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14th Experts Live CTO
The annual Euro CTO meeting
September 2nd - 3rd, 2022. Mainz, Germany
Road to CTO expert 2022 – how to build your CTO toolkit
When the “uncrossable” becomes crossable
Lunch Symposium by Asahi
EURO CTO CLUB
Gregor Leibundgut, MD
University Hospital Basel, Switzerland
Without wiring no CTO-PCI
Uncrossable Proximal Cap
Power Knuckle
Carlino
(hydrolic dissection)
BASE
Side-BASE
Scratch & Go
Dual Lumen Microcatheter
Support Puncture
Power Puncture
Undilatable Proximal Cap
BAM
Rotational
atherectomy
Carlino
(hydrolic dissection)
Stiffer or lower profile
microcatheter
Antegrade proximal cap
external crush
Retrograde proximal cap
external crush
Laser
Progressive balloon
tracking
Uncrossable & Undilatable Distal Cap
Retrograde
Scratch & Go
Retrograde Carlino
Retro-BASE
Retro-BAM
Antegrade distal cap
external crush
Dual lumen microcatheter
supported puncture
Wiring in outer space
Dissection re-entry techniques
The Concept
Wiring in outer space
(habitable zone)
(lower space)
(outter space)
How to travel in the subintimal space?
How to travel in the subintimal space
Travel both ways
Wiring in outer space
RDR
Retrograde
Dissection
Re-Entry
ADR
Antegrade
Dissection
Re-Entry
The Boss
How to travel in the subintimal space
CrossBoss Antegrade Only
Knuckling
Wire-based technique
of blunt dissection
The Knuckle-wire Technique
Knuckling
• The knuckle technique is used to
create a deliberate blunt dissection
plane in various CTO techniques.
• The guidewire, usually a polymer-
jacketed guidewire, is pushed until
a complex loop is formed and
advanced through the lesion
When should we knuckle?
Knuckling
• Antegrade dissection Re-entry (ADR)
- Whenever the wire escalation strategy (parallel wiring) failed
- In tortuous anatomy
- Ambiguous vessel course
- Ideally NO sidebranches
- NO distal bifurcation
• Retrograde dissection Re-entry (RDR)
- Preferably do retrograde knuckling (safer, more predictable)
- Modified reverse CART (controlled antegrade and retrograde subintimal tracking)
Tip load is a function of the core wire
Knuckling
10mm
gap
Guidewire Tips
Knuckling
• non-tapered & round tip
- Workhorse wires
• non-tapered & pointed tip
- Gaia family
- Pilot 200
• tapered & round tip
- Fielder XT, XT-A, XT-R
- Confianza Pro 12
• tapered & pointed tip
- Stingray wire
Penetration Power
Knuckling
Penetration Power
=
Tip load / Tip area
mm2
g
The Knuckle Analogy
Knuckling
Penetration wire
(e.g. CP12)
Knuckle wire
(e.g. Gladius MG)
Trust the Knuckle!
Tip load vs Penetration power
Knuckling
High Tip load
non-polymeric wire
High Tip load
polymeric wire
with knuckle
VS
Polymer Jacket
Knuckling
Polymer Jacket Coils
Specialty Guidewires
Knuckling
COATING
Polymeric jacket
Soft
Non-tapered
Soft
Tapered-tip
Harder
Non-tapered
Whisper
Pilot 50
Fielder FC
Sion Black
Pilot 150
Fielder XT-R
Fielder XT
Bandit
Fielder XT-A
Fighter
Pilot 200
Gladius EX
Raider
Gladius MG
SUOH 03
Sion
Turntrac
Samurai RC
Gaia 1st
Gaia 2nd
Gaia 3rd
Progress 200T
Confianza Pro 9
Confianza Pro 12
Hornet 14
Warrior
Infiltrac Plus
Astato 20/40
Suitable guidewires for the knuckle technique
Knuckling
• Polymer jacketed guidewires
• large knuckle
- Pilot 200 (4.7g)
- Gladius EX (4.2g)
- Raider (g)
• small knuckle
- Fielder XT (0.8g)
- Fielder XT-A (g)
- Bandit (g)
• powerfull intermediate knuckle
- Gladius MG
Large knuckle = subintimal space
Small knuckle = intimal (vessel lumen)
Types of knuckles
Knuckling
Tiny Small Large Huge
Fielder XT-A Gladius MG Fielder XT-A
Gladius EX
Gladius EX
Pilot 200
After Knuckling
Knuckling
• The knuckle permanently deforms
the guide wire due to a bend in the
core wire
• Gladius MG is the only guidewire
that can be reused for regular
wiring after knuckling (e.g. tip-in)
Gladius EX
• Non-tapered, ACT ONE
• Tip load 3.0 g
• Tip radiopacity 3.0 cm
• Polymer jacket: 40 cm
Gladius MG
Knuckling
Gladius MG
• Non-tapered, ACT ONE
• Tip load 3.0 g
• Tip radiopacity 3.0 cm
• Polymer jacket: 41 cm
• Knuckle point at 8 mm
Preshaped micro-bend (similar to Gaia family)
“Knuckle point”
Key feature: Micro gap
The micro gap
0.
