To improve the quality of care and access to care for Native American communities, the Indian Health Service (IHS) has created two new state-of-the-art healthcare facilities: Kayenta Health Center located in northern Arizona on the Navajo Nation, and Fort Yuma Health Care Center located on the Arizona-California border to serve the Cocopah and Quechan tribes. Both facilities prioritize preventative care, contradicting the perceived hierarchy of medicine and inpatient care over outpatient and therapy services. Instead, each facility emphasizes cultural traditions as well as current trends and theories of healthcare that put Wellness first. This session was presented at the 2018 PDC Summit and considered two case studies to demonstrate how evidence-based design, a cultural understanding of wellness, and state-of-the-art healthcare can intersect to improve patient outcomes and support IHS’s proactive mission to keep people healthy. Learn more at https://www.dpsdesign.org/blog/improving-patient-care-culture-and-evidence-based-design.