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A DISRUPTIVE TECHNOLOGY FOR
DIABETICS AND THOSE AT RISK
August 29, 2016
Transforming Health Through Innovation 1
© 2016 Alertgy LLC Proprietary and Confidential
Transforming Health Through Innovation
Transforming Health Through Innovation 2
Alertgy was founded in 2016 to develop and commercialize a
noninvasive blood sugar monitor and also enabling continuous
monitoring to:
#StopThePrick!
Unique, Multi-billion Dollar Opportunity
Technology
•New sensor technology
•Miniaturization
•New materials
•Increased computational power
Market
•Diabetes and prediabetes populations growing
•Closer monitoring/better control reduces healthcare costs
•Current products not ideal for patient acceptance (blood stick)
•Increased use of smart phones
OUTCOME
•New technology that will disrupt current approaches
•Time to market 3 years
•Investment payments align to milestones to mitigate risk
•.> 100% revenue ROI in year 4 (multi-billion dollar revenue by end of year 4)
Transforming Health Through Innovation 3
The Right People to Make it Happen!
Transforming Health Through Innovation 4
Marc Rippen CEO & Founder
Engineer / Scientist
Craig Nelson COO
Manufacturing Guru
Dr. Helga Rippen CMO
MD, PhD, MPH, FACPM
© 2016 Alertgy LLC Proprietary and Confidential
“I have been involved in healthcare
for over 20 years and know when a
new technology can make a
difference! Alertgy’s non-invasive
blood sugar monitor is technically
possible and will revolutionize the
care diabetics and prediabetics
receive.”
“I have been providing cutting edge
solutions for the military for over 20
years. My wife is a diabetic and my
concern for her health has
redirected my focus to solving her
challenges. We have a highly viable
technological approach and are
poised to disrupt the market.”
“I have been setting designing
automated mass production lines
for flexible micro electronic products
for over 30 years. I am a diabetic
and I know this technology will
drastically improve my life quality. It
will also help my doctor better assist
me in maintaining my health.
Transforming Health Through Innovation 5
© 2016 Alertgy LLC Proprietary and Confidential
Non-Invasive
Glucose Sensor
Array A/D
SoC
Processor
WiFI
Battery
Powered
Base Circuit Architecture of Wristband Sensor System
Analog
Pre/Post
conditioning
Interface
D/A
• The Noninvasive Glucose Wireless Monitor Alert System converts electrical signals generated by the
sensors in a wrist band into a data file, communicating the data in a secure encrypted mode using
wireless Bluetooth protocol to a smartphone.
• The smartphone app will conduct Multivariate Analysis to normalize the blood sugar data to
provide accurate real time blood sugar levels and display them on screen on demand and/or to alert
user when blood sugar levels are too high or low.
• Based on blood sugar levels detected, the app can alert the user, immediate family, and physicians
as programmed by the user.
• The Alertgy app will be able to operate on both Android and Apple platforms.
Technology Overview
#StopThePrick!
Base Technology is Proven
• The Alertgy non-invasive continuous glucose monitoring system is
based on impedance spectroscopy, which is very well documented
in numerous published sources in the literature.
• In the proof of principal study the sensor used in the experiments is
the size of a finger tip worked to create an open resonant circuit
coupled to the skin and a circuit to perform an impedance
measurement.
• The results of testing with the gen 1 finger tip sensor are presented
in a plot comparison with the standard prick and stick glucometer
method on the next page of this presentation.
• The results of this first series of experiments are considered as a
proof of concept for this novel non-invasive monitoring approach.
Transforming Health Through Innovation 6
#StopThePrick!
Dielectric Sensor Versus One Touch
Transforming Health Through Innovation 7
Composite Glucometer Calibration Results
50
70
90
110
130
150
170
50 70 90 110 130 150 170
OneTouch Standard
PredictedValue
© 2016 Alertgy LLC Proprietary and Confidential
#StopThePrick!
