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Nano Biomaterials

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Nano Biomaterials

  1. 1. Alpesh Maru, 5th Semester, Biomedical Department. October 5th , 2016 Smaller World of Large Surface Area Nano Biomaterials
  2. 2. o Nanomaterials ¬
  3. 3. o Classification of Nanomaterials ¬ (a) 0D spheres and clusters, (b) 1D nanofibers, wires, and rods, (c) 2D films, plates, and networks, (d) 3D nanomaterials.
  4. 4. o Tissue regeneration and tissue engineering ¬  Development of tissues and organs is typically driven by the the action of multiple growth factors. Role of vascular growth factors in vessel formation. • Stage A: Vasculogenesis • Stage B: Angiogenic remodelling • Stage C: Stabilization and maturation • Stage D: Destabilization • Stage E: Regression • Stage F: Sprouting
  5. 5. o Tissue regeneration and tissue engineering ¬  Polymer scaffold fabrication for growth factor release. • Growth factors incorporated into polymer scaffolds by either (1) mixing with polymer particles before processing into scaffolds, (2) pre-encapsulating the factors into polymer microspheres that are then used to form scaffolds.
  6. 6. o Degradable solid polymers ¬
  7. 7. o Classes of materials used in vivo ¬  Biodegradable: Breaks down by hydrolysis or enzymatic cleavage to form metabolized products  Bioeliminable: Do not degrade; water-soluble, excretable  Permanent or retrievable materials: Not degradable or excretable; requires surgery for removal
  8. 8. o Estimated values of e and Lcritical for selected degradable polymers ¬
  9. 9. o Targeted Drug Delivery System ¬
  10. 10.  References ¬ i. Introduction to Nanomaterials by A. Alagarasi. ii. Nanomaterials, Application in medicine & biology by Kim A. Woodrow by University of Washington. iii. Fundamental of Nanomaterial, MTX9100(M.I.T. Lecture series).

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