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May 25, 2021 Perioperative Geriatrics
1. Canadian Geriatrics Society – Resident Day 05.25.2021
Dr. Camilla Wong, MD FRCPC MHSc
Twitter: @camilla_wong Email: camilla.wong@unityhealth.to
2. A painting showing the shore of Lake Ontario and part of Toronto, - then known as
York. This piece was completed in 1804, a year prior to the Toronto Purchase.
Indigenous Peoples have higher rates of death and adverse events after surgery,
while also encountering barriers accessing surgical procedures.
Library and Archives Canada
CMAJ 2021;193(20):E713-E722.
3. I have received research grant funding from the Ministry of Health (Ontario) and the
Canadian Orthopedic Foundation for work related to the development, implementation
and evaluation of cross-specialty collaborative care models. I have received a speaker’s
honoraria from the Hong Kong Health Authority. I am finally supported by the Li Ka Shing
Knowledge Institute through a research stipend.
4. 1. Apply the pre-operative and perioperative ACS NSQIP/AGS guidelines and
quality standards.
2. Appraise the evidence for perioperative geriatric models of care.
3. Incorporate common surgical and anesthesiology considerations every
geriatrician should know into the comprehensive geriatric assessment.
10. “Why is it acceptable care if the physical therapist doesn’t come every day but
not acceptable care if antibiotics are not given daily? Or acceptable to miss
meals all day waiting for procedures that are often cancelled? Why do the
alarms go off in the patient’s room if it is the nurse who should be notified? For
debilitated patients, why can’t testing and procedures be done in the afternoon,
so the mornings and evenings can be used for physical therapy, optimizing
nutrition, self-care, rest, and time with family?
Why does medical treatment trump recovery?”
JAMA. 2019;321(13):1253-1254.
11. A comprehensive geriatric assessment (CGA) is a
multidimensional, interdisciplinary diagnostic
process to determine the medical, psychological,
and functional capabilities of a frail elderly person in
order to develop a coordinated and integrated plan
for treatment and long-term follow-up
12. “older people who received CGA probably have lower risk of dying, and
that after discharge, were more likely to return to the same location they
lived in before hospital admission (RR 0.71, 95% CI 0.55 to 0.92)”
“CGA also lowers delirium rates (RR 0.75, 95% CI 0.60 to 0.94)”
Cochrane Database of Systematic Reviews 2018,
Issue 1. Art. No.: CD012485
Pro Tip:
evidence
16. Determine goals and expectations.
Assess cognitive ability and capacity to understand anticipated
surgery.
Screen for depression.
Identify and manage risk factors for delirium.
Screen for substance dependence.
Document functional status, mobility and falls.
Determine frailty.
Assess nutritional status and offer interventions.
Determine support system.
Order appropriate diagnostic tests.
Perform a preoperative cardiac evaluation.
Perform a preoperative pulmonary evaluation and implement
optimization strategies.
Take a medication history and make any appropriate perioperative
adjustments.
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J Am Coll Surg. 2012;215(4):453-66.
PRE-OP
36. “The risk calculators are meant to serve as
decision aids. Numbers, whether taken in
isolation or as an index, are NOT a substitute
for clinical evaluation and clinical judgment.”
JAMA Intern Med. 2019
37. COMMUNICATE THE RISK
patient, family, all team members
Knowing the risk is a pre-requisite for actions to modify risk.
Pro Tip:
Act
40. P U L M O N A R Y
Risk assessment for and strategies to reduce
perioperative pulmonary complications for
patients undergoing noncardiothoracic
surgery. Ann Intern Med. 2006;144(8):575-80.
A N T I M I C R O B I A L
Clinical practice guidelines for antimicrobial
prophylaxis in surgery. American Journal of
Health-System Pharmacy 2013;70:195-283.
N U T R I T I O N
The European Society for Clinical Nutrition
and Metabolism guidelines.
http://www.espen.org/education/espen-
guidelines
C A R D I O V A S C U L A R
2017 Canadian Cardiovascular Society
Guidelines on Perioperative Cardic Risk
Assessment and Management. Can J Cardiol.
