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Infective
Endocarditis
Chapter 37
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Infective Endocarditis (IE)
 Infection of the inner layer of heart,
including the cardiac valves
 Improved prognosis with antibiotic
therapy
 10,000–15,000 new cases
diagnosed in the U.S. each year
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Layers of the Heart
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Classification
 Subacute form
 Preexisting valve disease
 Longer clinical course
 Acute form
 Healthy valves
 Rapidly progressive
 Also classified by cause or site of
involvement
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Causative Organisms
 Bacterial most common
 Streptococcus viridans
 Staphylococcus aureus
 Viruses
 Fungi
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Etiology and Pathophysiology
 Occurs when blood turbulence
within heart allows causative
organism to infect previously
damaged valves or other
endothelial surfaces
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Case Study
 E.F. is a 72-year-old man who
comes to the clinic with “flulike”
symptoms.
 He has a history of hypertension,
past MRSA infection, and a recently
implanted pacemaker.
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
iStockphoto/Thinkstock
Case Study
 What risk factors for IE does E.F.
have?
 What other risk factors would you
assess E.F. for?
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
iStockphoto/Thinkstock
Risk Factors
 Cardiac, noncardiac, procedural
 Principal risk factors
 Age
 IV drug abuse (IVDA)
 Prosthetic valves
 Use of intravascular devices
 Renal dialysis
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Etiology and Pathophysiology
 Vegetation
 Fibrin, leukocytes, platelets, and
microbes
 Adhere to the valve or endocardium
 Parts break off and enter circulation
(embolization)
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Bacterial Endocarditis of
MitralValue
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Pathogenesis of IE
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Case Study
 What clinical manifestations of IE
does E.F. present with?
 What other clinical manifestations
of IE would you assess him for?
iStockphoto/Thinkstock
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Clinical Manifestations
 Nonspecific
 Low-grade fever occurs in 90% of
patients
 Chills
 Weakness
 Malaise
 Fatigue
 Anorexia
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Clinical Manifestations
 Subacute form
 Arthralgias
 Myalgias
 Back pain
 Abdominal discomfort
 Weight loss
 Headache
 Clubbing of fingers
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Clinical Manifestations
 Vascular manifestations
 Splinter hemorrhages in nail beds
 Petechiae
 Osler’s nodes on fingers or toes
 Janeway’s lesions on palms or soles
 Roth’s spots
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Osler’s Nodes
From: Marrie, T. J., (2008). Osler’s Nodes and Janeway Lesions . American
Journal of Medicine, 121(2), 105-106.
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Janeway Lesion
From: Zitelli, Basil, et al. (2007).
Zitelli and Davis' Atlas of Pediatric Physical
Diagnosis. Mosby.
From: Marrie, T. J., (2008). Osler’s Nodes and
Janeway Lesions . American Journal
of Medicine, 121(2), 105-106.
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Roth Spots
From: Swartz, M. H..
Textbook of Physical
Diagnosis: History and
Examination, 6th Edition.
W.B. Saunders Company
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Clinical Manifestations
 Murmur in most patients
 Heart failure
 Manifestations secondary to embolism
 Spleen
 Kidneys
 Limbs
 Brain
 Lungs
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Case Study
 E.F. has petechiae in the conjunctivae
and splinter hemorrhages in his nail beds.
 His blood pressure is 138/64, heart rate
80, respiratory rate 18, and temperature
99.5° F (37.5° C).
 A heart murmur is noted.
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
iStockphoto/Thinkstock
Case Study
The health care provider suspects
infective endocarditis.
E.F. is sent to the hospital for further
workup and treatment.
What diagnostic studies would you
expect the admitting health care provider
to order for E.F.?
