It is the compilation of common neurodegenerative diseases.

1. PRESENTED BY-
CHARU PUNDIR
(09270300011)
B.PHARM
DEPARTMENT OF PHARMACEUTICAL SCIENCES,
S.B.S.P.G.I, BALAWALA DEHRADUN

2.  NEURONS
 CELL BODIES
 AXONS AND DENDRITES
 NERVE IMPULSE
 TYPES OF NERVES- SENSORY , MOTOR AND
MIXED
 SYNAPSE
 NEUROTRANSMITTERS
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3.  BRAIN CELLS- ASTROCYTES,
OLIGODENDROCYTES, MICROGLIA AND
EPENDYMAL CELLS.
 MENINGES- DURA MATER, PIA MATER AND
ARACHNOID MATER.
 VENRICLES OF BRAIN- RIGHT AND LEFT
VENRICLE, THIRD VENTRICLE AND FOURTH
VENTRICLE.
 CSF- WATER, MINERAL SALTS, GLUCOSE,
PLASMA PROEINS, CREATININE,
 UREA AND A FEW LEUCOCYTES.
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4.  CEREBRUM- LOBES (FRONTAL, PARIETAL,
TEMPORAL AND OCCIPITAL), BASAL GANGLIA,
THALAMUS, HYPOTHALAMUS.
 MIDBRAIN
 PONS
 MEDULLA OBLONGATA THE BRAIN STEM
 CEREBELLUM
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5.  SPINAL NERVES- CERVICAL, THORACIC,
LUMBAR, SACRAL AND COCCYGEAL
 GREY MATER
 WHITE MATER
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6.  31 PAIRS OF SPINAL NERVES
 12 PAIRS OF CRANIAL NERVES
 THE AUTONOMIC NERVOUS SYSTEM
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7.  SYMPATHETIC
 PARASYMPATHETIC
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8.  VERTICULOGRAPHY
 CAT SCAN
 MRI
 PNEUMOENCEPHALOGRAPHY
 CEREBRAL ANGIOGRAPHY
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9.  ALZHEIMER
 PRION
 ALS
 HUNTINGTON
 PARKINSON
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10.  OXIDATIVE STRESS
 EXCITOTOXICITY
 PROTEIN MISFOLDING
 INFECTIOUS ORGANISM
 GENETICS
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11.  PRESENILE
DEMENTIA
 ARISES SHARPLY
WITH AGE
 LOSS OF NEURONS
 SHORT TERM
MEMORY LOSS
COGNITIVE
DEFICITS
 DEPOSITION OF BETA
AMYLOID PLAQUES
 NEUROFIBRILLARY
TANGLES- TAU
PHOSPHORYLATION
 SECRETASES CAUSES
APP CLEAVAGE INTO
AB40 AND AB42
CAUSING AMYLOID
FORMATION
 DECREASE ACH LEVELS
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12.  CHOLINERGICS
 ANTIOXIDANTS
 NSAIDS
 STATINS
 HORMONE REPLACEMENT THERAPY
 DIET MODIFICATION
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13.  LADOSTIGIL
 DIMEBOLIN
 GINKO BILOBA
 SIMVASTATIN
 VALPROATE
 DHA
 TACRINE
 RIVASTIGMINE
 DONEPAZIL
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14.  INHERITED
AUTOSOMAL
DOMINANT
DISORDER
 JERKLIKE
MOVEMENTS
 PARANOIA
 DELUSIONAL STATES
 IMPAIRMENT OF
RAPID EYE
MOVEMENT
 TREATMENT-
FLUOXETINE,
CARBAMAZEPINE,
CLOZAPINE,
QUETIAPINE,
RESERPINE,
VALPROIC ACID
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15.  SPONGIFORM
ENCEPHALOPATHY
 PROPAGATE
THROUGH
INFECTIOUS AGENT
 FORMATION OF
PRION RODS,
ALPHA SY NUCLEIN
FIBRILLS, PRP
AMYLOID PAQUES,
AND LEWY BODY
 TREATMENT-
QUINACRINE,
CHLORPROMAZINE
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16.  DISTURBENCE IN
MOTOR NEURON OF
VENTRAL HORN OF
SPINAL CORD AND
CORTICAL NEURON
 SPASTICITY
 MUSCLE WEAKNESS
 FASCICULATIONS
 RESPIRATORY
COMPROMISE
 TREATMENT-
RILUZOLE,
BACLOFEN,
 TIZANIDINE,
CLONAZEPAM
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17.  CHARACTERISED BY
MOVEMENT
DISORDERS
 TREMOR AT REST
 MUSCLE RIGIDITY
 SUPRESSION OF
VOLUNTARY
MOVEMENTS
 SHUFFLING GAIT,
HYPOKINESIS
 ENVIRONMENTAL
TREGERS
 PROTEIN MISFOLDING
AND AGGREGATION
 EXCITOTOXICITY
 OXIDATIVE STRESS
 APOPTOSIS
 DEGENERATIVE LESION
IN SN-PC AND
DECREASED
DOPAMINERGIC INPUT
 IMBALANCE BTW DA
AND ACH
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18.  MEDICATION- COMT INHIBITORS, MAO
INHIBITORS, DOPAMINERGICS,
ANTICHOLINERGICS
 ADJUNCT THERAPIES- PHYSIOTHERAPY,
OCCUPATIONAL THERAPY, SPEECH AND
LANGUAGE THERAPY
 SURGICAL TREAMENTS
 AYURVEDIC APPROACH
 DIET
 CELL THERAPY
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19.  ENTACAPONE
 TOLCAPONE
 LEVODOPA- CARBIDOPA
 ATMAGUPTA- HERB
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