1. Rewarding properties of β-endorphin as measured by co nditioned place preference
M Amalric, EJ Cline, JL Martinez, FE Bloom, GF Koob - Psychopharmacology, 1987
Abstract The role of β-endorphin as a possible mediator in the reinforcing properties of
opiates was investigated using a conditioned place preference paradigm. Heroin, a
synthetic opiate known to have reinforcing properties, produced a strong preference for an
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[PDF] semanticscholar.org
Ketanserin pretreatment reverses alfentanil-induced muscle rigidity.
MB Weinger, EJ Cline, NT Smith, GF Koob - Anesthesiology, 1987
Abstract Systemic pretreatment with ketanserin, a relatively specific type-2 serotonin
receptor antagonist, significantly attenuated the muscle rigidity produced in rats by the
potent short-acting opiate agonist alfentanil. Following placement of subcutaneous
Cited by 15 Related articles All 4 versions Cite
Localization of brainstem sites which mediate alfentanil-induced muscle rigidity in the rat
MB Weinger, EJ Cline, NT Smith, TA Blasco, GF Koob - … Biochemistry and Behavior, 1988
Abstract Previous work has demonstrated that direct injections of methylnaloxonium (MN), a
relatively lipophobic quaternary opiate antagonist, in the area of the nucleus raphe pontis
(RPn) significantly attenuated alfentanil-induced rigidity. It was hypothesized that other
Cited by 18 Related articles All 5 versions Cite
A possible role for dopamine in the locomotor effects of nicotine My Citations
EJ Cline - 1988
A Possible Role for Dopamine in the Locomotor Effects of Nicotine. Elizabeth J Cline 1988.
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Behavioral effects of intracerebral administration of the nicotine analogue cytisine in rats My
Citations
EJ Cline - 1990
Drugs with high abuse potential are self-administered by rodents and humans. Many of
these drugs also produce locomotor activation upon systemic or central administration.
Several lines of evidence support a role for the mesolimbic dopamine system as a
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Behavioral effects of novel cocaine analogs: a comparison with in vivo receptor binding potency.
My Citations
EJ Cline, U Scheffel, JW Boja, FI Carroll, JL Katz… - Journal of Pharmacology …, 1992
Abstract Several novel cocaine analogs, previously shown to be very potent in in vitro
binding studies, have been examined for their stimulatory effects on locomotor activity and
for their ability to displace [3H] WIN 35,428 binding in vivo in mice. These compounds, like
Cited by 90 Related articles All 5 versions Cite
Stimulus generalization from cocaine to analogs with high in vitro affinity for dopamine uptake
sites. My Citations
EJ Cline, P Terry, FI Carroll, MJ Kuhar, JL Katz - Behavioural pharmacology, 1992

2. Abstract Previous research has shown that phenyltropane derivatives of cocaine are very
potent ligands for dopamine transporters in in vitro binding and uptake, and in in vivo
binding assays. In the present study, these analogs were tested for their ability to substitute
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In vivo binding of [125I] RTI‐ 55 to dopamine transporters: Pharmacology and regional
distribution with autoradiography My Citations
EJ Cline, U Scheffel, JW Boja, WM Mitchell, F Carroll… - Synapse, 1992
Abstract Previous studies have demonstrated that para-substituted WIN 35,065-2 analogs of
cocaine show high binding affinity for dopamine uptake sites both in vitro and in vivo, and
inhibit DA uptake in vitro. These analogs also produce potent cocaine-like behavioral effects
Cited by 72 Related articles All 4 versions Cite
DOPAMINE TRANSPORTER AS A COCAINE RECEPTOR: RECENT IMAGING AND
MOLECULAR STUDIES. My Citations
JW Boja, FI Carroll, D Wong, R Dannals, U Scheffel… - Behavioural Pharmacology, 1992
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Imaging neurotransmitter uptake sites in brain My Citations
MJ Kuhar, U Scheffel, J Boja, IF Carroll, E Shaya… - International Journal of …, 1992
Dopamine is an important neurotransmitter, and like other catecholamine neurotransmitters,
its action at the synapse is thought to be terminated by reuptake. The dopamine reuptake
carrier or transporter is a drug receptor for cocaine since the binding of cocaine to this
Cited by 2 Related articles All 3 versions Cite
[123/125I] RTI‐ 55, an in vivo label for the serotonin transporter My Citations
U Scheffel, RF Dannals, EJ Cline, GA Ricaurte… - Synapse, 1992
Abstract [123 I] RTI-55, an iodinated derivative of the cocaine analog 3β-phenyltropane-2β-
carboxylic acid methyl ester, was evaluated as an agent for in vivo labeling of the serotonin
transporter. Labeling of the precursor of RTI-55 with I-123 was efficient and yielded a high
Cited by 84 Related articles All 6 versions Cite
High potency cocaine analogs: neurochemical, imaging, and behavioral studies My Citations
JW Boja, EJ Cline, FI Carroll, AH Lewin, A Philip… - Annals of the New York …, 1992
Recent evidence suggests the behavioral properties of cocaine are related to its ability to
inhibit dopamine (DA) reuptake. 1.2 Specific binding sites tbr cocaine have been identified
with a host of Iqpnds, including [3H] cocaine. 3-5 However, the use of [3H] cocaine as a
Daily IV Cocaine Infusion Decreases In Vivo [^ 3H] WIN 35,428 Autoradiographic Binding in
Behaviorally Relevant Brain Areas Following Withdrawal My Citations
EJ Cline, NS Pilotte, U Scheffel, WM Mitchell… - NIDA RESEARCH …, 1994
Mesostriatal DA pathways are important for many of the behavioral and affective effects of
cocaine. In animals, daily iv cocaine treatment followed by withdrawal results in

