Zhang, X., Huang, H., Zhuang, D. et al. Biological, clinical and epidemiological features of COVID-19, SARS and MERS and AutoDock simulation of ACE2. Infect Dis Poverty 9, 99 (2020). https://doi.org/10.1186/s40249-020-00691-6.

2. Comparing SARS-CoV-2 with SARS-CoV & MERS-CoV

3. MERS-CoV
SARS-CoV-2
SARS-CoV
“These three viruses have caused widespread
epidemics that originated in animal reservoirs;
the high morbidity and mortality levels have
caused panic and substantial economic loss.”

4. Receptors
✓ ✓ ✓
✗ ✓ ✓

5. Transmission
⬥
⬥
⬥
⬥
⬥

6. R0 & Susceptible Population
2.8-3.9 3 <1
Undetermined 39.9 56

7. Zhang, X., Huang, H., Zhuang, D. et al. Biological, clinical and epidemiological features of COVID-19, SARS and MERS
and AutoDock simulation of ACE2. Infect Dis Poverty 9, 99 (2020). https://doi.org/10.1186/s40249-020-00691-6

8. Jin J-M, Bai P, He W, Wu F, Liu X-F, Han D-M, Liu S and Yang J-K (2020) Gender Di erences in Patients With
COVID-19: Focus on Severity and Mortality. Front. Public Health 8:152. doi: 10.3389/fpubh.2020.00152

9. CT Imaging Lesion Features
Distribution
Quantity
Shape
Density Concomitant signs
Needs to be distinguished from
other pathogens
or noninfectious
diseases

10. As of July 20th...
⬥
⬥

11. As of July 20th...
⬥ hydroxychloroquine lopinavir plus
ritonavir and arbidol mesenchymal stem cells
traditional Chinese medicine
glucocorticoid therapy
⬥ interferon atomization darunavir
cobicistat Arbidol remdesivir

12. “substantial decrease in the total number of
lymphocytes
a
low absolute value of lymphocytes could be
used as a reference index

13. AutoDock Simulations
⬥ ⬥
Zhang, X., Huang, H., Zhuang, D. et al. Biological, clinical and epidemiological features of COVID-19, SARS and MERS
and AutoDock simulation of ACE2. Infect Dis Poverty 9, 99 (2020). https://doi.org/10.1186/s40249-020-00691-6