2017;33(1):17-32.
T H R O M B O E M B O L I S M
American College of Surgeons' Guidelines for
the Perioperative Management of
Antithrombotic Medication. J Am Coll Surg.
2018 Nov;227(5):521-536.
D I A B E T E S
2018 Clinical Practice Guidelines for the
Prevention and Management of Diabetes in
Canada. Can J Diabetes. 2018;42:S1-S325.
41. Administer the CAGE Questionnaire.
If motivated, delay surgery for abstinence or
detoxification.
If at risk, give perioperative prophylaxis for
withdrawal syndromes.
In alcohol use disorder, give perioperative
daily multivitamin and high-dose thiamine.
J Am Coll Surg. 2012;215(4):453-66.
43. J Am Geriatr Soc. 2015;63(1):142-50.
Pro-tip:
caregivers
IDENTIFY POST-OP
DELIRIUM RISK
Age > 65, cognitive impairment, severe illness, hearing or
vision impairment, presence of infection, inadequately
controlled pain, depression, alcohol use, sleep deprivation
or disturbance, renal insufficiency, anemia, hypoxia or
hypercarbia, poor nutrition, dehydration, electrolyte
abnormalities, poor functional status, limited mobility, use
of psychotropic medications, risk of urinary retention of
constipation, presence of urinary catheter, aortic
procedures.
Caregiver support is associated with lower odds of
postoperative delirium (OR 0.69, 95% CI 0.52–0.91).
45. Ann Intern Med. 2019;171:474-484.
“There is limited evidence that second-generation antipsychotics may lower the
incidence of delirium in postoperative patients, but more research is needed.”
46. • cholinesterase inhibitors
• gabapentin
• tryptophan
fail
verb
be unsuccessful in achieving one's goal
in·trigue (n=1)
verb
arouse the curiosity or interest of
• parecoxib (joint replacement)
• methylprednisolone (hip fracture)
• IV acetaminophen (cardiac surgery)
• aripiprazole (neurosurgery)
• thiamine (GI surgery)
Melatonin / Ramelteon
47. IF SCREEN IS POSITIVE, THEN FURTHER
EVALUATION IS RECOMMENDED.
In the past 12 months, have you
ever had a time when you felt
sad, blue, depressed, or down
for most of the time for at least
2 weeks?
In the past 12 months, have you
ever had a time, lasting at least
2 weeks, when you didn’t care
about the things that you
usually cared about or when
you didn’t enjoy the things that
you usually enjoyed?
J Am Coll Surg. 2012;215(4):453-66.
48. Management of
ADLs and IADLS
History of
falls
Vision,
hearing,
swallowing
Gait and
balance
assessment
P E R F O R M A N C E S TAT U S
DEFICITS SHOULD PROMPT PROACTIVE DISCHARGE PLANNING
AND REFERRALS TO ALLIED HEALTH
J Am Coll Surg. 2012;215(4):453-66.
57. J Am Coll Surg. 2016;222(5):930-47.
“Definitive evidence does
not exist establishing the
superiority of regional
anesthesia compared with
general anesthesia when
used as a primary modality
for surgical anesthesia in
older adults.”
58. using processed EEG to help deliver
the optimal depth of anaesthesia
MAY reduce delirium incidence:
RR 0.71, 95% CI 0.59-0.85
3 RCTs, 2138 cases, low-quality evidence
PLoS One. 2020;15(2):e0229018.
59. PLoS One. 2019 Aug 16;14(8):e0218088.
D E X M E D E TO M I D I N E
reduces postoperative delirium
RR = 0.61, 95% CI 0.34–0.76, P = 0.001
61. Anesthesiology 2011;114:495-511.
Clear liquids may be ingested for up to 2
h before procedures requiring general
anesthesia, regional anesthesia, or
procedural sedation and analgesia..
