Allergy and Ginseng: Research Case Study Eugene Fung www.ginsengcare.com
Ginseng :  Anti-allergic and anti-inflammatory activities <ul><li>Ginsenoside Rh1 possesses anti-allergic and anti-inflamm...
BACKGROUND of the Study <ul><li>Ginseng (the root of Panax ginseng C.A. Meyer) has been reported to possess various biolog...
METHOD of the Study <ul><li>We isolated ginsenosides by silica gel column chromatography and examined their in vitro and i...
RESULTS of the Study <ul><li>Rh1 potently inhibited histamine release from rat peritoneal mast cells and the IgE-mediated ...
CONCLUSION <ul><li>The anti-allergic action of Rh1 may originate from its cell membrane-stabilizing and anti-inflammatory ...
Upcoming SlideShare
Loading in …5
×

Allergy And Ginseng Case Study

1,116 views

Published on

Ginsengcare.com in Toronto promotes health and wealth for refined ginseng powder

0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
1,116
On SlideShare
0
From Embeds
0
Number of Embeds
6
Actions
Shares
0
Downloads
6
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Allergy And Ginseng Case Study

  1. 1. Allergy and Ginseng: Research Case Study Eugene Fung www.ginsengcare.com
  2. 2. Ginseng : Anti-allergic and anti-inflammatory activities <ul><li>Ginsenoside Rh1 possesses anti-allergic and anti-inflammatory activities. </li></ul><ul><li>Park EK , Choo MK , Han MJ , Kim DH . </li></ul><ul><li>College of Pharmacy, Kyung Hee University, Seoul, Korea. </li></ul>
  3. 3. BACKGROUND of the Study <ul><li>Ginseng (the root of Panax ginseng C.A. Meyer) has been reported to possess various biological activities, including anti-inflammatory and antitumor actions. </li></ul><ul><li>In this study, we investigated the anti-allergic activity of ginsenosides isolated from ginseng. </li></ul>
  4. 4. METHOD of the Study <ul><li>We isolated ginsenosides by silica gel column chromatography and examined their in vitro and in vivo anti-allergic effect on rat peritoneal mast cells and on IgE-induced passive cutaneous anaphylaxis (PCA) in mice. </li></ul><ul><li>The in vitro anti-inflammatory activity of ginsenoside Rh1 (Rh1) in RAW264.7 cells was investigated. </li></ul>
  5. 5. RESULTS of the Study <ul><li>Rh1 potently inhibited histamine release from rat peritoneal mast cells and the IgE-mediated PCA reaction in mice. </li></ul><ul><li>The inhibitory activity of Rh1 (87% inhibition at 25 mg/kg) on the PCA reaction was found to be more potent than that of disodium cromoglycate (31% inhibition at 25 mg/kg); </li></ul><ul><li>Rh1 was also found to have a membrane-stabilizing action as revealed by differential scanning calorimetry. </li></ul><ul><li>It also inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expression in RAW 264.7 cells, and the activation of the transcription factor, NF-kappaB, in nuclear fractions. </li></ul>
  6. 6. CONCLUSION <ul><li>The anti-allergic action of Rh1 may originate from its cell membrane-stabilizing and anti-inflammatory activities. </li></ul><ul><li>Therefore, Ginsenoside Rh1 can improve the inflammation caused by allergies. </li></ul><ul><li>http://www.ncbi.nlm.nih.gov/pubmed/14739579 </li></ul>

×