7. O-GlcNAcylation has no effect on early
stage of muscle differentiation
P = 0.394
0
1
2
3
4
5
6
Vehicle TT04 ThG
FusionIndex(%)
0
2
4
6
8
10
12
Vehicle TT04 ThG
Fusionindex(%)
P = 0.196
P = 0.652P = 0.820
Day 1 Day 2
O-linked beta-D-N-acetylglucosamine (O-GlcNAc), a sugar derivative that links carbohydrate, lipid, protein, energy, and nucleotide metabolisms, is a novel nutrient sensor that functions in gluconeogenesis, circadian clock, and insulin resistance
Studies of knockout O-GlcNAc transferase in mice shows O-GlcNAc signaling plays critical role in the maintenance of satellite cell quiescence and function; O-GlcNAc signaling is an important regulator of skeletal muscle contractility and metabolism; O-GlcNAc signaling serves as nutrient sensor in perturbed nutritional status to maintain metabolic homeostasis in skeletal muscle