5] Czerminska M, Lyatskaya Y n.d., Improving Homogeneity in Breast Radiotherapy Plans , viewed 27 January 2016, http://chapter.aapm.org/NE/DOCUMENTS/Presentations/2012Summer/Czerminska_NE_AAPM_breast.pdf