El 12 de mayo de 2017 celebramos en la Fundación Ramó Areces una jornada con IS Global y Unitaid sobre enfermedades transmitidas por vectores, como la malaria, entre otras.

1. Vector Control
Textile Innovation for Personal Protection
Jessica M. Rockwood, President
International Public Health Advisors
on behalf of
Don Alexander, Anovotek, LLC
Bringing Innovation to the Frontline: New tools to advance the global response to vector-borne diseases
May 12, 2017
Madrid, Spain

2. Major vector-borne diseases transmitted and most at risk
Vector Disease
Aedes aegypti Dengue, yellow fever, chikungunya, Zika virus
Aedes albopictus Chikungunya, dengue, West Nile virus
Anopheles Malaria, lymphatic filariasis (in Africa)
Outdoor biting - and behavior shifting - is a significant contributor
The newly released 4th WHO Report on NTDs, released in April 2017, states explicitly:
“Developing novel tools and methods to curb the spread of the day-biting and outdoor-biting Ae. aegypti
mosquitoes that transmit dengue and chikungunya is a high priority, reinforced by the emergence of the Zika
virus.”
Further clarified for malaria by peer reviewed papers noting:

3. Global map of the predicted distribution of
Ae. Aegypti and Ae. albopictus
Global map of the predicted distribution of Ae. albopictus
Global map of the predicted distribution of Ae. aegypti
Source: Kraemer et al. eLife 2015;4:e08347. DOI: 10.7554/eLife.08347

4. Outdoor biting Personal Protection Recommendations:
not always realistic in tropical climates
Source: CDC 2016 https://www.cdc.gov/chikungunya/pdfs/fs_mosquito_bite_prevention_travelers.pdf
Source: WHO 2014
http://apps.who.int/iris/bitstream/10
665/111008/1/WHO_DCO_WHD_20
14.1_eng.pdf?ua=1

5. Innovation in Personal Protection
Innovation
ØRepellent Innovation – for direct skin application & textile
treatment
◦ New actives
◦ Spatial repellents
◦ Natural products
◦ Novel delivery mechanisms
◦ Limitations of longevity, efficacy
ØNon-chemical vector control textiles
◦ Reduced dependency on chemicals & limitations of repellents

6. Vector Control Fabric Consortium (VCFC)
Objectives
• To advance innovation for Personal Protection
• Multidisciplinary approach
• Demonstrate the proof of concept of patented technology to
prevent insect biting by modification of standard fabrics
• Develop and advance Insect Inhibitor Fabric to commercial
scale

7. Vector Control Fabric Consortium (VCFC)
Consortium Members
Anovotek, LLC
• Don Alexander
• Daniel Alexander
International Public Health Advisors
• Jessica Rockwood
NuNet Fabrics, LLC
• Jeff Hartdorn
R. Farlow Consulting, LLC
• Bob Farlow
United States Department of Agriculture
• Uli Bernier

8. Insect Inhibitor Fabric -Technology Overview
Innovative
• Non-chemical personal protection
• Reduces the possibility of insect proboscis from penetrating the fabric and blood
feeding
Rapid scalability
• Converts existing fabrics to Personal Protection Fabrics – by modifying the existing
fabric
• Can be used on a variety of different substrates and materials – cotton, polyester,
nylon, etc..
ØApplicable to at-risk populations
ØReduces dependency on topical repellents and insecticides
ØSamples created by Anovotek and tested at USDA-CMAVE to demonstrate viability of
approach

9. Top of fabric
Tip of deformation
in fabric touching the table
Space preventing
insect biting
Space preventing
insect biting
(prototype 5 to 6mm)
Coating applied to
prevent insects from
biting through when they
are closer to the skin
How it Works

10. Bioassay Testing and Biting Inhibition
• Testing followed standard sleeve bioassay protocol with Aedes
aegypti
“LABORATORY EVALUATION OF BITE PROTECTION FROM
PERMETHRIN-IMPREGNATED UNITED STATES MILITARY CLOTHING”
Protocol – IRB version 03.09.04
• Representatives at USDA-CMAVE processed the Insect Inhibitor
Fabric samples and created “sleeve” cutouts. These cutouts were
sewn into sleeves prior to testing. The sleeves were cut and sewn to
provide enough material with a tight fit to cover the arm from the
wrist up to just below the elbow.
• Bite protection assays were conducted June 8, 2016 with laboratory-
reared 6 day-old female Aedes aegypti mosquitoes.

11. Picture of Insect Inhibitor Fabric samples - sleeve bioassay testing

12. -
10.00
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30.00
40.00
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60.00
70.00
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90.00
100.00
Control A B C D
%ReductioninMosquitoBiting
VCFC Insect Inhibitor Fabric SamplesTested at USDA-CMAVE
Reduction in Mosquito Biting
Cotton
#1 IIF
Cotton
#3 IIF
Cotton
#4 IIF
Cotton
#1 STD
Cotton
#2 IIF

13. Biting Inhibition Results
Results:
• The Insect Inhibitor Fabric samples provided varying degrees of biting
protection, based on the characteristics of the modifications – gained valuable
information regarding what works.
• Results from the cotton based series of fabric samples indicated significant
improvements in biting protection with modifications to samples.
• Compared to the control fabric, the cotton converted Insect Inhibitor fabrics
reduced biting by 42%, 60%, 85.5%, and 94.8%.
• The positive reduction in Aedes biting indicates that non-chemical
modification of fabric can prevent vector biting and potentially contribute to
prevention of disease transmission.

14. Thank you!