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(JAMA Network Open)
omega-3
(meta-analysis) (1)
omega-3
omega-3
omega-3
omega-3
(dopaminergic)
(glutamatergic)
(serotonergic)
(2, 3)
(citation) omega-3
omega-3
(poly-unsaturated fatty
acid, PUFA)
PUFA
(Post-traumatic stress disorder, PTSD) (4)
(anxiety disorder) (5)
omega-3
omega-3
omega-3
(6-8)
vs.
(placebo
effect)
JAMA Network Open
placebo
effect
19
omega-3
(
Alzheimer
)
19
omega-3
3
(placebo)
3
16
16
omega-3
omega-3
(
)
omega-3
19
(
)
(
)
(subgroup analysis)
omega-3
omega-3
omega-3
omega-3
omega-3
2000 (at least 2000 mg/
day)
omega-3
omega-3
(
PUFA )
( 5FU/
LV, oxaliplantin, irrinotecan )
( anti-VEGF monoclonal antibody,
anti-EGFR monoclonal antibody)
regorafenib
VEGFR-1,
-3 RAF BRAF
regorafenib
28 21
160mg
regorafenib
regorafenib FOLFIRI
73 100 4
(pT3N1M0)
FOLFOX
101 9
101 10 102 5
FOLFIRI
capecitabine 102 5 103
5 5
103 11
104 9 FOLFIRI
Bevacizumab 12
105 6 FOLFIRI
regorafenib
29 29
regorafenib
CORRECT CONCUR
regorafenib
(overall
survival) 23 45%
(progression free
survival) 51 69%
regorafenib (disease
control rate) 41 51.5%
Schmieder
regorafenib irinotecan
regorafenib
irinotecan
Schultheis
regorafenib FOLFIRI
regorafenib FOLFOX
regorafenib
FOLFIRI
UGT1A1 irinotecan
regorafenib
UGT1A1
TA6/TA6 TA6/TA7 irinotecan
180 mg/m2

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高雄醫師會誌102期-醫學專欄~曾秉濤-文獻導讀:以統合分析來探討omega-3對焦慮症狀的影響

  • 1. (JAMA Network Open) omega-3 (meta-analysis) (1) omega-3 omega-3 omega-3 omega-3 (dopaminergic) (glutamatergic) (serotonergic) (2, 3) (citation) omega-3 omega-3 (poly-unsaturated fatty acid, PUFA)
  • 2. PUFA (Post-traumatic stress disorder, PTSD) (4) (anxiety disorder) (5) omega-3 omega-3 omega-3 (6-8) vs. (placebo effect) JAMA Network Open placebo effect 19 omega-3 ( Alzheimer ) 19 omega-3 3 (placebo) 3 16 16 omega-3
  • 4.
  • 5. ( 5FU/ LV, oxaliplantin, irrinotecan ) ( anti-VEGF monoclonal antibody, anti-EGFR monoclonal antibody) regorafenib VEGFR-1, -3 RAF BRAF regorafenib 28 21 160mg regorafenib regorafenib FOLFIRI 73 100 4 (pT3N1M0) FOLFOX 101 9 101 10 102 5 FOLFIRI capecitabine 102 5 103 5 5
  • 6. 103 11 104 9 FOLFIRI Bevacizumab 12 105 6 FOLFIRI regorafenib 29 29 regorafenib CORRECT CONCUR regorafenib (overall survival) 23 45% (progression free survival) 51 69% regorafenib (disease control rate) 41 51.5% Schmieder regorafenib irinotecan regorafenib irinotecan Schultheis regorafenib FOLFIRI regorafenib FOLFOX regorafenib FOLFIRI UGT1A1 irinotecan regorafenib UGT1A1 TA6/TA6 TA6/TA7 irinotecan 180 mg/m2