Competition
Transforming Health Through Innovation 8
METHOD LEVEL OF INTRUSIVENESS
MONITORING
RATE MONTITORING MODE COST
Smart Phone
Alert
Finger Prick Meter and Stick High (finger prick) 8 Times Daily Manual 6 dollars a day No
Dexcom chip (7 day)
High (Injected chip / needle sub-
cue) Continous Automatic
16 dollars a
day Yes
Watch Electrophorsis (<50% can
use) High (micropricks can cause rash) Continous Automatic
20 dollars a
day No
Optical Spectroscopy
Medium (Clap on ear in finger
web) 8 Times Daily Manual 5 dollars a day No
Alertgy Dielectric Sensor (30 day) None (wristband) Continuous Automatic 4 dollars a day Yes
Echo Star (15 day)
Medium (patch and abrasion of
skin) Continuous Automatic 7 dollars a day Yes
© 2016 Alertgy LLC Proprietary and Confidential
Potential US Market Size of
120 Million and Growing
Estimated 9.3% of the US adult population have diabetes and 37% are pre-diabetic
Diagnosed**,
22,000,000,
19%
Undiagnosed*,
8,100,000, 7%
Gestational
diabetes,
366,705, 0%
Prediabetics,
86,000,000,
72%
Quantifiable
self,
2,500,000,
2%
Transforming Health Through Innovation 9
*2012 numbers, CDC; **2014 numbers for diagnosed; *** WHO
© 2016 Alertgy LLC Proprietary and Confidential
International Market – 422 million; 8.5% of world population and growing***
* 2010, US, CDC, US
** http://www.medscape.com/viewarticle/809547
Economic Cost Estimated to be $245
billion/year*
Transforming Health Through Innovation 10
Lifetime, direct health care cost for one patient: $55,000 -
$130,000**
© 2016 Alertgy LLC Proprietary and Confidential
Diabetics have a Decreased Quality of Life,
Higher Complication Rates, and Shorter
Life Expectancy
• 7th leading cause of death in the US
• 28.5% of diabetics older than 40 have diabetic retinopathy (vision loss)
• 44% of kidney failure caused by diabetes
• Heart attack rates 1.8 times higher for diabetics, deaths 1.7 time higher
• Stroke hospitalization rates 1.5 times higher for diabetics
• 60% of non-traumatic lower limb amputations (20 and older) are diabetics
Transforming Health Through Innovation 11
© 2016 Alertgy LLC Proprietary and Confidential
Best Practices: Clinical Blood Glucose
Goals for Patients to Follow*
• Goals:
– Pre-meal 80-130 mg/dL;
– Post-meal < 180 mg/dL [1-2 hrs
after beginning of meal]
Transforming Health Through Innovation 12
*http://care.diabetesjournals.org/content/suppl/2015/12/21/39.Supplement_1.DC2/2016-Standards-of-Care.pdf
© 2016 Alertgy LLC Proprietary and Confidential
• High/Low levels
– Low <= 70 mg/dL
– High
• Pre-meal >130
• Post-meal >=180
Prototype to Market Over Three Year
Time Period
Transforming Health Through Innovation 13
Phase I Gen 2
Prototype
Develop Gen / Test 2 Prototype:
• Test with other sensors
• Enhance technology
• Develop / build gen 2 Prototype for
wristband form factor.
• Preliminary testing with patients
for final sensor selection
Gen 2 Product
Manufacture
Gen 2 :
• Complete Generation 2:
Enhancements
• Complete Software/ hardware
• ASIC Design / Build
• Manufacture, test beta product
Phase II
Market
Launch
Introduce to Market
• Clinical Trials
• FDA approval
• Quality control (device)
• Consumer/Patient data
• Correlation algorithm
• Sensitivity/Specificity (alert)
• Continuous monitoring performance
• Consumer views
© 2016 Alertgy LLC Proprietary and Confidential
Strategic Partners
Transforming Health Through Innovation 14
© 2016 Alertgy LLC Proprietary and Confidential
Moving Forward
Alertgy is seeking investment for equity.
Revenue: $ 2,000 million in year 4
Profit: 30 %
Funding goal: $ 20 million
ROI: 300 %
Transforming Health Through Innovation 15
© 2016 Alertgy LLC Proprietary and Confidential
Questions?
