I'm sharing my presention & the topic is adhesive drug delivery systems.The formulation,approaches,technologies & systems for transporting a pharmaceuticals compound in the body

1. ADHESIVE DRUG DELIVERY
SYSTEM
PRESENTED BY:
G.DILIP KUMAR(117012101284)
M.EVANGELIN FLORA(117011101285)
S.GAYATHRI(117011101286)

2. SYNOPSIS
• DRUG DELIVERY SYSTEM
• TYPES
• CLASSIFICATION
• BIO/MUCOADHEDION
• IDEAL CHARACTERS
• THEORIES
• FACTORS AFFECTING
• COMPOSITIONS
• MECHANISMS

3. DRUG DELIVERY SYSTEM
• Method of administering pharmaceutical
compound to achieve a therapeutic effect in
humans or animals
• It refers to approaches , formulations,
technologies and systems for transporting a
pharmaceuticals compound in the body

4. TYPES OF DRUG DELIVERY SYSTEMS
• Oral drug delivery systems( Buccal and
Sublingual)
• Parental drug delivery systems
• Mucosal drug delivery systems
• Nasal drug delivery systems
• Pulmonary drug delivery systems
• Ocular drug delivery systems
• Transdermal drug delivery systems

5. • Vaginal & intrauterine drug delivery systems
• Rectal drug delivery systems
• Targeted drug delivery systems
• Gastro intestinal delivery systems

6. CLASSIFICATION
ORAL
BUCCAL
MUCO
ADHESIVE
NASAL

7. CLASSIFICATION
RECTAL
OCULAR
MUCO
ADHESIVE
VAGINAL

8. BIO/MUCOADHESIVE FORMULATIONS
• These formulations have been targeted to
various anatomical locations to aid drug
delivery as well as absorption
• These targets posses mucous membranes that
protects the cell from damage
• There are different drug delivery to various
anatomical region

9. BODY SITES AND SYSTEM OF DRUGS
• EYE- Mucoadhesive eye drops/ inserts
• Nasal Cavity- Nasal drug delivery systems
• Oral Cavity- Dental gels/ buccal systems
• Skin- Patches, tapes, dressings
• Vagina- Local vaginal delivery systems
• Rectum- Local/ synthetic rectal delivery
systems

10. IDEAL CHARACTERISTICS
• Rapid Adherence- without any change in
physical property of delivery matrix
• Minimum interference- release of active
agent
• BIODEGRADABLE without producing any toxic
by products
• Enhance penetration- Active agent is to be
absorbed from delivery site

11. Process of Bioadhesion may be defined as,
- Chemical(electronic and adsorption theory)
- Physical( wetting , Diffusion and cohesive
theory)

12. BIOADHESION
• Ability of a material to adhere to a biological
tissue for an extended period of time
• Polymer attached to mucin layer-
Mucoadhesion
• They are designed to,
-enable prolonged retention
-Controlled rate of drug release
-Improved therapeutic outcome

13. THEORIES OF MUCOADHESION
• Electronic Theory
• Wetting Theory
• Adsorption Theory
• Diffusion Theory
• Mechanical Theory
• Cohesive Theory
• Fracture Theory

14. FACTORS AFFECTING MUCOADHESION
1. Polymer Related Factors
• Molecular weight
• Concentration of active polymer
• Flexibility of polymer chains
2. Environment Related Factors
• pH of polymer- substrate interface
• Applied strength
• Initial contact time

15. • Swelling
3. Physiological Factors
• Mucin turn over
• Disease state

16. MODES OF MUCOADHESION DRUG
DELIVERY

17. COMPOSITION OF MUCOUS
Mucous is composed of mainly,
• Water(>95%)
• Glycoproteins of exceptionally high molecular
weight
• Mineral salts-1%
• Free proteins-0.5 to 1%

19. The Basic Three Step Processes
STEP 1- Wetting and swelling of
Polymer
STEP 2- Interpretation between the
polymer chains and the mucosal
membrane
STEP 3- Formation of chemical bonds
between the entangled chains

21. STEP 1
• Polymer spreads over the surface of
mucosal membrane to develop
intimate contact
• Bioadhesives bond with tissues by
surface tension and forces at the site
of adsorption or contact

22. Swelling- Polymers have affinity for
Water

23. STEP 2
• BIOADHESIVE Bond Formation- Polymer chains
of Bioadhesive and mucous membrane
intermingle and Entangles to form Semi-
Permeable Adhesive Bonds(Strong Bonds)
• Properties:
- One polymer group must be soluble in the other
- Both polymer must have similar Chemical
Structure

24. The Interpretation Of Polymer Chains

25. STEP 3
• Formation of Weak Chemical Bonds between
the entangled polymer chains(Both Primary &
Secondary)
Primary Bonds:
- Covalent Bonds
Secondary Bonds:
- Van derwaals interaction & Hydrogen Bonds
- These are weaker Bonds

26. • PRIMARY AND SECONDARY BONDS
-EXPLOITED in manufacturing of Bioadhesive
Formulations
- Here Strong Adhesions between Polymers are
formed

27. MECHANISM OF BIOADHESION

28. TYPES OF MUCOADHESIVE DOSAGE
FORMS
• Mucoadhesive Buccal Films
• Mucoadhesive Patches
• Mucoadhesive Microspheres
• Mucoadhesive Tablets

29. ADVANTAGES
• Improve and Enhance
bioavailability of Drugs
• Modification of tissue
permeability for absorption
of Macromolecules
• Prolonged resistance time
of Dosage
• Cheap and less transport
cost
DISADVANTAGES
• Sometimes undergo drug
destruction due to smaller
area of Absorption
• Ingestions result in more
exposure to GI tract
• Adversely affected by
presence of food
• Cannot bypass liver
metabolism and affect
natural microbial flora of
mouth

30. PHYSIOLOGICAL FACTORS
• Age
• Gastric Emptying
• Intestinal Transit
• Gastro-intestinal ph
• Disease state
• Gastro-intestinal contents
• Presystemic metabolism
EVALUATION TEST
• Weight Variation
• Hardness
• Friability
• Content Uniformity
• Swelling index
• Water sorption Studies
• Mucoadhesive Strength
• Drug Release Study