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Mike Silverman
 Rodion Stolyar
Francis McCarthy
The Power of Modern Neuroscience

• http://www.youtube.com/watch?feature
  =player_embedded&v=nsjDnYxJ0bo#!
1. Mind Reading   2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
   Summary        representation      environments      representation    and Discussion
1. Mind Reading   2. Simple thought     3. Familiar   4. Complex thought   5. Conclusions
   Summary        representation       environments      representation    and Discussion


                                      History
  • First “Brain Imaging
    Experiment”

  • Angelo Mosso

  • Italian Physiologist

  • Major Break through
1. Mind Reading   2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
   Summary        representation      environments      representation    and Discussion


                  How does fMRI work?
  • What causes an fMRI signal? Is it A or B?

  • A) fMRI measures the REDUCTION in the
    amount of paramagnetic deoxygenated
    hemoglobin in neural tissue from a resting
    state to an active state.
  • B) fMRI measures the INCREASE in the amount
    of paramagnetic deoxygenated hemoglobin in
    neural tissue from a resting state to an active
    state.
1. Mind Reading   2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
   Summary        representation      environments      representation    and Discussion


                  How does fMRI work?
              Resting State                               Active State
1. Mind Reading   2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
   Summary        representation      environments      representation    and Discussion



                  Just and Mitchell’s Methods
                  • fMRI data from 9 healthy college aged
Tom Mitchell        participants
                  • Randomly viewed 60 different word-
                    picture pairs 6x
                  • Signal for each word-picture pair was
 Marcel Just        recorded and averaged.
                  • Average signal used as baseline and
                    compared to new fMRI signal from a
                    new participant
1. Mind Reading   2. Simple thought    3. Familiar        4. Complex thought     5. Conclusions
   Summary        representation      environments           representation      and Discussion




                                                     Repeated for all 9 participants.
1. Mind Reading   2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
   Summary        representation      environments      representation    and Discussion


             Do different people have the same
             type of brain activation patterns?
1. Mind Reading   2. Simple thought          3. Familiar      4. Complex thought      5. Conclusions
   Summary        representation            environments         representation       and Discussion




                                      NEW participant gets in the fMRI machine and looks at the
                                      same word-pictures
                                      BUT this time the computer does not know what pictures
                                      the participant is looking at, it ONLY sees the brain activity
                                      pattern
1. Mind Reading      2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
   Summary           representation      environments      representation    and Discussion


                  Do different people have the same
                       type of brain activation?

 New participants’
 brain activity
 patterns
1. Mind Reading    2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
    Summary         representation      environments      representation    and Discussion




John-Dylan Haynes

                            Have you been
                            here before?
1. Mind Reading    2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
    Summary         representation      environments      representation    and Discussion




John-Dylan Haynes
1. Mind Reading    2. Simple thought      3. Familiar     4. Complex thought       5. Conclusions
    Summary         representation        environments        representation        and Discussion




                            The earliest technique to see unconscious processing.

John-Dylan Haynes           Haynes elaborates on this phenomenon.
1. Mind Reading    2. Simple thought        3. Familiar     4. Complex thought         5. Conclusions
    Summary         representation          environments        representation          and Discussion




                           Neural decision before conscious
                             awareness of the decision
John-Dylan Haynes                                                         Conscious decision




                                    EEG signals before the “feeling of wanting”
                                    entered consciousness!

                                    Challenged our concept of free will
1. Mind Reading    2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
    Summary         representation      environments      representation    and Discussion




John-Dylan Haynes
1. Mind Reading    2. Simple thought     3. Familiar   4. Complex thought   5. Conclusions
     Summary         representation       environments      representation    and Discussion




                        Step 1: decode

John-Dylan Haynes


        Step 2: give to
        computer to classify



                        Step 3: predict
1. Mind Reading   2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
   Summary        representation      environments      representation    and Discussion



    Conclusions
  • Using fMRI data, software can now accurately
    predict what a human is thinking.

  • fMRI data is incredibly useful and flexible.