100.
200.
300.
400.
500.
1.5 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
Load
(mN)
Distance from the tip (mm)
Comparison of tip rigidity
Gladius MG
PILOT200
8 mm
300 mN
30 mm
250 mN
Bench model performance
_
Gladius MG
Pilot 200 | Gladius EX
HOW TO GET BACK?
How to get back
Subintimal wire position
STAR/miniSTAR
How to get back
Subintimal tracking and re-entry
LAST
How to get back
Limited antegrade subintimal tracking
AFR
How to get back
Antegrade fenestration and re-entry
Stingray based Re-entry
How to get back
Contemporary ADR
Stingray based Re-entry
How to get back
Stick and swap & stick and drive
New Methods
How to get back
Device based targeted re-entry with ReCross dual-lumen microcatheter
Subintimal Hematoma
How to get back
MAP
80 mmHg
Capillary pressure
15 mmHg
True lumen compression
How to get back
STRAW
Subintimal Transcatheter Withdrawal (of Hematomas)
Aspirate
Reverse CART
Retrograde re-entry
Controlled antegrade and
retrograde tracking and
dissection
Reverse CART
Retrograde re-entry
Controlled antegrade and
retrograde tracking and
dissection
Reverse CART
Retrograde re-entry
Controlled antegrade and
retrograde tracking and
dissection
Reverse CART
Retrograde re-entry
Controlled antegrade and
retrograde tracking and
dissection
WHAT CAN GO WRONG?
Space Shuttle Columbia, February 1st 2003
Precautions
What can go wrong on re-entry?
• Never spin the knuckled guidewire → creates a knot
• Knuckles tend to go into side branches → risk of perforation
• Big knuckles can weaken/rupture the vessel
• Small knuckles can cause distal perforations
• Knuckles with non-polymeric wires, especially penetration wires can
damage the microcatheter on retrieval and get stuck.
• In general, knuckles cause large subintimal hematomas
- Block antegrade flow, Do NOT inject antegradely, STRAW
_
Case 1
Weak knuckles
_
Retrograde knuckle
• Fielder XT-A retrograde in proximal
RCA
_
Case 2
Reverse knuckle
Controled retrograde knuckle
• Gladius MG retrograde
• Push until knuckle forms
• Keep pushing without twisting
• Retrograde Gladius MG
• Excellent tip retention
Enter the antegrade guide
• Use same Gladius MG
• Or fresh straight workhorse wire
without tip shape
Tip-in
• Advance antegrade microcatheter
• If drilling needed feed antegrade
guidewire into the mc to prevent
lumen collaps
Antegrade conversion
Case 3
Calcium and tortuosity
_
Tandem CTO of the LAD
Septal collaterals from ipsilateral
Antegrade wiring
Teleport control & Fielder XT-A
Retrograde knuckling with
Fielder XT-A
Retrograde knuckling with
Gladius MG
Small knuckle!
Reverse CART with Gladius MG
Retrograde re-entry
with Gladius MG
Unfolds nicely from the knuckle!
Final angiographic result
Final angiographic result

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