A light meal may be ingested for up to 6
h before elective procedures requiring
general anesthesia, regional anesthesia,
or procedural sedation and analgesia.
Anesthesiology. 2017;126(3):376-393.
Pro-tip: first
morning case
67. orientation strategies vision and hearing aids sleep environment
family participation uncluttered hallways multimodal pain control
remove urinary catheters
and other tethers
WHAT IS GOOD
FOR DELIRIUM,
IS GOOD FOR
FALLS, IS GOOD
FOR FUNCTIONAL
DECLINE.
wound care: minimize
pressure, friction,
humidity, shear force
avoid potentially
inappropriate medications
resume diet early and
provide dentures, if needed
chest physiotherapy and
incentive spirometry
early, multidisciplinary
involvement
nutritional supplement,
if needed
early mobilization, using
walking aids if needed
scheduled toileting
aspiration precautions
68. A. Start Lorazepam 0.5-1.0 mg po q4h prn
A. Start Haloperidol 0.25 mg po/im/iv q4h prn
B. Apply soft restraints so he will not pull out the catheter or
touch his sternal wound.
C. Request a sitter.
D. Remove the catheter.
Antipsychotics do NOT shorten the duration or reduce the severity.
Cochrane Database Syst Rev. 2018 Jun 18;6:CD005594.
69. A. Start Lorazepam 0.5-1.0 mg po q4h prn
A. Start Haloperidol 0.25 mg po/im/iv q4h prn
B. Apply soft restraints so he will not pull out the catheter or
touch his sternal wound.
C. Request a sitter.
D. Remove the catheter.
Insufficient evidence for benzodiazepines to treat delirium.
Cochrane Database Syst Rev. 2020;2(2):CD012670.
70. A. Start Lorazepam 0.5-1.0 mg po q4h prn
A. Start Haloperidol 0.25 mg po/im/iv q4h prn
B. Apply soft restraints so he will not pull out the catheter or
touch his sternal wound.
C. Request a sitter.
D. Remove the catheter.
Cholinesterase inhibitors do NOT shorten the duration.
Cochrane Database Syst Rev. 2018;6(6):CD012494.
71. NeuroVISION
Study
COVERT STROKE
• not uncommon (7%)
• increased perioperative delirium HR 2.24 (95% CI 1.06-4.73)
• cognitive decline at one year aOR 1.98 (95% CI 1.22-3.20)
• stroke/TIA at one year HR 4.13 (95% CI 1·14–14·99)
Lancet 2019;21;394:1022-1029
72. BJA Education 2021; 21(2):75e82.
Anesthesiology. 2018;129(5):872-879.
Postoperative Cognitive Dysfunction (POCD)
is a research construct defined as “new cognitive impairment after a
surgical procedure”.
Time Period
Perioperative Cognitive Disorders
Mild NCD Major NCD
Emergency from
anesthesia
emergence delirium
Immediate post-op
until expected
recovery (to 30 days)
postoperative
delirium
delayed
neurocognitive
recovery
delayed
neurocognitive
recovery
From expected
recovery (to 30 days)
until 12 months
minor NCD (POCD) major NCD (POCD)
Beyond 12 months mild NCD major NCD
74. COMMON COMPONENTS OF
TRANSITION CARE MODELS
• Coordinated care with primary care physician
• Engagement of caregiver (RR 0.75, 95% CI 0.62-0.91)
reduces re-hospitalization
• Patient-centered medical record
• Post-discharge follow up plan
• Medication management
• Knowledge of important signs and symptoms
J Am Coll Surg. 2016;222(5):930-47.
J Am Geriatr Soc. 2017;65(8):1748–1755.