Transforming Health Through Innovation 16
© 2016 Alertgy LLC Proprietary and Confidential

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VC Short Alertgy Overview

  • 1. A DISRUPTIVE TECHNOLOGY FOR DIABETICS AND THOSE AT RISK August 29, 2016 Transforming Health Through Innovation 1 © 2016 Alertgy LLC Proprietary and Confidential Transforming Health Through Innovation
  • 2. Transforming Health Through Innovation 2 Alertgy was founded in 2016 to develop and commercialize a noninvasive blood sugar monitor and also enabling continuous monitoring to: #StopThePrick!
  • 3. Unique, Multi-billion Dollar Opportunity Technology •New sensor technology •Miniaturization •New materials •Increased computational power Market •Diabetes and prediabetes populations growing •Closer monitoring/better control reduces healthcare costs •Current products not ideal for patient acceptance (blood stick) •Increased use of smart phones OUTCOME •New technology that will disrupt current approaches •Time to market 3 years •Investment payments align to milestones to mitigate risk •.> 100% revenue ROI in year 4 (multi-billion dollar revenue by end of year 4) Transforming Health Through Innovation 3
  • 4. The Right People to Make it Happen! Transforming Health Through Innovation 4 Marc Rippen CEO & Founder Engineer / Scientist Craig Nelson COO Manufacturing Guru Dr. Helga Rippen CMO MD, PhD, MPH, FACPM © 2016 Alertgy LLC Proprietary and Confidential “I have been involved in healthcare for over 20 years and know when a new technology can make a difference! Alertgy’s non-invasive blood sugar monitor is technically possible and will revolutionize the care diabetics and prediabetics receive.” “I have been providing cutting edge solutions for the military for over 20 years. My wife is a diabetic and my concern for her health has redirected my focus to solving her challenges. We have a highly viable technological approach and are poised to disrupt the market.” “I have been setting designing automated mass production lines for flexible micro electronic products for over 30 years. I am a diabetic and I know this technology will drastically improve my life quality. It will also help my doctor better assist me in maintaining my health.
  • 5. Transforming Health Through Innovation 5 © 2016 Alertgy LLC Proprietary and Confidential Non-Invasive Glucose Sensor Array A/D SoC Processor WiFI Battery Powered Base Circuit Architecture of Wristband Sensor System Analog Pre/Post conditioning Interface D/A • The Noninvasive Glucose Wireless Monitor Alert System converts electrical signals generated by the sensors in a wrist band into a data file, communicating the data in a secure encrypted mode using wireless Bluetooth protocol to a smartphone. • The smartphone app will conduct Multivariate Analysis to normalize the blood sugar data to provide accurate real time blood sugar levels and display them on screen on demand and/or to alert user when blood sugar levels are too high or low. • Based on blood sugar levels detected, the app can alert the user, immediate family, and physicians as programmed by the user. • The Alertgy app will be able to operate on both Android and Apple platforms. Technology Overview #StopThePrick!
  • 6. Base Technology is Proven • The Alertgy non-invasive continuous glucose monitoring system is based on impedance spectroscopy, which is very well documented in numerous published sources in the literature. • In the proof of principal study the sensor used in the experiments is the size of a finger tip worked to create an open resonant circuit coupled to the skin and a circuit to perform an impedance measurement. • The results of testing with the gen 1 finger tip sensor are presented in a plot comparison with the standard prick and stick glucometer method on the next page of this presentation. • The results of this first series of experiments are considered as a proof of concept for this novel non-invasive monitoring approach. Transforming Health Through Innovation 6 #StopThePrick!
  • 7. Dielectric Sensor Versus One Touch Transforming Health Through Innovation 7 Composite Glucometer Calibration Results 50 70 90 110 130 150 170 50 70 90 110 130 150 170 OneTouch Standard PredictedValue © 2016 Alertgy LLC Proprietary and Confidential #StopThePrick!
