Nutraceuticals Now

Spring Issue 2019
| Available by subscription only |

Manufacturers of natural ingredients with the highest quality and
purity criteria to enhance people’s life and create value to the
company and its customers.
Vitapherole®
IP Mixed tocopherols
and IP natural Vitamin E
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MANUFACTURERS OF WELLNESS
VISIT US A
VITAFOODS
EUROPE 2019
07-09 MAY
BOOTH E180

Spring Issue 2019 | 03
foreword
Increasingly health-aware, today’s digi-
tally savvy consumers are taking a more
proactive approach to maintaining their
mental and physical welfare. While the
wellness industry once focused on per-
sonal care and beauty, the remit has
broadened to cover anything from
healthy eating and mental health to per-
sonalized medicine and sports nutrition1.
This presents an unprecendented op-
portunity for the nutraceutical industry
to capitalise on the growing demand for
solutions that support healthier lifestyles.
But what does nutraceutical mean to the
average consumer?
The term ‘nutraceutical’ was originally
introduced by Dr. Stephen L. DeFelice,
founder and chairman of the Foundation
of Innovation in Medicine, in 1989, com-
bining ‘nutrition’ and ‘pharmaceutical’.
Three decades later, the industry has seen
innovations from personalized nutrition
to 3D-printed ingredients, which once
seemed impossible. Trends such as plant-
based and sustainability have also gained
momentum. The meaning of nutraceuti-
cals has therefore evolved drastically, and
the demands of the increasingly health-
and environmentally-conscious consumer
have accelerated the industry’s pursuit of
new ingredients and products that fit into
the nutraceutical category.
The challenge now is that while there are a
broad range of descriptions in circulation,
no universally understood definition of
‘nutraceutical’ has yet been agreed. Con-
sidering the diverse needs of this growing
industry, sending a clear and unified mes-
sage will be crucial to successfully appeal
to today’s consumer. In pursuit of an an-
swer, we asked 165 stakeholders from
across the health, wellness and nutraceu-
tical industries to share their opinions on
the meaning of nutraceutical.
Industry insights
The results confirmed the predicted lack
of clarity within the industry. While 45 per
cent of people surveyed described ‘nutra-
ceutical’ as ‘food that provides medicinal
or health benefits including prevention
and treatment of disease’, 26 per cent
think it is ‘food that has a component in-
corporated to give it a specific medical or
physiological benefit’. Another 21 per cent
defined nutraceuticals as ‘products made
from foods but sold in pills, powders and
other medicinal forms not generally asso-
ciated with food’. These results suggest
that perhaps the industry needs to find a
balance between medicine and food, as
well as the health, preventative and cura-
tive benefits of nutraceuticals.
This became evident when we asked in-
dustry respondents to select the most
accurate description of a nutraceutical
product. The benefit-led and universal-
ly understood terms such as ‘nutritional
supplements’ (44 per cent), ‘functional
(27 per cent) and health-related foods’ (15
per cent) were most popular, while the
more scientific and technical terms, such
as ‘medical food’ (10 per cent) and ‘phy-
tochemical’ (7 per cent), received much
fewer votes. When it comes to driving
consumer awareness and demand for nu-
traceutical products, these insights raise
the question if a less scientific but more
benefit-led term would create a stronger
appeal to consumers.
When asked to describe nutraceuticals to
friends and families, respondents again
focused on the benefits; ‘wellness, con-
sumer-friendly, feel-good’ and ‘natural,
effective, safe’, as well as terms that
highlighted the ‘innovative, challenging,
game-changing’ nature of the industry
- confirming the argument for establish-
ing a more mainstream and simplified
definition of nutraceutical. The industry
has a responsibility to work together to find
common ground on what a nutraceutical
is. How can we expect consumers to get
behind the benefits these products deliver
if we don’t communicate them clearly?
The full results and analysis of the survey
will be shared as part of the Sustainability
Square at Vitafoods Europe 2019, where
visitors will be able to find out more about
the latest consumer and market insights,
as well as debate the meaning of
nutraceuticals – now and in the future.
By facilitating this debate, we’re hoping to
dispel the confusion surrounding the term
and better understand the opportunities
and challenges that lie ahead. Ultimately,
a more unified vision of nutraceuticals will
create a more compelling and credible
appeal to today’s savvy consumer.
EXPLORING THE
EVOLVING MEANING
OF NUTRACEUTICALS
April 2019
..........................................................................
References
1 Global Wellness Economy Monitor (October
2018), Global Wellness Institute
..........................................................................
Marion Schumacher
Content Manager, at Informa
Health & Nutrition
N
nutra

04 | Nutraceuticals Now
contents
Editor:
Charles Faulkner
Operations Manager:
Daniel Peacock
Consultant:
Christopher McIntyre
Accounts:
Steve Clark
Designer:
Highland Print & Design
Published by:
Johnson-Johnsen Publishing

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IV2 3QA Scotland
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Email:
info@nutraceuticalsnow.com
Website:
www.nutraceuticalsnow.com
Printed by:
Harrisons
Available by subscription only
Nutraceuticals Now is a technical review providing
the latest information on functional products and
ingredients which are defined as having a disease
preventing and/or health promoting benefit in addition
to their nutritional value.
It is targeted at manufacturers of food and drink, who
are producing finished products aimed at the ever
increasingly health conscious consumer.
The opinions expressed in our published works are
those of the author(s) and do not reflect the opinions
of Johnson-Johnsen Publishing or its Editors.
Information contained in our published works have
been obtained by Johnson-Johnsen from sourc-
es believed to be reliable. However, neither John-
son-Johnsen nor its authors guarantees the accuracy
or completeness of any information published herein
and neither Johnson-Johnsen nor its authors shall be
responsible for any errors, omissions, or claims for
damages, including exemplary damages, arising out of
the use of or inability to use information, or with re-
gard to the accuracy or sufficiency of the information
contained in this publication.
All rights reserved. No part of any Johnson-Johnsen
published work may be reproduced, stored in a
retrieval system, or transmitted in any form or by
any means, electronic, mechanical, photocopying,
recording, or otherwise, without written permission
from the publisher.
ISSN - 1478-6605
ARTICLES
Foreword-Exploring the evolving meaning of Nutraceuticals..............................................03
Vitafoods Europe 2019: Show Preview..........................................................................................06
Business News........................................................................................................................................08-11
Demand for alternative protein sources continues to grow in Europe .............................12
Zynamite®
under the looking glass:................................................................................................13-14
Focus on reformulation......................................................................................................................16-17
Connecting mitochondrial biogenesis and aging.....................................................................16-17
Botanicals for a healthy heart...........................................................................................................18-19
Chitosan for natural healing and skin harmony.........................................................................20-21
Veri-teTM
Resveratrol for Bone & Joint Health: Explore the Possibilities...........................24-25
Enhancement of focus and sustained attention using alpinia galanga,.............................26-27
with or without caffeine
Vitamins K2 & D3: Essential companions for calcium..............................................................28-29
Searching for the key to longevity .................................................................................................30-31
Introducing joint comfort softgel: An innovative nutritional supplement.......................32
Fuel your body and mind with plant-based solutions..............................................................36-37
Interview: Healthy aging with calcium plus vitamins...............................................................40-41
Endogenous thresholds for athletically banned substances.................................................43-44
Innovation for when life is hard to swallow.................................................................................46-47
Clean label capsules: Harnessing the colors of nature to enhance the.............................48
consumer experience
Does the gut microbiome hold the key to preventing.............................................................51-52
and managing chronic disease?
Ayurvedic plants for leaky gut syndrome, damaged intestinal barrier...............................54&56
Science is our nature: Indena's approach in supporting sports nutrition.........................58-59
Long chain omega fatty acids: Their roles in supporting optimal health..........................60-61
and development in infants and children
Connecting mitochondrial biogenesis and aging.....................................................................62-63
FortiquinTM
boosts men's sexual performance naturally.........................................................63
ADVERTISERS
VitaeNaturals..................................................02
Lonza.................................................................05
Sabinsa.............................................................07
Frutarom..........................................................13
Zynamite..........................................................15
RSSL...................................................................17
Primex...............................................................22
NattoPharma..................................................23
Kaneka..............................................................27
Neumentix.......................................................33
enXtra...............................................................34
IFT19..................................................................35
Triskelion.........................................................38-39
Euromed..........................................................41
NSF.....................................................................42
Sibelius.............................................................44
Sintal Dietetics...............................................45
Quimdis............................................................49
Free from Expo 2019....................................50
Optibiotix........................................................53
Vidya Europe..................................................55
Taiyo..................................................................56
Indena...............................................................57
NTC Europe.....................................................59
Mitsubishi Gas Chemical America...........64

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As environmental awareness reaches new
heights and the world’s population contin-
ues to rise, the issue of providing sustaina-
ble foods which also offer a high nutrition-
al value is set to grow, in both importance
and complexity, over the next decade.
It is with these considerations in mind that
Vitafoods Europe 2019 has developed its
agenda.Thethree-dayevent(7-9May2019,
Palexpo, Geneva) will this year focus
on bringing the industry together to dis-
cuss key challenges such as sustainable
sourcing, and wider trends including free-
from, plant-based ingredients, and hemp
extracts and CBD.
This year’s show is expected to attract
22,000 visitors and will play host to over
1,200 leading global suppliers active in
ingredients and raw materials; dietary sup-
plements; contract manufacturing and
private label; and services and equipment,
exhibiting thousands of quality ingredients
and products.
As a meeting point for the nutraceutical
industry, Vitafoods Europe 2019 will offer
visitors an opportunity to source innova-
tive, high quality ingredients and finished
products conveniently at one location,
saving both time and resources, and
eliminating logistic difficulties.
The event has also added to its portfolio
and introduced a range of new features,
including a brand-new Sustainability
Square, which will showcase the latest
consumer and market insights from across
the industry, allowing visitors to make
informed and future-focused buying
decisions.
To clear-up any confusion around updated
or newly introduced EU and global
VITAFOODS
EUROPE 2019:
SHOW PREVIEWregulations and allow manufacturers to
speed up the process to market, Vitafoods
has invited experts from the European
Federation of Associations of Health
Products Manufacturers (EHPM), who will
be offering one-to-one consultations as
part of a new Regulatory Clinic.
While a new Clinical Trials Zone will offer
a step-by-step guide to the clinical trial
process, a Diversity & Inclusion Roundta-
ble will open the discussion on the impor-
tance of establishing diversity in the work-
force to create an inclusive environment
and the benefits this will bring.
Additionally, the Vitafoods Education
Programme will return this year with a
new flexible structure, giving delegates
the chance to attend specific sessions,
individual days or the full three-day agenda.
Running throughout the event the
programme will have 11 summits and over
50 industry and business experts, to discuss
and debate breakout trends and the
industry’s latest studies.
To give visitors the opportunity to network
in a more relaxed setting, supplemen-
tary events are also taking place across
the three days, including the Community
Breakfast, Diversity & Inclusion Round-
table, Nutrition Capital Network’s sixth
annual European Investor Meeting, Good
Manufacturing Practices (GMP) Training
by EAS Consulting Group, NutraIngredi-
ents Awards, 5K Run and Yoga Wellness
sessions.
Chris Lee, Managing Director, Global
Health and Nutrition Network, Europe, at
Informa Exhibitions, said: “Sustainability
is a crucial influencer in the purchasing
decision making process for consum-
ers who are becoming more health and
environmentally-conscious. This and the
need to provide enough food supply for a
growing population, has led us to identify
the sustainability of the industry as a key
concern and opportunity for the nutraceu-
tical industry.
“Our goal with Vitafoods Europe 2019 is to
bring the community together and open
the discussion about the challenges and
opportunities ahead. This way we hope to
encourage collaboration across the entire
nutraceutical industry and affect the move
towards true circularity.”
For more information on new and return-
ing features and to register for free tickets,
please visit: www.vitafoods.eu.com
Connecting the community
A key focus for this year’s Vitafoods Europe
is to connect the community to encour-
age collaboration and discussions around
key issues, such as creating a more
sustainable future for the nutraceutical
industry. While the dedicated zones, spe-
cialised theatres and other features will
own the stage from a professional point
of view, additional events are taking place
across the three days to give visitors the
opportunity to network in a more relaxed
setting. Events include the Community
Breakfast, Nutrition Capital Network’s sixth
annual European Investor Meeting, the
Diversity & Inclusion Roundtable, the Good
Manufacturing Practices (GMP) Training by
EAS Consulting Group, the NutraIngredi-
ents Awards, the 5K Run and the Yoga Well-
ness sessions. For more information, visit
vitafoods.eu.com/events.
For more information and to register for
free tickets to Vitafoods Europe, please
visit: www.vitafoods.eu.com
...............................................................................

