facility management

3. Hilton J. Klein, M.S., V.M.D. Overview and introduction

4. What is a program?

5. Rising costs of research and research trends …

6. Rapidly increasing R&D costs

7. New targets from genomics

15. Performance standards

16. "Performance standards define an outcome in detail and provide criteria for assessing that outcome, but do not limit the methods by which to achieve that outcome."

20. Hager Hauler

24. Kathryn A. L. Bayne, M.S., Ph.D., D.V.M. Review of commonly cited facility problems

25. Over 640 accredited institutions ... … in 18 countries

26. Proportion of accredited units By facility size (sq. feet)

27. Animal care and use program deficiencies

40. www.aaalac.org/connection_1su1998.htm

42. James F. Taylor, D.V.M., M.S. Design of facilities – the AAALAC perspective

65. Stephen T. Kelley, M.S., D.V.M. Performance standards and facility design and operation

66. AAALAC International uses recognized references for performance standards… www.aaalac.org/resources

74. Facility location and traffic patterns

76. Traffic - reduce potential for contamination

89. Standard operating procedures and training

90. The key element necessary to assure high levels of performance standards: Well trained and dedicated personnel

91. Case studies

92. Case Study #1 HVAC Observation Site visitors conducted a site visit at a respected, small research institute conducting infectious disease studies involving Biosafety Level 2 agents. There were a total of six (6) animal rooms housing either rats or mice. The HVAC report below was provided as an attachment to the program description.

93. Room No. Filtration Air Exchanges Air Pressure Differential 1101 HEPA 11.8/hr (fresh) Negative 1202 HEPA 8.2/hr (fresh) Negative 1303 HEPA 7.8/hr (fresh) Negative 1404 HEPA 10.4/hr (fresh) Negative 1505 HEPA 12.0 (fresh) Negative 1606 HEPA 8.0 (fresh) Negative Surgery/Necropsy HEPA 14.0/hr (fresh) Negative

94. Follow up All rooms were sanitized at weekly intervals by wet-mopping the floor and wiping the walls down with an appropriate mild quaternary ammonium disinfectant. Cages were sanitized appropriately twice weekly. Bedding was also changed once in a hood between cage sanitation cycles. Upon entering the rooms, site visitors observed the following cage and stocking densities …

96. Case Study #2 Elevator access Observation A site visit to a large university biomedical research program indicated that a small colony (n=25 adults) of macaques was housed in the top floor of a “satellite” building. The research involved behavioral testing and brain imaging which was conducted in separate laboratories within the same building. The behavioral test lab and the imaging lab were accessible only by an elevator which was also used to transport non-laboratory personnel. Cage washing facilities were located in the basement of the building.

99. Case Study #3 After-hours monitoring Upon careful review of the written Program Description, site visitors concluded that after-hours monitoring of the animal rooms in a 45 year old animal facility consisted of: a) recording the high-low temperature readings in the room on a log sheet by the animal caretaker, and b) the security guard making rounds to ensure the corridor and hallway doors are closed. This process was confirmed during the site visit. more…

100. Case Study #3 After-hours monitoring (cont’d) Additional background information revealed a steam injector valve in the room humidification control system had stuck in the open position overnight six months prior to the site visit. This room housed 50 rats on a respiratory/inhalation study at the time. Animal care staff realized the room temperature had reached 105ºF overnight because of the steam valve defect. Fifteen animals were found dead the next morning. Within two days, the study was terminated because of twenty (80%) percent mortality in the controls and test animals. Excessive respiratory problems were observed in the remaining animals which invalidated the study.