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
iStockphoto/Thinkstock
Diagnostic Studies
 History
 Laboratory tests
 Blood cultures
 CBC with differential
 ESR, C-reactive protein (CRP)
 Echocardiography
 Chest x-ray
 ECG
 Cardiac catheterization
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Collaborative Care
 Prophylactic antibiotic treatment
for select patients having
 Certain dental procedures
 Respiratory tract incisions
 Tonsillectomy and adenoidectomy
 GI wound infection
 Urinary tract infection
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Case Study
 E.F.’s blood culture results are
positive for Staphylococcus aureus
 Echocardiogram demonstrates
vegetations on his mitral valve.
 What treatment would you expect
the health care provider to order
for E.F.?
iStockphoto/Thinkstock
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Collaborative Care
 Accurate identification of organism
 IV antibiotics (long-term)
 Repeat blood cultures
 Valve replacement if needed
 Antipyretics
 Fluids
 Rest
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Nursing Assessment
 Subjective data
 Health history
 Valvular, congenital, or syphilitic cardiac
disease
 Previous endocarditis
 Staph or strep infection
 Drugs
 Recent surgeries and procedures
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Nursing Assessment
 Subjective data: functional health patterns
 IVDA
 Alcohol abuse
 Weight changes
 Chills
 Hematuria
 Exercise intolerance, weakness, fatigue
 Cough, DOE, orthopnea, palpitations
 Night sweats
 Pain, headache, joint or muscle tenderness
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Nursing Assessment
 Objective data
 Fever
 Osler’s nodes
 Splinter hemorrhage
 Janeway’s lesions
 Petechiae, purpura
 Peripheral edema, clubbing
 Tachypnea, crackles
 Dysrhythmia, tachycardia, murmurs, S3, S4
 Retinal hemorrhages
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Case Study
E.F. is started on IV antibiotics and
seems to be resting comfortably.
He occasionally requests PRN drugs
for “achiness” and continues to
have a low-grade fever.
iStockphoto/Thinkstock
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Case Study
He is not demonstrating any
symptoms of heart failure at this
time.
Identify appropriate nursing
diagnoses and goals for E.F.
iStockphoto/Thinkstock
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Nursing Diagnoses
 Decreased cardiac output
 Hyperthermia
 Impaired comfort
 Activity intolerance
 Deficient knowledge
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Planning
 Patient will
 Have normal cardiac function
 Perform ADLs without fatigue
 Understand therapeutic regimen to
prevent recurrence
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Nursing Implementation
 Health promotion
 Identify those at risk
 Assess history and understanding of
disease process
 Teach importance of adherence to
treatment regimen
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Nursing Implementation
 Health promotion
 Patient teaching
 Stress need to avoid infectious people
 Avoidance of stress and fatigue
 Rest
 Hygiene
 Prophylactic antibiotics
 Drug rehabilitation
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Nursing Implementation
 Ambulatory and home care
 Antibiotic therapy for 4–6 weeks
 Assess home setting
 Monitor laboratory data, including
blood cultures
 Assess IV lines
 Coping strategies
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Nursing Implementation
 Ambulatory and home care
 Adequate rest
 Moderate activity
 Compression stockings
 ROM exercises
 Deep breath and cough every 2 hours
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Case Study
 E.F. has completed a week of IV
antibiotic therapy in the hospital
setting.
 He is afebrile and feeling better.
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
iStockphoto/Thinkstock
Case Study
 Social service has arranged home
IV antibiotic therapy in anticipation
of discharge to home.
 What important patient and
caregiver teaching should you
provide E.F. and his family?
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
iStockphoto/Thinkstock
Nursing Implementation
 Patient teaching
 Monitor body temperature
 Signs and symptoms of complications
 Nature of disease and reducing risk of
reinfection
 Stress follow-up care, good nutrition,
early treatment of common infections
 Signs and symptoms of infection
 Need for prophylactic antibiotic therapy
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
Evaluation
 Adequate tissue and organ
perfusion
 Normal body temperature
 Activity tolerance
 Comfort
 Verbalizes understanding
Copyright © 2014 by Mosby, an imprint of Elsevier Inc.

