Analytical Profile of Coleus Forskohlii | Forskolin .pdf
Itsuki Pitchdeck 2022
1. Itsuki in Japanese means timber tree. Timber trees are straight
and tall trees, symbol of safety, protection, aggregation and
energy
A tall tree which wants to offer comfort, and in general improve the
quality of life, through technology that increasingly surrounds us
We focus on your health and wellness, we want to sanitize and purify your
spaces, our products combine Japanese quality and Italian design
l i v e s m a r t e r
Tokyo, August 2022
2. TEAM
Stefano Valenzi
Researcher &
Cofounder
Stefano Valenzi
is a neuroscientist and
a technology-focused
innovator with 20
years of science and
R&D experience
Peter Jurica
Researcher &
Cofounder
Jurica Peter
is a research specialist
with more than 20
years of technical
consulting mostly in
professional research
settings
Our company is based in Tokyo
Kaito Miyahara
involved in launching a
variety of new
businesses, he is
specialized in finance
and investments. He
just left R-Startup
Studio where he was
working as a director
Kaito Miyahara
Finance &
Cofounder
3. PROBLEM
Bacteria, fungi and viruses are everywhere
and survive long time on surfaces or in droplets suspended in air (aerosol)
Germs are responsible for bad odors, molds,
and diseases like the seasonal flu
Before COVID-19 around 400,000 respiratory deaths per year were
associated with influenza globally*
*Paget, John, et al. "Global mortality associated with seasonal influenza epidemics: New burden estimates and predictors from the
GLaMOR Project." Journal of global health 9.2 (2019).
4. OUR SOLUTIONS
PurpleBlueTM
lighting technology
to sanitize and/or illuminate
Our LED lights offer a simple, effective and
non-intrusive countermeasure
against bacteria, viruses and other threats
JUST SANITIZATION
Images above show our LED strip
installed for a client in Tokyo who
wanted to just sanitize his offices
during night
5. MORE THAN LUXURY LIGHTING
high-end lighting (CRI* >95) with a remarkably
inexpensive sanitizing technology
PurpleBlueTM
sanitizes everywhere light can reach
PurpleBlueTM
sanitizes germs both on surfaces and in the air
*Color rendering index (CRI) quantitatively measures how much a light source is able to render
colors in a realistic, reliable way when it is compared to sunlight. Sunlight has a CRI equal to 100.
6. Two studies has been
conducted
by Virostatics, a CRO based in Italy, partner of the
NIH (National Institute of Health) and of many
other institutions, also attached to the University
of Sassari
concluding that
PurpleBlueTM
was effective
in inactivating SARS-CoV-2
See Appendix A for more information
VERIFIED TECHNOLOGY
Virostatics Laboratory
PurpleBlueTM
lights inside the Virostatics Laboratory
7. Eminent scientists that work in medical science have reviewed our scientific
evidence. Below their views on our technology:
“I think that this is an excellent idea to reduce viral titer. Viral titer is
linked to infections of SARS-CoV-2 as well as other viruses. The finding
that a source of light, which is not UV, is decreasing virus viability, is a
very welcome news to face the current and future pandemics.”
“The PurpleBlueTM
technology developed by Itsuki was tested with
SARS-CoV-2, the pathogenic virus of the new coronavirus infection that
has raged around the world. [..] Lights with this technology are extremely
simple and effective devices that can remove more than 99% of the virus.
Since it is safe to irradiate humans, it can be used comfortably to remove
viruses from fingers, the part of the body most likely to cause infections,
and excellent performance against infectious diseases can be expected.
It is a technology that can be seen as an aid to get out of this pandemic
that has completely changed the relationship between people, in
business, and in private life."