75. Pre-operative Intra-operative Post-operative Discharge
PROACTIVE Comprehensive Geriatric Assessment
Values-based
assessment
Surgical risk
assessment
Geriatric risk
assessment
Medical
optimization
Geriatric
optimization
Pre-habilitation
Anesthesia
Perioperative
Analgesia
Perioperative
Nausea
Delirium, pain, falls,
nutrition, function,
catheter, pressure ulcer,
pulmonary care bundles
Care Transitions
76. Pre-operative Intra-operative Post-operative Discharge
PROACTIVE Comprehensive Geriatric Assessment
Values-based
assessment
Surgical risk
assessment
Geriatric risk
assessment
Medical
optimization
Geriatric
optimization
Pre-habilitation
Anesthesia
Perioperative
Analgesia
Perioperative
Nausea
Delirium, pain, falls,
nutrition, function,
catheter, pressure ulcer,
pulmonary care bundles
Care Transitions
Palliative
Care
Family
Doctor
Geriatrics
Surgery
Internist
Pain
Service
Anesthesia
PT
RD
Pharmacy
Nursing
SW
OT
SLP
81. ENHANCED
RECOVERY
PROGRAMS
“ T H E I M M E D I AT E C H A L L E N G E TO
I M P R OV I N G T H E Q UA L I T Y O F
S U R G I C A L C A R E I S N OT
D I S C OV E R I N G N E W K N OW L E D G E ,
B U T R AT H E R H OW TO I N T E G R AT E
W H AT W E A L R E A DY K N OW I N TO
P R A C T I C E .”
17 systematic reviews and 12 additional
showed Enhanced Recovery After
Surgery (ERAS) programs may reduce
hospital stays by 0.5–3.5 days compared
with conventional care.
BMJ. 2005; 330(7505): 1401–1402.
BMJ Open 2014;4:e005015.
CMAJ. 2019;191(17):E469-E475
82. Age Ageing. 2007;36(2):190-6.
‘POPS’ IN
ORTHOPEDICS
• elective orthopedic
surgery
• 65 years +
• before-and-after
study (N=54)
LOS (4.9 vs 4.0 days,
P=0.01)
delirium (19% vs 6%,
P=0.036)
pneumonia (20% vs
4%, P=0.008)
urinary catheter use
(20% vs 7%, P=0.046)
83. Br J Surg. 2017;104(6):679-687
PREOPERATIVE
GERIATRIC
ASSESSMENT IN
VASCULAR SURGERY
• elective aortic aneurysm repair
or lower-limb arterial surgery
• 65 years +
• RCT, N=176
LOS (5.5 vs 3.3 d, P<.001)
delirium (11% vs 24%, P=.018)
cardiac complications (8% vs
27%, P=.001)
bowel/bladder complications
(33% vs 55%, P=.003)
84. ‘POPS’
UROLOGY-
GERIATRICS
LIAISON
• elective and
emergency urology
patients
• 65 years +
• before-and-after
study (N=242)
LOS (4.9 vs 4.0 days,
P=0.01)
postoperative
complications (RR
0.24, P=.001)
BJU Int. 2017 Jul;120(1):123-129.
85. J Orthop Trauma 2014;28:e49–e55.
JAGS 2017;65(7):1559-1565.
HIP FRACTURE–
ORTHOGERIATRICS
• Meta-analysis (N=242)
LOS (SMD -0.25)
in-hospital mortality (RR
0.60, 95% CI 0.42-0.84)
long term mortality (RR 0.83,
95% CI 0.74–0.94).
• Systematic review (4
studies)
delirium RR 0.81, 95%CI
0.69-0.94
86. ‘POSH’ IN
ABDOMINAL
SURGERY
• Elective abdominal
surgery
• 65 years +
• control cohort (N=326)
post-op complications
(.9 vs 1.4; P< .001)
LOS (4 vs 6 days, P<.001)
discharge home and
independent (62% vs
51%, p=.04)
JAMA Surg. 2018;153{5);454-462.
87. ‘POSH’ IN SPINE
SURGERY
• elective spine surgery
• 65 years +
• historical match (n=324)
LOS (4.7 vs 5.4 days; P =
.016)
J Am Geriatr Soc 00:1-9, 2021.
