1. Game Changers Cancer Immunotherapies:
Checkpoint Inhibitors
Precision Research & Consulting Pvt. Ltd.
www.idatainsights.com
September 2015

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Table of Content (Draft)Game Changers Cancer Immunotherapies:
Checkpoint Inhibitors
1. Executive Summary
2. Introduction
 PD-1/PD-L1 Pathway
 Role of PD-1/PD-L1 Pathway
 Drugs Targeting the PD-1 vs. PD-L1 Pathway
» Patterns and Evaluation of Response
» Safety
 PD-L1 Inhibitors
 PD-1 Inhibitors
 Rationale for Combination Therapies
 PD-L1 as a Predictive Biomarker
 Cytotoxic T-Lymphocyte Associated Antigen (CTLA-4)
Pathway
3. Case Study 1: Opdivo (Bristol-Myers Squibb)
 Product Profile
 Development Timeline
 Clinical Trial Profiles
 Pricing Scenario
 Regulatory Scenario
 Life Cycle Management Activities
4. Case Study 2: Keytruda (Merck)
 Product Profile
 Development Timeline
 Clinical Trial Profiles
 Pricing Scenario
 Regulatory Scenario
 Life Cycle Management Activities
5. Case Study 3: Yervoy (Bristol-Myers Squibb)
 Product Profile
 Development Timeline
 Clinical Trial Profiles
 Pricing Scenario
 Regulatory Scenario
 Life Cycle Management Activities
6. Efficacy and Safety Comparison on Opdivo,
Keytruda and Yervoy in Melanoma
7. Global Melanoma Market Overview
8. The PD-1 Wave: Opdivo and Keytruda Market Potential
9. KOL Comments: Analysis of Statements from Various KOLs
REPORT HIGHLIGHTS
A MUST BUY FOR
 How checkpoint inhibitors are revolutionizing treatment
options and expectations for cancer patients
 An overview of global melanoma market
 Case studies on Opdivo, Keytruda and Yervoy
 Market potential of Opdivo and Keytruda
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Game Changers Cancer Immunotherapies:
Checkpoint Inhibitors