Each January, the brightest minds in colorectal cancer research meet at the Gastrointestinal Cancer Symposium.
Fight Colorectal Cancer and The Colon Cancer Alliance are partnering to bring you the big news in colorectal cancer from the symposium. Dr. Allyson Ocean will be presenting.
Get insights about new types of treatments on the horizon, diagnostic tests available, research for upcoming drugs/biomarkers and the way colorectal cancer is treated. We’ll take a look back and a look forward. You’re not going to want to miss it.
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RESEARCH & TREATMENT NEWS: Highlights from the 2014 GI Cancer Symposium
1. ASCO GI 2014 Update:
Personalized Medicine in CRC
Colon Cancer Alliance/Fight Colorectal Cancer
Webinar
February 19, 2014
Allyson J. Ocean, M.D.
Associate Professor of Clinical Medicine
Weill Cornell Medical College
2. ASCO GI 2014 Update
Allyson Ocean, M.D.
Melissa Bjorklund
Randy Henniger
Kim Ryan
3. ABOUT THE COLON CANCER ALLIANCE
Our mission is to knock colon cancer out of the top three
cancer killers. We are doing this by championing prevention,
funding cutting-edge research and providing the highest
quality patient support services.
In 2013, the Colon Cancer Alliance:
5. PATIENT SUPPORT PROGRAMS
Whether you’re a patient, survivor, family
member or advocate, we’re here for you.
•Patient Support Navigator Program
•Toll-free Helpline
•My CCA Support Online Community
•Buddy Program
•Blue Note Fund Financial Assistance
•Community Outreach Volunteer
Program
6. GET INVOLVED
March is National Colon Cancer Awareness Month!
Find an event or join us at coloncancermonth.org.
Upcoming events:
March 1 – Colon Cancer Awareness Month Kickoff
March 5 – Colon Cancer Survivor Day
March 7 – National Dress in Blue Day
8. Fight Colorectal Cancer
FightColorectalCancer.org or call 1-877-427-2111
Mission
Fight Colorectal Cancer demands a cure for colon and rectal cancer. We
educate and support patients, push for changes in policy that will increase and
improve research, and empower survivors to raise their voices against the status
quo.
Facebook.com/FightCRC
Twitter.com/FightCRC
YouTube.com/FightCRC
Instagram.com/FightCRC
Pinterest.com/FightCRC
9. CRC: Epidemiology in 2013
Fourth most common cancer
diagnosis in US[1]
Estimated 142,820 new cases in
2013; 1:1 male:female ratio[2]
Second leading cause of cancer
deaths in 2013 (estimated 50,830
deaths)[1]
Steady decrease in age-adjusted
incidence rates of distal colon,
proximal colon, and rectal cancers
in 1976-2005[4]
Death Rates in 2008,
per 100,000[3], %
Male
Female
All races
20.2
14.1
White
19.5
13.6
Black
29.8
19.8
Asian/Pacific Islander
13.1
9.6
American Indian/ Alaska
Native
18.8
14.6
Hispanic
15.3
10.2
1. American Cancer Society. Cancer facts & figures. 2013. 2. Siegel R, et al. CA Cancer
J Clin. 2012;62:10-29. 3. SEER. Stat fact sheets: colon and rectum. 4. Cheng L, et al. Am Clin Oncol.
2011;34:573-580.
10. Colorectal Cancer in Young Adults
Incidence rising SHARPLY in younger adults in U.S.
Researchers analyzed SEER data for 383,241 patients
in whom CRC diagnosed between 1975 and 2010
Age-adjusted incidence of CRC fell steadily among >50
Annual percentage change in rates rose in patients
aged 35-49 at diagnosis and ESPECIALLY aged 20-34
Results similar for colon and rectum
Study lead author, Dr. Christina Bailey, M.D. Anderson, ASCO GI 2014 Poster
11. What does this mean for young
adults?
Predictive model suggested that if observed trends
persist between 2010 and 2030, incidences of colon
cancer and rectal cancer will rise by 90% and 124%
respectively among 20-34 yo and by 28% and 46%
respectively in 35-49 yo
Why? Possible reasons: Increasing obesity rates,
physical inactivity, diet high in fat and red meat
Primary care docs may be more alert for this cancer in
young adults with symptoms like rectal bleeding
12. Colorectal Cancer: Stage at Diagnosis
Stage
0
Stage IV
7%
19%
Stage I
24%
Stage III
25%
Stage II
25%
National Cancer Database.
13. Colorectal Cancer:
Standard Therapy Algorithm
Stage
Colon
Rectal
I (T1-T2, N0, M0)
Surgery only
Surgery only
II (T3-T4, N0, M0)
Surgery ±
chemotherapy
III (Tany, N+, M0)
Surgery
chemotherapy
Chemoradiation surgery
chemotherapy
OR
Surgery chemoradiation
+ chemotherapy
IV (Tany, Nany, M1)
Chemotherapy ±
surgery
NCCN. Clinical practice guidelines in oncology: colon cancer. v.1.2014.
