This study analyzed the association between maternal age and prevalence of Down syndrome (DS) in Bogota and Cali, Colombia from 2001-2018. The results showed that the risk of DS increases with maternal age, especially after age 35. For mothers aged 35 and older, the odds ratio of having a child with DS was 7.18 compared to younger mothers. Additionally, the temporal prevalence of DS for mothers 35 and older remained stable over the period studied, with an average of 51.9 cases of DS per 10,000 births.

1. ASSOCIATION BETWEEN PREVALENCEOF DOWN SYNDROME AND
MATERNAL AGES IN THE CITIES OF BOGOTÁ AND CALI, IN THE YEARS
2001 – 2018.
C. López-Burbano1,C.Tovar-Sanchez2,J. Holguín3,C. Rodríguez4,I .Zarante2,P. Hurtado-Villa1
OBJECTIVES
METHODS
RESULTS
CONCLUSIONS
REFERENCES
DISCUSSION
Determinate the association between maternal age and
the prevalence of Down syndrome (DS) in the cities of
Bogotáand Calibetweentheyears 2001 to 2018.
Determinate the temporal prevalence of DS in mothers
olderthan 35y.
The database of the Birth Defects Surveillance
Programme of Bogotá and Cali, was used in the years
2001-2018 to determine the association of maternal ages
and prevalence of DS. The patients were grouped by five-
year periods and the prevalence of each group was
calculated. ORs were calculated for mothers over 35
years of age.
Additionally, temporary prevalence was calculated in
patients over 35 years of age. All the prevalence rates per
10.000 were calculated with their respective limits by
PoissonMethodand ORswiththeirCI.
The age of the mother is the main factor that has been
shown to increase the risk of having a baby with DS. This
risk increases every year, especially after the mother is 35
years. Younger women are more likely to have babies so
the majority of total number of babies with DS is in women
under 35 years. However, more women are waiting to have
a child and births in mothers older than 35 years has
tripled . The prevalence of DS in > 40 years is 19 times the
prevalenceof < 30 years.
The global prevalence of DS found in this cohort is similar
atthe prevalencereported atthe literature.
Ministerio de la Protección Social. Resolución 2048 de 2015.
Repub. Colomb. Gob. Nac. 1–18 (2015).
García A, M. & Plata, S. Caracterización de las anomalías congénitas
desde la inclusión en el sistema de vigilancia Sivigila en Colombia,
2010-2013. Univ. Med. (2017). doi:10.11144/Javeriana.umed58-1.
Gibbon, S. & Aureliano, W. Inclusion and exclusion in the
globalisation of genomics; the case of rare genetic disease in Brazil.
Anthropol. Med. 25, 11–29 (2018).
March of Dimes. Rare birth defects. (2013). Available at:
https://www.marchofdimes.org/complications/rare-birth-
defects.aspx. (Accessed: 20th May 2018).
CORRESPONDINGAUTHOR
ClaudiaLópez
mdrural@javerianacali.edu.co
1 2
4
3
In those studies they argued that its results are due to
terminations of pregnancies and increasing prenatal
diagnosis.
In our country, we must focus on the search of the causes
of influencing this prevalence in order to contribute with
accuratelyinformationfor healthsystem planning.
8,5
6,5
6,3
7,5
10,9
35,5
122,4
12,9
< 14 15 - 19 20 - 24 25 - 29 30 - 34 35 - 39 40 - 55 GLOBAL
PREVALENCEOFDOWNSYNDROMEPER10.000
BIRTHS
MATERNAL AGE (YEARS)
For maternal age ≥ 35 years the odds ratio was 7,18 (95%
CI6,16-8,38).
Additionally was calculated the temporal prevalence of
DS in ≥ 35 years 2006 - 2018, finding no temporal
variation with an average prevalence of 51.9 births with
DSper 10.000 births.
Total births
Down Syndrome
cases
Bogotá 472.645 607
Cali 62.198 84
Total 534.843 691
Table 1. Distribution of births and Down Syndromes cases per
location.
Figure 1. Prevalence of Down Syndrome per 10.000 births,
distributed byquinquennials ofmaternalage.
Figure 2. Temporal prevalence of Down Syndrome per 10.000
births inmothers ≥35yearsinthelastdecade
338,2
301,2
135,6
103,9100,3
121,0
96,1101,7
162,5
129,7
104,099,3
2006
2007
2008
2009
2010
2011
2012
2013
2014
2015
2016
2017
PREVALENCE OF DOWN SYNDROME PER 10.000
BIRTHS
YEAR
ACKNOWLEDGMENTS