Prof. Hiroaki Nishikawa - Department of Medical Engineering. Kinki University. JAPAN
Piero Carninci PhD
Head of Genomics Research Center, Functional Genomics, Human Technopole. ITALY
Deputy Director of the Center for Integrative Medical Sciences, RIKEN., JAPAN
EXPERT OPINIONS
8. HOW IT WORKS
*Professor Toshikazu YOSHIKAWA and and Associate Professor Yuji NAITO, of the First Department of Medicine, at Kyoto Prefectural University of Medicine
PurpleBlueTM
technology deactivate harmful germs by oxidative stress,
“a state where oxidative forces exceed the antioxidant
systems due to loss of the balance between them”*
Ongoing oxidative stress brings virus inactivation
as aging brings vegetable to rot
Causing prolonged oxidative stress just to unwanted germs, our light
sanitization technology sanitizes surfaces and can also eliminate any
viruses floating in the air, so that it can decrease the spreading of:
SARS-CoV-2, seasonal flu, and future pandemics
9. 8 days in 30 seconds
A tangible germicidal evidence from a video made with images taken during a
short 8 days experiment. We exposed some blackberries to sunlight and to
AirTerasu (our sanitizing light). The berries for both conditions were placed
side by side, and they were left at room temperature.
https://youtu.be/hdWcxa43uS4
DAY 1
DAY 4
DAY 8
DAY 11
10. WHERE WE ARE AT
We have obtained golden samples of three LED strip
products and one LED tube product. Every product is
ready for mass production
product packaging
LED strip spool (5m)
LED strips installed inside
aluminum profiles, with a frosted
diffuser
B2C PRODUCT (AirTerasu)
A modern modular light aimed at 30-40y consumer that
provides a pleasant high-quality white light and
additional sanitizing function (using the LED
strips manufactured for B2B products) will be ready for
mass production in 3 months (images of the product
are available)
B2B PRODUCTS
MANUFACTURER
Our chinese manufacturer is able to provide
certifications for the largest market, and each product
will have 3 years warranty
See Appendix B for more information
11. We do not mention competitors that provide similar blue germicidal light bulbs with poor sanitizing performance. UVc competitors like Philips
have products that might deactivate viruses faster than blue light technologies, but are harmful for people or at least produce Ozone
Unique
tech
Virucidal
claims
Safe Ozone
Free
Luxury
lights
Eco
Energy
GERMICIDAL LIGHTS OVERVIEW
UVc
BLUE
LIGHTS
12. UNIQUE TECHNOLOGY
Improves the visible light sanitization technology:
● Unique combination of lights
● When combined with any white light increases its CRI
● It boosts plant growth
Money saved over the years exceed the product's retail
cost
High-end white light solutions offered by competitors
often exceed our retail prices
Several applications See Appendix C for more information
13. FEATURES AND BENEFITS
High Quality
White Light
>95% similar to
sunlight
Ideal for luxury
environment
helps to boost
positive feelings
No Blue
Hazard
No UV
No harmful
frequencies
Completely safe for
humans or
materials
Save Energy
see Appendix D
Highly efficient
LEDs make you
save 40%〜75%
users can decide
whether to just
sanitize or to
illuminate
Retrofit
Ideal for
retrofitting
existing lighting
systems
No chemicals
and disposable
Saves money and
time on daily
cleaning routines
and disposable
sanitizing
products
-40%
-75%
14. WHAT WE DO BETTER
THAN OUR COMPETITORS
Our products come with unique features:
Remote controls of our next B2C product can predict the time
needed to sanitize the location where they are placed
Unique combination of frequencies
Highest white light quality (CRI)
Sanitization 2X faster than e-commerce products
Tested on COVID-19 in droplets
High efficiency LED, low power consumption
15. INTELLECTUAL PROPERTY
PurpleBlueTM
technology is protected by the following patent
applications:
First application: Japanese Patent Application No. 2021-073994
International application number: PCT / JP2022 / 018832
Designated countries: All PCT designated countries
We are about to file two other patent applications protecting
further uses of PurpleBlueTM
technology
16. MARKET SIZE
