2.
Introduction
A rare but serious
blood condition that
occurs when your
bone marrow
cannot make
enough new blood
cells for your body
to work normally
3.
Autoimmune disorders+Idiopathic}
Inherited gene changes (falconi anemia)
Chemical Toxic substances(pesticides, arsenic and
benzene)
Radiation and chemotherapy for cancer
Viral infections such as(epstein-bar virus,hepatitis)
pregnancy
Causes
4.
No age prediction
Ne gender prediction
Initial symptoms depend upon which blood line
decreases initially which will eventually lead to
pancytopenia.
Fatigue
fever
Weakness
Shortness of breath
Easy bruising or bleeding
Clinical features
6.
Stem cell may be altered by any etiological
agent. This provokes an immune response
which activate t-cells to produce cytokines
such as interforen-ꙋ (INF-ꙋ) and TNF that
suppress and kill hematopoietic progenitors
reduced proliferative and differentiative
capacity
Pathogenisis
8.
Treatment will be based on how severe the
anemia is and what is causing it
Medicines to reduce your immune
response
Cyclosporine used to suppress T-cells
activity
Blood transfusion
Bone marrow stem cell transplant
treatment
9.
Aplastic anemia may be classified
according to blood cell counts into 3
subgroups:
Moderately severe aplastic anemia or
non severe AA (mSAA)
Severe aplastic anemia (SAA)
Very severe aplastic anemia(vSAA)
classification
10.
There are three possibilities on the basis
of which we classify aplastic anemia
Bone marrow cellularity<25%
Neutrophil count <500
Reticulocyte count <60,000
Platelets count <20,000
Neutrophil count<200
Marrow cellularity