88. GERIATRIC CO-
MANAGEMENT
IN CANCER
SURGERY
• cancer surgery
• 75 years +
• Retrospective cohort
study (N = 1892)
LOS 4 vs 5 days; P < .001
90-day mortality [OR
0.5, 95% CI 0.37-0.92]
JAMA Netw Open. 2020;3(8):e209265.
98. TOTA L H I P A R T H R O P L A S T Y
Postoperative precautions:
• avoid hip flexion > 90°
• do not cross legs
• avoid internal rotation
99. C A R D I A C S U R G E RY
Sternal precautions:
• no pushing
• no lifting
• no pulling
100. Parkinson’s Medications
In the immediate postoperative
period and due for medication
but too drowsy:
• levodopa (IR) disperses in
water for use in enteral
tubes, but degrades and
absorption is altered by
feeds
• ropinirole and pramipexole
disperses in water for use in
enteral tubes
• selegiline, rasagiline,
entacapone, amantadine are
not essential
Pro-tip:
NG intraop
102. 1. Apply the pre-operative and perioperative ACS NSQIP/AGS guidelines and
quality standards.
2. Appraise the evidence for perioperative geriatric models of care.
3. Incorporate common surgical and anesthesiology considerations every
geriatrician should know into the comprehensive geriatric assessment.
103. “If you want to go fast, go alone;
if you want to go far go
TOGETHER”
-- African Proverb
104. D r. C a m i l l a Wo n g
c a m i l l a .w o n g @ u n i t y h e a l t h .t o
Editor's Notes
I acknowledge the land I am living and working on today is the traditional territory of many nations including the Mississaugas of the Credit, the Anishnabeg, the Chippewa, the Haudenosaunee and the Wendat peoples and is now home to many diverse First Nations, Inuit and Métis peoples. I also acknowledge that Toronto is covered by Treaty 13 with the Mississaugas of the Credit.
Faculty: Camilla Wong
Relationships with financial sponsors:
Grants/Research Support: Ministry of Health (Ontario)
Speakers Bureau/Honoraria: Hong Kong Health Authority
Consulting Fees: None
Patents: None
Other: Li Ka Shing Knowledge Institute (research stipend)
Seeing the forest for the trees.
Moving from “What is the matter?” to
“What Matters to You?”
Ensure patient has an advance directive
Ensure there is a designated POA
Document preferences and expectations
Include a discussion of possible complications, including functional decline, need for rehabilitation, or nursing home.
Engaging Patients, Providers and Community Members to Develop a Tool to Improve Preoperative Decision Making for Older Adults Facing High-Risk Surgery. JAMA Surg. 2016 Oct 1; 151(10): 938–945.
The risk calculator was built using data collected from > 2.7 million operations from 586 hospitals participating in ACS NSQIP from 2010-14. Entering the most complete and accurate patient information will provide the most precise risk information. However, the estimates can still be calculated if some of the patient information is unknown.
BMC Geriatrics (2016) 16:157
“Evlauation of the patient for frailty syndrome and documentation of his or her frailty score is recommended”
Quantification of frailty that forecasts elevated surgical risk can modify care in 2 ways: First, the aggressiveness of surgery can be modified. Frailty assessment allows tailoring of surgical recommendations to the real physiologic capacity of the patient. Second, appropriate counselling of anticipated outcomes can be provided. Knowledge of need for post-discharge nursing home stays and increased risk of complications prepares patients and families for their postoperative course. Recognizing and addressing co-dependence of the frail older adults’ partner before a major hospitalization relieves family worry and burden.
Frailty matters. Although over treatment is a concern, older adults may also be undertreated because of potentially ‘ageist’ attitudes.
A delirium prediction model is a statistical model that either stratified individuals for their level of delirium risk, or assigned a risk score to an individual based on the number and/or weighted value of predetermined
modifiable and non-modifiable risk factors of delirium present. BMJ Open 2018;8:e019223.
variable definitions for the risk factors
assessment of outcome variable, delirium, was largely non-systematic and once daily
some include precipitating factors, which if collected after onset of delirium would exaggerate model performance
not all have external validation, and those that did were often narrow validation studies
Frailty should not be used to deny treatment, but rather tailor treatment to person.
