This document discusses various types of artificial tears that can be used to treat dry eyes. It describes low and high viscosity artificial tears as well as polymer-based tears such as HPMC-based and CMC-based tears. An ideal artificial tear formulation would be muco-adhesive, mimic the tear film, provide effective relief, have a neutral pH, address hyperosmolarity, protect the eye surface from stressors, and be preservative-free. The document also lists several commercial artificial tear products and their active ingredients and packaging.

1. Tear Substitutes

2. DryEyeTreatmentOptions
T
reatment
Options
Low viscosity
Artificial T
ears
High Viscosity
Artificial T
ears
Other
Lubricating
Polymerbased
Artificial T
ears
HPMC based
Artificial T
ears
CMC based
Artificial T
ears
Blended
polymer
based
Artificial T
ears

3. What really makes an ideal eye drop
formulation?
• Muco-Adhesive ability on the ocular surface
• Mimic the behavior of the tear film
• efficient drug delivery or symptomatic relief
• The pH is near neutral or slightly alkaline
• Addresses the hyperosmolarity of a dry eye
• Protects the ocular surface against the osmolar challenge
• Protects the ocular surface from stress (cold, dryness, high osmolarity)
• Free from preservatives & phosphates

4. Tear Substitutes Available
Hyalein Benzalkonium Chloride 0.0015% 5ml
Tears Naturale II Polyquaternium-1 0.011% 15ml
Systane Ultra Polyquaternium-1 0.001% 10ml
Systear Sodium Perborate 0.01% 10ml
Drylief Sodium Perborate 0.01% 10ml
TearsForte Evanish 0.09% 15ml
Hylosan Evanish 0.01% 5ml
SoftDrops SOC 0.01% 10ml
Tearfresh Liquigel SOC 0.0075% 10ml
TearDrops SOC 0.005% 10ml
Refresh Liquigel Purite 0.0075% 15ml
Refresh Tears Purite 0.005% 15ml
Optive Purite 0.005% 15ml
Optive UD Preservative FREE 0.4ml x 30
Restasis Preservative FREE 0.4ml x 30
OCULAR
TOXYCITY
LOW
HIGH