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Hypertension management will change more in the next 5 years than in the last 100

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Why will managing hypertension change more in the next 5 years than it has in the last 100?

There are several macro trends that are driving this change:

- Hypertension is a massive global health problem (over 1B people have high BP) and it is THE leading risk factor for the global burden of disease (its a comorbidity in every major chronic disease) - more of a risk factor than tobacco, obesity, poor diet, high blood glucose, etc. - according to the WHO.
- Sensor tech - there has been no meaningful innovation in BP sensors in over 100 years. The BP cuffs in use today are fundamentally the same as the first BP cuff that came to market in the early 1900's. That’s changing now with cuffless BP sensors that are being approved by regulatory bodies.
- Care delivery – healthcare "has left the building", moving out of the hospital, into the home and everyday life. This can be seen in the huge growth in remote patient monitoring, digital therapeutics, and digital health more broadly.
- Payer models – insurance coverage is moving from fee-for-service to value-based care that’s focused on prevention and monitoring. This is particularly important in hypertension management because high BP has no outward symptoms, making the frequency and ease of BP monitoring extremely important.

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Hypertension management will change more in the next 5 years than in the last 100

  1. 1. Hypertension Management: More Changes Coming in the Next 5 Years Than in the Last 100 Years
  2. 2. Agenda © 2021 Valencell, Inc 2 • Market trends • How we got here • Why hypertension? • Vectors of change • BP monitoring landscape
  3. 3. Wearables & medical devices are rapidly converging © 2021 Valencell, Inc 3 “Healthcare Spend in Wearables to Reach $60 Billion by 2023, as Monitoring Devices & Hearables Become ‘Must Haves’ in Delivering Care” - Juniper Research, January 2019 “70% of clinical trials will incorporate sensors by 2025” - Kaiser Associates-Intel, 2019 ”What was Apple's greatest contribution to mankind, it will be about health” - Tim Cook, Apple CEO, January 2019 “Wearable technology market to reach $81.5B by 2021 in spite of turbulence caused by Covid-19” - Gartner, January 2021 Health & Medical Devices Consumer Devices
  4. 4. Foundation is set to unlock large scale value creation © 2021 Valencell, Inc 4 › Simple activity tracking › Limited ongoing value led to high abandonment rates Generation 1 Basic Activity Tracking 2010-2015 Market Trends Relevant Markets Fitness | Step counting, calorie burn, etc. › Sensor technology advancements – PPG becomes the dominant sensor tech in wearables › Consumers taking more control over their health – rise of the “consumer patient” Generation 2 Deeper Insights 2015-2020 Fitness | Step counting, calorie burn, etc. Personal Health Heart rate, sleep tracking, stress monitoring, etc. Value Creation Generation 3 Medical Wearables & Digital Therapeutics 2020-2030 › Convergence of consumer and med devices – wearables as “early warning system” › COVID inflection point › Digital health (software, apps, wearables) integrated into care delivery › Meanwhile, healthcare spending and chronic disease are both accelerating FITNESS | Step counting, calorie burn, etc. PERSONAL HEALTH Heart rate, sleep tracking, stress monitoring, etc. DIGITAL HEALTH & THERAPEUTICS › Cardiovascular monitoring › Hypertension management › Diabetes management › Remote patient monitoring › Respiratory conditions › Stroke detection › Pain management › RWE for clinical trials › Hearing health
  5. 5. Hypertension is a massive global public problem © 2021 Valencell, Inc 5 › Convergence of consumer and med devices – wearables as “early warning system” › COVID inflection point › Digital health (software, apps, wearables) integrated into care delivery › Meanwhile, healthcare spending and chronic disease are both accelerating Generation 3 Medical Wearables & Digital Therapeutics 2020-2030 FITNESS | Step counting, calorie burn, etc. PERSONAL HEALTH Heart rate, sleep tracking, stress monitoring, etc. DIGITAL HEALTH & THERAPEUTICS 1 Billion people have high blood pressure worldwide1 More than 10 Million deaths per year Nearly half those US adults (35M) have uncontrolled hypertension2 75M US adults with high BP In 2017, the WHO’s Global Burden of Disease study showed high blood pressure accounted for 10.4M deaths per year.3 1. World Health Organization - https://www.who.int/news-room/fact-sheets/detail/hypertension 2. Centers for Disease Control https://pubmed.ncbi.nlm.nih.gov/27855138/ 3. World Bank & World Health Organization https://pubmed.ncbi.nlm.nih.gov/23245609/ › Cardiovascular monitoring › Hypertension management › Diabetes management › Remote patient monitoring › Respiratory conditions › Stroke detection › Pain management › RWE for clinical trials › Hearing health