08 | Nutraceuticals Now BUSINESS NEWS
BUSINESS NEWS • BUSINESS NEWS •E
Healthy ingredients have never been so
fun and flavorful to enjoy
Come see us at Vitafoods Europe 2019
where a number of natural, health-support-
ing ingredients will be featured in tasty ap-
plications that showcase Frutarom Health’s
ability to offer not only the ingredients
themselves but complete, turn-key integrat-
ed solutions.
Covering an extended range of health
benefits to address today’s driving health
concerns, Frutarom Health will present in-
novative natural ingredients that reflect the
global provider’s commitment to science
and quality. Come and taste the trends!
Frutarom’s commitment is also reflected in
the presentation of a new clinical study sup-
porting the positive effects on men’s health
of a unique ingredient manufactured using
the proprietary EFLA®
HyperPure production
process.
Afterward, join Vitafoods’ Education
Program and attend the Mental Wellness
Summit, where Itay Shafat, PhD, will be
presenting trends in new delivery systems of
functional foods and beverages for mental
wellness on Wednesday, May 8th at 10:30
AM.
It is all about natural ingredients supported
by science, now tastier than ever.
Visit us at Vitafoods Europe, Geneva, May
7-9 2019, Booth #J20.
FRUTAROM:
COME TASTE
THE TRENDS
is pleased to announce in association with a
Vulpes backed Cayman company, the creation
of a new business Seneb Products Limited. Si-
belius has exclusively licensed Chronoscreen™
Platform to Seneb for the investigation of the
Cannabis plant. The new laboratory will be lo-
cated at the Johnson and Johnson incubator,
JLabs, in the MaRS Centre, Toronto, Canada, a
country that fully federally legalized cannabis
in October 2018.
Over the last 12 months Sibelius has been under-
taking its largest ever investigation into a single
plant using the Chronoscreen™ Platform in order
that the new Seneb laboratory can undertake ob-
jective, detailed, verifiable investigations of bene-
ficial uses of cannabis with a view to the develop-
ment of innovative natural products
“At Sibelius, we have taken our investigative work
in the UK, as far as we can, within the current reg-
ulatory framework. This opportunity with Seneb
allows us to build on that great work” Peter Leyland
SIBELIUS
NATURAL
PRODUCTS
LTD.,
Seneb Products Ltd
Ankh Wedja Seneb is an Egyptian phrase common-
ly thought of as “life, prosperity, and health", and
even more beautifully described by one scholar as
‘Be alive, strong, and healthy"
Seneb Products Limited aims to apply this ancient
wisdom, alongside our very modern scientific
processes and understanding of genetics, to inves-
tigate one of the world’s oldest medicinal plants,
Cannabis sativa.
Our vision is for a world where Cannabis is backed
by deep research and being led by the science rath-
er than anecdote or plant lore.
Our mission is to help provide the best science to
the cannabis plant. A principal goal will be to con-
duct such investigations in a manner that allows
the science to guide us towards benefits, rather
than using anecdote and plant lore to determine
efficacy. Proud to announce that we will be occupy-
ing lab space in Johnson & Johnson’s Jlabs@To-
ronto at the Mars facility in downtown Toronto, our
vision is to take a proven and objective scientific
process, the proprietary Chronoscreen™ Platform,
utilizing the latest developments and apply them
to a plant that has been known for its therapeutic
benefit for millennia, including in ancient Egypt.
Cannabis is quite obviously a complex and phyto-
chemically rich plant; it’s now time to remove it
from the shadows and apply a scientific rigor to
its study that puts its effects within a framework of
detailed scientifically validated and verifiable
claims based on data and 21st century processes.

E• BUSINESS NEWS • BUSINESS NEWS
The global nutraceutical market is projected to
grow 8% per year (1)
-. This growth comes from
emerging countries, but also from aging popu-
lations, the rising cost of healthcare, increasing
on-the-go & health conscious consumers be-
ing proactive about their health, and consumers
selecting ingredients based on clean label or
dietary restrictions.
“Providing consumers with appealing, easy to take,
and affordable dosage supplements is our nutraceu-
tical customers’ first priority, which is why the perfor-
mance, quality and stability of their formulations is
our priority.” says Kelsey Achenbach, Head of Market-
ing Pharma at Roquette.
“Consumers increasingly want satisfying food choices
that they can feel good about and that better fit a
healthy lifestyle.” adds Virginie Teichman-Dubois,
Head of Marketing Food at Roquette.
Roquette is well positioned to meet these needs and
to help its customers get closer to the health &
nutrition market’s expectations. NUTRALYS®
pea
proteins, NUTRIOSE®
soluble fibers, GLUCIDEX®
nutri-
tive maltodextrins, SweetPearl®
maltitol and the XTAB
range of directly compressible polyols, including PEARL-
ITOL®
mannitol, NEOSORB®
sorbitol and XYLISORB®
xylitol… … this is just a glimpse of the solutions
offered by Roquette. Our ingredients are not only high
quality and affordable, they are also entirely plant-
based. These consumer-friendly solutions address key
challenges related to health, including Sports Nutrition,
changes in food consumption patterns and growing sup-
plement consumption around the world.
Come to meet us at Vitafoods and try our delicious sam-
ples addressing specific nutritional needs:
• Hi-protein RTD
Power your day or boost your workout with this vegan
high-protein, ready-to-drink beverage. Thanks to the
benefits provided by NUTRALYS®
pea protein and
NUTRIOSE®
soluble fiber, this on-the-go beverage
is high in protein and a source of fiber, and has a
delicious creamy texture. Non-dairy and non-soy, this
plant-based RTD is the perfect ally of sports nutrition.
• Vegan high-protein dough bar
With 25% protein -exclusively from NUTRALYS®
pea
proteins- this delicious vegan dough bar is dairy-free
and helps you feel full for longer while maintaining your
muscle mass.
• Indulgent table top fiber
Easily boost your fiber intake thanks to this easy-to-use,
sugar-free tabletop fiber with NUTRIOSE®
soluble
fiber. Additionally, NUTRIOSE®
has clinically proven
benefits for blood glucose management. Adding fiber to
your daily diet has never been so easy!
FORMULATING
PROMISING
NUTRACEUTICALS
TO HELP
MAINTAIN A
HEALTHY
LIFESTYLE!
(1) Nutraceutical Excipients Market Forecast to 2022, Markets and Markets.
(2) Roquette scientific poster on “The health benefits of NUTRALYS®
pea
protein in healthy volunteers: offering the best of plant-based nutrition to
meet specific needs at different steps of life”.
The health benefits of NUTRALYS®
pea proteins(2)
will also be displayed at the Vitafoods Europe Poster
Presentation area, after having been reviewed by the
Vitafoods Europe Executive Advisory Board.
Wish to meet active lifestyle challenges? Our technical
& nutritional experts will explain the scientific links
between the physiological and nutritional needs
of active individuals and introduce a new grade of
pea protein, especially designed for ready-to-drink
sports products. This free presentation will be given on
Tuesday 7th May from 11:40 to 12:10 at the Sports
Nutrition Theatre.
Roquette is dedicated to providing healthy and tasty
consumer-driven solutions as well as multifunctional
natural-based ingredients, so its customers can deliver
the highest-quality nutraceuticals to their customers.
The Roquette teams will be available to listen to your
needs and answer any questions at the Roquette booth
#I19.
Son, Netherlands – 15th April 2019 – Rousselot®
, a
Darling Ingredients global company and the leading
global producer of gelatin and collagen peptides, and
Pharmatech, one of Norway’s largest manufacturers
of natural medicine and health products, are proud to
announce the success of their cooperation to bring best-
in-class fortified confectionery to the EMEA market.
Thanks to Rousselot’s SiMoGelTM
, the renowned con-
tract manufacturer is the first company in Europe to
successfully qualify the production of gelatin-based nu-
traceutical gummies. A revolutionary solution, SiMoGel
was launched in 2018 and enables the production of
fortified gummies in a starch free environment, elimi-
nating the risk of cross-contamination associated with
the production in starch molds. The optimized produc-
tion process enables to create gummies with unmatched
gelatin texture with only a few minutes of drying.
The two teams worked closely on-site from the qualifi-
cation process throughout all industrial trials to develop
a specific sugar-free recipe, to optimize the production
process and lower the production costs.
“The partnership between Pharmatech and Rousse-
lot goes back a long way and we were delighted to
support them in this pioneering project with SiMoGel,
especially since they already had the necessary equip-
ment for molding the gummies. It was a pleasure to see
Pharmatech operators produce high-quality, fortified
gummies within a few hours.” explained Jeff Daelman,
Product & BD manager Rousselot.
“SiMoGel was proposed to us in early 2018”, Geir
Andreas Lund, Business Manager Pharmatech, said.
“Pharmatech was looking for a stable gelatin-based
formulation, starch free and easy to produce and
SiMoGel sounded perfect for our innovation projects.
By using SiMoGel we now have the ability to produce
more complex formulations with ingredients that are not
suitable for standard gelatin qualities.”
“The fact that SiMoGel is also available in a bovine
version is an added benefit which opens up a larger
market”, continues Lund.“Rousselot made the formu-
lation process extremely smooth by providing us with
SiMoGel samples and assisting on-site during the trials.
Thanks to the combined effort of both our teams and
the good technical advice from Rousselot, the end result
was very much satisfactory!”
ROUSSELOT
ANNOUNCES CONTRACT
MANUFACTURING
SUCCESS FOR FORTIFIED
GUMMIES IN EUROPE
Pharmatech is now able to offer a high-quality solu-
tion for all customers looking for premium functional,
nutraceutical or medicinal confectionery, produced in a
pharmaceutical FDA-approved facility. The flexible na-
ture of the production process allows to scale the batch
size to the customer needs, starting from as little as 500
kg, meaning between 75,000 and 250,000 gummies.
For any enquiries about a collaboration with Rousselot,
get in touch.