Visible lights against COVID-19 are new. A few products
exist at the moment, but research reports and advertisements of the technology
are on the rise
The related UV sanitizing market was valued USD 4.8 billion
in 2021, at a CAGR of 14.0% from 2021 to 2026 (sold mostly in healthcare
settings)
We aim to expand our business to the high-end lighting market
(offering same quality + sanitization for a lower price), a market valued USD
18.1 billion in 2020, at a CAGR of 6.1% from 2017 to 2025 (the revenue
forecast in 2025 is USD 24.3 billion)
17. LED B2C: using sale channels and e-commerce [see Appendix B]
GO TO MARKET
LED B2B: distribution agreements in different countries
Others:
a. Technology licensing (utilized in different products)
b.Air quality monitor, air purifier and other product ideas
See Appendix C for more information
18. Aug
2022
Nov
2022
2023 2024-5
ROAD MAP
Consolidate
market in
strategic
countries
Possible
Funding
Round
AIRTERASU
lamp
Crowdfunding
Campaign
New
products
Global
Expansion
Start of
the funding
phase
Air monitor
Crowdfunding
Campaign
B2B
Export
New Patents
Sept
2022
B2B
National
Sale
Technology
Licensing
20. We need 150,000,000 JPY (about 1,000,000 USD)
to expand our team and increase the number of projects
(products and patents) over the next 18 months
[see next slide for a breakdown of the costs]
FUNDRAISING
21. INVESTMENT BREAKDOWN
18 months - Amounts expressed in 万円 (10,000 JPY)
Personnel
(money X people X months)
55×5×18=4,950
Laboratory rent & utilities
(money X months)
25×18=450
Patents
(National - JPO)
100×5=500
(International - PCT)
300×2=600
Research and Materials expenses
(money X months)
100×18=1,800
Miscellaneous expenses
(money X months)
10×18=180
Inventory (500 units per product)
1,000
Marketing & Sales Force
4,468
Warehouse
(contract money + rent X months)
48 + 8x18 = 192
Travel expenses
(money X months)
10×18=180
Legal and Tax support
(money X months)
10×18=180
Reserve Fund
500
Total = 15,000万円
(around 1,000,000 USD)
24. APPENDIX A:
Experiments Data and results (1/2)
The following table illustrates a summary of viral titers obtained after exposure of virus drops to PurpleBlueTM
lamp
turned ON (or OFF for the control samples).
Table Virus titers in virus drops exposed to PurpleBlueTM
light for 1 hour and control viral titers.
Sample Viral titer (TCID50/mL) % % reduction
Control - replicate #1 3.98E+05 -
PurpleBlueTM
lamp – replicate #1 3.98E+04 90
Control - replicate #2 1.75E+06 -
PurpleBlueTM
lamp - replicate #2 2.31E+05 86.8
Table SARS-CoV-2 titers in virus drops exposed to PurpleBlueTM
light for 1 hour and control viral titers. Mean of two
experiments.
Sample Viral titer (TCID50/mL) % St. dev. % reduction
Control 1.07E+06 9.56E+05 -
PurpleBlueTM
lamp 1.35E+05 1.35E+05 87.4
25. APPENDIX A:
Experiments Data and results (2/2)
Figure Virucidal effect of PurpleBlueTM
lamp on SARS-CoV-2. Mean and standard deviation of two independent
experiments.
PurpleBlueTM
lamp was effective in reducing SARS-CoV-2 viral titer in two independent experiments.
Virucidal effect of PurpleBlueTM
lamp
PurpleBlueTM
- ON
PurpleBlueTM
- OFF
10000000,00
1000000,00
100000,00
10000,00
1000,00
100,00
10,00
1,00
Virus
titer
(TCID
50
/mL)
I
I
26. LED strips (3 products):
● Single mode: sanitize
(product code L18)
● Single mode: illuminate
(product code L18+)
● Dual mode: sanitize
and/or illuminate
(product code L36)
Following products are ready for mass production
product packaging
LED strip spool (5m)
LED strips installed inside
aluminum profiles, with a frosted
diffuser
APPENDIX B:
MASS PRODUCTION (1/5)
B2B PRODUCTS
False ceiling application
27. Sanitizing
Illuminating &
Sanitizing (3000k)
T8 tube
Polycarbonate
ports and
aluminum profile
T8 LED tube (1 product):
Dual mode LED tube to sanitize
and/or illuminate
● Function: just sanitizing light
● Function: illuminating with
sanitizing light
● Dimension: 4ft/120cm T8
● Box: 1 tube each
APPENDIX B:
MASS PRODUCTION (2/5)
B2B PRODUCTS
Following products are ready for mass production
28. Product will be ready for mass production in 3 months
AirTerasu, a slim room light (1 product):
AirTerasu is the name chosen for the Japanese market.