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THE ROLE OF PHARMACOGNOSY IN TRADITIONAL AND MODERN SYSTEM OF MEDICINE.pptx
 

IE_Grp 4.pptx

  • 1. Infective Endocarditis Chapter 37 Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 2. Infective Endocarditis (IE)  Infection of the inner layer of heart, including the cardiac valves  Improved prognosis with antibiotic therapy  10,000–15,000 new cases diagnosed in the U.S. each year Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 3. Layers of the Heart Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 4. Classification  Subacute form  Preexisting valve disease  Longer clinical course  Acute form  Healthy valves  Rapidly progressive  Also classified by cause or site of involvement Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 5. Causative Organisms  Bacterial most common  Streptococcus viridans  Staphylococcus aureus  Viruses  Fungi Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 6. Etiology and Pathophysiology  Occurs when blood turbulence within heart allows causative organism to infect previously damaged valves or other endothelial surfaces Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 7. Case Study  E.F. is a 72-year-old man who comes to the clinic with “flulike” symptoms.  He has a history of hypertension, past MRSA infection, and a recently implanted pacemaker. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. iStockphoto/Thinkstock
  • 8. Case Study  What risk factors for IE does E.F. have?  What other risk factors would you assess E.F. for? Copyright © 2014 by Mosby, an imprint of Elsevier Inc. iStockphoto/Thinkstock
  • 9. Risk Factors  Cardiac, noncardiac, procedural  Principal risk factors  Age  IV drug abuse (IVDA)  Prosthetic valves  Use of intravascular devices  Renal dialysis Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 10. Etiology and Pathophysiology  Vegetation  Fibrin, leukocytes, platelets, and microbes  Adhere to the valve or endocardium  Parts break off and enter circulation (embolization) Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 11. Bacterial Endocarditis of MitralValue Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 12. Pathogenesis of IE Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 13. Case Study  What clinical manifestations of IE does E.F. present with?  What other clinical manifestations of IE would you assess him for? iStockphoto/Thinkstock Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 14. Clinical Manifestations  Nonspecific  Low-grade fever occurs in 90% of patients  Chills  Weakness  Malaise  Fatigue  Anorexia Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 15. Clinical Manifestations  Subacute form  Arthralgias  Myalgias  Back pain  Abdominal discomfort  Weight loss  Headache  Clubbing of fingers Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 16. Clinical Manifestations  Vascular manifestations  Splinter hemorrhages in nail beds  Petechiae  Osler’s nodes on fingers or toes  Janeway’s lesions on palms or soles  Roth’s spots Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 17. Osler’s Nodes From: Marrie, T. J., (2008). Osler’s Nodes and Janeway Lesions . American Journal of Medicine, 121(2), 105-106. Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 18. Janeway Lesion From: Zitelli, Basil, et al. (2007). Zitelli and Davis' Atlas of Pediatric Physical Diagnosis. Mosby. From: Marrie, T. J., (2008). Osler’s Nodes and Janeway Lesions . American Journal of Medicine, 121(2), 105-106. Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 19. Roth Spots From: Swartz, M. H.. Textbook of Physical Diagnosis: History and Examination, 6th Edition. W.B. Saunders Company Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 20. Clinical Manifestations  Murmur in most patients  Heart failure  Manifestations secondary to embolism  Spleen  Kidneys  Limbs  Brain  Lungs Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 21. Case Study  E.F. has petechiae in the conjunctivae and splinter hemorrhages in his nail beds.  His blood pressure is 138/64, heart rate 80, respiratory rate 18, and temperature 99.5° F (37.5° C).  A heart murmur is noted. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. iStockphoto/Thinkstock
  • 22. Case Study The health care provider suspects infective endocarditis. E.F. is sent to the hospital for further workup and treatment. What diagnostic studies would you expect the admitting health care provider to order for E.F.? Copyright © 2014 by Mosby, an imprint of Elsevier Inc. iStockphoto/Thinkstock