10 | Nutraceuticals Now BUSINESS NEWS
BUSINESS NEWS • BUSINESS NEWS •E
GLATT WILL PRESENT SMALL
FLUID BED SYSTEM FOR
LARGE AGGLOMERATION
REQUIREMENTS
Vitafoods 2019, booth D-133:
Compact, fast, economical: Glatt's new plant system starts continuous production of
added-value ingredients after an installation time of just 12 days.
At Vitafoods 2019 in Geneva, plant engineering and process development specialist
Glatt Ingenieurtechnik will be presenting a new plant concept for continuous powder
agglomeration: "GF ModFlex" is extremely economical, fits into any hall thanks to its
modular design and can be flexibly adapted to meet individual customer requirements.
Transferring fine powders and powder mixtures into uniformly porous, practically dust-free,
highly soluble and perfectly meterable granulates – this is what the new "GF ModFlex" plant
concept achieves in an endless loop, with consistent safety and quality guaranteed. Multi-step
and multi-zone processes offer almost unlimited freedom in product design. The space-saving
innovation is based on the established Glatt fluid bed technology and, thanks to gentle process
control, preserves the nutritional and functional properties of the products. With its compact
modular system, Glatt caters for manufacturers who want to upgrade or renew their machinery
at short notice, in certain space conditions, and with target production volumes of between 100
kg/h and 3000 kg/h. The Atex-compliant concept, equipped with WIP cleaning, also boasts
an extremely short installation time of just 12 days. A demand-oriented operating, room and
zone concept is also supplied, alongside the self-developed "GlattView Varia" control system.
Applications for which fluidized bed agglomeration is perfectly suited include vitamin formula-
tions,mineralsandtraceelements:theirbulkdensitymustbeadjustedsotheycanbefilledtoan
accuracy of one-hundredth of a gram in cans, capsules or sachets, or pressed into effervescent
tablets. This also applies to dried probiotics or sports drinks. In the case of protein shakes, high
porosity and wettability is vital for protein powders to dissolve without residue in water, milk
or plant-based drinks. Polyols such as xylitol, maltitol or lactitol, raw materials with added
value and components for premixes can also be optimally adjusted by agglomeration. In the
fluidized bed, powders for capsule and coffee pad systems are also precisely metered, flowable
and uniformly adjusted, and their particle structure specially adapted to the equipment and the
packaging design.
Nacka (Sweden), February 2019 – From improved vision to skin health, mental sharpness and
bettermuscleperformance,naturalastaxanthinoffersscientificallybackedbenefitsforhealthyage-
ing. As the global pioneer in natural astaxanthin cultivation and R&D, AstaReal will be presenting
itshigh-qualityproductrangeandvariousprototypesatthisyear’sVitafoodsEurope.Thecompany
willshowcaseeffervescenttablets,softgumsandinnovativebulkproductsallcontainingthepowerful
antioxidant. At AstaReal’s booth, visitors can learn more about dosage forms and the company’s
impressivecultivationprocess.Inaddition,AstaReal’sexpert,DrMarkMiller,willhighlighthowthe
naturalnutrientcansupporthealthyageingonTuesday7Mayat15:40attheLifeStagesTheatre.
Attendees will be guided through the latest research findings and consumer trends within this cat-
egorywhichrevealwhynaturalastaxanthinisbecomingapremieringredientforhealthyageing.
Derived from the microalga Haematococcus pluvialis, astaxanthin is a natural carotenoid. Unlike
otherantioxidants,itsuniquestructureenablesittotargetfreeradicalsintheinnerandouterlayer
ofthecellmembrane,thusprotectingcellsfromoxidativestress.Indoingso,astaxanthincanboost
HEALTHY AGEING
WITH NATURAL
ASTAXANTHIN
AstaReal is the Trusted Leader in
Natural Astaxanthin Cultivation, R&D
and Clinical Science.
AstaReal®
is Proven to Support:
• Skin Health and Anti-Aging
• Muscle Performance
and Anti-Fatigue
• Eye Health
To put AstaReal’s
expertise to work for you
in developing the best way
to use natural astaxanthin in
your product, visit us at Vitafoods Europe
or contact us.
www.astareal.se | info@astareal.se
Discover the Power of AstaReal®
muscleendurance,counteractfatigue,reduceinflammation,improveskintexture,andenhancecapil-
larybloodflowintheeyesaswellasinthebrain.Thismakesitavaluableingredientforsupplements
boasting healthy ageing benefits, and those targeting active consumers. Top health concerns among
olderconsumersaretheabilitytomaintainmobility,propervision,hearthealthandmentalsharpness.
Andie Long, Marketing & Sales Manager at AstaReal, says: “The demand for wellness products will
continue to rise. Functional antioxidants like astaxanthin that have tangible health benefits are per-
formingverywellonthemarket.Astaxanthin’spopularityisincreasingquicklyinEurope,notonlydue
to its antioxidant potential but also because it offers clinically validated benefits that consumers can
feelworking.AstaReal®naturalAstaxanthincanbeusedinmanydifferentformulastargetingsports
andrecovery,skinhealth,eyeandbrainhealth,cardiovascularsupportandimmunity.Inaddition,itis
scientificallybacked,safeandofthehighestquality.Thecultivationprocessourcompanyhasinplace
featuresthetightestcontrolsintheindustryandyieldsaningredientwithoutstandingpurity,stability
andwiththemostrigorousspecifications.”

E• BUSINESS NEWS • BUSINESS NEWS
TENSHI AND DOLCAS
ANNOUNCE JOINT VENTURE
New joint-venture company to focus on
commercialization of researched high-quality
ingredients
New Jersey, USA – Tenshi Kaizen Private, Ltd. (Tenshi),
Bengaluru, India, and DolCas Biotech, LLC (DolCas)
announce the signing of an agreement for the creation
of a joint-venture company. The joint venture between
Tenshi, a technology-focused specialty pharmaceutical
company, and DolCas, a leading US-based strategic
marketing and distribution firm specializing in branded
nutraceutical ingredients, will be incorporated under the
name of its signatories, DolCas-Tenshi Bioceuticals, Inc.
DolCas-Tenshi Bioceuticals (DTB) will focus exclusively
on the research, development, and commercialization
of novel nutraceutical lines for key global markets, in-
cluding the US, Canada, Europe, and Japan. The two
partners have equal interest and headquarters will be
based in New Jersey.
The joint venture will allow the new company to cre-
ate unique positioning for its products in the global
nutraceuticals, functional food and beverage markets.
It brings together the diverse capabilities of the two es-
tablished partners, both with many years of experience
in building and scaling innovative businesses.
Tenshi brings proprietary technologies in developing
and manufacturing highly bioavailable nutraceutical
products, and DolCas, with strong front-end capabilities,
will spearhead the commercialization and go-to-market
efforts. DolCas has a proven, 10-year track record in es-
tablishing and marketing for two leading nutraceutical
brands in the pain management and general well-being
categories.
“Tenshi is delighted to partner with DolCas to build a
significant branded dietary supplement business for
the global markets,” says Venkat Iyer, Co-Founder of
Tenshi. “We strongly believe that DolCas’ legacy and
reputation of bringing to market science-led dietary
supplements offers the perfect complement to Tenshi’s
development platform for its novel ingredients.”
According to industry reports , the global nutraceutical
market is projected to reach $578 billion by 2025,
driven predominantly by growing consumer awareness
of the value of nutraceuticals in conjunction with the
steady innovation of high-performance natural ingre-
dients.
“With DolCas’ exemplary go-to-market abilities, the
synergies of the two partners will accelerate the devel-
opment of, and accessibility to, affordable, high quality
nutraceuticals,” notes Iyer. “We are on course with the
launch of our first two products at VitaFoods 2019 in
May.”
“I am excited about our joint venture with Tenshi, an
impressive conglomerate of the pharmaceutical indus-
try,” says K G Rao, president of DolCas Biotech. “At the
hallmark of my 27th year in the nutraceutical sector,
I am looking forward to the positive impact this joint
venture will have in the space, and the contribution it
will make to the end-user. The new company will op-
erate with full vertical integration to ensure maximum
transparency for our clients and consumers. Borrowing
from pharma’s highly standardized manufacturing pro-
cesses and strict regulatory guidelines and expectations,
I see this venture contributing to the dietary supplement
landscape in a distinctive way.”
DolCas-Tenshi Bioceuticals will exhibit for the first time
at this year’s Vitafoods Europe 2019. The company is
entering the market with two new branded ingredient
launches.
Visit us at Vitafoods 2019 in Geneva, booth #F200
With a focus on preventing injuries and wear and tear,
GELITA will offer visitors to Vitafoods Europe in-depth
information on specific collagen peptides that support
the musculoskeletal system. Overuse-induced tendon
and ligament injuries are common in both amateur
and professional sportspeople. However, scientific studies
confirm that TENDOFORTE®
, which has been specifically de-
veloped to keep tendons and ligaments strong and flexible,
has both a preventive effect and accelerates regeneration,
helping athletes to return to their previous performance lev-
els more quickly.
The Bioactive Collagen Peptides®
stimulate the struc-
ture-forming cells of the tendons and ligaments to form
more matrix molecules and thus keep them powerful and
resilient. With its unique mode of action, this clean label
ingredient is especially suitable for the booming sports
nutrition market.
To show how this could work in a finished product, GELITA
has developed the Yoga Bar especially for the show. Visitors
are invited to taste it at the GELITA booth.
Plus, as it makes up 95% of the organic bone matrix,
collagen is also essential for strong and stable bones. A
GELITA’S COLLAGEN PROTEINS
PREVENT SPORTS INJURIES AND
PROMOTE FASTER HEALING
new study has investigated the long-term effects of specific
collagen peptide supplementation on bone health. Experts
will be available at the GELITA booth to talk visitors through
the promising results, which confirm a pronounced increase
in bone mineral density after FORTIBONE®
supplementa-
tion.
The modes of action of GELITA’s other collagen peptides have
also been scientifically proven. BODYBALANCE®
helps active
people to build muscle mass and reduce fat — and thus
get their figure into shape faster — whereas FORTIGEL®
promotes joint health by helping to rebuild cartilage tissue.
VERISOL®
, by contrast, has been specially developed to
promote beauty-from-within concepts.
Tailored fill release performance
By adjusting the production process of gelatine, GELITA can
modify the specific effect, timing and duration of the fill re-
lease of soft gelatine capsules to accommodate consumer
needs. The latest addition to its portfolio is GELITA® EC, the
first and only gelatine product for true enteric performance.
As of now, the company can deliver a wide array of fill re-
lease profiles and even eliminate the “fishy” side-effects of
omega-3 supplementation.
Experts on stage
GELITA’s leadership in the field of collagen proteins is
reflected in two presentations, which will take place in the
Life Stages Theatre and in the Sports Nutrition Zone:
• Tuesday 7 May, 13.00–13.30, Healthy Ageing Block,
Life Stages Theatre:
Dr Stephan Hausmanns, Vice President BU Health & Nutri-
tion, will present new perspectives on bone and skin health,
addressing bone density and healing, as well as beau-
ty-from-within, diabetic wound care and reduced steroid use
in skin disease
• Tuesday 7 May, 14.20–14.50, Sports Nutrition Theatre:
Suzane Leser, Director Nutrition Communication, will discuss
TENDOFORTE®
— the first collagen solution for stronger
connective tissue in sports and exercise, including emerging
science and a case study

