Why Coffee Protects Against Type II Diabetes
http://buyorganiccoffee.org/1543/why-coffee-protects-against-type-ii-diabetes/
Researchers have known for years that drinking coffee reduces the risk of type II diabetes as we noted in our article, More Organic Coffee Can Lead to Less Diabetes. Now researchers have identified a specific bioactive substance in coffee that stimulates insulin secretion and sugar uptake by muscle cells. The report is in the Journal of Natural Products.
Cafestol, a Bioactive Substance in Coffee, Stimulates Insulin Secretion and Increases Glucose Uptake in Muscle Cells: Studies in Vitro
Diet and exercise intervention can delay or prevent development of type-2-diabetes (T2D), and high habitual coffee consumption is associated with reduced risk of developing T2D. This study aimed to test whether selected bioactive substances in coffee acutely and/or chronically increase insulin secretion from β-cells and improve insulin sensitivity in skeletal muscle cells. Insulin secretion from INS-1E rat insulinoma cells was measured after acute (1-h) and long-term (72-h) incubation with bioactive substances from coffee.
Coffee, Coffea arabica Benth. (Rubiaceae) and Coffea canephora Benth. (Rubiaceae), contains a diversity of bioactive components that varies with coffee species and the roasting and brewing methods.(8-10) The large number of substances includes methylxanthines (especially caffeine), diterpenes (like cafestol and kahweol), the lignan secoisolaricresenol, phenolic acids (e.g., caffeic-, ferulic-, chlorogenic- and quinic acid), trigonelline, minerals, and degradation products.
The specific substance in coffee that stimulates insulin secretion and subsequent uptake of sugar by muscle cells is cafestol. A related compound, caffeic acid has similar effects.