A brief description on Ebola.

2. A PRESENTATION ON
Samiran Kumar Ghosh (13-
05406)
Abdur Nur Tushar (14-
06043)
L-5, S-I, FASVM,SAU
Submitted to :
DR. Shah Jungy Ibna Karim
Lecturer,
Dept. of Medicine & Public
Health,
FASVM, SAU

3. Ebola virus disease (EVD), also known as Ebola
hemorrhagic fever (EHF) or simply Ebola, is a viral
hemorrhagic fever of humans and other non-human
primates such as monkeys, chimpanzees, and gorillas
caused by ebolaviruses.

4. • Order : Mononegavirales
• Enveloped, nonsegment, negative stranded RNA viruses
• Family : Filoviridae, contains 3 genera :
I. Ebola virus (1976)
II. Marburg virus
III.Cueva virus
• Genus : Ebola virus, named after the ebola river where it was
first found.

6. The disease was first identified in 1976, in two simultaneous outbreaks: one in Nzara (a
town in South Sudan) and the other in Yambuku (Democratic Republic of the Congo), a
village near the Ebola River from which the disease takes its name.
Between 1976 and 2013, the World Health Organization reports 24 outbreaks involving
2,387 cases with 1,590 deaths.
The largest outbreak to date was the epidemic in West Africa, which occurred
from December 2013, to January 2016, with 28,646 cases and 11,323 deaths.
In July 2019, the WHO declared the Congo Ebola outbreak a world health
emergency.

14. • Symptoms are non-specific; clinical diagnosis may be difficult.
• Differential diagnosis includes other viral haemorrhagic fevers,
yellow fever, malaria, typhoid fever, shigellosis, and other viral and
bacterial diseases.
• Patient history is essential and should include:
a) Contact with a dead or sick animal;
b) Contact with a suspected, probable or confirmed Ebola patient

15. Reverse transcriptase polymerase chain reaction (RT-PCR)
assay
IgG and IgM antibodies with enzyme-linked immunosorbent
assay (ELISA)
Antigen detection tests
Virus isolation by cell culture
Serum neutralization test.
Electron microscopy

16. • There are no licensed specific treatment.
• Patients are Frequently dehydrated and requires oral rehydration with
solution containing electrolyte.
• New drug therapies are bieng evaluated.
• Recommended care includes:
Volume repletion
Maintenance of blood pressure (with vasopressors if needed)
Maintenance of oxygenation
 Pain control
Nutritional support
Treating secondary bacterial infections and pre-existing comorbidities.

18. Vaccination :
•An experimental Ebola vaccine proved
highly protective against EVD in a major
trial in Guinea in 2015. The vaccine,
called rVSV-ZEBOV.