....
Across Europe, the popularity of plant-
based and alternative protein sources
continues to grow. This is something
that is being driven by two factors. Firstly,
dietary habits are changing across the re-
gion, with consumers looking to reduce
intake of meat – a primary source of
protein intake. Secondly, protein con-
tinues to be highly popular among
everyday consumers whoassociate the
ingredient with maximizing health and
wellness.Thisisleadingtodemandfornew
product development based around al-
ternative protein sources. The key for
brands is ensuring that products are
deemed to be as tasty as “mainstream”
protein sources such as meat and dairy.
Consumers in Europe are cutting down
on meat. In Q4 2018, FMCG Gurus inter-
viewed 5,000 consumers across France,
Germany, Italy, Spain and the UK. The
research found that 18% of consumers
ae trying to reduce their intake of meat.
When probed as to why this was the
case, consumers were particularly likely
to cite health (18%) and sustainability (29%)
purposes. Meanwhile. 34% of consumers
identify themselves as flexitarian where
they are looking to limit their intake of
meat.
At the same time, consumers are
looking to maximize their intake of
protein. Indeed, a total of 40% of con-
sumers say that they want more protein in
their diet. This reflects how everyday con-
sumers are looking to increase their intake
of protein as they seek out products that
contain ingredients associated with offer-
ing a convenient health boost. In many
cases, this desire is one that is often aspi-
rational rather than a necessity, with many
consumers unable to cite how much pro-
tein they consumed in the last 24 hours
or what the daily recommended intake
of protein is. Nevertheless, as consumers
look to increase their intake of protein but
at the same time cut down on meat, plant-
based protein is becoming popular among
consumers. Currently, a total of 34% of
consumers cite plant-based food as a
source where they get their protein from.
When it comes to different types of plant-
based protein, consumers are most likely
to be familiar with quinoa, tofu and lentils.
When it comes to the benefits of protein,
mainstream consumers are more likely to
associate protein with general health and
wellness (36%) compared to muscle de-
velopment (31%). As such when it comes
to plant-based protein products, brands
should look to promote ingredients that
have the most awareness among con-
sumers and align these ingredients with
general – rather than specialized – health
benefits.
Consumers continue to become more
concerned about their health and contin-
ue to take an interest in different ingredi-
ents. However, it must be remembered
that when it comes to food and drink,
consumers are primarily motivated by
taste and indulgence. This is something
that can pose a challenge to the alterna-
tive protein industry, with 50% of consum-
ers saying that they believe plant-based
protein is inferior in taste compared to
animal protein. In the long-term, it is
important that plant-based protein is
deemed to be compromise-free in the eyes
oftheconsumerwhenitcomestotasteand
enjoyment.
In recent years, another alternative source
of protein that has been hyped in the in-
dustry is insect protein. However, whilst
there is demand for such products, it
needs to be noted that attitudes towards
insect protein is polarized. Whilst 36% of
consumers say that they would be willing
to try insects as a form of protein, a total of
55% say that they would not. When ques-
tioned why, 48% said that they find the
concept of eating insects to be revolting.
From a demographic perspective, younger
adults are much more likely than sen-
ior consumers to be open to the idea of
insect protein. Nevertheless, the reality is
that insect protein is likely to remain some-
thing of a specialist market as opposed to
having long-term mainstream appeal.
Across Europe, the popularity of protein
will continue to grow, driven by consum-
ers continuing to be concerned about their
health. At the same time, dietary habits will
continue to evolve, with consumption per
capita of red meat continuing to decline-
year-on-year. This will continue to pave
the way for new product development
around alternative protein sources. The
key for the industry is focusing on sources
that consumers know and trust and are
receptive to, and that taste is not seen as
an issue.
Mike Hughes is Head of Research and
Insight for FMCG Gurus
In Q4 2018, FMCG Gurus interviewed
10,000 consumers across 10 countries
on the topic of protein. The findings in
this article are based on 5,000 consumers
surveyed across France, Germany, Italy,
Spain and the UK
..........................................................................
DEMAND FOR ALTERNATIVE
PROTEIN SOURCES CONTINUES
TO GROW IN EUROPE

Demand for alternative protein sources continues to grow in Europe
Across Europe, the popularity of plant-based and alternative protein sources
continues to grow. This is something that is being driven by two factors.
Firstly, dietary habits are changing across the region, with consumers looking
to reduce intake of meat – a primary source of protein intake. Secondly,
protein continues to be highly popular among everyday consumers who
associate the ingredient with maximizing health and wellness. This is leading
to demand for new product development based around alternative protein
sources. The key for brands is ensuring that products are deemed to be as
tasty as “mainstream” protein sources such as meat and dairy.
Consumers in Europe are cutting down on meat. In Q4 2018, FMCG Gurus
nterviewed 5,000 consumers across France, Germany, Italy, Spain and the UK. The
research found that 18% of consumers ae trying to reduce their intake of meat.
When probed as to why this was the case, consumers were particularly likely to cite
health (18%) and sustainability (29%) purposes. Meanwhile. 34% of consumers
dentify themselves as flexitarian where they are looking to limit their intake of meat.
At the same time, consumers are looking to maximize their intake of protein. Indeed,
a total of 40% of consumers say that they want more protein in their diet. This
23%
17% 17%
14%
18%
France Germany Italy Spain UK
Proportion of consumers who have looked to
reduce meat intake in the last year. Q4 2018

mainstream consumers are more likely to associate protein with general health and
wellness (36%) compared to muscle development (31%). As such when it comes to
plant-based protein products, brands should look to promote ingredients that have
the most awareness among consumers and align these ingredients with general –
rather than specialized – health benefits.
Consumers continue to become more concerned about their health and continue to
take an interest in different ingredients. However, it must be remembered that when
it comes to food and drink, consumers are primarily motivated by taste and
indulgence. This is something that can pose a challenge to the alternative protein
industry, with 50% of consumers saying that they believe plant-based protein is
inferior in taste compared to animal protein. In the long-term, it is important that
plant-based protein is deemed to be compromise-free in the eyes of the consumer
when it comes to taste and enjoyment.
42%
49%
61%
46%
50%
France Germany Italy Spain UK
Proportion of consumers who believe plant
protein is not as tasty as animal protein. Q4 2018

ZYNAMITE®
UNDER THE
LOOKING
GLASS:We take a closer look at Nektium’s latest
science based innovation
........Interview
Question and Answer interview with
Dr. Julia Wiebe, Research and Development
Director: Nektium Pharma, Spain
...continued overleaf ~
Zynamite®
is the latest product from your
new product development pipeline and the
ingredient has already won an important
award. Can you briefly describe what it is
and what it does?
Zynamite®
is our patent-pending proprietary
extract of Mangifera indica leaves (mango)
and it is a highly versatile nutraceutical ingre-
dient for the enhancement of mental and
physical energy. The convergent results of our
in-vitro, ex-vivo, in-vivo studies, toxicological
studies and 5 double-blind, randomized pla-
cebo controlled clinical studies demonstrate
that Zynamite®
is not only safe and free of
cardiovascular and other side-effects, but it
has nootropic and ergogenic effects. The
nootropic activities include enhanced mental
activation, calculation performance, faster
reaction time, and reduced stress and fatigue,
while the sports performance activities include
increased power output, brain and muscle
oxygenation, and VO2max.
Why were you interested in developing a
product from mango leaves and can you
tell us a bit more about how your product
development process unfolded for this
ingredient?
Four years ago, after noting the worrying glob-
al trend of increasing adverse reactions from
excessive consumption of highly caffeinated

