34. Indications for and Contraindications to Parenteral Anticoagulant Agents www.freelivedoctor.com Anticoagulant Agent Class Approved & Appropriate Indications Contraindication Unfractionated heparin Enoxaparin ( Lovenox ) Dalteparin ( Fragmin ) Tinzaparin ( Innohep ) Antithrombin III inhibitor Low-molecular-weight heparin Low-molecular-weight heparin Low-molecular-weight heparin Treatment of venous thromboembolism or unstable angina; used when rapid reversal is important Prophylaxis in moderate-risk or high-risk patients, treatment of venous thromboembolism or unstable angina Prophylaxis in moderate-risk or high-risk patients, treatment of venous thromboembolism or unstable angina Prophylaxis in moderate-risk or high-risk patients, treatment of venous thromboembolism ? Prophylactic treatment Regional anesthesia Pregnancy Prosthetic Heart Valves Regional anesthesia Regional anesthesia
35. Indications for and Contraindications to Parenteral Anticoagulant Agents (cont’d) www.freelivedoctor.com Ardeparin Lepirudin Argatroban Danaparoid Bivalirudin Fondaparinux ( Arixtra ) Low-molecular-weight heparin Hirudin derivative Direct thrombin inhibitor Heparinoid Hirudin derivative Synthetic factor Xa inhibitor Approved; not being marketed Heparin-induced thrombocytopenia with thrombosis Heparin-induced thrombocytopenia with thrombosis Prophylaxis against thrombosis in heparin-induced thrombocytopenia Unstable angina or angioplasty Prophylaxis in high-risk patients? Regional anesthesia Thrombocytopenia other than heparin-induced thrombocytopenia Thrombocytopenia other than heparin-induced thrombocytopenia Thrombocytopenia other than heparin-induced thrombocytopenia Unknown Unknown
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