  • Mind “Reading” is now a reality in laboratories
    with fMRI machines.
1. Mind Reading   2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
   Summary        representation      environments      representation    and Discussion




        Discussion question 1
        In the realm of criminal justice, do you think brain pattern
        activation is equivocal with physical evidence such as DNA,
        semen, etc. or is it equivocal with personal testimony and
        protected by the fifth amendment?
1. Mind Reading   2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
   Summary        representation      environments      representation    and Discussion




        Discussion question 2
        Can we be decisive when making conclusions about what a
        pattern of brain activity means?

        i.e. What if my brain says “I love chocolate chip cookies”
        but I say that I don’t like chocolate chip cookies at all.
        Can we be CERTAIN?




                                          =
1. Mind Reading   2. Simple thought    3. Familiar   4. Complex thought   5. Conclusions
   Summary        representation      environments      representation    and Discussion




        Discussion question 3
        We mentioned Hayne’s study where Haynes could predict
        what decision you’re going to make 7 seconds before you
        are consciously aware of your own decision. Do you think
        this interferes with the notion of free will?
The End
SkyNet is coming…be prepared…

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Mind Reading

  • 1. Mike Silverman Rodion Stolyar Francis McCarthy
  • 2. The Power of Modern Neuroscience • http://www.youtube.com/watch?feature =player_embedded&v=nsjDnYxJ0bo#!
  • 3. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion
  • 4. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion History • First “Brain Imaging Experiment” • Angelo Mosso • Italian Physiologist • Major Break through
  • 5. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion How does fMRI work? • What causes an fMRI signal? Is it A or B? • A) fMRI measures the REDUCTION in the amount of paramagnetic deoxygenated hemoglobin in neural tissue from a resting state to an active state. • B) fMRI measures the INCREASE in the amount of paramagnetic deoxygenated hemoglobin in neural tissue from a resting state to an active state.
  • 6. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion How does fMRI work? Resting State Active State
  • 7. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion Just and Mitchell’s Methods • fMRI data from 9 healthy college aged Tom Mitchell participants • Randomly viewed 60 different word- picture pairs 6x • Signal for each word-picture pair was Marcel Just recorded and averaged. • Average signal used as baseline and compared to new fMRI signal from a new participant
  • 8. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion Repeated for all 9 participants.
  • 9. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion Do different people have the same type of brain activation patterns?
  • 10. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion NEW participant gets in the fMRI machine and looks at the same word-pictures BUT this time the computer does not know what pictures the participant is looking at, it ONLY sees the brain activity pattern
  • 11. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion Do different people have the same type of brain activation? New participants’ brain activity patterns
  • 12. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion John-Dylan Haynes Have you been here before?
  • 13. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion John-Dylan Haynes
  • 14. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion The earliest technique to see unconscious processing. John-Dylan Haynes Haynes elaborates on this phenomenon.
  • 15. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion Neural decision before conscious awareness of the decision John-Dylan Haynes Conscious decision EEG signals before the “feeling of wanting” entered consciousness! Challenged our concept of free will
  • 16. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion John-Dylan Haynes
  • 17. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion Step 1: decode John-Dylan Haynes Step 2: give to computer to classify Step 3: predict
  • 18. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion Conclusions • Using fMRI data, software can now accurately predict what a human is thinking. • fMRI data is incredibly useful and flexible. • Mind “Reading” is now a reality in laboratories with fMRI machines.
  • 19. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion Discussion question 1 In the realm of criminal justice, do you think brain pattern activation is equivocal with physical evidence such as DNA, semen, etc. or is it equivocal with personal testimony and protected by the fifth amendment?
  • 20. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion Discussion question 2 Can we be decisive when making conclusions about what a pattern of brain activity means? i.e. What if my brain says “I love chocolate chip cookies” but I say that I don’t like chocolate chip cookies at all. Can we be CERTAIN? =
  • 21. 1. Mind Reading 2. Simple thought 3. Familiar 4. Complex thought 5. Conclusions Summary representation environments representation and Discussion Discussion question 3 We mentioned Hayne’s study where Haynes could predict what decision you’re going to make 7 seconds before you are consciously aware of your own decision. Do you think this interferes with the notion of free will?
  • 22. The End SkyNet is coming…be prepared…