The risk calculators are meant to serve as decision aids. Numbers, whether taken in isolation or as an index, are NOT a substitute for clinical evaluation and clinical judgment.
Strong recommendations included: 1) measuring brain natriuretic peptide (BNP) or N-terminal fragment of proBNP (NT-proBNP) before surgery to enhance perioperative cardiac risk estimation in patients who are 65 years of age or older, are 45-64 years of age with significant cardiovascular disease, or have a Revised Cardiac Risk Index score ≥ 1; 2) against performing preoperative resting echocardiography, coronary computed tomography angiography, exercise or cardiopulmonary exercise testing, or pharmacological stress echocardiography or radionuclide imaging to enhance perioperative cardiac risk estimation; 3) against the initiation or continuation of acetylsalicylic acid for the prevention of perioperative cardiac events, except in patients with a recent coronary artery stent or who will undergo carotid endarterectomy; 4) against α2 agonist or β-blocker initiation within 24 hours before surgery; 5) withholding angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker starting 24 hours before surgery; 6) facilitating smoking cessation before surgery; 7) measuring daily troponin for 48 to 72 hours after surgery in patients with an elevated NT-proBNP/BNP measurement before surgery or if there is no NT-proBNP/BNP measurement before surgery, in those who have a Revised Cardiac Risk Index score ≥1, age 45-64 years with significant cardiovascular disease, or age 65 years or older; and 8) initiating of long-term acetylsalicylic acid and statin therapy in patients who suffer myocardial injury/infarction after surgery.
Table 2 contains a list of postoperative delirium risk factors. Patients with 2 or more risk factors should be considered at greater risk than patients with zero or 1 risk factor. In general, the risk for delirium is greater in the emergency setting in comparison with the elective setting.
Delirium is a critically relevant outcome for older adults due to its close relation-ship to adverse postoperative outcomes including increased complications, prolonged length of stay, increased discharge to a skilled nursing facility or nursing home, and death.
RR 0.69, 95% CI 0.59 to 0.81
In a systematic review published in September 2019 in the Annals of Internal Medicine.
2 cardiac surgery (risperidone)
1 ortho join replacement (olanzapine) – in those that developed delirium, longer and more severe.
Other drugs
Prevalence of depression in 71 years or older is 11%.
Preoperative depression is associated with increased mortality after CABG and longer LOS after CABG/valve surgeries.
Depression associated with higher pain perception and increased postoperative analgesic use.
Counseling the family on non-pharmacologic prevention strategies
Using electro
Cochrane systematic review underway
0.58 (95% CI, 0.33-0.99; P = .047)
Eight randomised controlled trials with 856 patients were included. Three studies used a mixed intervention (including either aerobic exercises or breathing exercises); five studies used inspiratory muscle training.
In this pilot study, a 1-month trimodal prehabilitation program improved postoperative functional recovery (functional walking capacity as measured by the 6MWT 8 weeks after surgery). A randomized trial is ongoing.
Moderate aerobic exercise plus resistance training (30 minutes, three times per week)
Nutrition counseling plus protein supplement
3. Relaxation and breathing exercises (90 minute visit with psychologist)
The patients in the prehabilitation program had better postoperative walking capacity at both 4 weeks (mean difference, 51.5 ± 93 m; p = 0.01) and 8 weeks (mean difference, 84.5 ± 83 m; p < 0.01). At 8 weeks, 81 % of the prehabilitated patients were recovered compared with 40 % of the control group (p < 0.01).
a recent Cochrane review suggests there may be benefits to selecting regional versus general anesthesia as a primary anesthetic modality in certain patient groups (see the following table), this issue remains controversial due to the quality of the studies and the lack of consideration of the risks of neuraxial blockade in many of the studies. The overall approach to the determination of the planned primary anesthetic technique for surgery in older adults should occur in a multidisciplinary fashion, involving the surgeon, anesthesiologist, and, whenever possible, the geriatrician.
