Background- Many diseases have been correlated with mitochondrial decl.docx

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Background: Many diseases have been correlated with mitochondrial decline (inability to work) including Alzheimer's, heart disease, and Parkinson's. Many of these diseases can be attributed lack of hydrogen chemical gradients in the electron transport chain. Question: Using your knowledge of cellular respiration, come up with a way of increasing the number of hydrogens and electrons in the electron transport chain. (focus on where these hydrogens/electrons are produced/stored and think of ways of increasing those molecules. Injecting hydrogens or electrons is dangerous and will lead to instant death.) .

Background: Many diseases have been correlated with mitochondrial decline (inability to work)
including Alzheimer's, heart disease, and Parkinson's. Many of these diseases can be attributed
lack of hydrogen chemical gradients in the electron transport chain. Question: Using your
knowledge of cellular respiration, come up with a way of increasing the number of hydrogens
and electrons in the electron transport chain. (focus on where these hydrogens/electrons are
produced/stored and think of ways of increasing those molecules. Injecting hydrogens or
electrons is dangerous and will lead to instant death.)

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Based on this information, and the binding kinetics illustrated in this chart , would the use of HbF as a potential therapy in this patient be successful? Case 3: A 15-year old girl with cystic fibrosis is rushed to the hospital for an acute respiratory infection and suspected pneumonia. The admission chest x -ray showed extensive bronchiectasis and persistent complete atelectasis in the lower left lobe. Despite aggressive therapy including IV antibiotics, the patient's pulmonary function remained poor and level of consciousness was diminished with no verbal responses but eyes open to voice. Sputum samples were collected via airway suctioning, arterial blood gasses were draw and pH was determined to be 7.32 (normal pH: 7.4 ). As a radical therapy for this patient an infusion of fetal hemoglobin is suggested to potentially increase oxygen perfusion. Fetal hemoglobin (HbF) has different oxygen binding kinetics when compared to the oxygen binding displayed by adult hemoglobin (illustrated below). This difference is in part due to the inability of HbF to interact with 2,3 bisphosphoglycerate ( 2 , 3 BPG ) . Based on this information would the use of HbF as a potential therapy in this patient be successful? .

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Based on the information presented in lecture and your text, in which eon and era of earth's history would the following have first appeared? shark lizard mammal Animals are multicelluar eukaryotes. Al eukaryotes posses mitochondria which they use for aerobic respiration but animals are further distinguished as having some form of internal digestive cavity as well as embryos. Cnidarians, which include such organisms as medusas and anemones, represent some of the most ancient. animals. The have simple body plans characterized by radial symmetry and only two distinct types of tissue ectoderm and endoderm (- diploblastic body plan). More complex animals demonstrate bilateral symmetry and three distinct types of tissues - eco, endo, and mesoderm (= triploblastic body plan). Flatworms such as the planarian Dugesia represent some of the simplest of these triploblastic bilaterally symmetrical'organisms. More complex bilaterally symmetrical triploblastic organisms, such as squid. have internal fluid filled cavities lined with mesoderm ( c coloems) which are lacking in flatworms. Vertebrates are bilaterally symmetrical, triploblastic and coclomate animals which have a backbone. The simplest examples of vertebrates are fish such as the great white shark. Amphibians (such as salamanders) are vertebrates that have walking legs (= tetrapod) and breath air with lungs. While they can live out of water, they must lay there eggs in water. More recent vertebrates such as reptiles and mammals, have an amniotic egg which has a fluid filled sac protected by a shell and this had freed them of the need to lay their eggs in water. Reptiles (which include both lizards and birds) possess keratinous scales and birds in addition have feathers which they use for both insulation and flight. Mammals such as the shrew, have fur instead of keratinous scales and in addition they have mammary glands which they use to nurse their young after birth. The figures below summarize these characteristics that are found in examples of all these group5. .

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