  • 8. Competition Transforming Health Through Innovation 8 METHOD LEVEL OF INTRUSIVENESS MONITORING RATE MONTITORING MODE COST Smart Phone Alert Finger Prick Meter and Stick High (finger prick) 8 Times Daily Manual 6 dollars a day No Dexcom chip (7 day) High (Injected chip / needle sub- cue) Continous Automatic 16 dollars a day Yes Watch Electrophorsis (<50% can use) High (micropricks can cause rash) Continous Automatic 20 dollars a day No Optical Spectroscopy Medium (Clap on ear in finger web) 8 Times Daily Manual 5 dollars a day No Alertgy Dielectric Sensor (30 day) None (wristband) Continuous Automatic 4 dollars a day Yes Echo Star (15 day) Medium (patch and abrasion of skin) Continuous Automatic 7 dollars a day Yes © 2016 Alertgy LLC Proprietary and Confidential
  • 9. Potential US Market Size of 120 Million and Growing Estimated 9.3% of the US adult population have diabetes and 37% are pre-diabetic Diagnosed**, 22,000,000, 19% Undiagnosed*, 8,100,000, 7% Gestational diabetes, 366,705, 0% Prediabetics, 86,000,000, 72% Quantifiable self, 2,500,000, 2% Transforming Health Through Innovation 9 *2012 numbers, CDC; **2014 numbers for diagnosed; *** WHO © 2016 Alertgy LLC Proprietary and Confidential International Market – 422 million; 8.5% of world population and growing***
  • 10. * 2010, US, CDC, US ** http://www.medscape.com/viewarticle/809547 Economic Cost Estimated to be $245 billion/year* Transforming Health Through Innovation 10 Lifetime, direct health care cost for one patient: $55,000 - $130,000** © 2016 Alertgy LLC Proprietary and Confidential
  • 11. Diabetics have a Decreased Quality of Life, Higher Complication Rates, and Shorter Life Expectancy • 7th leading cause of death in the US • 28.5% of diabetics older than 40 have diabetic retinopathy (vision loss) • 44% of kidney failure caused by diabetes • Heart attack rates 1.8 times higher for diabetics, deaths 1.7 time higher • Stroke hospitalization rates 1.5 times higher for diabetics • 60% of non-traumatic lower limb amputations (20 and older) are diabetics Transforming Health Through Innovation 11 © 2016 Alertgy LLC Proprietary and Confidential
  • 12. Best Practices: Clinical Blood Glucose Goals for Patients to Follow* • Goals: – Pre-meal 80-130 mg/dL; – Post-meal < 180 mg/dL [1-2 hrs after beginning of meal] Transforming Health Through Innovation 12 *http://care.diabetesjournals.org/content/suppl/2015/12/21/39.Supplement_1.DC2/2016-Standards-of-Care.pdf © 2016 Alertgy LLC Proprietary and Confidential • High/Low levels – Low <= 70 mg/dL – High • Pre-meal >130 • Post-meal >=180
  • 13. Prototype to Market Over Three Year Time Period Transforming Health Through Innovation 13 Phase I Gen 2 Prototype Develop Gen / Test 2 Prototype: • Test with other sensors • Enhance technology • Develop / build gen 2 Prototype for wristband form factor. • Preliminary testing with patients for final sensor selection Gen 2 Product Manufacture Gen 2 : • Complete Generation 2: Enhancements • Complete Software/ hardware • ASIC Design / Build • Manufacture, test beta product Phase II Market Launch Introduce to Market • Clinical Trials • FDA approval • Quality control (device) • Consumer/Patient data • Correlation algorithm • Sensitivity/Specificity (alert) • Continuous monitoring performance • Consumer views © 2016 Alertgy LLC Proprietary and Confidential
  • 14. Strategic Partners Transforming Health Through Innovation 14 © 2016 Alertgy LLC Proprietary and Confidential
  • 15. Moving Forward Alertgy is seeking investment for equity. Revenue: $ 2,000 million in year 4 Profit: 30 % Funding goal: $ 20 million ROI: 300 % Transforming Health Through Innovation 15 © 2016 Alertgy LLC Proprietary and Confidential
  • 16. Questions? Transforming Health Through Innovation 16 © 2016 Alertgy LLC Proprietary and Confidential