The American Geriatric Society, the European Society of Anesthesiologists, and the UK’s National Institute for Health and Care Excellence all recommend that intraoperative electroencephalogram monitoring should be considered to prevent excessive anesthetic administration to patients at high risk of postoperative delirium.
Anaesthesia administration guided by the indices from a processed EEG (bispectral index) probably reduces the risk of POD within seven days after surgery with risk ratio (RR) of 0.71 (95%CI 0.59 to 0.85; number needed to treat for an additional beneficial outcome: (NNTB) of 17, 95% CI 11 to 34; 2197 participants; 3 RCTs; moderate quality of evidence).
STRIDE and ENGAGES trial since this review. Contradicting results.
One of the most important baseline patient-related factors contributing to adverse postoperative cognitive outcomes is preexisting cognitive impairment. Therefore, the depth of anesthesia may simply be a marker for patient’s baseline brain vulnerability to the effects of anesthetics. The differentiation between direct effects of anesthetic effects on the brain versus patients’ baseline vulnerability is critical to understanding the relationship between delirium and the role of the use of processed electroencephalogram-guided anesthesia.
Two trials underway:
ENGAGES-Canada Trial
Balanced Anesthesia Trial (primary outcome of mortality was just reported in the Lancet in Oct 2019)
Dexmedetomidine for the prevention of postoperative delirium in elderly patients undergoing noncardiac surgery: A meta-analysis of randomized controlled trials. PLoS One. 2019 Aug 16;14(8):e0218088.
Dexmedetomidine, a highly selective alpha-2 adrenoreceptor agonist, has the positive sedation, anti-anxiety, and analgesic effects
A total of 6 RCTs with 2102 participants were included. Compared with placebo, dexmedetomidine significantly reduced the prevalence of POD (RR = 0.61, 95% CI 0.34–0.76, P = 0.001, I2 = 66%), and the risk of tachycardia (RR = 0.48, 95% CI 0.30–0.76, P = 0.002, I2 = 0%), hypertension (RR = 0.59, 95% CI 0.44–0.79, P < 0.001, I2 = 20%), stroke (RR = 0.22, 95% CI 0.06–0.76, P = 0.02, I2 = 0%), and hypoxaemia (RR = 0.50, 95% CI 0.32–0.78, P = 0.002, I2 = 0%) in elderly patients who underwent noncardiac surgery. However, dexmedetomidine accelerated the occurrence of bradycardia (RR = 1.36, 95% CI 1.11–1.67, P = 0.003, I2 = 0%). Furthermore, no significant differences were observed in the incidence of hypotension, myocardial infarction, and all-cause mortality between the dexmedetomidine and placebo groups.
Fluid fasting for more than 6 h is an independent risk factor for postoperative delirium (OR = 10.6; 95% CI: 1.4–78.6)!
** PRACTICE TIP * schedule as first morning case!
Clear liquids may be ingested for up to 2 h before procedures requiring general anesthesia, regional anesthesia, or procedural sedation and analgesia.
A light meal may be ingested for up to 6 h before elective procedures requiring general anesthesia, regional anesthesia, or procedural sedation and analgesia
An Updated Report by the American Society of Anesthesiologists
Task Force on Preoperative Fasting and the Use of Pharmacologic
Agents to Reduce the Risk of Pulmonary Aspiration
J Am Coll Surg. 2016;222(5):930-47.
When added to general anesthesia and compared with systemic opioid-based pain relief, regional techniques in select patients can reduce pain, sedation frequency, duration of tracheal intubation and mechanical ventilation, time to return of gastrointestinal function, risk of perioperative myocardial infarction, and overall risk of perioperative cardiovascular complications.