  • 23. Diagnostic Studies  History  Laboratory tests  Blood cultures  CBC with differential  ESR, C-reactive protein (CRP)  Echocardiography  Chest x-ray  ECG  Cardiac catheterization Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 24. Collaborative Care  Prophylactic antibiotic treatment for select patients having  Certain dental procedures  Respiratory tract incisions  Tonsillectomy and adenoidectomy  GI wound infection  Urinary tract infection Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 25. Case Study  E.F.’s blood culture results are positive for Staphylococcus aureus  Echocardiogram demonstrates vegetations on his mitral valve.  What treatment would you expect the health care provider to order for E.F.? iStockphoto/Thinkstock Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 26. Collaborative Care  Accurate identification of organism  IV antibiotics (long-term)  Repeat blood cultures  Valve replacement if needed  Antipyretics  Fluids  Rest Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 27. Nursing Assessment  Subjective data  Health history  Valvular, congenital, or syphilitic cardiac disease  Previous endocarditis  Staph or strep infection  Drugs  Recent surgeries and procedures Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 28. Nursing Assessment  Subjective data: functional health patterns  IVDA  Alcohol abuse  Weight changes  Chills  Hematuria  Exercise intolerance, weakness, fatigue  Cough, DOE, orthopnea, palpitations  Night sweats  Pain, headache, joint or muscle tenderness Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 29. Nursing Assessment  Objective data  Fever  Osler’s nodes  Splinter hemorrhage  Janeway’s lesions  Petechiae, purpura  Peripheral edema, clubbing  Tachypnea, crackles  Dysrhythmia, tachycardia, murmurs, S3, S4  Retinal hemorrhages Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 30. Case Study E.F. is started on IV antibiotics and seems to be resting comfortably. He occasionally requests PRN drugs for “achiness” and continues to have a low-grade fever. iStockphoto/Thinkstock Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 31. Case Study He is not demonstrating any symptoms of heart failure at this time. Identify appropriate nursing diagnoses and goals for E.F. iStockphoto/Thinkstock Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 32. Nursing Diagnoses  Decreased cardiac output  Hyperthermia  Impaired comfort  Activity intolerance  Deficient knowledge Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 33. Planning  Patient will  Have normal cardiac function  Perform ADLs without fatigue  Understand therapeutic regimen to prevent recurrence Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 34. Nursing Implementation  Health promotion  Identify those at risk  Assess history and understanding of disease process  Teach importance of adherence to treatment regimen Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 35. Nursing Implementation  Health promotion  Patient teaching  Stress need to avoid infectious people  Avoidance of stress and fatigue  Rest  Hygiene  Prophylactic antibiotics  Drug rehabilitation Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 36. Nursing Implementation  Ambulatory and home care  Antibiotic therapy for 4–6 weeks  Assess home setting  Monitor laboratory data, including blood cultures  Assess IV lines  Coping strategies Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 37. Nursing Implementation  Ambulatory and home care  Adequate rest  Moderate activity  Compression stockings  ROM exercises  Deep breath and cough every 2 hours Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 38. Case Study  E.F. has completed a week of IV antibiotic therapy in the hospital setting.  He is afebrile and feeling better. Copyright © 2014 by Mosby, an imprint of Elsevier Inc. iStockphoto/Thinkstock
  • 39. Case Study  Social service has arranged home IV antibiotic therapy in anticipation of discharge to home.  What important patient and caregiver teaching should you provide E.F. and his family? Copyright © 2014 by Mosby, an imprint of Elsevier Inc. iStockphoto/Thinkstock
  • 40. Nursing Implementation  Patient teaching  Monitor body temperature  Signs and symptoms of complications  Nature of disease and reducing risk of reinfection  Stress follow-up care, good nutrition, early treatment of common infections  Signs and symptoms of infection  Need for prophylactic antibiotic therapy Copyright © 2014 by Mosby, an imprint of Elsevier Inc.
