8. Figure 2. Diagram for the screening of hemoglobin variants, a/b-thalassemia and HPFH/db-
thalassemia.doi:10.1371/journal.pone.0055024.g002
9.
10.
11. G / D (26,7%, 18/73) y de
Q (17,8%, 13/73) y los grupos E (26,7%, 18/73)
grupo K (16,4%, fueron los principales tipos
de hemoglobina anormal.
12/73).
F. mutación de genes de F. mutación de genes de
cadenas cadenas
a-globina = 1.0861023, a-globina = 1.0861023,
b-globina = 1,31. b-globina = 1,31.
61023(73/15299) 61023(73/15299)
Frecuencia heterocigótica de
11,24% -- A talasemia y B 11 muestras tenían
talasemia en la región talasemia A y B
Meizhou frecuencia de 0,63%
un 7,11% de la a-talasemia y
4,13% de b-talasemia
(11/1743).
277 casos de
Hay supresión del Sea
microcitosis (VCM, 82
pa a- talasemia, y
fl)----------- de
supresión o deleccion
15,89% (es decir,
de A3.7-A4.2
277/1743).
12. Resultados de la secuenciación de ADN de los 9 tipos de hemoglobina anormal
(excepto HbE) .
13. Figure 3.
Hemoglobin analysis
of hemoglobin
variants with
cellulose acetate
electrophoresis at
pH= 8.6. The
electrophoresis
phenomenon
includes H, J, K,
Normal, F/Q, G/D
and E.
14. Figure 5. Results of a and b thalassemia in gene chip. A: The results of
a and b thalassemia in the gene chip; B: The location of the probes
dotted in the gene chip used for the reverse dot blot assay. Locations of
wild-type and mutant probes are denoted N and M, respectively.
15. Figure 6. Results of 2 cases of Vietnamese HPFH (FPFH7) were
identified by Gap-PCR.
16.
17. What said? Is true since the article??
Du RF, ed. (2004) The frequency of hemoglobin Not
variants
in the Meizhou region is higher
than the average of
Guangdong
province (0.368%, P,0.05).
Xu XM, Zhou YQ, Luo GX, Liao Our study reveals a high Yes
C, Zhou M, et al. prevalence of a/b-thalassemia
in the
region, which is similar to the
average level of Guangdong
province (11.07%, P = 0.842).
Wang YZ, Jiang GA, Zhang JH, The prevalence of hemoglobin Not
Su WJ, Chen HZ, et al. variants in the Meizhou region
reported in this study (0.477%)
is lower than that reported for
this
area 30 years ago (0.575%)
Du RF, ed. (2004) In this study, the proportion of Yes
abnormal hemoglobin of the
G/D group of the Hakka people
in Meizhou is higher than that
in the
pearl river delta region, such
as Guangzhou.
18.
19. entist
ntries, the sci
that in all cou is diseases,
portant dies abo
ut th tion
Is so im ng stu etter informa
beg i n t o do i , we c an get b edium
ecause with this nd for t
his m
recuency
of
b ple, a the f
about our peo prevalence and and
nate t he bette r explain
determi an d give a es.
semias, t io nal diseas
the tala the rela
nts to
treatme
Taken of : http://es.123rf.com/photo_4193149_caricatura-
cientifico--ilustracion-vectorial.html
20. With the stu
dies that wa
the scientists s di d,
could get t
variations in he
the hemoglo
and wich we bine,
re the estruc
changes in e tural
ach one of t
since some mo hese,
lecular testin
gs.
Taken of:
http://www.oni.escuelas.edu.ar/2011/SANTA_FE/1681/pagina_
nueva_2.htm
21. new
e nerated
pe ople, g o if the
n of the globine, s in
igratio he hemo rld a nd live at
The m ns in t he wo bility of th
io dt
mutat ravel aroun ve a posi g to
t h a his goin
people s countries, alasemia, t ia.
nt ft m
difere ome type o pe of talase
es r ty
if hav wit h othe
co mbine
Taken of: http://desmotivaciones.es/tag/Chinos/6
22. In the fa
milies of
topic, In now
some pop , the money is a
largest, ulations difficult
for this the diffic
governme is so im ulties are
nt, gene portant
people, w rate pro that the
ith money grams to
to the sick help this
.
Taken of:http://www.tuscaloosada.com/office-
divisions/restitution-recovery-unit/money/
26. Bibliography
•Hemoglobinopathy: Molecular Epidemiological
Characteristics and Health Effects on Hakka People in
the Meizhou Region, Southern China, 01 February 2013,
in http://www.ncbi.nlm.nih.gov/pubmed/23383304.
•MARTINEZ S. LINA MARIA, Biología molecular. 6 ed.
Medellin; UPB.fac. de medicina 2011, p 10-14;42-55.