A word about PCA, REGIONAL BLOCKS
TAP transverse abdominal plane
ILEOSTOMY vs COLOSTOMY
Anterior vs Posterior
Include a prophylactic pharmacologic bowel regimen such as a stool softener (for example, docusate) and stimulant laxative (for example, stool softener, bisacodyl) when appropriate
PCOD
Neurovision Study and covert stroke
2 RCTs
12 academic centres in nine countries, in which we assessed patients aged 65 years or older who underwent inpatient, elective, non-cardiac surgery and had brain MRI after surgery.
BJA Education, 21(2): 75e82 (2021).
Postoperative cognitive dysfunction describes a decline in
cognitive ability from a patient’s baseline that starts in the
days after surgery and is prevalent in 1% of elderly patients
after 1 y
Discharge planning in the older adult following surgery
The health care team should assess the patient’s social support and need for home health prior to discharge. Where appropriate, the family and caregivers should be involved with discharge planning.
Patient or patient caregiver should be given a complete list of all medications and dosages to continue upon discharge from the hospital. Medication changes made during the hospital stay should be emphasized. A discussion with the patient or patient caregiver should be held and documented with a health care professional regarding the purpose of each drug, how it is to be taken, and the expected side effects and adverse reactions of new medications.
Patients should undergo assessments of the following prior to discharge, and an appropriate follow-up plan should be initiated:
Nutrition (Mini Nutritional Assessment)
b. Cognition (3-Item Recall or Mini Mental State Exam)
c. Ambulation ability (Timed Up and Go Test)
d. Functional statuse. Presence of delirium
If an elderly patient undergoes elective or nonelective inpatient surgery and is being discharged from a hospital to home or to a nursing home, then written discharge instructions should be given and the following should be performed:
Comprehension of verbal discharge instructions should be assessed by checking ability of patient or caretaker to repeat back to the health care provider the discharge instructions
Documentation of pending laboratory tests or diagnostic studies, if applicable
Documentation of follow-up appointment for nonsurgeon physician visits or medical treatments, if applicable
Documentation of follow-up appointment with the surgeon or telephone contact with the surgeon within two to four weeks of discharge
The health care team should document and communicate the clinical history of the patient’s operation, its results, and any postoperative events or concerns with the patient’s primary care doctor.
And interdisciplinary
Frailty
ERAS pathways have been created and implemented in general surgery (colorectal, thyroidectomy, cholecystectomy, hernia), thoracic surgery (esophageal and lung resection) and urology (prostatectomy).
ERAS programs encompass preoperative, intraoperative and postoperative phases. Principal elements include: 1. Preoperative patient education and preparation for surgery; 2. Anesthetic, analgesic and surgical techniques that decrease the surgical stress response, pain and discomfort and postoperative nausea and vomiting; 3. Aggressive postoperative rehabilitation. The aim of the program is to allow for pain and stress-free surgery with reduced complications, faster recovery and to increase patient autonomy and empowerment to participate in their care.
At the intervention site, in-hospital major complications or death decreased by 19% (51 of 153 [33.3%] vs 19 of 140 [13.6%]; P < .001; DID P = .06), and mean (SE) Comprehensive Complication Index decreased by 12.2 (2.5) points (P < .001; DID P < .001). Median length of stay decreased by 3 days (10 [interquartile range (IQR), 6-17] days to 7 [IQR, 5-14] days; P = .001; DID P = .61), and fewer patients required an alternative level of care at discharge (61 of 153 [39.9%] vs 29 of 140 [20.7%]; P < .001; DID P = .11).
Improvement in postoperative pain control and reduction in the use of opioids [2], [3], [4], [5], [6], [7]
Reduction in hospital length of stay [10], [11]
Prevention of hospital readmissions [16]
Reduction in postoperative nausea and vomiting [2]
Faster movement to phase 2 recovery and/or postanesthesia care unit bypass [13]
Earlier participation in physical therapy [10]
Improved patient satisfaction
no difference in rates of recatheterization between early and late catheter removal, with no long-term urinary concerns
Mechanical bowel prep with antibiotics reduces surgical site infections