The word "terasu" (照らす) is a japanese verb meaning "to
illuminate", but also "to irradiate".
AirTerasu is a modern modular light aimed at 30-40y
consumer that provides a pleasant high-quality white
light and additional sanitizing function (using the LED
strips manufactured for B2B products)
Light elements can be rotated and their junctions allow
users to shape the light elements
Two stands provide wall, ceiling and surface options
APPENDIX B:
MASS PRODUCTION (3/5)
B2C PRODUCTS
29. APPENDIX B:
MASS PRODUCTION (4/5)
LED PRODUCTS
3000K
SOFT WHITE
HOMES
HOTEL ROOMS
LOBBIES
RETAILS STORES
3500K
NEUTRAL
EXECUTIVE OFFICES
RECEPTION AREAS
SUPERMARKETS
4000K
DAYLIGHT
OFFICES
CLASSROOMS
MASS MERCHANDISERS
SHOWROOMS
Ideal solutions for lighting and retrofitting of existing systems, our 5
LED products are currently available in three temperature colors:
30. Over the last 2 years we have been evaluating
the product quality of multiple manufacturers
We decided to use the same Chinese
manufacturer for all our LED products (B2B and
B2C)
Manufacturer can produce 10,000 pieces of each
product without setting up a new production line
Products which provide illumination function are
available in 2 different color temperatures (3000K
and 3500K)
Manufacturer provides a 3 year warranty and
the following certifications:
1. PSE
2. UL
3. CE Rohs
APPENDIX B: MASS PRODUCTION (5/5)
MANUFACTURER
31. APPENDIX C:
Product ideas (1/3)
The first crowdfunding campaign will start in July with a modular light (images
below):
The second crowdfunding campaign will start in September
with a floor lamp that embodies an air purifier
(on the right 3 concept designs):
32. In order to increase possible uses of our lights, especially for the B2C market, we
intend to sell or bundle a device that notifies predicted sanitization levels in
locations where device is placed. In this way you can use our light also to sanitize
specific target. E.g.: sanitize your facial mask, mobile or the grocery bag on the
kitchen table.
Others:
We are developing a series of other products that employ our lighting
technology, and/or that are linked to the indoor air quality:
APPENDIX C:
Product ideas (2/3)
A: B: C:
a B2C (A) and a B2B(B) air purifier and a B2C(C) air monitoring device.
33. APPENDIX C:
Product ideas (3/3)
Developing and Licensing options
We have documented inventions and data collected from the
following applications:
● extended food preservation (solutions for refrigerated spaces)
● mold growth control
● air hygiene and quality control
● odor removal
● sanitizing components of other products (e.g.heating, ventilation and air
conditioning systems)
34. Costs of
1KWh
Total consumption 40,000h (KWh) Money saved*
L36(1m) 1 incandescent
bulb(150W)
1.5 fluorescent
tube (40W)
L36 over
incandescent
bulb
L36 over
fluorescent
tube
26.88¥
1440 6000 2400
120,149¥ 25,421¥
14.19c 647$ 136$
0,19248€ 877.71€ 184.78€
Money saved from the electrical bill are enough to cover the
cost of our products when retrofitting standard lighting
technologies
APPENDIX D:
Saving money (1/2)
35. We calculated the “Money saved” as the savings resulting by
the reduced energy consumption relative to incandescent
bulb and fluorescent tube. The money saved by not
repeating the purchase of alternative light solutions is not
considered in this table.
Lifespan of our products is 40,000h without any
performance decrease, while the lifespan of an
incandescent light bulb is on average 2000h, and a
fluorescent tube is on average 10,000h. This means you will
replace 20 light bulbs or 4 fluorescent tubes before a single
replacement of any of our LED products.
Price reference:
1: https://www.tepco.co.jp/ep/private/plan/old01.html
2: https://www.eia.gov/electricity/monthly/epm_table_grapher.php?t=epmt_5_6_a
3: https://www.facile.it/energia-luce-gas/tag/costo-kwh.html
APPENDIX D:
Saving money (2/2)