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Ferdos	
  Albayedh	
  
Supervisor:	
  
Dr.	
  James	
  Chow	
  
Medical	
  Physics	
  4th-­‐year	
  Undergraduate	
  Thesis	
  –	
  Fall	
  2015	
  
!  A	
  Brief	
  on	
  the	
  Topic	
  
!  Research	
  Hypothesis	
  
!  Aims	
  and	
  Objectives	
  
!  Proposed	
  Methodology	
  
!  Progress	
  Made	
  to	
  Date	
  
(Cano	
  et	
  al.,	
  2014)	
  (Web2.clarkson.edu,	
  2015)	
  
(Dorsey	
  et	
  al.,	
  2013)	
  
!  Which	
  tissue	
  used	
  will	
  give	
  the	
  better	
  results	
  
and	
  which	
  size	
  of	
  the	
  phantom	
  would	
  be	
  the	
  
idealist	
  in	
  this	
  study?	
  	
  
(Interactive	
  Biology,	
  with	
  Leslie	
  Samuel,	
  2012)	
  
(Visualsunlimited.photoshelter.com,	
  2015)	
  
!  The	
  focus	
  of	
  this	
  project	
  is	
  to	
  determine	
  the	
  
relationship	
  between	
  the	
  contrast	
  ratio	
  and	
  
concentration	
  of	
  the	
  gold	
  nanoparticle	
  in	
  
radiotherapy	
  	
  
(Ashworth	
  Creative,	
  2009)	
  
Phantom	
  
Photon	
  
Beam	
  
(E-­‐keV)	
  
results	
  
AuNP	
  
Thickness	
  
of	
  the	
  
tissue	
  
Radiation	
  
dose	
  
Calculate	
  
Contrast	
  ratio	
  
(AuNP	
  added	
  
and	
  not	
  added)	
  
•  Literature	
  survey	
  and	
  background	
  review	
  
•  Study	
  design	
  
!  Cano,	
  I.,	
  Chapman,	
  A.,	
  Urakawa,	
  A.	
  and	
  van	
  Leeuwen,	
  P.	
  (2014).	
  Air-­‐Stable	
  Gold	
  Nanoparticles	
  
Ligated	
  by	
  Secondary	
  Phosphine	
  Oxides	
  for	
  the	
  Chemoselective	
  Hydrogenation	
  of	
  Aldehydes:	
  
Crucial	
  Role	
  of	
  the	
  Ligand.	
  J.	
  Am.	
  Chem.	
  Soc.,	
  136(6),	
  pp.2520-­‐2528.	
  
!  Web2.clarkson.edu,	
  (2015).	
  Fine	
  Particle	
  Research	
  Group	
  (Goia's	
  Group)-­‐	
  Glutathione	
  Modified	
  Gold	
  
Nanoparticles.	
  [online]	
  Available	
  at:	
  http://web2.clarkson.edu/programs/goia_group/
res_materials_modif_au.php	
  [Accessed	
  22	
  Nov.	
  2015].	
  
!  Interactive	
  Biology,	
  with	
  Leslie	
  Samuel,	
  (2012).	
  How	
  do	
  we	
  breathe?	
  (Lungs	
  and	
  Pleura)	
  -­‐	
  
Interactive	
  Biology,	
  with	
  Leslie	
  Samuel.	
  [online]	
  Available	
  at:	
  http://www.interactive-­‐biology.com/
3331/how-­‐do-­‐we-­‐breathe-­‐lungs-­‐and-­‐pleura/	
  [Accessed	
  22	
  Nov.	
  2015].	
  
!  Ashworth	
  Creative,	
  (2009).	
  client	
  relationships	
  =	
  building.	
  stewarding.	
  harboring.	
  -­‐	
  Ashworth	
  
Creative.	
  [online]	
  Available	
  at:	
  http://www.ashworthcreative.com/blog/2009/09/client-­‐
relationships-­‐building-­‐stewarding-­‐harboring/	
  [Accessed	
  22	
  Nov.	
  2015].	
  
!  Demosthenes.info,	
  (2012).	
  demosthenes.info	
  archive	
  for	
  October	
  2012.	
  [online]	
  Available	
  at:	
  http://
www.demosthenes.info/archive.php?month=10&year=2012	
  [Accessed	
  22	
  Nov.	
  2015].	
  
!  Visualsunlimited.photoshelter.com,	
  (2015).	
  X-­‐ray	
  of	
  a	
  hand	
  showing	
  the	
  gesture	
  for	
  the	
  word	
  peace	
  
|	
  Visuals	
  Unlimited.	
  [online]	
  Available	
  at:	
  http://visualsunlimited.photoshelter.com/image/
I0000UuJkjkpIw8Y	
  [Accessed	
  22	
  Nov.	
  2015].	
  