Chemotherapy ±
surgery
15. Oncotype DX News
Through an analysis of physician recommendations and patient
treatment preferences before and after receiving the Oncotype
DX colon cancer test results, this study demonstrated that the
test greatly increased concordance between physician and
patient treatment choice (from 66 percent to 96 percent).
Recurrence Score® result influenced a majority of patients'
treatment decisions (85 percent) and physicians' treatment
recommendations (69 percent), and it increased physicians'
confidence in their own recommendations (84 percent).
Patients' anxiety was also significantly reduced, which may
improve adherence to their treatment plan and ultimately lead
to better health outcomes.
16. Oncotype DX
The review of four validation studies of the Oncotype DX
colon cancer test (3,315 patients) with early stage colon
cancer, consistently demonstrated a significant association
(p < 0.05) between the test results and recurrence risk and
cancer-specific survival.
Three decision impact studies with a total of 502 patients
showed that the test changed treatment
recommendations in 29 to 45 percent of stage II colon
cancer cases, leading to a net reduction in adjuvant
chemotherapy use.
17. Final Results of NSABP R-04
Phase III randomized trial in neoadjuvant rectal cancer- mature
results presented
Combining preoperative radiation with oral capecitabine
(Xeloda) was equally as effective as our old standby, infusional
5-FU chemo, in terms of local-regional recurrence rates
Largest clinical trial showing no difference in clinical benefit
Provides for better quality of life for patients
Not tied down to getting a catheter treatment and able to take
an oral agent
Adding oxaliplatin to either treatment did not improve clinical
response rates
Allegra et. al ASCO GI 2014 Abstract 390
18. Phase III GCR-3 Trial
Spanish trial for pre-operative (neoadjuvant) treatment of rectal cancer
Tips the balance in favor of induction chemotherapy followed by
chemoradiotherapy and then surgery vs. the standard approach of
chemoradiotherapy followed by surgery and then adjuvant chemotherapy in
patients with locally advanced rectal cancer
Pathologic CR rates, locoregional recurrence, distant recurrence, diseasefree survival, and overall survival all proved similar between the two
approaches out to 5 years
Less acute toxicity and better compliance to chemotherapy component of
the regimens was identified with the induction approach vs. the standard
approach
Need large phase III randomized trials to definitively find best approach
ASCO GI 2014 Abstract 383
20. Personalizing Treatment in mCRC:
Considerations
Extent of disease
Intent of treatment
(palliative vs potentially
curative)
Performance score
Age
Comorbid illnesses
Previous adjuvant therapy
within 1 yr
Molecular markers
Organ function: hepatic and
renal
Risks for toxicity: active
CAD/CVD, proteinuria, active
bleeding, nonhealed wound,
allergy to mAb, neuropathy,
IBD, ILD, Gilberts
Convenience
Cost/resources
Patient preferences and
goals
21. Maintenance Capecitabine/Bevacizumab
Delays Disease Progression
Phase III CAIRO3 trial
Data provides guidance about how big a treatment holiday
to give patients following induction therapy
Maintenance treatment with Xeloda and Avastin after 6
cycles of CAPOX-B (Xeloda, Oxaliplatin, Avastin)
significantly prolonged time to disease progression
Overall survival benefit for maintenance treatment in
certain patient groups (synchronous disease with resection
of primary tumor and in patients with complete or partial
response as best response on induction treatment)
Koopman et. al ASCO GI 2014 LBA
22. Improving outcome for CRC patients
Studies focused on leveraging prognostic and predictive
information
More extensive genetic testing for RAS gene mutations
beyond routine analysis of K-RAS exon 2 may soon become
a new standard of care to pinpoint which patients stand to
benefit from anti-EGFR therapy
K-RAS mutations present in approximately 40-50% of mCRC
tumors
If K-RAS mutation present- can’t use Erbitux or Vectibix
Peeters et. al, ASCO GI 2014 Abstract LBA387
23. Irinotecan drug-eluting beads
(DEBIRI)
Addition of DEBIRI to 1st line FOLFOX in unresectable liver-limited
metastatic CRC enables downstaging and subsequent resection
in more than 1/3 of patients
Placement of the beads in the hepatic artery did not increase
chemotherapy toxicity or compromise overall treatment delivery
This phase II trial was conducted in 70 patients with CRC with
liver metastases
Irinotecan beads administered to hepatic artery during off week
of chemotherapy; outpatient procedure
Key is finding the patients most appropriate for this therapy
Martin et. al, ASCO GI 2014 Abstract 174
24. Thoughts/Conclusions/Questions
Personalized medicine: What does it mean for YOU?
Ask about the genetics of your tumor
Ask about the K-RAS mutations of your tumor
Ask about genome sequencing of your tumor
Take advantage of educational websites
CCA, Fight CRC, Michael’s Mission
Connect with other patients and survivors
Links to novel treatments