also be exploited to dramatically reduce the
dose of caffeine in a product. These results
have been published (Dimpfel et al. 2018).
We have completed 5 RCT clinical trials in
humans with Zynamite®
, and a further two
clinical studies on sports performance that will
be concluded by the 4th quarter of 2019. Two
clinical trials demonstrated the mental activa-
tion activity of Zynamite®
through changes
in brain cortical electrical activity (quantitative
EEG) in response to cognitive challenges. We
could also show improvement of reaction
time and exclude negative cardiovascular
effects, with no changes in blood pressure or
heart rate variability.
After seeing these positive CNS results we
wanted to interrogate the ergogenic effect of
Zynamite®
in two caffeine-free patent pend-
ing formulations. Professor Jose López Cal-
bet, one of Europe’s leading academic sports
physiologists was the Principal Investigator of
theserandomized,doubleblind,placebo-con-
trolled studies conducted at the University of
Las Palmas in Spain. These studies focused
on power output, oxygen consumption and
cerebral oxygenation. Mean power output
and peak power output, typical measures of
athletic performance during exercise, were
studied. The results were astounding! Zyna-
mite®
containing formulations were shown
to exert a remarkable ergogenic effect in
fatigued male and female subjects, increased
both peak and mean power output and also
increases peak VO2 (oxygen consumption)
and brain oxygenation during prolonged
sprinting. The results of these two studies
have been published (Gelabert-Rebato, M. et
al. 2018, and Gelabert-Rebato, M. et al. 2019).
That sounds like a powerful ingredient! How
does it actually work in the body?
Zynamite®
is a complex standardized
polymolecular ingredient that acts non-selec-
tively on multiple CNS targets to achieve its
profound mental activation effect. We stud-
ied the binding and enzyme inhibition of
Zynamite®
on 90 CNS targets, and found that
the major bioactive in Zynamite®
, mangiferin,
is a COMT inhibitor enhancing endogenous
noradrenergic and dopaminergic signaling.
Interestingly, mangiferin did not bind to aden-
osine receptors, or inhibit PDE4, activities
foundforcaffeine,andcontributingtoadverse
effects of caffeine in high doses. Interesting-
ly, COMT-inhibitors are targets for treating
addiction, as we discovered that Zynamite®
does not cause dependence or tolerance. It
can further be extrapolated from our ex-vivo
LTP study that modulation of glutamatergic
signaling plays a role, while attenuation of
prominent alpha-2 wave in the in-vivo EEG
supports that there is modulation of dopamin-
ergic signaling.
Metabolomic and transcriptomic studies have
shown that isolated mangiferin enhances the
expression and activity of succinate dehydro-
genase, leading to increased ATP production.
At the transcriptional level, mangiferin induced
mRNAs of mitochondrial genes and their
transcriptional factors. These data suggest
that mangiferin upregulates mitochondrial
oxidative capacity.
So, it looks like Zynamite®
works similar to
caffeine but through an entirely different
mechanism and doesn’t have the negative
side effects of caffeine? This is an ingredient
sports fanatics will love! Is it safe to use?
Yes, you’re right, we are very excited by the
enormous potential of this disruptive innova-
tion! Zynamite®
does not have any negative
side effects, it has a better ergogenic activity
than caffeine. If we look at results for caffeine
in sports performance, the increase of power
output reported is around 2-4% (in those stud-
ies that showed an effect at all, some studies
showed no effect) while Zynamite®
improved
power output 5-7% in fatigued conditions, and
11-19% in the most extreme fatigue of exercise
post ischaemia-reperfusion.
We invested in two in-vivo toxicology studies
on Zynamite®
, a 14-day repeat dose study,
and a 90-day repeat dose study with the
USA company AIBMR. Both studies proved
that Zynamite®
did not cause adverse physi-
cal, behavioral or histological effects in rats
in the highest daily doses used of 2000mg/
kg bw/day. Our toxicology research has
been submitted for publication. Zynamite®
is
also doping-free, tested for the presence of
WADA-banned substances by NSF Interna-
tional, and is non-addictive.
What do you plan for the future of
Zynamite®
?
We anticipate a great future for Zynamite®
.
It´s an innovation with enormous potential.
We expect the ingredient to be widely used
in place of caffeine for its nootropic and ergo-
genic activities in diverse finished products by
men and women of all ages. This is the perfect
time for a lifestyle ingredient that can enhance
mental energy, focus and concentration, and
physical performance and endurance.
Nektium has invested a great deal in the
research supporting the ingredient and the
protection of intellectual property. In addi-
tion to trade secrets relating to the extract
process, Zynamite®
is protected by three
international patent applications. Our strategy
is to build Zynamite®
into a strong, perennial
evidence-based brand through continued
investment in clinical studies.
products, our R&D and innovation team
began a global search for a safe and effective
ingredient that could not only replace caf-
feine, but be superior to caffeine. The highly
challenging research imperative we commit-
ted to was to develop a rapidly acting botan-
ical extract with nootropic and sports perfor-
mance activities, free of cardiovascular and
other side-effects, and without addictive and
tolerance potential.
We are fortunate that Dr. Nigel Gericke, a
medical doctor and ethnobotanist was part of
our discovery and innovation team and under
his guidance we started the challenging quest
for a botanical with these unique attributes.
Our search involved extensive reviews of the
international ethnobotanical literature, of the
uses of plants in the traditions of Ayurvedic
Medicine and Traditional Chinese Medicine,
and reviews of Nektium’s own ethnobotanical
records from European, Russian, Amazonian,
and African plants.
An initial selection of fifty botanical candidates
was made and reviewed in terms of safety,
potential efficacy, plant chemistry, pharma-
cology, sustainability of supply, and cost of
production among other criteria. Multivariate
analysis revealed an intriguing pattern among
the candidate plants, revealing that a cluster
of disparate species contained appreciable
concentrations of the xanthone mangiferin.
Since there was a well-established safe food
and beverage use of leaves of the mango,
Mangifera indica, which are rich in mangifer-
in, we decided to make a proprietary stand-
ardized extract of the leaves, and then took
this special extract (M52P), which we later
trademarked as Zynamite®
, into pre-clinical
and clinical research.
Can you briefly share the results of your
pre-clinical and clinical research on
Zynamite®
?
We first did a Long-Term Potentiation ex-vivo
study which demonstrated that Zynamite®
displayed a similar Long-Term Potentiation
activity to caffeine in the hippocampus of
rats. This classical pharmacology indicates
potential in enhancing memory and attention.
We conducted cutting edge in-vivo studies
on the effect of Zynamite®
on brain electrical
activity (EEG) from the frontal cortex, hip-
pocampus, striatum and reticular formation of
nine rats. From this study we could conclude
that bioactive compounds in Zynamite®
cross
the blood brain barrier to give a similar pattern
of stimulation of the central nervous system
to caffeine. Since Zynamite®
, combined with
caffeine, results in a synergistic stimulant
action, we could conclude that the two have
different molecular mechanisms of action,
which we confirmed through receptor
binding studies.
Zynamite®
can thus be characterized as a
novel natural nootropic that can be used to
replace caffeine. The synergy of Zynamite®
in
combination with low doses of caffeine can
...continued from the previous page ~
..........................................................................
References
Dimpfel W. et al. 2018. Zynamite®
(Mangifera indica
leaf extract) and caffeine act in a synergistic manner
on electrophysiological parameters of rat central nerv-
ous system. Food and Nutrition Sciences, 9(05), p.502.
Gelabert-Rebato, M. et al. 2018. Mangifera indica L.
leaf extract in combination with luteolin or quercetin
enhances VO2peak and peak power output, and pre-
serves skeletal muscle function during ischemia-rep-
erfusion in humans. Frontiers in physiology, 9, p.740.
Gelabert-Rebato, M. et al. 2019. Enhancement of Ex-
ercise Performance by 48 Hours, and 15-Day Supple-
mentation with Mangiferin and Luteolin in Men. Nutri-
ents, 11(2), p.344.
..........................................................................

From alternative fats and plant-based
proteins to cannabidiol (CBD oil), the food
industry is constantly reinventing itself with
a stream of ingredient innovations. Getting
to grips with changing dynamics is a daily
challenge for formulators, but one which
can be addressed with the right techni-
cal approach. Carole Bingley, Technical
Specialist – Product and Ingredient Inno-
vation at Reading Scientific Services Ltd
(RSSL) explains.
Product reformulation has become a
driving force in many manufacturers’ de-
velopment strategies. Consumers seeking
new taste experiences, adopting flexitar-
ian eating habits or choosing sustainable
brands are just some of the recent trends
influencing new directions. Factor in the
added pressure of high-profile health
initiatives - such as achieving the 20%
sugar content reduction target content
set by Public Health England - and it’s not
surprising that revamping product portfolios
remains firmly on the agenda.
From a technical perspective, however, any
change to a product’s formulation can’t be
viewed in isolation. Such is the inherently
complex nature of product recipes, process-
ing and packaging regimes that an adjust-
ment in just one ingredient can potentially
impact any number of product characteris-
tics; from texture and flavour to stability and
flow behaviour.
That’s why it is so important to take a ho-
listic view; where every aspect of the im-
pact of the specified ingredient is analysed
and understood in the context of the over-
all product concept, so that any neces-
sary adjustments measures can be taken
to ensure consistently positive product
performance.
In the world of health and wellness,
redesigning products to align with the lat-
est trends is nothing new. But for formu-
lators focused on creating the required
nutritional profile or integrating the latest
fashion-forward ingredient, understand-
ing how these changes impact overall
product quality is essential.
‘Healthy’ fats
The replacement of highly saturated fats
with mono- and poly-unsaturated alterna-
tives has long been supported on health
grounds due to their associated benefits
with heart and brain functions. In addition,
palm oil has come under scrutiny recently
due to environmental concerns which has
accelerated moves to find sustainable or
completely different sources across food
applications.
Whatever the rationale for reformulating
with lower saturated fats, consideration
must be given to two important effects.
Firstly, let’s consider the physical properties
of the food. Fat provides a number of func-
tional properties during processing and
in the final product, which are depend-
ent on the physical properties of the fat.
Unsaturated fats, such as rapeseed and
sunflower oil, have a lower melting point
and are therefore more liquid at room
temperature compared to their saturat-
ed counterparts. In bakery products for
example, this may require changes in the
formulation and process to compensate for
the inability to cream liquid oils with sugar
during cake making.
Other applications may also need attention.
Cereal bars, for example, can appear greasy
as a result of oil moving within the food ma-
trix and migrating to the surface, while the
use of a softer fat in the creamer in pow-
dered beverages may cause the product to
clump and not rehydrate as easily.
Secondly, let’s consider rancidity. Caused
by the oxidative deterioration of unsatu-
rated fats in foods, this is one of the ma-
jor causes of quality deterioration in foods
and is marked by unpleasant odours or fla-
vours. Highly saturated fats have a greater
resistance to oxidation, so replacement with
unsaturated oils will reduce this effect and
consequently shorten the shelf-life of the
product.
These reformulation issues can be ad-
dressed using advanced techniques de-
signed to evaluate the potential impact on
product quality and organoleptic character-
istics. A Thermal Desorption Unit (TDU) GC-
MS, for example, can be used to measure
the individual compounds that are respon-
sible for giving the rancid off-notes caused
by oxidation of the products. Analysing lipid
oxidation markers at concentrations which
extend below the perceivable sensory
threshold levels for off-odours and off-tastes
(in the parts per billion (ppb) to parts per mil-
lion (ppm) range), enables the early stages of
oxidation to be monitored.
In addition, because the TDU method does
not involve sample extraction it can be ap-
plied directly to both raw ingredients and fin-
ished products. This end-to-end evaluation
not only improves consistency of results, but
is also much quicker than traditional tech-
niques and an ideal way to monitor the oxi-
dation of fats within food over time.
Vital vitamins
When it comes to reformulating products
containing vitamins and minerals, the main
problem formulators need to address is sta-
bility. Many factors can affect whether vita-
mins (and any other active ingredients) can
survive in the product up to its proposed
use-by date. These include the presence of
oxygen, light and other vitamins. Even minor
modifications to the formulation can have a
major impact.
In practice this means that any changes to
a fortified product - such as the introduc-
tion of a new botanical - can cause inter-
ference with the vitamins already present.
As a result, the original methods designed
to validate their presence in the matrix
can be rendered ineffective. This clearly
has major implications for brands in terms
of labelling and on-pack claims
substantiation.
Boosting the nutritional content of a pro-
tein shake, for example, may mean that
one or more vitamins in the formulation
can no longer be analysed using the orig-
inal extraction method - despite having
previously been successful in validating
both shelf life and label claims. Similarly,
expanding an established beverage range
with the introduction of a different flavour
can sometimes cause similar interferenc-
es. The flavour may degrade over time
and the degradants may impact on the
original analysis process so that it is not able
to accurately quantify vitamins in the new
product - even though this aspect of the for-
mulation has not been altered.
Changes may also be made to the vitamin
format. A move from liquid to encapsulated,
for example, may be deemed advantageous
in terms of improved solubility or product
stability. But again, such steps could impact
on the analysis of the vitamin in the product;
the method may no longer be fit for pur-
pose and result in the need to optimise the
extraction procedure of the analytical meth-
od in order to support label claims.
Plant power
One of the hottest food trends of recent
years, the plant-based revolution shows no
signs of slowing and product developers are
naturally keen to capitalise on this growing
market. Achieving a formulation with the
desired characteristics, however, is often
not an easy task and requires a high level of
technical expertise due to the inherent prob-
lems associated with these ingredients.
Using plant proteins in place of dairy
sources, for example, in a bid to appeal
to growing vegetarian and flexitarian
audiences raises issues of texture and fla-
vour. Soya and pea are well-known for their
distinctive taste and careful selection of the
cleanest tasting protein source together
with flavour masking may be required to op-
timise acceptability. Some of the newer pro-
teins on the market can be even more chal-
lenging in this respect and some bring the
added issue of a visually unappealing colour.
Gritty sedimentation caused by the lower
solubility of these plant protein ingredients
may also be an issue, but this can be mini-
mised by modifying any hydrocolloids pres-
ent to improve suspension and create the
desired creamy texture - a measure which
is particularly important in beverage applica-
tions.
In addition, the lower quality of some plant
proteins compared to milk based options - as
determined by the PDCAAS method of eval-
uation which assesses both the amino acid
profile and digestibility - means that different
sources may need to be blended together
to achieve the required protein profile. For
example, in sports nutrition products, this
may translate to a formulation containing a
careful combination of three different plant
proteins; pea protein (high in lysine but low
in cysteine and methionine) with rice and
FOCUS ON
REFORMULATION

