Modern technologies like chemiluminescence and fluorescence aid in oral cancer screening and diagnosis. Chemiluminescence uses acetic acid and light sources to highlight abnormal tissues, while fluorescence detects tissue changes through autofluorescence. Devices like ViziLite, Microlux, and VELscope use these principles in portable, non-invasive screenings to improve early detection of oral cancers. Emerging tools like OSCAN aim to make screening even more accessible by integrating it with smartphone cameras. Overall, oral cancer screening helps detect cancers earlier and improve clinical outcomes.

2. ORAL Cancer
screening- FUTURE

3. • With the help of modern technologies, the diagnosis and
treatment planning by the clinician improves……

4. RECENT ADVANCES- OPTICAL
CHEMILUMINESCENCE
• VIZILITE
• MICROLUX DL
AUTO FLUORESCENCE
• VELSCOPE

5. Cellular changes in dysplasia
• Altered thickness of
epithelium
• Higher density of
nuclear content
• Higher density of
mitochondrial matrix

6. Chemiluminescence
PROCEDURE:
• The patient must have a 1% acetic acid solution
oral wash
• Followed by direct visual examination of the oral
cavity using a blue-white light source.

7. Clinical view of ventral tongue
under incandescent light.
After acetic acid rinse, area
viewed under chemiluminescent
illumination.

8. Action of acetic acid
• Improves penetration of light through
epithelium by removing
 surface debris &
 glycoprotein barrier
• Changes retractile property of
chemiluminescent light on the epithelium
by
 dehydrating the cytoplasm

9. Normal epithelium
absorbs the light and
appears dark.
Abnormal tissues
reflects light and
appears bright white.
Under blue-white illumination,
normal epithelium appears
lightly bluish while abnormal
epithelium appears distinctly
white.

10. Chemiluminescence
• Enhance the identification of oral mucosal
abnormalities.
• Currently marketed as ViziLite Plus and
MicroLux DL

11. ViziLite Plus with TBlue630
• It is comprised of a chemiluminescent light source
(ViziLite) and a blue phenothiazine dye to mark
those lesions identified by ViziLite.

12. Microlux diagnostic Light
• After noting any white soft tissue lesions during a
routine exam, have the patient rinse with 1% acetic
acid solution for 1 minute. Then repeat the oral
exam using Microlux DL.

13. Orascoptic DK
• Works in conjunction with a mild acetic acid
rinse to improve the visualization of oral lesions.

14. • It includes a transillumination instrument and
lightened mirror.
• It uses a battery powered handled LED light
source and three interchangeable diagnostic
instruments.
Armamentarium

15. Tissue fluorescence spectroscopy
• Involves exposure of tissues to various
excitation wavelengths so that differences
between normal and abnormal tissues can be
identified.
• It results in the auto fluorescence of cellular
fluorophores after excitation.

16. Cellular alterations will change the cellular
concentrations of fluorophores, which will affect the
scattering and absorption of light in the tissue, thus
resulting in changes in color that can be observed
visually.

17. VELSCOPE
VELscope is a fluorescence imaging method that
involves the exposure of tissue to a specific
wavelength of light.

18. • Under intense blue excitation light, normal oral mucosa
emits a pale green auto fluorescence and in contrast,
abnormal or suspicious tissue exhibits decreased levels
of normal auto fluorescence and appears dark by
comparison to the surrounding healthy tissue.

19. VELSCOPE

20. TIME TO TAKE A CLOSER
LOOK…
• Simple device that is portable,
easy to handle and store.
• Painless and comfortable for patient as no chemical
agents are used.
• No unpleasant odour, taste or sensation.
• Procedure time < 3 minutes
• Can be used as a part of patient’s preventive examination
during routine check up.

21. The Cancer Screening That Runs on Your Smartphone
snapping a photo with your smartphone.
That's what Manu Prakash, a bioengineer at Stanford
University, hopes to achieve with OScan

22. OSCAN
• OScan is as an attachment that fits over the camera of a
mobile phone.
• It works by shining a blue fluorescent light into a
patient's mouth, a process that causes lesional tissue to
show up as dark spots on the resulting image.

23. OSCAN…
• The screening is fast, painless,
and doesn't require a
professional to carry out.
• When the procedure is
complete, the pictures can be
uploaded instantly to off-site
medical professionals for
analysis and diagnosis.

24. GET IT EARLY, GET IT ALL…
• Improves clinical decision and treatment
planning.
• Helps in detection of borders in both
surgical biopsy and excision.
• Non invasive nature of examination.

25. • These technologies does not diagnose oral
cancer, its just an adjunct to oral examination.
• They are screening devices that allows the
clinician to more easily visualize suspicious
lesions.

26. Salivary markers
• More than 100 potential OSCC salivary
biomarkers have been reported in the literature,
based mainly on comparing the levels found in
OSCC patients to the levels found in non-OSCC
normal controls.

28. Conclusion
• Oral cancer screening has proved to be the best
method for early detection and diagnosis of
potentially malignant and malignant lesions.
• Screening and early detection of diseases in
population at risk have been proposed to
decrease both the morbidity and mortality
associated with oral cancer.
• In combination with the public awareness,
screening aids may help in the early detection of
oral cancer, thereby helping in long term survival
rate.