  • 41. Evaluation  Adequate tissue and organ perfusion  Normal body temperature  Activity tolerance  Comfort  Verbalizes understanding Copyright © 2014 by Mosby, an imprint of Elsevier Inc.

Editor's Notes

  1. Infective endocarditis (IE) is an infection of the endocardial layer of the heart. It also affects the cardiac valves. Treatment of IE with antibiotic therapy has improved the prognosis of this disease. Though relatively uncommon, an estimated 10,000 to 15,000 new cases of IE are diagnosed in the United States each year.
  2. The endocardium is the innermost layer of the heart and heart valves. Therefore, IE affects the valves.
  3. IE can be classified as subacute or acute. The subacute form typically affects those with preexisting valve disease and has a clinical course that may extend over months. In contrast, the acute form typically affects those with healthy valves and manifests as a rapidly progressive illness. IE can also be classified based on the cause (e.g., intravenous drug abuse IE [IVDA IE], fungal endocarditis) or site of involvement (e.g., prosthetic valve endocarditis [PVE]).
  4. The most common causative organisms of IE, Staphylococcus aureus and Streptococcus viridans, are bacterial. Other possible pathogens include fungi and viruses.
  5. IE occurs when blood turbulence within the heart allows the causative organism to infect previously damaged valves or other endothelial surfaces.
  6. Pacemaker, history of MRSA Have students brainstorm and then discuss with next slide.
  7. IE can occur in individuals with a variety of underlying cardiac and noncardiac conditions, as well as those undergoing invasive procedures (have students look at Table 37-1 in textbook). At one time, rheumatic heart disease was the most common cause of IE. However, now it accounts for less than 20% of cases. The main contributing factors to IE include (1) aging (more than 50% of older people have aortic stenosis), (2) IVDA, (3) use of prosthetic valves, (4) use of intravascular devices resulting in health care-associated infections (e.g., methicillin-resistant Staphylococcus aureus [MRSA]), and (5) renal dialysis.
  8. Vegetations, the primary lesions of IE, consist of fibrin, leukocytes, platelets, and microbes that adhere to the valve surface or endocardium. The loss of parts of these fragile vegetations into the circulation results in embolization.
  9. This is a picture of vegetations growing on the mitral valve.
  10. This diagram depicts the pathogenesis of IE. Once vegetations occur, they can break off, causing embolization (as discussed on previous slide). As many as 50% of patients with IE will experience systemic embolization. This occurs from left-sided heart vegetation, progressing to various organs (e.g., brain, kidneys, spleen) and to the extremities, causing limb infarction. Right-sided heart lesions embolize to the lungs, resulting in pulmonary emboli. The infection may spread locally and damage the valves or their supporting structures. This causes dysrhythmias, valve dysfunction, and eventual invasion of the myocardium, leading to heart failure (HF), sepsis, and heart block.
  11. Flu-like symptoms Have students brainstorm and then discuss with next four slides.
  12. The clinical manifestations of IE are nonspecific and can involve multiple organ systems. Low-grade fever occurs in more than 90% of patients. Other nonspecific manifestations include chills, weakness, malaise, fatigue, and anorexia.
  13. Arthralgias, myalgias, back pain, abdominal discomfort, weight loss, headache, and clubbing of fingers may occur in subacute forms of endocarditis.
  14. Vascular manifestations of IE include splinter hemorrhages (black longitudinal streaks) that may occur in the nail beds. Petechiae may occur as a result of fragmentation and microembolization of vegetative lesions. They can occur in the conjunctivae, lips, buccal mucosa and palate, and over the ankles, feet, and antecubital and popliteal areas. Osler’s nodes (painful, tender, red or purple, pea-size lesions) may be found on the fingertips or toes. Janeway’s lesions (flat, painless, small, red spots) may be seen on the palms and soles. Funduscopic examination may reveal hemorrhagic retinal lesions called Roth’s spots.
