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MUMTAZ ALI
JPMC KARACHI
Anatomy
 Cerebellum : posteriorly
 brainstem : anteriorly
 middle cerebellar peduncle : laterally
 aqueduct of Sylvius to the obex
 ventral floor : dorsal surface of the lower midbrain
 lateral wall : superior, middle, and inferior
cerebellar peduncles
 lateral recess
 superior part of the roof : lingula, the superior
medullary velum, and the fastigium
 inferior part of the roof : tela choroidea, the
choroid plexus, the inferior medullary velum, the
uvula and nodulus of the vermis
Ependymomas
 most common
 2–3%
 Ependymal cells
 lower floor of the fourth ventricle
 occupy : ventricular cavity
 extend : foramen of Luschka or foramen of Magendie
 soft, grayish or red tumors : cysts or mineral
calcifications
 ultrasonic aspirator
 Types :
myxopapillary ependymomas
subependymomas,
Ependymomas
anaplastic ependymomas
 Grading :
Similarty to ependymal cells
 10–15% spread : CSF
Medulloblastomas
 Primitive underdeveloped cells
 childhood
 1st described : Harvey Cushing (1930)
 Spongioblastoma cerebelli ; a soft suckable tumor
 7 %
 not invade the floor of the fourth ventricle
 middle cerebellar peduncles
 completely filled with tumor up to the aqueduct
 neuraxis and cerebellum
 highly vascularized
Hemangioblastomas
 highly vascularized lesions
 PICA and choroid plexus
 digital subtraction angiograms
 cannot be debulked because of their typical
morphology
Epidermoid Cysts
 fill the fourth ventricle completely and expand into the
lateral recess
 separated by firm arachnoid membranes
Pilocytic Astrocytomas
 well-circumscribed
 Very rare tumor
Clinical Features
 deep location within the brain
 neural and vascular structures
 CSF physiology alteration
 compressive or destructive effects
 Headache
 Vertigo
 Nausea and vomitting sec to Acute HCP
 motor weakness
 memory deficits
 gait disturbances
Investigations
 Routine :
cbc
suce
pt/aptt/inr
LFT
Hep B and C
chest xray
Ecg and Echo
G/A fitness
 Specific :
CT scan
MRI
Angiogram
DSA
• Relevant :
Perimetry
visual acuity
fundoscopy
Surgery
 Tumors often hidden :
Vermis
the cerebellar tonsils
part of the cerebellar hemispheres
Brain stem
• tumor extends through the foramen of Luschka :
Cerebellomedullary cisterns
Premedullary cisterns
Prepontine cisterns
anterior spinal cisterns
 has relation :
cranial nerves
 vertebral arteries
basilar arteries
Transvermian approach
 splitting the vermis : Dandy
 vermal split syndrome :
removal of midline tumors involving the vermis
disturbed coordination of tandem gait
neurobehavioral changes
Telovelar Approach
 Transcerebellomedullary fissure approach
 standard median suboccipital craniotomy
 transverse sinus to the foramen magnum
 Sitting or prone
 C1 lamina
 The dura : Y-shaped fashion
 arachnoid membranes
 PICA and its branches
 cerebellomedullary fissure
 telovelar incision :
opening of the tela choroidea
inferior medullary velum
incision of the tela
Complications
 Intraoperative :
Injury to PICA
Injury to CN
Injury to vertebral arteries
 Postoperative :
HCP
CSF leak
Seizure
Cognitive functions
Wound infection
THANKYOU

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Fourth ventricular tumors

  • 2. Anatomy  Cerebellum : posteriorly  brainstem : anteriorly  middle cerebellar peduncle : laterally  aqueduct of Sylvius to the obex  ventral floor : dorsal surface of the lower midbrain
  • 3.  lateral wall : superior, middle, and inferior cerebellar peduncles  lateral recess  superior part of the roof : lingula, the superior medullary velum, and the fastigium  inferior part of the roof : tela choroidea, the choroid plexus, the inferior medullary velum, the uvula and nodulus of the vermis
  • 4. Ependymomas  most common  2–3%  Ependymal cells  lower floor of the fourth ventricle  occupy : ventricular cavity  extend : foramen of Luschka or foramen of Magendie  soft, grayish or red tumors : cysts or mineral calcifications  ultrasonic aspirator
  • 5.  Types : myxopapillary ependymomas subependymomas, Ependymomas anaplastic ependymomas  Grading : Similarty to ependymal cells  10–15% spread : CSF
  • 6.
  • 7. Medulloblastomas  Primitive underdeveloped cells  childhood  1st described : Harvey Cushing (1930)  Spongioblastoma cerebelli ; a soft suckable tumor  7 %
  • 8.  not invade the floor of the fourth ventricle  middle cerebellar peduncles  completely filled with tumor up to the aqueduct  neuraxis and cerebellum  highly vascularized
  • 9.
  • 10.
  • 11. Hemangioblastomas  highly vascularized lesions  PICA and choroid plexus  digital subtraction angiograms  cannot be debulked because of their typical morphology
  • 12.
  • 13. Epidermoid Cysts  fill the fourth ventricle completely and expand into the lateral recess  separated by firm arachnoid membranes
  • 14.
  • 16.
  • 17. Clinical Features  deep location within the brain  neural and vascular structures  CSF physiology alteration  compressive or destructive effects
  • 18.  Headache  Vertigo  Nausea and vomitting sec to Acute HCP  motor weakness  memory deficits  gait disturbances
  • 19. Investigations  Routine : cbc suce pt/aptt/inr LFT Hep B and C chest xray Ecg and Echo G/A fitness
  • 20.  Specific : CT scan MRI Angiogram DSA • Relevant : Perimetry visual acuity fundoscopy
  • 22.  Tumors often hidden : Vermis the cerebellar tonsils part of the cerebellar hemispheres Brain stem • tumor extends through the foramen of Luschka : Cerebellomedullary cisterns Premedullary cisterns Prepontine cisterns anterior spinal cisterns
  • 23.  has relation : cranial nerves  vertebral arteries basilar arteries
  • 24. Transvermian approach  splitting the vermis : Dandy  vermal split syndrome : removal of midline tumors involving the vermis disturbed coordination of tandem gait neurobehavioral changes
  • 25. Telovelar Approach  Transcerebellomedullary fissure approach  standard median suboccipital craniotomy  transverse sinus to the foramen magnum  Sitting or prone  C1 lamina  The dura : Y-shaped fashion  arachnoid membranes  PICA and its branches
  • 26.  cerebellomedullary fissure  telovelar incision : opening of the tela choroidea inferior medullary velum incision of the tela
  • 27.
  • 28. Complications  Intraoperative : Injury to PICA Injury to CN Injury to vertebral arteries  Postoperative : HCP CSF leak Seizure Cognitive functions Wound infection