3. neurochemical alterations in these areas consistent with decreased dopaminergic function.
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Substituted 3 -Phenyltropane Analogs of Cocaine: Effects on Behavior and on [^ 3H] WIN
35,428 Binding In Vivo My Citations
EJ Cline, P Terry, U Scheffel, JW Boja, FI Carroll… - NIDA RESEARCH …, 1994
It has been established that binding of cocaine to striatal dopamine transporters and the
resulting inhibition of dopamine uptake is related to potency of cocaine self-administration,
and to the psychomotor stimulant effects of this drug. As an extension of this relationship,
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Occupancy of the serotonin transporter by fluoxetine, paroxetine, and sertraline: In vivo studies
with [125i] rti‐ 55 My Citations
U Scheffel, S Kim, EJ Cline, MJ Kuhar - Synapse, 1994
Abstract [125 I] RTI-55 was used in tracer doses to label serotonin (5-HT) transporters in vivo
in the mouse brain. Fluoxetine, paroxetine, and sertraline, potent antidepressants and
selective inhibitors of serotonin transporter sites, were administered in various doses and at
Cited by 45 Related articles All 4 versions Cite
Repeated intravenous cocaine administration to rats produces behavioral sensitization without
changing brain cocaine levels My Citations
RA Orona, RD Mayfield, EJ Cline, NR Zahniser - Neuroscience letters, 1994
Abstract Repeated intraperitoneal (ip) administration of cocaine to rats results in behavioral
sensitization. However, augmented brain cocaine levels are also produced by this treatment.
In the present study, a 43% increase in cocaine levels was observed in striatum in response
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Medial dorsal striatum is more sensitive than lateral dorsal striatum to cocaine inhibition of
exogenous dopamine clearance: relation to [3 H] mazindol binding, but not … My Citations
EJ Cline, CE Adams, GA Larson, GA Gerhardt… - Experimental neurology, 1995
Previous studies have shown that acute systemic cocaine inhibits dopamine (DA) transport
and thereby produces dose-dependent changes in exogenous DA clearance in the brain.
This measure reflects the dynamic activity of the DA transporter. There are also differential
Cited by 27 Related articles All 5 versions Cite
Relationship Between Cocaine-Induced Changes in Dopamine Clearance and Striatal In Vivo
Electrochemical Electrode Localization My Citations
EJ Cline, CE Adams, GA Larson, GA Gerhardt… - NIDA RESEARCH …, 1995
Acute systemic cocaine injection inhibits dopamine (DA) transport and thereby produces
dose-dependent changes in DA clearance in the brain. This measure reflects the activity of
the DA transporter. Understanding the nature of this inhibition is important because it is
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Effects of ethanol and nomifensine on NE clearance in the cerebellum of young and aged
Fischer 344 rats My Citations

4. AMY Lin, PC Bickford, MR Palmer, EJ Cline… - Brain research, 1997
Rapid chronoamperometric recordings coupled with local application of drugs by pressure
ejection were used to investigate the effects of nomifensine and ethanol (EtOH) on
exogenous norepinephrine (NE) clearance in the cerebellum of young (5-month-old) and
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Caloric restriction enhances evoked DA overflow in striatum and nucleus accumbens of aged
Fischer 344 rats My Citations
LH Diao, PC Bickford, JO Stevens, EJ Cline… - Brain research, 1997
Previous studies have shown deficits in DA neuronal systems in senescence. Other studies
indicate that prolonged dietary restriction can attenuate many of the detrimental effects of
age. We have shown previously using in vivo electrochemistry that K+-evoked striatal DA
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Effects of ethanol on striatal dopamine overflow and clearance: an in vivo electrochemical study
My Citations
Y Wang, MR Palmer, EJ Cline, GA Gerhardt - Alcohol, 1997
Previous studies have shown that the neurotransmitter dopamine (DA) is implicated in the
reinforcing effects of ethanol and other abused drugs. Ethanol also alters DA overflow and
uptake in vivo. Further studies of the role of DA in the behavioral and neurochemical effects
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[PDF] researchgate.net
Effects of intra-striatal GDNF on motor coordination and striatal electrophysiology in aged F344
rats☆ My Citations
KE Bowenkamp, L Ujhelyi, EJ Cline, PC Bickford - Neurobiology of aging, 2000
The purpose of this study was to examine whether improvement in motor function could be
demonstrated in old rats, and to see if GDNF affected post-synaptic DA function. Aged (20
month old) versus young rats were tested following GDNF treatment for postural control by
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