Carole Bingley
Technical Specialist – Product and
Ingredient Innovation at Reading
Scientific Services Ltd (RSSL)
oat proteins (low in lysine but relatively high
in cysteine and methionine).
Indeed, this ability to draw on specialist in-
gredients expertise is vital when working
with different sources and types of plant
protein; each of which has individual char-
acteristics which must be understood in the
context of each application, so that com-
pensatory steps can be taken to create a
well-balanced product.
With so much attention focused on
plant-based ingredients, keeping pace
with developments in order to capital-
ise on emerging trends requires an agile
approach to formulation. New ingredients,
come with new challenges which need to
be understood. One of the most recent ex-
amples is CBD oil. Although its use in food
and drinks has not yet secured regulatory
approval, this hemp derived extract is already
gathering momentum as some manufac-
turers seek to make the most of consumer
interest by incorporating CBD flavours into
beverages.
This is just one emerging trend but it demon-
strates the need for product developers to
be able to adapt formulations - and under-
lines the importance of having access to
technical specialists capable of developing
analytical methods to target novel ingredi-
ents.
Formulating a strategy
Of course, reformulating a product can also
lead to new challenges in the manufactur-
ing process. Understanding how the modi-
fied product is likely to behave under exist-
ing processing conditions is a critical part of
any development project.
Any problems in terms of texture, taste, ap-
pearance or quality, resulting from changes
to the formulation, will need to be resolved
at key points in the production process. For
example, changes may affect:
• Flow behaviour: Due to a difference in
particle size distribution or moisture absorp-
tion. A liquid oil, for example, would reduce
viscosity in a cake batter. Solutions may in-
clude measuring flow powder behaviour
and tailoring the design of common equip-
ment such as silos, hoppers, dosers and
screw feeders.
• Product caking and re-crystallisation:
Potential risks of this unwanted phenom-
ena can be identified and prevented us-
ing techniques such as Dynamic Vapour
Sorption (DVS) which investigates moisture
absorbance of powders - and so helps to
determine critical processing and relative
humidity. Sugar and salts are also important
ingredients for regulating free water.
• Shelf-life: The evaluation of water activity
on a formulation over time or in conditions
that accelerate aging can be used to esti-
mate the shelf life of the new formulation.
Knowledgeable selection of ingredients can
also help to prevent rancidity, such as the
use of sugar and hard fat in cereal bars.
Only by building a detailed picture of the
many factors involved with the production
of a reformulated concept - from manufac-
turing to distribution, storage and use by the
consumers - can developers be confident
that the repositioned product will deliver
on every level. A strategy which requires
an extensive range of scientific techniques
and expertise in order to ensure an efficient
development process.
..........................................................................
For further details contact customer services on:
Tel: +44 (0)118 918 4076 Email: enquiries@rssl.com Web: www.rssl.com
Optimal Solutions for Functional
Foods and Ingredients
RSSL provides a comprehensive range of
services to assist you with product
development, claim substantiation, taste
optimisation, due diligence, labelling and
ingredient stability of foods, ingredients
and supplements.
Our expertise in a wide range of matrices includes:
yy Product development
yy Analysis – vitamins, minerals, functional
ingredients, natural products, lipids and herbals
yy Stability studies
yy Analytical method development and validation
RSSL Nutraceuticals magazine Feb 2015 AW.indd 1 10/04/2019 16:08

Cardiovascular diseases (CVD) are current-
ly one of the greatest global health chal-
lenges. While many people will develop
some form of CVD, it is not an inevitable
part of ageing. Lifestyle factors are a sig-
nificant contributor to heart health issues.
Balanced nutrition from a young age helps
prevent CVD, while regular exercise can
counteract high blood pressure and high
cholesterol levels before they become
problematic. However, many people, in-
cluding the younger generation, are now
beginning to recognise the role nutrition
can play, and are turning to natural ingre-
dients to help support their cardiovascular
health.
Olives: trusted since ancient times
Olive oil is widely known to have proven
Andrea Zangara, Scientific Marketing Manager at Euromed
health benefits. As a key component of the
Mediterranean diet, which is linked to low
levels of CVD mortality, it is rich in unsatu-
rated fatty acids and polyphenols. Inspired
by the Mediterranean eating pattern, Eu-
romed has developed the natural olive
fruit extract Mediteanox™. The company
is a leading producer of standardised herb-
al extracts and natural active substances
for the international pharmaceutical, nu-
traceutical, food and cosmetic industries.
Annually, a biomass of more than 5000
tonnes is extracted at Euromed’s manu-
facturing facilities in Spain.
Based on its high standardised content
of hydroxytyrosol — a natural antioxidant
polyphenol — Mediteanox™ can contrib-
ute to promoting healthy blood circulation
and reducing LDL cholesterol oxidation
levels. Oxidised LDL cholesterol is a risk
factor for atherosclerosis. Produced us-
ing a proprietary osmotised water-based
extraction process, this ingredient has US
and European patents related to its use for
cardiovascular health applications.
According to EFSA, olive oil polyphenols
(antioxidants) contribute to the protection
of blood lipids from oxidative damage.1
To carry this claim, the daily intake must
contain at least 5 mg of hydroxytyrosol and
its derivatives in 20 ml of olive oil. Euromed
owns a patent-protected process to pre-
pare Secret to Live®
, an extra virgin olive
oil (EVOO) enriched with Mediteanox™ to
support cardiovascular health. With more
antioxidants than conventional non-forti-
fied olive oils, unpublished research with
Secret to Live®
suggests that an intake of
just 20 ml per day reduces the oxidation
of LDL cholesterol by 35 per cent com-
pared with regular EVOO (with an average
hydroxytyrosol level). The suggested daily
dose of 20 ml of Secret to Live®
delivers
5 mg of natural hydroxytyrosol and other
beneficial compounds naturally present in
EVOO. The physical properties of the oil
and taste are unaffected by the enrich-
ment process.
The PREDIMED trial2
, which looked at the
BOTANICALS
FOR A
HEALTHY HEART
long-term effects of a Mediterranean diet
in people at high risk of a cardiovascular
event, further supports the heart healthy
benefits of olive oil polyphenols. Over
five years, Mediterranean diet participants
who supplemented with extra virgin olive
oil had a 30 per cent decrease in cardio-
vascular events compared to those on a
low-fat diet. Those following a Mediter-
ranean diet also had improved blood
pressure, insulin sensitivity, lipid pro-
files, lipoprotein particles, inflammation,
oxidative stress and carotid atheroscle-
rosis. Euromed’s most recent published
data from a study3
with a combination of
Mediteanox™ and Pomanox™ are consist-
ent with some of the benefits observed in
this study.
The goodness of whole pomegranate
One of the most important age-related
changes in the cardiovascular system is
endothelial dysfunction. This is caused
by the synergy of inflammation, reduced
antioxidant capacity, dyslipidemia and in-
creased blood pressure, all of which occur
naturally during ageing. In turn, endotheli-
al problems raise the risk of cardiovascular
diseases. With a global population that is
getting increasingly older, preventative ap-
proaches are vital.
For this reason, Euromed has developed
Pomanox™ – a full-spectrum polyphenol
pomegranate extract. Through an an-
ti-inflammatory mechanism, it has been
shown to lower both blood pressure and
cholesterol levels, and helps to improve
endothelial health. In addition, it works
as an antioxidant and has a positive effect
on endurance and mood. The source of
these benefits are punicalagins, pome-
granate-derived, water-soluble polyphe-
nols. Proprietary water-only extraction
technology, the Pure-Hydro Process™,
makes for an extra-safe product, free from
toxic alkaloids potentially linked to alco-
holic solvents.
Since evidence suggests that pomegran-
ate juice consumption may alleviate CVD
risk factors, a double-blind, randomised,