  15. Left: Osler’s node on the toe pad of the fourth toe. Note the multiple petechiae on the foot. Right: Osler’s node on the anterior surface of the distal phalange of the long finger. The purplish area was tender to palpation.
  16. Left: Janeway lesion on hypothenar eminence. Also note a smaller Janeway lesion at the base of the long finger. Right: Note the small (painless) nodules on the sole of a patient with bacterial endocarditis.
  17. Hemorrhagic retinal lesions called Roth’s spots.
  18. The onset of a new or changing murmur is noted in most patients with IE. The aortic and mitral valves are most often affected. HF occurs in up to 80% of patients with aortic valve endocarditis and in approximately 50% of patients with mitral valve endocarditis. Clinical manifestations secondary to embolization may be present in various body organs. Embolization to the spleen may cause sharp, left upper quadrant pain and splenomegaly, local tenderness, and abdominal rigidity. Embolization to the kidneys may cause flank pain, hematuria, and renal failure. Emboli may lodge in small peripheral blood vessels of the arms and legs, and may cause ischemia and gangrene. Embolization to the brain may cause neurologic damage resulting in hemiplegia, ataxia, aphasia, visual changes, and change in the level of consciousness. Pulmonary emboli may occur in right-sided endocarditis and cause dyspnea, chest pain, hemoptysis, and respiratory arrest.
  19. Have students brainstorm and then discuss the next slide.
  20. Have students brainstorm and then discuss the next slide.
  21. The patient’s recent health history is important in assessing IE. Ask patients if they have had any recent (within the past 3 to 6 months) dental, urologic, surgical, or gynecologic procedures, including normal or abnormal obstetric delivery. Document any previous history of IVDA, heart disease, recent cardiac catheterization, cardiac surgery, intravascular device placement, renal dialysis, or infections (e.g., skin, respiratory, urinary tract)—risk factors already discussed. Two blood cultures drawn 30 minutes apart from two different sites will be positive in more than 90% of patients. Culture-negative endocarditis is often associated with antibiotic usage within the previous 2 weeks, or due to a pathogen not easily detected by standard culture procedures. Negative cultures should be kept for 3 weeks if the clinical diagnosis remains endocarditis because of the possibility of slow-growing organisms. A mild leukocytosis occurs in acute IE (uncommon in subacute). The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels may also be elevated. Echocardiography is valuable in the diagnostic workup for a patient with IE when the blood cultures are negative, or for the patient who is a surgical candidate and has an active infection. Transesophageal echocardiogram and two- or three-dimensional (3-D) transthoracic echocardiograms can detect vegetations on the heart valves. A chest x-ray is done to detect cardiomegaly (an enlarged heart). An electrocardiogram (ECG) may show first- or second-degree atrioventricular (AV) block. Heart block occurs because the cardiac valves lie close to conductive tissue, especially the AV node. Cardiac catheterization may be used to evaluate valve functioning and to assess the coronary arteries when surgical intervention is being considered. Major criteria to diagnose IE include at least two of the following: positive blood cultures, new or changed heart murmur, or intracardiac mass or vegetation noted on echocardiography.
  22. Refer students to Table 37-2 in textbook or discuss below: Target Groups for Prophylactic Antibiotics People with the following heart conditions should have prophylactic antibiotics when they have the conditions or procedures listed below. Prosthetic heart valve or prosthetic material used to repair heart valve Previous history of infectious endocarditis Congenital heart disease (CHD)* Unrepaired cyanotic CHD (including palliative shunts and conduits) Repaired congenital heart defect with prosthetic material or device for 6 months after the procedure Repaired CHD with residual defects at the site or adjacent to the site of prosthetic patch or prosthetic device Cardiac transplantation recipients who develop heart valve disease   Conditions or Procedures Needing Antibiotic Prophylaxis When the above risk groups have the following conditions or procedures, they need prophylactic antibiotics. Oral Dental manipulation involving the gums or roots of the teeth Dental manipulation involving puncture of the oral mucosa Dental extractions/dental implants Prophylactic teeth cleaning with expected bleeding   Respiratory Respiratory tract incisions (e.g., biopsy) Tonsillectomy and adenoidectomy   Gastrointestinal/Genitourinary Presence of wound infection Presence of urinary tract infection * Except for the conditions listed above, prophylaxis is no longer recommended for any form of CHD.
