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IMMUNOLOGY
CLASS 1 – BASIC CONCEPTS
CELLULAR IMMUNITY
TERMS USED IN IMMUNOLOGY
• CD: cluster of differentiation (CD1, CD2, CD3…)
• CYTOKINE: substances, such as interferon,
interleukin, and growth factors, that are secreted
by certain cells of the immune system and have an
effect on other cells.
• CHEMOKINE: a class of cytokines with functions that
include attracting white blood cells to sites of infection.
• INTERLEUKIN: are a group of cytokines that were first
seen to be expressed by white blood cells (leukocytes).
CHEMOKINE 2 adjacent cysteine residues
AA
CELLULAR VS. HUMORAL
IMMUNITY
• INNATE IMMUNE SYSTEM
• ADAPTIVE IMMUNE SYSTEM
• CELL-MEDIATED IMMUNITY
• HUMORAL (ANTIBODY)-MEDIATED IMMUNITY
IMMUNE CELLS
• MONOCYTES/MACROPHAGES
• GRANULOCYTES
• NEUTROPHILS
• EOSINOPHILS
• BASOPHILS
• MAST CELLS
• DENDRITIC CELLS
• NK CELLS
• T CELLS
• B CELLS
• PLASMA CELLS
MACROPHAGES
PHAGOCYTOSIS OPSONIZATION
NEUTROPHILS
PHAGOCYTOSIS OF
BACTERIA
EOSINOPHILS
FIGHT MULTICELLULAR PARASITES
INVOLVED IN ALLERGIC RESPONSES
•major basic protein (MBP)
•eosinophil cationic protein (ECP)
•eosinophil peroxidase (EPX)
•eosinophil-derived neurotoxin (EDN)
MAST CELLS
ROLE IN ALLERGY AND ANAPHYLAXIS
SECRETE HISTAMINE AND HEPARINE
DENDRITIC CELLS
ANTIGEN PRESENTATION TO INITIATE THE
ADAPTIVE IMMUNE RESPONSE
CONVENTIONAL DC
PLASMOCYTOID DC
NATURAL KILLER (NK) CELLS
ROLE IN KILLING CELLS INFECTED BY
VIRUS AND CANCER CELLS
T CELLS
• ADAPTIVE IMMUNITY – CELLULAR IMMUNITY
• T helper (Th) – express CD4 – Th1, Th2, Th3, Th9,
Th17, T regulatory (Treg), T follicular (Tfh) – MHC-II
restricted
• T cytotoxic (Tc) – express CD8 – MHC-I restricted
• NKT cells
• gd T cells
B CELLS
• ADAPTIVE IMMUNITY – HUMORAL IMMUNITY
• DIFFRENTIATE INTO PLASMA CELLS TO SECRETE
ANTIBODIES
Gustavo Batista de Menezes
Cirurgião-Dentista
Mestre em Farmacologia - UFMG
Doutoramento em Ciências - UFMG
Sydney - Austrália
THE
INFLAMMATORY
PROCESS
Inflammation
 A localized physical condition in which part of the
body becomes reddened, swollen, hot, and often
painful, especially as a reaction to injury or infection.
The ability of vascularized tissues to organize an
inflammatory response to lesions was an important
evolutionary acquisition, since the inflammatory
process aims to reestablish the homeostasis.
“Rubor cum calore, tumore et dolore” (Celsus, I d.C)
The Innate Immune System
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
Mast cell
degranulation–
Histamine
SKIN
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
Macrophage
C3b
The Complement System
Membrane Attack
Complex
1 IgM or 6 IgGs
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
Opsonization
C3b
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
, PGs, LTB4
C3b
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
C3b
Edema
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
Neuropeptides
(SP, CGRP)
Inflammatory Mediators
(PGs, Bk, 5-HT, LTB4)
C3b
Pain
Nociceptor
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
Almost the entire middle lobe of this right lung is involved by a chronic
abscess as seen here on section. The area of abscess is yellow tan, and it
was very firm.The infectious agent responsible here was Nocardia,
which is known to produce chronic abscessing inflammation.
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm
www.rx.uga.edu/main/home/cas/inflammation/inflammation.htm

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class_1.pptx