placebo-controlled exploratory study
investigated the effects of consuming
pomegranate extract on blood pressure,
insulin resistance, stress hormone levels
(cortisol/cortisone) and quality of life in 29
healthy volunteers.4
All participants con-
sumed either a Pomanox™ capsule with
210 mg punicalagins – the recommended
daily intake to obtain the beneficial effects
of these antioxidants – or a placebo daily
for four weeks.
Blood pressure, salivary cortisol and
cortisone levels were assessed, and fasting
blood was also obtained and compared
to glucose, insulin and insulin resistance
parameters. The researchers found that
systolic blood pressure was significantly
reduced in the Pomanox™ group from
120.3 to 115.6 mmHg. Also, there was a
27 per cent reduction in insulin resist-
ance, and glucose, insulin and uric acid
all decreased from baseline. No signifi-
cant changes were recorded in volunteers
taking the placebo. Pomegranate extract
consumption caused a significant drop of
salivary cortisol levels, which may prove
beneficial for people suffering from chron-
ic stress. Likewise, those taking the pome-
granate extract capsules experienced
significant improvement in general health.
These results suggest that Pomanox™
intake may ameliorate cardiovascular risk
factors, reduce stress levels and improve
overall quality of life.
High blood pressure is the greatest con-
tributor to CVD worldwide and one of the
most common risk factors. Thus, another
randomised, double-blind, placebo-con-
trolled clinical trial investigated the effect
of Pomanox™ on blood pressure and
body composition in 55 healthy adults.5
Participants were assigned to consuming
capsules either with pomegranate ex-
tract or a placebo for eight weeks. In the
Pomanox™ group, there was a significant
decrease in diastolic blood pressure after
eight weeks by 2.79 points, with no chang-
es in body composition. In conclusion,
pomegranate extract may reduce blood
pressure and, as a consequence, help
maintain normal blood pressure in the
normotensive population during aging.
In addition, supplementation with Poman-
ox™ and Mediteanox™ appears to have a
synergistic, beneficial effect on endothelial
function: a clinical study just published by
Nutrients, evaluated the combined admin-
istration of Mediteanox™ and Pomanox™
on 67 apparently healthy middle-aged vol-
unteers. The 8-week intervention with the
supplement exerted anti-atherosclerotic
effects, compared to placebo, by improv-
ing endothelial function, blood pressure,
and levels of circulating oxidised low-den-
sity lipoproteins, especially in middle-aged
persons showing alterations in these
parameters, as reported by the authors.3
Quality and traceability
Mediteanox™ and Pomanox™ are per-
fect for inclusion in food supplements,
functional foods, cosmetics and pharma-
ceuticals. They are manufactured using a
patented, eco-friendly extraction process
without organic solvents. As a herbal in-
gredient supplier, quality management
and supply chain controls are key to Eu-
romed. The company starts with botani-
cals that are verified, grown and harvested
properly to preserve plant integrity and
bioactive profiles.
Each production batch, from the herb to
the final extract, undergoes at least 20
laboratory tests for identity, potency and
potential impurities to guarantee the high-
est standards. From botanical macro- and
micro-identification to chromatograph-
ic analyses, the company tests plant raw
materials exhaustively, in accordance with
international regulations. With Euromed’s
PhytoProof®
seal, manufacturers can high-
light the reliable sourcing and quality of
the botanicals on their herbal supplement
labels.
Outlook
As long as CVD remains a serious risk for
consumers, there will be a demand for
nutritional solutions and a market for car-
diovascular health-supporting ingredients.
Consumers also recognise that there are
many factors involved with heart health,
and particular concerns require tailored
nutritional intervention. With its broad
range of natural extracts, Euromed can
help manufacturers meet the demands
..........................................................................
References
1 COMMISSION REGULATION (EU) No. 432/2012
(May 25th, 2012).
2 Estruch R. et al., N Engl J Med. 2013;368:1279-
1290.
3 Quirós-Fernández R. et al., Nutrients 2019, 11,
640.
4 Stockton A. et al., EC Nutrition. 2015; 2.4:396-411.
5 Stockton A. et al., J Nutr Sci. 2017 Aug 9;6:e39.
..........................................................................
of a rapidly expanding global nutraceu-
tical market that is looking for pharma-
ceutical-grade, plant-based solutions that
support health and wellbeing.
Sustainability is key
Today’s consumers demand more from
their products, including sustainable har-
vesting and supply chain transparency.
Thus, Euromed is engaging in strategies
that emphasize the company’s commit-
ment to better business practices for the
planet. For instance, Euromed is one of 17
inaugural underwriters of the Sustainable
Herbs Program – a partner of the Amer-
ican Botanical Council (ABC) and a new
educational resource for the internation-
al herb and medicinal plant communities
that promotes responsible information on
herb sustainability. It is aimed at increas-
ing awareness of sustainable sourcing to
benefit all parties involved in the supply
chain, from growers and businesses to
consumers.
www.euromed.es

Our skin epidermis is continuously re-
newed by a process called homeosta-
sis, maintaining a barrier that protects
us against major environmental stresses.
An inability to correctly maintain the skin
barrier function due to the dysregulation
of epidermal components can lead to skin
disorders. Natural products, like chitosan,
can help to protect our skin and contrib-
ute to its homeostasis. Chitosan is a natural
and biocompatible amino-polysaccharide
with structural functions along with several
biological properties to benefit our skin in
so many ways.
Our skin, the largest organ of the body, is
composed of three main layers of tissue
with the epidermis being the one in contact
with our environment. The skin epidermis is
continuously renewed by a process called
homeostasis. Although barely thicker than
paper, the skin epidermis protects us against
major environmental stresses, such as water
loss and microorganism infection. The
stratum corneum, the outermost layer of
the epidermis, is the efficient biological
barrier that regulates epidermal permeabil-
ity and homeostasis. External factors, like
stress, sleep deprivation, humidity changes
and soaps, will destabilize our skin leading
to decreased lipid levels, increased pH, de-
creased barrier function and increased tran-
sepidermal water loss. This will result in a
drier skin with deprived barrier properties. An
inability to correctly maintain the skin barrier
function due to the dysregulation of epider-
mal components can lead to skin disorders.
How can chitosan help in supporting
skin healing and homeostasis
Chitosan is a natural polymer obtained by
deacetylation of chitin extracted from crus-
tacean shell. Chitin is similar to cellulose,
but it is a long chain polymer of N-acetyl-
glucosamine units with ẞ-(1->4)-linkages.
Chitin is deacetylated to obtain the desired
chitosan products, resulting in a range of
natural amino-polysaccharides with dif-
ferent properties. Chitosan therefore pos-
sesses amino/actamido groups along with
both primary and secondary hydroxyl func-
tional reactive groups. The arrangement
and distribution of these functional groups
are the main factors contributing to the
chitosan structural, physical and chemical
properties1
. Once dissolved under mild acid-
ic conditions (pH <6) chitosan becomes
positively charged (NH3+), contributing
to its mucoadhesive properties. Chitosan,
being non-toxic and the only naturally oc-
curring cationic polymer, is an interesting
alternative in skin care and medical products
because of its beneficial biological proper-
ties; being biodegradable2
, biocompatible,
antioxidative, mucoadhesive, film-forming3
,
hemostatic4
, antimicrobial5
, analgesic6
and
stimulating healing7
.
Chitosan exhibits structural similarity to
glycosaminoglycans (GAGs) of the skin ex-
tracellular matrix, which have an important
role in cell-to-cell adhesion8
. Due to the
positively charged amino groups in the chi-
tosan structure under acidic environment,
it has the ability to bind negatively charged
components9
. Chitosan is used in cos-
metic and personal care formulations as a
film-forming or hair-fixing agent. A chitosan
film formed on the skin can prevent its de-
hydration and contamination, protecting it
from the external environment. Chitosan
is an excellent mucoadhesive in its swollen
state and a natural bio-adhesive polymer
that can adhere to hard and soft tissues by
electrostatic binding, supported by hydro-
gen bonding as well as hydrophobic inter-
actions10
. The hydrophilic surface of cati-
onic chitosan maintains and attracts fluids
and cells to the defect site8
, contributing to
natural healing and skin renewal. Once on
the skin, chitosan favours epidermis regen-
eration. Cationic chitosan also provides an
analgesic effect when applied as a solution
on the skin, due to the physical absorption
of proton ions released at the inflammato-
ry site. Acidified chitosan reduces the pH of
the affected area and causes the effective
analgesic influence. Chitosan therefore in-
duces analgesia as it provides a cool and
pleasant soothing effect when applied on
the skin11
. Chitosan, being a good humec-
tant, helps in the recovery of skin barrier
function and cooling of the skin, both
contributing to its anti-pruritic effect. Skin
redness occurs when the skin becomes in-
flamed and swollen. It can be diminished
by a chitosan film applied on the skin
owing to all above mentioned properties of
chitosan but specifically to its antioxidant
properties, by binding and inactivation of
free radicals12
.
PRIMEX offers natural, effective solu-
tions for skin healing and homeostasis
Primex Iceland is an Icelandic marine
biotech company and a global leader in the
manufacture and supply of high quality mul-
ti-functional chitosan. Primex ChitoClear®
chitosan is produced from coldwater shrimp
shell, Pandalus borealis wild caught in the
North Atlantic Ocean. Because of the needs
for natural alternatives in the cosmetic and
medicalmarkets,PrimexIcelandhasrecently
developed two lines of chitosan-based
products to fulfil these needs: ChitoCare®
Beauty and ChitoCare®
Medical.
ChitoCare®
Beauty launched last year two
body care products. The Body Scrub is
enriched with natural, exfoliating, refreshing
and stimulating ingredients that tighten and
tone the skin, leaving it smooth, firm and
radiant. Including a touch of caffeine rich in
antioxidants, it stimulates microcirculation
to fight skin fatigue and cellulite. An ideal
chitosan-based shower treatment to lock-
in moisture, restoring your skin suppleness
and integrity. The Body Lotion contains nat-
ural, deeply moisturizing and potent marine
ingredients that hydrate the skin deeply and
leaves it smooth, firm and radiant. Chitosan,
as a natural moisturizing ingredient, reduces
irritation and provides skin protection. With
a touch of caffeine rich in antioxidants and
stimulating microcirculation to fight skin
fatigue and cellulite, the skin feels lavishly
rejuvenated. ChitoCare®
Beauty Body Scrub
& Body Lotion are a perfect duo for a beau-
tiful skin, being complementary to each
other and excellent for sensitive and
problem skins.
ChitoCare®
Medical recently entered the
market, introducing two medical devices:
ChitoCare®
gel and spray intended for skin
protectionandhealingofirritated,inflamed
skin and with defects. The key ingredient,
chitosan, creates a thin, mucoadhesive film
on the skin, mechanically protecting intact
and irritated skin and providing moisture
control. Based on these physical properties,
the products lower the risk for infection and
enable proper epithelization of the epithe-
lium tissue and shorten scar, pimples, cold
sores, diaper and skin rash, eczema, burn or
sunburn healing period. The products are
suitable for all age groups. There are no con-
traindications for ChitoCare®
products. Even
individuals with shellfish allergy should not
react to the products based on sensitizing
and allergy skin testing.
The following photos clearly demonstrate
the efficacy of the ChitoCare®
Medical
productsandincrediblepowerofchitosanto
help us naturally heal and contribute to our
skin harmony. ChitoCare®
Medical products
reduce inflammation, itching, redness and
calm the skin (Fig. 1-3), contributing to skin
renewal and homeostasis (Fig. 2-3). Skin
rash and eczema (Fig. 3) on sensitive skin can
also be appropriately shielded while treated
with ChitoCare®
Medical products. They
also heal and correct skin defects as seen
CHITOSAN FOR
NATURAL HEALING
AND SKIN HARMONY