!  Dorsey,	
  J.,	
  Sun,	
  L.,	
  Joh,	
  D.,	
  Witztum,	
  A.,	
  Zaki,	
  A.,	
  Kao,	
  G.,	
  Alonso-­‐Basanta,	
  M.,	
  Avery,	
  S.,	
  Tsourkas,	
  
A.	
  and	
  Hahn,	
  S.	
  (2013).	
  Gold	
  nanoparticles	
  in	
  radiation	
  research:	
  potential	
  applications	
  for	
  imaging	
  
and	
  radiosensitization.	
  Translational	
  Cancer	
  Research,	
  [online]	
  2(4),	
  pp.280-­‐291.	
  Available	
  at:	
  
http://www.thetcr.org/article/view/1547/html	
  [Accessed	
  22	
  Nov.	
  2015].	
  
!  Ahn,	
  S.,	
  Jung,	
  S.	
  and	
  Lee,	
  S.	
  (2013).	
  Gold	
  Nanoparticle	
  Contrast	
  Agents	
  in	
  Advanced	
  X-­‐ray	
  Imaging	
  
Technologies.	
  Molecules,	
  18(5),	
  pp.5858-­‐5890.	
  

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Proposal presentation

  • 1. Ferdos  Albayedh   Supervisor:   Dr.  James  Chow   Medical  Physics  4th-­‐year  Undergraduate  Thesis  –  Fall  2015  
  • 2. !  A  Brief  on  the  Topic   !  Research  Hypothesis   !  Aims  and  Objectives   !  Proposed  Methodology   !  Progress  Made  to  Date  
  • 3. (Cano  et  al.,  2014)  (Web2.clarkson.edu,  2015)   (Dorsey  et  al.,  2013)  
  • 4. !  Which  tissue  used  will  give  the  better  results   and  which  size  of  the  phantom  would  be  the   idealist  in  this  study?     (Interactive  Biology,  with  Leslie  Samuel,  2012)   (Visualsunlimited.photoshelter.com,  2015)  
  • 5. !  The  focus  of  this  project  is  to  determine  the   relationship  between  the  contrast  ratio  and   concentration  of  the  gold  nanoparticle  in   radiotherapy     (Ashworth  Creative,  2009)  
  • 6. Phantom   Photon   Beam   (E-­‐keV)   results   AuNP   Thickness   of  the   tissue   Radiation   dose   Calculate   Contrast  ratio   (AuNP  added   and  not  added)  
  • 7. •  Literature  survey  and  background  review   •  Study  design  
  • 8. !  Cano,  I.,  Chapman,  A.,  Urakawa,  A.  and  van  Leeuwen,  P.  (2014).  Air-­‐Stable  Gold  Nanoparticles   Ligated  by  Secondary  Phosphine  Oxides  for  the  Chemoselective  Hydrogenation  of  Aldehydes:   Crucial  Role  of  the  Ligand.  J.  Am.  Chem.  Soc.,  136(6),  pp.2520-­‐2528.   !  Web2.clarkson.edu,  (2015).  Fine  Particle  Research  Group  (Goia's  Group)-­‐  Glutathione  Modified  Gold   Nanoparticles.  [online]  Available  at:  http://web2.clarkson.edu/programs/goia_group/ res_materials_modif_au.php  [Accessed  22  Nov.  2015].   !  Interactive  Biology,  with  Leslie  Samuel,  (2012).  How  do  we  breathe?  (Lungs  and  Pleura)  -­‐   Interactive  Biology,  with  Leslie  Samuel.  [online]  Available  at:  http://www.interactive-­‐biology.com/ 3331/how-­‐do-­‐we-­‐breathe-­‐lungs-­‐and-­‐pleura/  [Accessed  22  Nov.  2015].   !  Ashworth  Creative,  (2009).  client  relationships  =  building.  stewarding.  harboring.  -­‐  Ashworth   Creative.  [online]  Available  at:  http://www.ashworthcreative.com/blog/2009/09/client-­‐ relationships-­‐building-­‐stewarding-­‐harboring/  [Accessed  22  Nov.  2015].   !  Demosthenes.info,  (2012).  demosthenes.info  archive  for  October  2012.  [online]  Available  at:  http:// www.demosthenes.info/archive.php?month=10&year=2012  [Accessed  22  Nov.  2015].   !  Visualsunlimited.photoshelter.com,  (2015).  X-­‐ray  of  a  hand  showing  the  gesture  for  the  word  peace   |  Visuals  Unlimited.  [online]  Available  at:  http://visualsunlimited.photoshelter.com/image/ I0000UuJkjkpIw8Y  [Accessed  22  Nov.  2015].   !  Dorsey,  J.,  Sun,  L.,  Joh,  D.,  Witztum,  A.,  Zaki,  A.,  Kao,  G.,  Alonso-­‐Basanta,  M.,  Avery,  S.,  Tsourkas,   A.  and  Hahn,  S.  (2013).  Gold  nanoparticles  in  radiation  research:  potential  applications  for  imaging   and  radiosensitization.  Translational  Cancer  Research,  [online]  2(4),  pp.280-­‐291.  Available  at:   http://www.thetcr.org/article/view/1547/html  [Accessed  22  Nov.  2015].   !  Ahn,  S.,  Jung,  S.  and  Lee,  S.  (2013).  Gold  Nanoparticle  Contrast  Agents  in  Advanced  X-­‐ray  Imaging   Technologies.  Molecules,  18(5),  pp.5858-­‐5890.