the presentation is on a currently ongoing new system of drug delivary sytem, muca adhesive drug delivary system, for further details please do knock hasnat2484@gmail.com
4. Definition
interact with the mucus layer
covering the mucosal epithelial
surface, & mucin molecules
increase the residence time
of the dosage form
a part of controlled
delivery system
5. Types of MDDS
• Buccal delivery system
- Theophylline
• Vaginal delivery
system
- Metronidazole
• Sublingual delivery system
• Rectal delivery
System - Quinine
• Nasal delivery
System - Insulin
• Ocular delivery
System - Diclofenac
• Gastro intestinal delivery system
6. Advantage
• Excellent
accessibility
• Avoid of first
pass metabolism
• Painless
administration
• Targeted and
localized
• Improved patient
compliance
• Prolonged
residence time
7. Disadvantage
• Low permeability of the buccal
membrane
• Unpleasant feelings
• Continuous secretion of saliva
• Costly drug delivery system
8. Mucus layer
• Translucent and viscid secretion, forms a
thin continuous gel adherent to mucosal
epithelial surface
• Water 95%
• Glycoprotein and lipids 0.5-5%
• Free proteins 0.5-1%
• Mineral salt 1%
9.
10. Reason for formulating MDDS
• Prolonged
residence time
• Does not cause
irritation
• Improved
therapeutic performance
• High drug loading
capacity
• Controlled drug
release
• Avoidance of First
pass Metabolism
13. Mechanism Of Mucoadhesion
The mechanisms responsible in the formation of
mucoadhesive bonds are not fully known, however most
research has described mucoadhesive bond formation as a three
step process.
Step 1 : Wetting and swelling of polymer (the contact stage)
Step 2 : Interpenetration between the polymer chains and the
mucosa membrane
Step 3 : Formation of chemical bonds between the entangled
chains (both known as consolidation stage)
14. Step 1
•The wetting and swelling step occurs
• When the polymer spreads over the surface
•Develop an intimate contact with the
substrate.
15. Step 2
Mucoadhesive bond formation
• The mucoadhesive polymer chains and the mucosal
polymer chains intermingle
• Entangle to form
semipermeable adhesive bonds.
• The strength of these bonds
• depends on the degree of penetration between the two
polymer groups.
16. Step 3
• The formation of weak chemical bonds (between the
entangled polymer chains)
• Both primarily and secondary bonds are exploited
• Which forms strong adhesions between polymers
17. Five theories of Mucoadhesive Drug Delivery:
1. Electronic theory
2. Wetting theory
3. Adsorption theory
4. Diffusion theory
5. Fracture theory
Reference: http://www.scielo.br/scielo.php?pid=S1984-82502010000100002&script=sci_arttext
Theories of Mucoadhesive Drug Delivery
18. Step 3
• The formation of weak chemical bonds (between the
entangled polymer chains)
• Both primarily and secondary bonds are exploited
• Forms strong adhesions between polymers
25. Formulation Design
Mucoadhesive dosage forms need various functional agents-
Mucoadhesive agents-
1 2 2 2
Should be-
Non toxic, non absorbable, good wetting,
swelling, biodegradable, high mol.weight,
hydrophilicity, flexibility.
Ex- NaCMC, Sodium Alginate etc.
26. Formulation Design
Penetration enhancer-
1 2 2
Reduces viscosity of mucus
Acts on desmosomes
Alters partition co efficient
Example-Surfactants, Fatty acid and derivatives, Sulfoxide, Chelating agent etc.
27. Formulation Design
Enzyme inhibitors-
Drug + Enzyme Protein stabilization protein conformation
inhibitors
decrease enzymatic degradation change in enzyme activities
Example- Aprotinin, Bestatin, Puromycin, Bile salts .
29. Delivery System
Oral delivery system (GIT)-
Gels and Ointments-
Retention
Example-
Viscosity
Sustained and controlled release
Polymers –NaCMC , xanthan gum etc.
31. Factors Affecting MDDS
1. Molecular weight
2. Flexibility
3. Cross-linked density
increase the density of cross linkage insufficient of s
welling decrease rate of interpenetration between pol
ymer and mucin.
41. • vaccine formulations and delivery of small proteins/
peptides
• non-parenteral drug delivery systems for protein for
mulations,
• vaccines able to attach to mucous membranes to
stimulate local immunity.
42.
43.
44.
45. Intestinal Mucoadhesive Devices
For Oral Delivery Of Insulin
• a combination of intestinal devices and a permeation enha
ncer, dimethyl palmitoyl ammonio propanesulfonate
(PPS), for oral delivery of insulin.
• pH-responsive enteric coating
46. • The devices adhere to intestinal mucosa,
• release protein load unidirectionally
• prevent enzymatic degradation in the gut.
• Devices were found to completely release their drug l
oad within 3-4 hours and showed excellent strength of
mucoadhesion to porcine intestine.
47. Thank You
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