with new (Fig. 4) and old (Fig. 5) scars, as well
as reduce hyperpigmentation (Fig. 5). A scar
is caused by the overexpression and differ-
ent arrangement of collagen during wound
repair. Hypertrophic and atrophic scars are
formed by collagen bundles assembled in
such a way that they block further skin re-
generation. This is why a scar normally stays
for a lifetime. A scar can be diminished by
chitosan application, promoting a smoother
and well structured skin development. Once
applied, chitosan is slowly degraded by nat-
urally occurring skin enzymes. This results in
the presence of chitosan‘s building blocks,
glucosamine and N-acetylglucosamine
(NAG) which occurs throughout nature
and in all human tissues. NAG is recognized
primarily for its function as a precursor to
hyaluronic acid which plays a significant
role in the structure and hydration of the
extracellular matrix in skin (both dermis and
epidermis)13-15
. Studies have shown that glu-
cosamine16-18
and NAG18
effectively reduce
the production of melanin in human cell
culture systems. These agents inhibit the
glycosylation of tyrosinase which is cen-
tral to melanin formation. Topical applica-
tion of a NAG-containing moisturizer has
shown that it can reduce the appearance of
hyperpigmentation20-21
. This may explain the
fading of hyperpigmentation by ChitoCare®
gel seen in Fig. 5.
Indeed, ChitoCare®
Medical products may
heal or alleviate skin disorders, such as skin
pathological symptoms developing due to
reduced skin barrier and undesirable skin
microbiota shifts. Atopic dermatitis (AD) is a
complex disease that requires a multidimen-
sional treatment approach. The possibility of
modulating the skin microbiome, namely its
staphylococcal community, which has long
been recognized as one of the main deter-
minants of skin inflammation, is an appeal-
ing strategy. Chitosan, a natural biopolymer
with immunomodulatory and antimicrobial
properties, has been considered poten-
tially useful. A randomized controlled trial
assessed the clinical utility of Primex Chito-
Clear®
chitosan by coating garments used
against AD. Dermatology Quality of Life
Index Score significantly improved in
chitosan group (P = 0.02) and a signifi-
cant increase of skin coagulase negative
..........................................................................
References
1. I Younes, M Rinaudo (2015) Mar Drugs 13: 1133-74.
2. S.H. Pangburn et al. (1982) Biomater 3(2): 105-8.
3. I. Aranaz et al. (2009) Curr Cheml Biol3(2): 203-30.
4. J. Smith et al. (2004) Pharmac Res 21(1): 43-49.
5. A.E. Pusateri et al. (2003) J Trauma 54: 177-82.
6. A.K. Azad et al. (2004) J Biomed Mater Res B Appl
Biomater 69: 216-22.
7. E.I. Rabea et al. (2003) Biomacromolec 4: 1457-65.
8. A.R. Costa-Pinto et al. (2011) Tissue Eng Part B Rev
17: 331-47.
9. P. Sivashankari, M. Prabaharan (2016) Int J Biol
Macromolec 93: 1382-9.
10. M. Dash et al. (2011) Prog Polym Sci 36: 981-1014.
11. G.G. Allan et al. (1984) Biochemical applications of
chitin and chitosan. In: J.P. Zikatis, Chitin, chitosan
and related enzymes (pp.119-33). Orland, FL:
Academic Press.
12. T.M. Tamer et al. (2016) J Appl Pharmac Sci 6(4):
195-201.
13. G. Weindl et al. (2004) Skin Pharmacol Physiol 17:
207-13.
14. T. Sayo et al. (2004) Skin Pharmacol Physiol 17:
77-83.
15. I. Ghersetich et al. (1994) Int J Dermatol 33: 119-22.
16. G. Imokawa, Y. Mishima (1986) J Invest Dermatol 87:
319-25.
17. Y. Mishima, G. Imokawa (1983) J Invest Dermatol 81:
106-14.
18. G. Imokawa, Y. Mishima (1982) Cancer Res 42:
1994–2002.
19. D. Bissett, S. McPhail (2006) Pigment Cell Res 19:
373 (Abstract PP-05).
20. D. Bissett, L. Robinson (2006) Pigment Cell Res 19:
376 (Abstract PP-019).
21. D. Bissett et al. (2006) J Am Acad Dermatol 54: (3
Suppl. 1): AB43 (Abstract P236).
22. C. Lopes et al. (2015) PLoS ONE 10(11): e0142844.
..........................................................................
Figure 4. A week-old scar treated with ChitoCare® gel for 8 months
Figure 1. After sunburn, ChitoCare® spray applied
and result shown 6 h later
Figure 2. Face burn following gas explosion -
ChitoCare®
gel applied at night and ChitoCare®
spray and ChitoCare®
Body lotion applied regularly
during the day – Skin healed after 12 days.
Figure 3. Child eczema treated with ChitoCare®
gel applied daily for 2 weeks
Figure 5. Eleven year-old atrophic scar from
surgery treated with ChitoCare®
gel for 6 months
Staphylococci(P=0.02)wasseen,indicating
a beneficial microbiota modulation. The fact
that chitosan-coated textiles impacted on
disease severity by modulating skin staphy-
lococcal profile, resulting in improved quality
of life, suggests that the use of ChitoCare®
Medical products for skin protection and
inflammatory relief should be considered as
part of dermatitis treatments.
ChitoCare®
Medical and Beauty products
manufactured by Primex Iceland are an
alternative and natural way to maintain skin
homeostasis by providing skin protection
and hydration. Primex Iceland is an Icelan-
dic marine biotech company dedicated to
innovate and market scientifically sound and
novel, natural chitosan-based products for
numerous markets.
More information on Primex chitosan-based
products at www.primex.is
Dr. Hélène L. Lauzon, R&D Director
Primex ehf - Oskarsgata 7, 580-Siglufjordur,
Iceland info@primex.is

ICELANDIC
INNOVATION AWARD
visit us
at booth
#I20
UNIQUE INNOVATION FROM ICELAND
New BODY LOTION and BODY SCRUB
from the pristine waters around Iceland
Fights cellulite
Soothes sunburns
Soft and effective exfoliation
Cooling effect
Reduces redness and itching
Moisturizing and softening
ChitoCare®
promotes healing of minor burns,
scars, pimples, cold sores, diaper rash, eczema,
sunburns and skin inflammation.
• Protects skin
• Relieves minor burns and pain
• Reduces scars
• Reduces redness and itching
• Natural healing of irritated skin
Treatment starts after
stitch removal
Day 6 of ChitoCare
treatment
Day 38 of treatment

Today’s diets are missing an essential nutrient that supports bone and heart health. Vitamin K2 helps
the body direct calcium to the bones while keeping it out of arteries and blood vessels.
MenaQ7®
is the only Vitamin K2 as MK-7 proven in clinical studies to deliver these benefits.
• 19+ published clinical trials confirm:
• Safety
• Efficacy
• Highest quality:
• Vegan
• Halal
• Non-GMO
• 100% all-trans Vitamin K2 as MK-7
• The most comprehensive K2 Portfolio:
• MenaQ7®
Natto (soy-based)
• MenaQ7®
Natural (allergen-free)
• MenaQ7®
PharmaPure (nature-identical)
• NEW MenaQ7®
Full Spectrum K2
Visit us at
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NattoPharma, the world leader in Vitamin K2 research and development, offers MenaQ7®
Vitamin K2 as MK-7 for dietary supplements, functional foods, and
medical foods. Learn about the value MenaQ7®
K2 from NattoPharma, the trusted Vitamin K2 Expert, can bring to your brand!
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Trans-resveratrol (a.k.a. resveratrol or
3,5,4’-trihydroxy-trans stilbene) is a polyphe-
nol produced in plants such as grapes, pea-
nuts and berries in response to environmen-
tal stress as part of a defense mechanism to
protect itself.1
Resveratrol was brought into
the spotlight based on the French paradox
which highlighted that French people have
a lower rate of cardiovascular diseases
despite their relatively high calorie and wine
intake when compared to other populations.
This paradox helped reserachers discover
resvertarol as one of the most abundant bi-
oactive polyphenols in red wine and raised
attention for its health benefits.2
Since then,
researchers and clinicians have been investi-
gating the promising features of resveratrol,
making this molecule one of the best char-
acterized polyphenols today with over 170
finalized and 30 ongoing clinical studies. Its
main popularity is based on being a pow-
erful antioxidant; however, it also exhibits a
number of beneficial functions on cellular
and systemic levels, setting resveratrol apart
from other ingredients that function mainly
as antioxidants.3
Beyond Antioxidants
One breakthrough area of research includes
findings that demontate resveratrol exhib-
its promising effects in reducing oxidative
stress and inflammation in cartilage, which
improves conditions caused by arthritis for
instance.4
First, resveratrol is able to neutral-
ize reactive oxygen species and downregu-
late a response of inflammation. Secondly,
it was observed that resveratrol promotes
osteogenic differentiation of stem cells and
potentially triggers bone formation. These
positive outcomes for bone and joint health
have motivated researchers to further study
resveratrol’s impact on these conditions.5
Overall Bone Health with Resveratrol
In 2014, Evolva launched the first two
clinical studies on the impact of resveratrol
(Veri-te™) on bone health. These findings
showed that Veri-te™ has an overall prom-
ising impact on bone health. The first study
discovered that Veri-te™ has a positive in-
fluence on bone metabolism and is able to
possibly preserve bone integrity denoted by
a primary anabolic modality, confirmed by
an increase in plasma levels of bone-spe-
cific alkaline phosphatase (BAP).6
The
results confirmed that Veri-te™ significant-
ly increases the plasma levels of BAP, a
biomarker for bone formation, in com-
parison to the placebo. The second study
affirmed that Veri-te™ supplementation can
increase in the volumetric bone mineral
density.7
Additionally, research indicates the potential
reduction of chronic pain in age-related
osteoarthritis with an oral intake of 75 mg
resveratrol twice a day.8
In terms of safety
and efficacy, another clinical study showed
that resveratrol with meloxicam is superior
to meloxicam alone for the treatment of
pain and improvement of physical function
in patients with knee osteoarthritis.9
Women’s Health Focus with Veri-te™
Resveratrol
Menopause heightens a woman’s risk of
osteoporosis10
as a result of the decline in
estrogen production. Therefore, postmen-
opausal women have been identified as
a vulnerable population who may benefit
from resveratrol supplementation, a strategy
that can be easily incorporated into the daily
diet.11
Daily resveratrol supplments can offer
women a convenient, science-backed ap-
proach for managing menopause-related
symptoms and counteracting accelerated
physical decline and the loss of bone
mineral density caused by menopause.
It is recommended that bone density be
quantified by X-Rays on a regular basis for
postmenopausal women and men 50 and
older, especially if they have recently broken
a bone. This enables the diagnosis of
Author: Johannes Haerle, PhD
Veri-te™ Resveratrol for
Bone & Joint Health:
Explore the Possibilities

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