  6. 6. Hypertension comorbidities & cumulative high blood pressure multiply the impact © 2021 Valencell, Inc 6 Generation 3 Medical Wearables & Digital Therapeutics 2020-2030 FITNESS | Step counting, calorie burn, etc. PERSONAL HEALTH Heart rate, sleep tracking, stress monitoring, etc. DIGITAL HEALTH & THERAPEUTICS › Convergence of consumer and med devices – wearables as “early warning system” › COVID inflection point › Digital health (software, apps, wearables) integrated into care delivery › Meanwhile, healthcare spending and chronic disease are both accelerating › Cardiovascular monitoring › Hypertension management › Diabetes management › Remote patient monitoring › Respiratory conditions › Stroke detection › Pain management › RWE for clinical trials › Hearing health Sources: 1Impact of comorbidities in hypertension https://journals.lww.com/co-cardiology/Citation/2016/07000/Impact_of_comorbidities_in_hypertension.6.aspx 2 Longitudinal Patterns of Change in Systolic Blood Pressure and Incidence of Cardiovascular Disease https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.115.06769 Coronary heart disease Stroke Congestive heart failure Chronic kidney disease Diabetes Dementia Comorbidities associated with hypertension1 Cumulative effect of high blood pressure “…our results suggest that the cumulative systolic BP load, rather than the temporal pattern of change in systolic BP itself, plays a role in determining the risk of CVD, independent of BP level measured at one point in time.”2
  7. 7. Hypertension management will change more in the next 5 years than in last 100 © 2021 Valencell, Inc 7 Cuffless BP monitoring technology in wearables and hearables Sensor Tech Care Delivery Moving to value-based care that’s focused on prevention and monitoring Payer Models Remote Patient Monitoring Digital Therapeutics Digital Health
  8. 8. Sensor Tech: We’ve seen this play out before © 2021 Valencell, Inc 8 Generation 1 Basic Activity Tracking Generation 2 Deeper Insights Generation 3 Medical Wearables & Digital Therapeutics 2010-2015 2015-2020 2020-2030 Sources: IDC, Strategy Analytics, Grandview Research, Valencell analysis 20M HRM Chest Straps ~400-500M Optical HRM’s in wearables ~400-500M Cuffless BP Monitors 15-20M Traditional BP cuffs
  9. 9. Care Delivery: Moving outside the healthcare facility © 2021 Valencell, Inc 9 Care Delivery Remote Patient Monitoring Digital Therapeutics Digital Health Sources: McKinsey - https://www.mckinsey.com/industries/healthcare-systems-and-services/our-insights/telehealth-a-quarter-trillion-dollar-post-covid-19- reality# Rock Health - https://rockhealth.com/reports/h1-2021-digital-health-funding-another-blockbuster-year-in-six-months/
  10. 10. Care Delivery: Moving outside the healthcare facility © 2021 Valencell, Inc 10 Care Delivery Remote Patient Monitoring Digital Therapeutics Digital Health
  11. 11. Payer Models: © 2021 Valencell, Inc 11 Moving to value-based care that’s focused on prevention and monitoring Payer Models • CPT 99473 - Self-measured blood pressure using a device validated for clinical accuracy; patient education/training and device calibration • CPT 99474 - Separate self-measurements of two readings one minute apart, twice daily over a 30-day period (minimum of 12 readings), collection of data reported by the patient and/or caregiver to the physician or other qualified health care professional, with report of average systolic and diastolic pressures and subsequent communication of a treatment plan to the patient “Most importantly, the out-of-office measurements are more predictive of future cardiovascular risk than measurements taken in the office,” said Dr. Michael Rakotz, AMA Vice President of Health Outcomes Two new CPT codes approved in 2020 for reimbursement Source: https://www.ama-assn.org/practice-management/cpt/new-year-new-cpt-codes-self-measured-bp
  12. 12. Huge opportunity to impact patient outcomes and public health costs © 2021 Valencell, Inc 12 Source: https://www.cdc.gov/chronicdisease/programs-impact/pop/high-blood-pressure.htm
  13. 13. Valencell is on a mission to improve the quality of life for more than one billion people worldwide through cuffless, calibration-free BP monitoring solutions
  14. 14. Blood Pressure Monitoring Landscape © 2021 Valencell, Inc 14 Digital Therapeutics Devices Sensors
  15. 15. Summary © 2021 Valencell, Inc 15 • Hypertension is a massive global public health problem and cost burden on healthcare systems around the world • Numerous technology advancements, regulatory, and incentive changes are lining up to make big change in hypertension management • Still early days - there remains much work to be done to impact individual and public health and systemic costs
  16. 16. Thank you! Ryan Kraudel VP Marketing
  • TomiSiikaluoma

    Aug. 15, 2021

Why will managing hypertension change more in the next 5 years than it has in the last 100? There are several macro trends that are driving this change: - Hypertension is a massive global health problem (over 1B people have high BP) and it is THE leading risk factor for the global burden of disease (its a comorbidity in every major chronic disease) - more of a risk factor than tobacco, obesity, poor diet, high blood glucose, etc. - according to the WHO. - Sensor tech - there has been no meaningful innovation in BP sensors in over 100 years. The BP cuffs in use today are fundamentally the same as the first BP cuff that came to market in the early 1900's. That’s changing now with cuffless BP sensors that are being approved by regulatory bodies. - Care delivery – healthcare "has left the building", moving out of the hospital, into the home and everyday life. This can be seen in the huge growth in remote patient monitoring, digital therapeutics, and digital health more broadly. - Payer models – insurance coverage is moving from fee-for-service to value-based care that’s focused on prevention and monitoring. This is particularly important in hypertension management because high BP has no outward symptoms, making the frequency and ease of BP monitoring extremely important.

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