1. Analysis of Prognostic Factors Influencing the Survival of Patients with Relapsed Follicular Lymphoma M.V.LOMONOSOV MOSCOW STATE UNIVERSITY FAULTY OF BASIC MEDICINE Presented by: Dr.Zaw Htet Scientific supervisors: Prof.Dr.B.I.Polikov, Dr.D.A.Bykov Moscow,2010

7. Main Characteristics of Patients at diagnosis and at relapse (n=69)

8. Prognostic factors for survival from progression(SFP) in patients with follicular lymphoma at relapse : Results of univariate analysis (n=69) Variable No. of Patients Mortality (%) 5-year SFP P value Stage at diagnosis I-II III-IV Age <60 years ≥ 60 years Bulky disease No Yes ECOG 0-1 ≥ 2 Serum LDH <450 U/L ≥ 450 U/L Bone marrow involvement No Yes 11 61 42 30 56 7 57 8 38 10 18 15 14 53 41 54 35 89 37 90 27 67 17 53 82 42 60 28 54 22 53 11 56 44 81 23 0.02 0.07 0.007 0.0002 0.015 0.002

9. Continued: Variable No. of patients Mortality (%) 5-year SFP P value Stage at relapse I-II III-IV IPI Low Inter/High Duration of response <2 years ≥ 2 years Transformation No Yes Initial Response CR PR Response to salavage therapy CR PR NR 22 44 38 28 41 31 28 7 31 38 26 22 15 26 51 25 66 55 36 33 33 44 49 26 48 90 68 34 72 13 33 63 63 62 44 48 57 59 0 0.003 <0.0001 0.012 NS NS <0.0001

12. 5-years SFP according to response duration(RD) to first line therapy

13. 5-years SFP according to performance status (ECOG) and response duration(RD)

14. 5-years SFP according to performance status(ECOG) and response duration (RD)

16. Cause-specific survival from progression