Editor's Notes

  1. The left clip is a segment of a Hollywood movie trailer that the subject viewed while in the magnet. The right clip shows the reconstruction of this segment from brain activity measured using fMRI. The procedure is as follows:[1] Record brain activity while the subject watches several hours of movie trailers.[2] Build dictionaries (i.e., regression models) that translate between the shapes, edges and motion in the movies and measured brain activity. A separate dictionary is constructed for each of several thousand points at which brain activity was measured.(For experts: The real advance of this study was the construction of a movie-to-brain activity encoding model that accurately predicts brain activity evoked by arbitrary novel movies.)[3] Record brain activity to a new set of movie trailers that will be used to test the quality of the dictionaries and reconstructions.[4] Build a random library of ~18,000,000 seconds (5000 hours) of video downloaded at random from YouTube. (Note these videos have no overlap with the movies that subjects saw in the magnet). Put each of these clips through the dictionaries to generate predictions of brain activity. Select the 100 clips whose predicted activity is most similar to the observed brain activity. Average these clips together. This is the reconstruction.
  2. Paul Root Wolpe
  3. Check this with Jonides
  4. EXPLANATION: At both the resting state and active state, fMRI measures the amount of paramagnetic deoxygenated hemoglobin in a neural tissue.Logically you would think, active tissue uses more oxygen, expect to see more deoxygenated hemoglobin in neural tissue during an active stateBUT the increased blood flow pushes deoxygenated hemoglobin out of the area so fast that fMRI actually measures a REDUCTION from the resting stateTo the active state.
  5. Learned voxelactivation signatures for3 of the 25 semantic features,for participant P1(top panels) and averagedover all nine participants(bottom panels). Just onehorizontal z slice is shownfor each. The semantic featureassociated with theverb “eat” predicts substantialactivity in rightpars opercularis, which isbelieved to be part of thegustatory cortex. The semanticfeature associatedwith “push” activates theright postcentralgyrus,which is believed to beassociated with premotorplanning. The semantic feature for the verb “run” activates the posterior portion of the right superior temporalsulcus, which is believed to be associated with the perception of biological motion.
  6. Edit this image to have new word - pictures
  7. How accurate?Learned voxelactivation signatures for3 of the 25 semantic features,for participant P1(top panels) and averagedover all nine participants(bottom panels). Just onehorizontal z slice is shownfor each. The semantic featureassociated with theverb “eat” predicts substantialactivity in rightpars opercularis, which isbelieved to be part of thegustatory cortex. The semanticfeature associatedwith “push” activates theright postcentralgyrus,which is believed to beassociated with premotorplanning. The semantic feature for the verb “run” activates the posterior portion of the right superior temporalsulcus, which is believed to be associated with the perception of biological motion.
  8. http://www.bccn-berlin.de/digitalAssets/0/680_HaveYouBeenHereBefore_Xvid_English_LowResolution.aviThis will take some time 3-4 minutes
  9. Example of voxel selectivity for a representativesearchlight (position with peak decoding accuracy in frontopolar cortex). Thespherical clusters at that position are shown for all 12 subjects. The selectivity foreach voxel for either a left or right decision is colour coded in blue and yellowrespectively. The selectivity profiles clearly indicate that some voxels areactivated stronger preceding either left or right decisions, thus pointing towards adistributed encoding of long-term predictive information.If all three of these brain regions are activated 7 seconds prior, we can
  10. At a resting state, fMRI measures the amount of paramagnetic deoxygenated hemoglobin in a neural tissue.Active State,Increased Blood Flow,Oxygenated blood-paramagnetic,fMRI measures signal difference
  11. Learned voxelactivation signatures for3 of the 25 semantic features,for participant P1(top panels) and averagedover all nine participants(bottom panels). Just onehorizontal z slice is shownfor each. The semantic featureassociated with theverb “eat” predicts substantialactivity in rightpars opercularis, which isbelieved to be part of thegustatory cortex. The semanticfeature associatedwith “push” activates theright postcentralgyrus,which is believed to beassociated with premotorplanning. The semantic feature for the verb “run” activates the posterior portion of the right superior temporalsulcus, which is believed to be associated with the perception of biological motion.
  12. Mental representations of objects vary between people.However, similarities exist.Not a carbon copy, but similar enough.