  23. Have students brainstorm and then discuss with the next slide.
  24. Accurate identification of the infecting organism is the key to successful treatment of IE. Long-term treatment is necessary to kill dormant bacteria within the valvular vegetations. Complete elimination of the organism generally takes weeks to achieve, and relapses are common. Initially, patients are hospitalized and IV antibiotic therapy, based on blood cultures, is started. The effectiveness of therapy is assessed with subsequent blood cultures. Cultures that remain positive indicate inadequate or inappropriate selection of antibiotic, aortic root or myocardial abscess, or the wrong diagnosis (e.g., an infection elsewhere). Fungal endocarditis and PVE respond poorly to antibiotic therapy alone. Early valve replacement followed by prolonged (≥6 weeks) antibiotics is recommended in these situations. Valve replacement (has become an important adjunct procedure in the management of IE. Fever may persist for several days after treatment has been started and can be treated with aspirin, acetaminophen (Tylenol), ibuprofen (Motrin), fluids, and rest. Complete bed rest is usually not indicated unless the temperature remains elevated or there are signs of HF.
  25. Obtain the following health information from the client: Past health history: Valvular, congenital, or syphilitic cardiac disease (including valve repair or replacement); previous endocarditis, childbirth, staphylococcal or streptococcal infections, hospital-acquired bacteremia Drugs: Immunosuppressive therapy Surgery or other treatments: Recent obstetric or gynecologic procedures; invasive techniques, including catheterization, cystoscopy, intravascular procedures; recent dental or surgical procedures, GI procedures (e.g., endoscopy)
  26. Also obtain the following important health information related to pertinent functional health patterns: Health perception–health management: IV drug abuse, alcohol abuse; malaise Nutritional-metabolic: Weight gain or loss; anorexia; chills, diaphoresis Elimination: Bloody urine Activity-exercise: Exercise intolerance, generalized weakness, fatigue; cough, dyspnea on exertion, orthopnea; palpitations Sleep-rest: Night sweats Cognitive-perceptual: Chest, back, or abdominal pain; headache; joint tenderness, muscle tenderness
  27. Perform a focused physical assessment for the following clinical manifestations: General Fever Integumentary Osler’s nodes on extremities; splinter hemorrhages under nail beds; Janeway’s lesions on palms and soles; petechiae of skin, mucous membranes, or conjunctivae; purpura; peripheral edema, finger clubbing Respiratory Tachypnea, crackles Cardiovascular Dysrhythmia, tachycardia, new murmurs, S3, S4; retinal hemorrhages
  28. Have students brainstorm and discuss with the next two slides.
  29. Nursing diagnoses for the patient with IE may include, but are not limited to, the following: Decreased cardiac output related to altered rhythm, valvular insufficiency, and fluid overload as evidenced by heart murmur, S3, tachycardia, diminished peripheral pulses, adventitious breath sounds, decreased urine output, unexplained weight gain and/or restlessness Hyperthermia related to infection of cardiac tissue as evidenced by temperature elevation, diaphoresis, chills, malaise, tachycardia, and tachypnea Impaired comfort related to illness symptoms including generalized weakness, arthralgia, anorexia, and/or expressed anxiety and frustration concerning prolonged intravenous antibiotic therapy as evidenced by fatigue, malaise, weakness, painful joints, dyspnea, dysrhythmias, cardiac murmurs and reports of anxiety, anger, and/or fear Activity intolerance related to generalized weakness, arthralgia, and alteration in O2 transport secondary to valvular dysfunction Deficient knowledge related to lack of experience and exposure to information about disease and treatment process as evidenced by verbalization of misconceptions about desired or prescribed health behaviors as well as requests for information
  30. The overall goals for the patient with IE include: Normal or baseline cardiac function Performance of activities of daily living (adls) without fatigue Knowledge of the therapeutic regimen to prevent recurrence of endocarditis
  31. The incidence of IE can be decreased by identifying individuals who are at risk for the development of IE. Assessment of the patient’s history and an understanding of the disease process are crucial for planning and implementing appropriate health promotion strategies. Teaching the patient at high risk for IE helps reduce the incidence and recurrence of the disease. Teaching is crucial for the patient’s understanding of and adherence to the planned treatment regimen.
