it is the study of factors influencing the rate and amount of drug that reaches the systemic circulation and the use of this information to optimize the therapeutic efficacy of the drug product. It is the science of preparing, using, and administering drugs to living organisms or tissues Metabolism (biotransformation): irreversible transformation of parent compounds into daughter metabolites. Elimination ( Excretion): removal of the drug from the body and terminate it action. Drug deposition- together they k/w as distribution and elimination

1. Biopharmaceutics and
Pharmacokinetics
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2.  Biopharmaceutics
 It is the science of preparing, using, and administering drugs to living organisms
or tissues
Biopharmaceutics
Bio
Relating to living
organisms or tissues
Pharmaceutics
Involves the
preparation, use, or
dispensing of medicines
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3. Biopharmaceutics
 It is study of factor influencing rate and extent of drug reaches the
systemic circulation and the use of this information to optimize the
efficacy of the drug product.
 It is the interrelationship of the physicochemical properties of the drug
(API) and the drug product (dosage form) based on the biological
performance of the drug.
 Bioavailability: The rate and extent of drug absorption
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5.  Biopharmaceutics uses
 Quantitative methods
 Theoretical models
 Purpose
 To evaluate the effect of the drug substance, dosage form, and routes of
drug administration on the therapeutic requirements of the drug and drug
product in a physiological environment.
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7. Pharmacokinetics:
 The study of the time course (kinetics) of ADME and their relationship with it
therapeutics and toxic effect of drug.
 It is the kinetics of ADME or KADME
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8.  Absorption: movement of drug from its site of administration to systemic
circulation.
 Distribution: movement of drug between blood and extravascular tissue.

9.  Metabolism (biotransformation): irreversible transformation of parent
compounds into daughter metabolites.
 Elimination ( Excretion): removal of the drug from the body and terminate it
action.
 Drug deposition- together they k/w as distribution and elimination

10.  Clinical pharmacokinetics – use of pharmacokinetics principle in
optimizing the drug dosage to suit individual patient need and
achieving maximum therapeutic utility.
 Dosage regimen- manner in which drug should be taken

11.  Studies of biopharmaceutics involves both in-vitro and in-vivo methods.
 In-vitro methods involve test apparatus without involving laboratory animals or
humans.
E.g. disintegration tests, dissolution tests etc.
 In-vivo test involves measurement of systemic drug availability (bioavailability)
after giving a drug product to an animal or human

13.  Drugs - substances intended for use in the diagnosis, cure, mitigation,
treatment, or prevention of disease.
 Drugs are given in a variety of dosage forms or drug products such as
solids, semisolids, liquids etc, for systemic or local therapeutic activity.

14.  Dose: Amount of drug that is safe, measured and clinically effective for
human administration is called dose.
 Drug products can be considered to be
 Drug delivery systems that release and deliver drug to the site of
action for the desired therapeutic effect
 Drug product performance- Release of the drug from the drug product either for
 Local drug action
 Systemic action ( drug absorption into the plasma).
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15. Application of biopharmaceutics
 With help of biopharmaceutics we can change various formulation factors to
obtain optimum onset of action and duration of action.
 Bioavailability of new tablets is compared with the old tablets ( if bioequivalent)
then the new tablets will be permitted to market (by FDA).
 To understand process administration of drug , which affects onset and intensity
of biological response.
 To access plasma drug concentration response to given dose .
 In design and utilization of in vitro model system
 In design and development of new drug and their appropriate dosage regimen.

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