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Christine Candelora
213 West Third Street Mount Carmel, PA 17851
Phone: (570) 452-9109
E-mail: ccandelora@mail.usciences.edu
Education
University of the Sciences in Philadelphia Philadelphia, PA
- Master’s Degree Candidate in the Department of Chemistry and Biochemistry, (Anticipated December 2016),
Advisor: Dr. Zhihong Wang
- Tentative Thesis: A Novel In Vitro Study Elucidating the Molecular Mechanism of Wild Type Full-Length BRAF by
Phosphorylation, Dimerization, and ATP-Competitive Inhibitors
- GPA: 3.817/4.0
Albright College Reading, PA
Bachelor of Science, Biochemistry and Biotechnology, May 2013
GPA: 3.85/4.0
ResearchExperience
University of the Sciences in Philadelphia
Advisor: Dr. Zhihong Wang, Biochemistry, Fall 2014-Present
 Purified Wild Type Full Length (WTFL) BRAF and mutated (V600E) BRAF from HEK 293 mammalian expression
system
 Deduced a mechanism of auto-phosphorylation in WTFL BRAF which plays an inhibitory role in kinase activity
 Recapitulated the paradoxical effect in vitro indicating that BRAF inhibitors such as dabrafenib and vemurafenib
act as activators of WTFL BRAF
 Elucidated a novel strategy for fine-tuning the amplitude and duration of MAPK signaling, which provides more
insight into the complex regulation of this pathway in cellular kinetics
 Developed radioactive P-32 assays to complete a thorough study of the following: BRAF, CRAF, and a B/CRAF
heterodimer kinetics, dimerization, and phosphorylation events
Albright College
Advisor: Dr. Frieda Texter, Biochemistry, Winter 2011-Spring 2013
 Purified β-2-Microglobulin as well as ΔN20-β-2-Microglobulin and elucidated both functions in dialysis related
amyloidosis through the formation of fibrils, which form plaques in joints resembling arthritis for which there is no
treatment
Publications
 Christine Candelora and Zhihong Wang. In Vitro Enzyme Kinetics and Analysis of EGFR. Methods in Molecular
Biology (1487) 257-268. (2016).
Presentations
 Christine Candelora, Nicholas Cope, Kenneth Wong, Philip A. Cole, and Zhihong Wang. Poster presentation at 2nd
Annual University of the Sciences Departments of Biology, Chemistry/Biochemistry, and Pharmaceutical Sciences
Retreat; Molecular Mechanism of BRAF by Phosphorylation, Dimerization, and ATP-Competitive Inhibitors; Malvern,
PA; September 2016
 Christine Candelora, Nicholas Cope, Kenneth Wong, Philip A. Cole, and Zhihong Wang. Poster presentation at
252ndAmerican Chemical Society National Meeting; Molecular Mechanism of BRAF by Phosphorylation, Dimerization,
and ATP-Competitive Inhibitors; Philadelphia, PA; August 2016
 Christine Candelora, Nicholas Cope, Kenneth Wong, Philip A. Cole, and Zhihong Wang. Poster presentation at 8th
Annual Frontiers in Biology and Chemistry Interface Symposium; Molecular Mechanism of BRAF by Phosphorylation,
Dimerization, and ATP-Competitive Inhibitors; Baltimore, MD; May 2016

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 Christine Candelora, Nicholas Cope, Kenneth Wong, Philip A. Cole, and Zhihong Wang. Poster presentation at
Molecular Mechanism of BRAF by Phosphorylation, Dimerization, and ATP-Competitive Inhibitors; 14th Annual
University of the Sciences Research Day; Philadelphia, PA; April 2016
 Christine Candelora, Nicholas Cope, Kenneth Wong, Philip A. Cole, and Zhihong Wang. Poster presentation at
Molecular Mechanism of BRAF by Phosphorylation, Dimerization, and ATP-Competitive Inhibitors; Philadelphia ACS
Younger Chemists Committee Poster Session; Philadelphia, PA; February 2016
 Christine Candelora, Nicholas Cope, Kenneth Wong, Philip A. Cole, and Zhihong Wang. Poster presentation at
Studies of ΔN20-β-2-Microglobulin at Neutral pH; Albright College Annual Honors Thesis Research Symposium;
Reading, PA; May 2013
 Christine Candelora, Nicholas Cope, Kenneth Wong, Philip A. Cole, and Zhihong Wang. Poster presentation at
Studies of ΔN20-β-2-Microglobulin at Neutral pH; Lebanon Valley College Annual Research Symposium; Annville,
PA; June 2012
TeachingExperience
University of the Sciences in Philadelphia
Graduate Student Instructor; Fall 2014-Fall 2016
Courses:
CH-104: General Chemistry I; Instructor/Teaching Assistant; Spring 2016/Spring 2015
 Provided pre-lab lectures to pharmacy and physical therapy majors in a section of 24 students describing experiment
theory and procedure
 Assisted students by teaching proper analytical technique, analysis, and waste disposal using general lab chemicals
CH-103: General Chemistry I; Instructor/Teaching Assistant; Fall 2015/Fall 2014
 Provided pre-lab lectures to pharmacy and physical therapy majors in a section of 24 students describing experiment
theory and procedure
 Assisted students by teaching proper analytical technique, analysis, and waste disposal using general lab chemicals
Mount Carmel Area Junior/Senior High School
Permanent Substitute Teacher; Fall 2013-Summer 2014
Courses:
MAT100: 7th Grade Math
 Successfully taught 100 students basic mathematic principles through the use of self-made problem sets, exams, and
lectures
 Assisted students after school with questions and concerns about class and problem sets
Albright College
Laboratory Assistant; Spring 2010-Spring 2013
Courses: CH 201/202 and BIO201/202
CH201/202: General Organic Chemistry I/II
 Assisted Organic Chemistry professors with classes of 20 students
 Facilitated laboratory experiments for students including the demonstration of proper techniques of instruments
resulting in greater understanding of material by the students and attainment of accurate skills
BIO201/202: General Biology I/II
 Assisted Biology professors with 3 General Biology classes totaling 50 students
 Facilitated laboratory experiments for students including display of greater understanding of the material and proper
use of instruments, resulting in a greater understanding of the material by the students

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Awards & Honors
 Jacob Albright Scholarship Recipient; Albright College; Reading, PA; 2009-2013 Academic Years
 Eileen Walker Chemistry Excellence Award; Albright College; Reading, PA; May 2013
 Musical Excellence Award; Albright College; Reading, PA; May 2013