  32. Tell the patient to avoid persons with infection, especially upper respiratory infection, and to report cold, flu, and cough symptoms. Stress the importance of avoiding excessive fatigue and the need to plan rest periods before and after activity. Good oral hygiene, including daily care and regular dental visits, is also important. Instruct the patient to inform health care providers performing certain invasive procedures of the history of IE. Be certain the patient understands the importance of prophylactic antibiotic therapy before certain invasive procedures. You should refer the patient with a history of IVDA for drug rehabilitation.
  33. IE generally requires treatment with antibiotics for 4 to 6 weeks. After initial treatment in the hospital, the patient may continue treatment at home if hemodynamically stable and compliant. Assess the home setting for adequate support. Patients who receive outpatient IV antibiotics will require vigilant home nursing care. Monitor laboratory data to determine the effectiveness of the antibiotic therapy. Ongoing monitoring of the patient’s blood cultures is necessary to ensure destruction of the infecting organism. Assess IV lines for patency and signs of complications (e.g., phlebitis). The patient may experience anxiety and fear associated with the illness. You must recognize this and implement strategies to help the patient cope with the illness. Administer antibiotics as scheduled and monitor the patient for any adverse drug reactions. .
  34. The patient with IE needs adequate periods of physical and emotional rest. Bed rest may be necessary when fever is present or when there are complications (e.g., heart damage). Otherwise the patient may ambulate and perform moderate activity. To prevent problems related to reduced mobility, tell the patient to wear elastic compression stockings, perform ROM exercises, and deep breathe and cough every 2 hours.
  35. (A) Normal or baseline cardiac function, (B) performance of activities of daily living (ADLs) without fatigue, and (C) knowledge of the therapeutic regimen to prevent recurrence of endocarditis Teach him what the treatment will involve and what he will need to do after treatment to prevent recurrence, such as prophylactic antibiotics, the need to avoid infectious people, avoidance of stress and fatigue, rest, and hygiene.
  36. Fever, chronic or intermittent, is a common early sign. Instruct the patient or caregiver about the importance of monitoring body temperature. Persistent temperature elevations may mean that the drug therapy is ineffective. Patients with IE are at risk for life-threatening complications, such as stroke, pulmonary edema, and HF. Teach patients and caregivers to recognize signs and symptoms of these complications (e.g., change in mental status, dyspnea, chest pain, unexplained weight gain). Management will also focus on teaching the patient and caregiver the nature of the disease and on reducing the risk of reinfection. Explain to the patient the relationship of follow-up care, good nutrition, and early treatment of common infections (e.g., colds) to maintain health. Instruct the patient about symptoms that may indicate recurrent infection (e.g., fever, fatigue, chills). Tell the patient to notify the health care provider if any of these symptoms occur. Finally, inform the patient about the need for and importance of prophylactic antibiotic therapy before certain invasive procedures.
  37. The overall expected outcomes for a patient with IE include: Maintains adequate tissue and organ perfusion Maintains normal body temperature Performs activities to minimize adverse changes in physical and emotional functioning Reports an increase in physical and emotional comfort Describes disease process, appropriate treatments, and measures to prevent recurrence of disease